Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice

Another step forward in blood-based diagnostics for Alzheimer’s disease

(2020) Randall J. Bateman et al.   NATURE MEDICINE

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

(2020) Matthias Arnold et al.   Nature Communications

Metformin Ameliorates Aβ Pathology by Insulin-Degrading Enzyme in a Transgenic Mouse Model of Alzheimer’s Disease

(2020) Xin-Yi Lu et al.   Oxidative Medicine and Cellular Longevity

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease

(2019) Francesco Panza et al.   Nature Reviews Neurology

GSK-3β at the Intersection of Neuronal Plasticity and Neurodegeneration

(2019) Tomasz Jaworski et al.   NEURAL PLASTICITY

FDG-PET as an independent biomarker for Alzheimer’s biological diagnosis: a longitudinal study

(2019) Ya-Nan Ou et al.   Alzheimers Research & Therapy

Nutrients in the Prevention of Alzheimer’s Disease

(2019) Anna Laura Cremonini et al.   Oxidative Medicine and Cellular Longevity

Metformin and risk of Alzheimer’s disease among community-dwelling people with diabetes: a national case-control study

(2019) Janet K Sluggett et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Subregional Density of Neurons, Neurofibrillary Tangles and Amyloid Plaques in the Hippocampus of Patients With Alzheimer’s Disease

(2019) Diana Furcila et al.   Frontiers in Neuroanatomy

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease

(2018) David Baglietto-Vargas et al.   AGING CELL

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

(2018) Jared M. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease

(2018) Pedro Cisternas et al.   JOURNAL OF NEUROCHEMISTRY

Central insulin dysregulation and energy dyshomeostasis in two mouse models of Alzheimer's disease

(2017) Ramon Velazquez et al.   NEUROBIOLOGY OF AGING

Microtubule-associated tau contributes to intra-dendritic trafficking of AMPA receptors in multiple ways

(2017) Mamiko Suzuki et al.   NEUROSCIENCE LETTERS

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex

(2017) Susann Schweiger et al.   Scientific Reports

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Bapineuzumab for mild to moderate Alzheimer’s disease in two global, randomized, phase 3 trials

(2016) Rik Vandenberghe et al.   Alzheimers Research & Therapy

Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan

(2016) Mario Baumgart et al.   Cell Systems

Age-dependent impairment of glucose tolerance in the 3xTg-AD mouse model of Alzheimer’s disease

(2015) Milene Vandal et al.   FASEB JOURNAL

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density

(2015) Xiaobing Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White Matter Lipids as a Ketogenic Fuel Supply in Aging Female Brain: Implications for Alzheimer's Disease

(2015) Lauren P. Klosinski et al.   EBioMedicine

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

(2015) Liang Zhang et al.   EBioMedicine

Resveratrol Directly Binds to Mitochondrial Complex I and Increases Oxidative Stress in Brain Mitochondria of Aged Mice

(2015) Naïg Gueguen et al.   PLoS One

Phosphorylation of the AMPA receptor GluA1 subunit regulates memory load capacity

(2014) Laura Olivito et al.   Brain Structure & Function

Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

(2014) M. L. Frandemiche et al.   JOURNAL OF NEUROSCIENCE

Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation

(2014) Un Young Yu et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

Protein phosphatase 2A dysfunction in Alzheimer’s disease

(2014) Jean-Marie Sontag et al.   Frontiers in Molecular Neuroscience

The co-occurrence of mtDNA mutations on different oxidative phosphorylation subunits, not detected by haplogroup analysis, affects human longevity and is population specific

(2013) Nicola Raule et al.   AGING CELL

AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity

(2013) S. Park et al.   CELL CALCIUM

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease

(2013) Harsh Sancheti et al.   PLoS One

The Central Role of AMP-Kinase and Energy Homeostasis Impairment in Alzheimer’s Disease: A Multifactor Network Analysis

(2013) Laura Caberlotto et al.   PLoS One

Adaptive Response, Evidence of Cross-Resistance and Its Potential Clinical Use

(2012) Irina Milisav et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Protein Phosphatase PP2A/Bα Binds to the Microtubule-associated Proteins Tau and MAP2 at a Motif Also Recognized by the Kinase Fyn

(2012) Jean-Marie Sontag et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Reversible Early Oxidized Redox State That Precedes Macromolecular ROS Damage in Aging Nontransgenic and 3xTg-AD Mouse Neurons

(2012) D. Ghosh et al.   JOURNAL OF NEUROSCIENCE

The Balance between Receptor Recycling and Trafficking toward Lysosomes Determines Synaptic Strength during Long-Term Depression

(2012) M. Fernandez-Monreal et al.   JOURNAL OF NEUROSCIENCE

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau

(2011) Isabelle Landrieu et al.   PLoS One

Mice lacking phosphatase PP2A subunit PR61/B'  (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3 

(2011) J. V. Louis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Alzheimer's failure raises questions about disease-modifying strategies

(2010) Andy Extance   NATURE REVIEWS DRUG DISCOVERY

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Adiponectin-Activated AMPK Stimulates Dephosphorylation of AKT through Protein Phosphatase 2A Activation

(2009) K.-y. Kim et al.   CANCER RESEARCH

Inhibition of Alzheimer’s amyloid toxicity with a tricyclic pyrone moleculein vitroandin vivo

(2009) Hyun-Seok Hong et al.   JOURNAL OF NEUROCHEMISTRY

Tyrosine Phosphorylation of the 2B Subunit of the NMDA Receptor Is Necessary for Taste Memory Formation

(2009) L. Barki-Harrington et al.   JOURNAL OF NEUROSCIENCE

Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling

(2009) R. Anne McKinney   JOURNAL OF PHYSIOLOGY-LONDON

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation

(2009) K. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: Relationship with the progression of Alzheimer's disease

(2007) Afia Akram et al.   NEUROBIOLOGY OF AGING