Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mitochondrial Dysfunction: a Potential Therapeutic Target to Treat Alzheimer’s Disease
Authors
Keywords
-
Journal
MOLECULAR NEUROBIOLOGY
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-05-27
DOI
10.1007/s12035-020-01945-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- AMP‐activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics
- (2020) Caroline M. Voss et al. GLIA
- Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease
- (2020) Peng Yang et al. BIOMATERIALS
- The Role of PI3K/Akt and ERK in Neurodegenerative Disorders
- (2019) Sachchida Nand Rai et al. NEUROTOXICITY RESEARCH
- Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease
- (2019) Michiel Van Bulck et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Autophagy Activator Drugs: A New Opportunity in Neuroprotection from Misfolded Protein Toxicity
- (2019) Stefano Thellung et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Current Status of Healthy Aging and Dementia Research: A Symposium Summary
- (2019) P. Hemachandra Reddy et al. JOURNAL OF ALZHEIMERS DISEASE
- Role of endolysosomes and inter-organellar signaling in brain disease
- (2019) Zahra Afghah et al. NEUROBIOLOGY OF DISEASE
- ROS as Regulators of Mitochondrial Dynamics in Neurons
- (2018) Carolina Cid-Castro et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- Fueling thought: Management of glycolysis and oxidative phosphorylation in neuronal metabolism
- (2018) Gary Yellen JOURNAL OF CELL BIOLOGY
- Coenzyme Q10 Supplementation in Aging and Disease
- (2018) Juan D. Hernández-Camacho et al. Frontiers in Physiology
- Potential Immunotargets for Alzheimer's Disease Treatment Strategies
- (2018) Patricia L. Fernández et al. JOURNAL OF ALZHEIMERS DISEASE
- Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases
- (2018) Bee Ling Tan et al. Frontiers in Pharmacology
- Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation
- (2018) Elisabet Cuyàs et al. Frontiers in Endocrinology
- Autophagy impairment in Parkinson’s disease
- (2017) Cansu Karabiyik et al. Essays in Biochemistry
- Mammalian mitophagy - from in vitro molecules to in vivo models
- (2017) Catherine E. Rodger et al. FEBS Journal
- Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance
- (2017) Sophia M. Raefsky et al. FREE RADICAL BIOLOGY AND MEDICINE
- Aqua-soluble DDQ reduces the levels of Drp1 and Aβ and inhibits abnormal interactions between Aβ and Drp1 and protects Alzheimer’s disease neurons from Aβ- and Drp1-induced mitochondrial and synaptic toxicities
- (2017) Chandra Sekhar Kuruva et al. HUMAN MOLECULAR GENETICS
- Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
- (2017) Eric Tönnies et al. JOURNAL OF ALZHEIMERS DISEASE
- mTORC2 (Rictor) in Alzheimer’s Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons
- (2017) Han-Kyu Lee et al. JOURNAL OF ALZHEIMERS DISEASE
- Immunomodulation of Parkinson’s disease using Mucuna pruriens (Mp)
- (2017) Sachchida Nand Rai et al. JOURNAL OF CHEMICAL NEUROANATOMY
- Uncoupling protein 2 and metabolic diseases
- (2017) Annapoorna Sreedhar et al. MITOCHONDRION
- Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms
- (2017) Jesse S. Kerr et al. TRENDS IN NEUROSCIENCES
- Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease
- (2017) Amit U. Joshi et al. Oncotarget
- Mucuna pruriens Protects against MPTP Intoxicated Neuroinflammation in Parkinson’s Disease through NF-κB/pAKT Signaling Pathways
- (2017) Sachchida N. Rai et al. Frontiers in Aging Neuroscience
- Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans
- (2017) Simon Vann Jones et al. Frontiers in Immunology
- A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease
- (2017) Renato X. Santos et al. JOURNAL OF ALZHEIMERS DISEASE
- The Alzheimer's Disease Mitochondrial Cascade Hypothesis
- (2017) Russell H. Swerdlow et al. JOURNAL OF ALZHEIMERS DISEASE
- Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis
- (2016) Ramesh Kandimalla et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges
- (2016) Aiwu Cheng et al. Cell Metabolism
- Collapsin Response Mediator Protein-2 (CRMP2) is a Plausible Etiological Factor and Potential Therapeutic Target in Alzheimer’s Disease: Comparison and Contrast with Microtubule-Associated Protein Tau
- (2016) Kenneth Hensley et al. JOURNAL OF ALZHEIMERS DISEASE
- BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy
- (2016) Tongmei Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
- (2016) Dongryeol Ryu et al. NATURE MEDICINE
- Alterations in Mitochondrial Quality Control in Alzheimer’s Disease
- (2016) Qian Cai et al. Frontiers in Cellular Neuroscience
- Lifelong brain health is a lifelong challenge: From evolutionary principles to empirical evidence
- (2015) Mark P. Mattson AGEING RESEARCH REVIEWS
- Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay
- (2015) Eirini Lionaki et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
- Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight
- (2015) Aashiq Hussain Bhat et al. BIOMEDICINE & PHARMACOTHERAPY
- Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model
- (2015) Aaron N Long et al. BMC Neurology
- Measuring In Vivo Mitophagy
- (2015) Nuo Sun et al. MOLECULAR CELL
- The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
- (2015) Jin-Mi Heo et al. MOLECULAR CELL
- Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
- (2015) Konstantinos Palikaras et al. NATURE
- A cell-penetrating ester of the neural metabolite lanthionine ketimine stimulates autophagy through the mTORC1 pathway: Evidence for a mechanism of action with pharmacological implications for neurodegenerative pathologies
- (2015) Marni E. Harris-White et al. NEUROBIOLOGY OF DISEASE
- The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state
- (2015) Ergul Belge Kurutas Nutrition Journal
- A review on Alzheimer's disease pathophysiology and its management: an update
- (2015) Anil Kumar et al. Pharmacological Reports
- Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats
- (2015) Natalia A. Stefanova et al. Oncotarget
- Characterization of Aldh2 -/- mice as an age-related model of cognitive impairment and Alzheimer’s disease
- (2015) Yohan D’Souza et al. Molecular Brain
- Senescence-accelerated OXYS rats: A model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease
- (2014) Natalia Stefanova et al. CELL CYCLE
- Fasting: Molecular Mechanisms and Clinical Applications
- (2014) Valter D. Longo et al. Cell Metabolism
- Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)
- (2014) Teresa Valero CURRENT PHARMACEUTICAL DESIGN
- Genetic Reduction of Mammalian Target of Rapamycin Ameliorates Alzheimer's Disease-Like Cognitive and Pathological Deficits by Restoring Hippocampal Gene Expression Signature
- (2014) A. Caccamo et al. JOURNAL OF NEUROSCIENCE
- Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
- (2014) Dmitry B. Zorov et al. PHYSIOLOGICAL REVIEWS
- Parkin and PINK1: much more than mitophagy
- (2014) Leslie A. Scarffe et al. TRENDS IN NEUROSCIENCES
- Loss of UCP2 Attenuates Mitochondrial Dysfunction without Altering ROS Production and Uncoupling Activity
- (2014) Alexandra Kukat et al. PLoS Genetics
- Amyloid-β and Tau
- (2014) George S. Bloom JAMA Neurology
- The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model
- (2013) Xiao-rui Cheng et al. AGEING RESEARCH REVIEWS
- Transgenic models of Alzheimer's disease: Better utilization of existing models through viral transgenesis
- (2013) Thomas L. Platt et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives
- (2013) Russell H. Swerdlow et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
- (2013) Xinglong Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
- (2013) Justine D. Miller et al. Cell Stem Cell
- Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1–42)-induced rat model of Alzheimer's disease
- (2013) E. Turunc Bayrakdar et al. FREE RADICAL RESEARCH
- Mitochondria and Reactive Oxygen Species: Physiology and Pathophysiology
- (2013) Subhashini Bolisetty et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Banking iPS cells
- (2013) Nuala Moran NATURE BIOTECHNOLOGY
- Oxidative Stress and the Pathogenesis of Alzheimer's Disease
- (2013) Yan Zhao et al. Oxidative Medicine and Cellular Longevity
- The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
- (2013) E. S. Vincow et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy and apoptosis dysfunction in neurodegenerative disorders
- (2013) Saeid Ghavami et al. PROGRESS IN NEUROBIOLOGY
- Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
- (2013) Samantha Giordano et al. Redox Biology
- Amyloid β-Peptide (1–42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression
- (2012) D. Allan Butterfield et al. ANTIOXIDANTS & REDOX SIGNALING
- Mitophagy: mechanisms, pathophysiological roles, and analysis
- (2012) Wen-Xing Ding et al. BIOLOGICAL CHEMISTRY
- Ubiquitination and selective autophagy
- (2012) S Shaid et al. CELL DEATH AND DIFFERENTIATION
- The pathways of mitophagy for quality control and clearance of mitochondria
- (2012) G Ashrafi et al. CELL DEATH AND DIFFERENTIATION
- The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
- (2012) Carles Cantó et al. Cell Metabolism
- Multiple Defects in Energy Metabolism in Alzheimers Disease
- (2012) I. L. Ferreira et al. CURRENT DRUG TARGETS
- Rhomboid Protease PARL Mediates the Mitochondrial Membrane Potential Loss-induced Cleavage of PGAM5
- (2012) Shiori Sekine et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research
- (2012) Melita Salkovic-Petrisic et al. JOURNAL OF NEURAL TRANSMISSION
- Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession
- (2012) Dong Liu et al. NEUROBIOLOGY OF AGING
- Neuroprotective effects of creatine
- (2011) M. Flint Beal AMINO ACIDS
- Synaptic Mitochondrial Pathology in Alzheimer's Disease
- (2011) Heng Du et al. ANTIOXIDANTS & REDOX SIGNALING
- Abnormal tau, mitochondrial dysfunction, impaired axonal transport of mitochondria, and synaptic deprivation in Alzheimer's disease
- (2011) P. Hemachandra Reddy BRAIN RESEARCH
- The Beclin 1 network regulates autophagy and apoptosis
- (2011) R Kang et al. CELL DEATH AND DIFFERENTIATION
- Mitophagy and Disease: New Avenues for Pharmacological Intervention
- (2011) Robert Taylor et al. CURRENT PHARMACEUTICAL DESIGN
- Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises
- (2011) M. C. Marchetto et al. HUMAN MOLECULAR GENETICS
- Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer’s disease: a long-term follow up study
- (2011) Melita Salkovic-Petrisic et al. JOURNAL OF NEURAL TRANSMISSION
- Inhibition of Amyloid- (A ) Peptide-Binding Alcohol Dehydrogenase-A Interaction Reduces A Accumulation and Improves Mitochondrial Function in a Mouse Model of Alzheimer's Disease
- (2011) J. Yao et al. JOURNAL OF NEUROSCIENCE
- Post-translational modifications of tau protein: Implications for Alzheimer's disease
- (2011) Ludovic Martin et al. NEUROCHEMISTRY INTERNATIONAL
- 2-Deoxy-D-Glucose Treatment Induces Ketogenesis, Sustains Mitochondrial Function, and Reduces Pathology in Female Mouse Model of Alzheimer's Disease
- (2011) Jia Yao et al. PLoS One
- Mitochondrial degradation by autophagy (mitophagy) in GFP-LC3 transgenic hepatocytes during nutrient deprivation
- (2010) Insil Kim et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Short-term fasting induces profound neuronal autophagy
- (2010) Mehrdad Alirezaei et al. Autophagy
- The sites and topology of mitochondrial superoxide production
- (2010) Martin D. Brand EXPERIMENTAL GERONTOLOGY
- A Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines
- (2010) H. Zempel et al. JOURNAL OF NEUROSCIENCE
- Alzheimer's disease: clinical trials and drug development
- (2010) Francesca Mangialasche et al. LANCET NEUROLOGY
- Autophagy and the Integrated Stress Response
- (2010) Guido Kroemer et al. MOLECULAR CELL
- The benefits and limitations of animal models for translational research in neurodegenerative diseases
- (2010) Mathias Jucker NATURE MEDICINE
- Cellular Stress Responses, Mitostress and Carnitine Insufficiencies as Critical Determinants in Aging and Neurodegenerative Disorders: Role of Hormesis and Vitagenes
- (2010) Vittorio Calabrese et al. NEUROCHEMICAL RESEARCH
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model
- (2010) H. Du et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Mitochondria: A therapeutic target in neurodegeneration
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
- (2009) Bayani Uttara et al. Current Neuropharmacology
- Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
- (2009) X. Wang et al. JOURNAL OF NEUROSCIENCE
- Neurotrophic Effects of Tianeptine on Hippocampal Neurons: A Proteomic Approach
- (2009) Chin-Chen Chu et al. JOURNAL OF PROTEOME RESEARCH
- Targeting Mitochondria
- (2008) Adam T. Hoye et al. ACCOUNTS OF CHEMICAL RESEARCH
- How mitochondria produce reactive oxygen species
- (2008) Michael P. Murphy BIOCHEMICAL JOURNAL
- Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease
- (2008) Carl Julien et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Microtubule-associated protein tau in development, degeneration and protection of neurons
- (2008) Jian-Zhi Wang et al. PROGRESS IN NEUROBIOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started