Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

(2022) Chenglong Xie et al.   Nature Biomedical Engineering

Accumulation of APP-CTF induces mitophagy dysfunction in the iNSCs model of Alzheimer’s disease

(2022) Seung-Eun Lee et al.   Cell Death Discovery

Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?

(2021) Frédéric Checler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease

(2021) Vicente Roca-Agujetas et al.   Molecular Neurodegeneration

microRNA-204 Silencing Reduces Mitochondrial Autophagy and Reactive Oxygen Species Production in a murine Alzheimer's Disease model via the TRPML1-Activated STAT3 Pathway

(2021) Lu Zhang et al.   Molecular Therapy-Nucleic Acids

Re-emphasizing early Alzheimer’s disease pathology starting in select entorhinal neurons, with a special focus on mitophagy

(2021) Asgeir Kobro-Flatmoen et al.   AGEING RESEARCH REVIEWS

PINK1 Activation Attenuates Impaired Neuronal-Like Differentiation and Synaptogenesis and Mitochondrial Dysfunction in Alzheimer’s Disease Trans-Mitochondrial Cybrid Cells

(2021) Fang Du et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Pathway in Alzheimer’s Disease

(2021) Harald Hampel et al.   MOLECULAR PSYCHIATRY

ApoE4 attenuates autophagy via FoxO3a repression in the brain

(2021) Hee-Young Sohn et al.   Scientific Reports

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

(2021) Se-In Lee et al.   Stem Cell Reports

Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover

(2021) Karolina Drabik et al.   Antioxidants

Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing

(2021) Ole Kristian Reiten et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Parkin overexpression attenuates Aβ-induced mitochondrial dysfunction in HEK293 cells by restoring impaired mitophagy

(2020) Hongmei Wang et al.   LIFE SCIENCES

Treadmill Exercise Attenuates Aβ-Induced Mitochondrial Dysfunction and Enhances Mitophagy Activity in APP/PS1 Transgenic Mice

(2020) Na Zhao et al.   NEUROCHEMICAL RESEARCH

Dietary flavonols and risk of Alzheimer dementia

(2020) Thomas M. Holland et al.   NEUROLOGY

β-Asarone Inhibits Amyloid-β by Promoting Autophagy in a Cell Model of Alzheimer's Disease

(2020) Nanbu Wang et al.   Frontiers in Pharmacology

Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

(2020) Leena P. Bharath et al.   Cell Metabolism

Tetrahydroxy stilbene glycoside alleviated inflammatory damage by mitophagy via AMPK related PINK1/Parkin signaling pathway

(2020) Yan Gao et al.   BIOCHEMICAL PHARMACOLOGY

Trehalose against Alzheimer's Disease: Insights into a Potential Therapy

(2020) Masoomeh Khalifeh et al.   BIOESSAYS

Mitophagy regulates integrity of mitochondria at synapses and is critical for synaptic maintenance

(2020) Sinsuk Han et al.   EMBO REPORTS

β-Asarone improves learning and memory in Aβ1-42-induced Alzheimer’s disease rats by regulating PINK1-Parkin-mediated mitophagy

(2020) Yufeng Han et al.   METABOLIC BRAIN DISEASE

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

(2020) Eran Schmukler et al.   Cell Death & Disease

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy

(2020) Ming Yang et al.   Frontiers in Cell and Developmental Biology

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

(2020) Loan Vaillant-Beuchot et al.   ACTA NEUROPATHOLOGICA

Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans

(2020) Xin Yang et al.   Aging-US

Alterations in mitochondrial dynamic-related genes in the peripheral blood of Alzheimer’s disease patients

(2020) Nattaporn Pakpian et al.   Current Alzheimer Research

Long-term oral melatonin alleviates memory deficits, reduces amyloid-β deposition associated with downregulation of BACE1 and mitophagy in APP/PS1 transgenic mice

(2020) Cuimei Sun et al.   NEUROSCIENCE LETTERS

The effect of fasting or calorie restriction on mitophagy induction: a literature review

(2020) Sanaz Mehrabani et al.   Journal of Cachexia Sarcopenia and Muscle

Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin–mediated mitophagy

(2020) Na Zhao et al.   Journal of Sport and Health Science

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol

(2019) Adele Chimento et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders

(2019) Yan‐Rong Zheng et al.   CNS Neuroscience & Therapeutics

Mitophagy and NAD+ inhibit Alzheimer disease

(2019) Evandro F. Fang   Autophagy

Metformin promotes mitophagy in mononuclear cells: a potential in vitro model for unraveling metformin's mechanism of action

(2019) Shipra Bhansali et al.   Annals of the New York Academy of Sciences

Prevention and Treatment of Alzheimer’s Disease: Biological Mechanisms of Exercise

(2019) Hugo McGurran et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy Induction by Bexarotene Promotes Mitophagy in Presenilin 1 Familial Alzheimer’s Disease iPSC-Derived Neural Stem Cells

(2019) Patricia Martín-Maestro et al.   MOLECULAR NEUROBIOLOGY

A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ

(2019) Dylan Kwart et al.   NEURON

C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

(2019) Maria V. Pulina et al.   Alzheimers & Dementia

The Effects of APOE4 on Mitochondrial Dynamics and Proteins in vivo

(2019) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

(2019) Yahyah Aman et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment

(2019) Massimiliano Castellazzi et al.   Scientific Reports

APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain

(2019) Iliya Lefterov et al.   Alzheimers Research & Therapy

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

(2018) Paul A. Parcon et al.   Alzheimers & Dementia

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog–Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models

(2018) Thomas Goiran et al.   BIOLOGICAL PSYCHIATRY

Metformin treatment prevents amyloid plaque deposition and memory impairment in APP/PS1 mice

(2018) Zhenri Ou et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondria and Mitochondrial Cascades in Alzheimer’s Disease

(2018) Russell H. Swerdlow   JOURNAL OF ALZHEIMERS DISEASE

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3xTgAD and 2xTgAD mice

(2018) Alexandre Bourgeois et al.   NEUROBIOLOGY OF AGING

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

(2018) Gian-Luca McLelland et al.   eLife

Neuroprotective Role of Trans-Resveratrol in a Murine Model of Familial Alzheimer's Disease

(2018) David Porquet et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

(2018) Jared M. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

Disrupted-in-schizophrenia-1 protects synaptic plasticity in a transgenic mouse model of Alzheimer’s disease as a mitophagy receptor

(2018) Zhao-Tao Wang et al.   AGING CELL

The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial

(2018) Miranka Wirth et al.   CORTEX

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

(2018) Jin-Liang Chen et al.   EXPERIMENTAL NEUROLOGY

Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum

(2018) Lingling Zhang et al.   Oxidative Medicine and Cellular Longevity

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

(2018) Christy O.Y. Hung et al.   Cell Reports

Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer's disease

(2017) Jung-Hoon Koo et al.   EXPERIMENTAL NEUROLOGY

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions

(2017) Mei-Yao Lin et al.   NEURON

Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer’s Disease

(2017) Patricia Martín-Maestro et al.   Oxidative Medicine and Cellular Longevity

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

(2017) Jesse S. Kerr et al.   TRENDS IN NEUROSCIENCES

Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development

(2017) Qian Tang et al.   Cell Death & Disease

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation

(2017) Patricia Martín-Maestro et al.   Frontiers in Molecular Neuroscience

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology

(2016) Inger Lauritzen et al.   ACTA NEUROPATHOLOGICA

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

(2016) Dolores Del Prete et al.   JOURNAL OF ALZHEIMERS DISEASE

Validation of UHPLC–MS/MS methods for the determination of kaempferol and its metabolite 4-hydroxyphenyl acetic acid, and application to in vitro blood-brain barrier and intestinal drug permeability studies

(2016) Fahimeh Moradi-Afrapoli et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

(2016) Yu Hu et al.   Oncotarget

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts

(2016) Yongmei Qi et al.   Scientific Reports

NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease

(2015) V. Corsetti et al.   HUMAN MOLECULAR GENETICS

PARK2 enhancement is able to compensate mitophagy alterations found in sporadic Alzheimer's disease

(2015) Patricia Martín-Maestro et al.   HUMAN MOLECULAR GENETICS

Parkin-mediated mitophagy in mutant hAPP neurons and Alzheimer's disease patient brains

(2015) Xuan Ye et al.   HUMAN MOLECULAR GENETICS

Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice

(2015) Marissa J. Schafer et al.   NEUROBIOLOGY OF AGING

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes

(2014) Hoang S. Nhan et al.   ACTA NEUROPATHOLOGICA

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

(2014) Michela Guglielmotto et al.   Autophagy

Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin

(2014) Ghazaleh Ashrafi et al.   JOURNAL OF CELL BIOLOGY

Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain

(2014) Susana Revilla et al.   NEUROPHARMACOLOGY

Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP

(2014) E.E. Coffey et al.   NEUROSCIENCE

Neuroprotective effects of resveratrol in Alzheimer disease pathology

(2014) Shraddha D. Rege et al.   Frontiers in Aging Neuroscience

AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons

(2013) G. Amadoro et al.   NEUROBIOLOGY OF DISEASE

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription

(2013) Eric Duplan et al.   Journal of Molecular Cell Biology

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

The  -Secretase-Derived C-Terminal Fragment of  APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus

(2012) I. Lauritzen et al.   JOURNAL OF NEUROSCIENCE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

The physiology of the β-amyloid precursor protein intracellular domain AICD

(2011) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY