Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

(2021) Che-Wei Chang et al.   SCIENCE

A large-scale nanoscopy and biochemistry analysis of postsynaptic dendritic spines

(2021) Martin S. Helm et al.   NATURE NEUROSCIENCE

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

(2020) Jacob W. Vogel et al.   Nature Communications

The mechanism of Hsp90-induced oligomerizaton of Tau

(2020) S. Weickert et al.   Science Advances

Identification of Conserved Proteomic Networks in Neurodegenerative Dementia

(2020) Vivek Swarup et al.   Cell Reports

Decreased synthesis of ribosomal proteins in tauopathy revealed by non‐canonical amino acid labelling

(2019) Harrison Tudor Evans et al.   EMBO JOURNAL

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

(2019) Peter Dongmin Sohn et al.   NEURON

Acetylation changes tau interactome to degrade tau in Alzheimer’s disease animal and organoid models

(2019) Heesun Choi et al.   AGING CELL

Tau interactome analyses in CRISPR-Cas9 engineered neuronal cells reveal ATPase-dependent binding of wild-type but not P301L Tau to non-muscle myosins

(2019) Xinzhu Wang et al.   Scientific Reports

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles

(2018) Francesc Guix et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein

(2018) Isabelle R. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17

(2018) Takahide Matsui et al.   JOURNAL OF CELL BIOLOGY

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

(2018) Joseph McInnes et al.   NEURON

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

(2018) Bahareh Eftekharzadeh et al.   NEURON

RNA binding proteins co-localize with small tau inclusions in tauopathy

(2018) Brandon F. Maziuk et al.   Acta Neuropathologica Communications

A conserved cytoskeletal signaling cascade mediates neurotoxicity of FTDP-17 tau mutationsin vivo

(2017) Farah H. Bardai et al.   JOURNAL OF NEUROSCIENCE

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Antibodies to biotin enable large-scale detection of biotinylation sites on proteins

(2017) Namrata D Udeshi et al.   NATURE METHODS

Tau association with synaptic vesicles causes presynaptic dysfunction

(2017) Lujia Zhou et al.   Nature Communications

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

(2017) Chao Wang et al.   Stem Cell Reports

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

(2017) Nicholas T. Seyfried et al.   Cell Systems

Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts

(2016) Ken H. Loh et al.   CELL

Accelerating Medicines Partnership: Alzheimer’s Disease (AMP-AD) Knowledge Portal Aids Alzheimer’s Drug Discovery through Open Data Sharing

(2016) Richard J. Hodes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease

(2016) Chang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment

(2016) Peter Dongmin Sohn et al.   Molecular Neurodegeneration

Neuronal activity enhances tau propagation and tau pathology in vivo

(2016) Jessica W Wu et al.   NATURE NEUROSCIENCE

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

(2016) Kathleen M. Schoch et al.   NEURON

Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

(2016) Tara E. Tracy et al.   NEURON

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

(2016) Tara Vanderweyde et al.   Cell Reports

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

(2016) Xinde Zheng et al.   eLife

Pre-synaptic C-terminal truncated tau is released from cortical synapses in Alzheimer's disease

(2015) Sophie Sokolow et al.   JOURNAL OF NEUROCHEMISTRY

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

(2015) C. Geeth Gunawardana et al.   MOLECULAR & CELLULAR PROTEOMICS

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

(2015) Marc Ehrlich et al.   Stem Cell Reports

Neuronal activity regulates extracellular tau in vivo

(2014) Kaoru Yamada et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

(2014) M. L. Frandemiche et al.   JOURNAL OF NEUROSCIENCE

Proteomic Mapping of the Human Mitochondrial Intermembrane Space in Live Cells via Ratiometric APEX Tagging

(2014) Victoria Hung et al.   MOLECULAR CELL

Directed evolution of APEX2 for electron microscopy and proximity labeling

(2014) Stephanie S Lam et al.   NATURE METHODS

Isolation of single-base genome-edited human iPS cells without antibiotic selection

(2014) Yuichiro Miyaoka et al.   NATURE METHODS

Physiological release of endogenous tau is stimulated by neuronal activity

(2013) Amy M Pooler et al.   EMBO REPORTS

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

The nuclear envelope LEM-domain protein emerin

(2013) Jason M Berk et al.   Nucleus

Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells

(2013) Helen Fong et al.   Stem Cell Reports

Analysis of the Tau-Associated Proteome Reveals That Exchange of Hsp70 for Hsp90 Is Involved in Tau Degradation

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

A New Link to Mitochondrial Impairment in Tauopathies

(2012) Kathrin L. Schulz et al.   MOLECULAR NEUROBIOLOGY

Tau Promotes Neurodegeneration via DRP1 Mislocalization In Vivo

(2012) Brian DuBoff et al.   NEURON

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

(2011) Xiaoyu Li et al.   EMBO JOURNAL

Interaction between NH2-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

(2011) Giuseppina Amadoro et al.   NEUROBIOLOGY OF AGING

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Phosphorylated Tau Interacts with c-Jun N-terminal Kinase-interacting Protein 1 (JIP1) in Alzheimer Disease

(2009) Lars M. Ittner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Rvb1/Tip49 Is Required for the Histone Acetyltransferase Activity of Tip60/NuA4 and for the Downregulation of Phosphorylation on H2AX after DNA Damage

(2008) S. Jha et al.   MOLECULAR AND CELLULAR BIOLOGY

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia

(2008) L. M. Ittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Importin-β: Structural and Dynamic Determinants of a Molecular Spring

(2008) Ulrich Zachariae et al.   STRUCTURE