Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice

Mitochondria at the neuronal presynapse in health and disease

(2018) Michael J. Devine et al.   NATURE REVIEWS NEUROSCIENCE

Caspase-12 Activation is Involved in Amyloid-β Protein-Induced Synaptic Toxicity

(2018) Ricardo Quiroz-Baez et al.   JOURNAL OF ALZHEIMERS DISEASE

Temporal and regional progression of Alzheimer’s disease-like pathology in 3xTg-AD mice

(2018) Ramona Belfiore et al.   AGING CELL

Long-Term Potentiation Requires a Rapid Burst of Dendritic Mitochondrial Fission during Induction

(2018) Sai Sachin Divakaruni et al.   NEURON

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

(2016) Ramesh Kandimalla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer’s disease

(2016) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease

(2016) Pamela V Martino Adami et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dopaminergic neurotransmission dysfunction induced by amyloid-β transforms cortical long-term potentiation into long-term depression and produces memory impairment

(2016) Perla Moreno-Castilla et al.   NEUROBIOLOGY OF AGING

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease

(2016) Lu Wang et al.   PLoS One

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Communication breakdown: The impact of ageing on synapse structure

(2014) Ronald S. Petralia et al.   AGEING RESEARCH REVIEWS

Familial Alzheimer’s disease–associated presenilin-1 alters cerebellar activity and calcium homeostasis

(2014) Diego Sepulveda-Falla et al.   JOURNAL OF CLINICAL INVESTIGATION

Energy Metabolism of Synaptosomes from Different Neuronal Systems of Rat Cerebellum During Aging: A Functional Proteomic Characterization

(2014) Federica Ferrari et al.   NEUROCHEMICAL RESEARCH

Synaptic Health

(2014) John H. Morrison et al.   JAMA Psychiatry

Synaptic Aging is Associated with Mitochondrial Dysfunction, Reduced Antioxidant Contents and Increased Vulnerability to Amyloid-β Toxicity

(2013) Ricardo Quiroz-Baez et al.   Current Alzheimer Research

Mechanisms underlying synaptic vulnerability and degeneration in neurodegenerative disease

(2013) T. H. Gillingwater et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

(2013) L. Mucke et al.   Cold Spring Harbor Perspectives in Medicine

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Calcium homeostasis in aging neurons

(2012) Vassiliki Nikoletopoulou et al.   Frontiers in Genetics

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Morphological changes in nerve cells during normal aging

(2011) Ennio Pannese   Brain Structure & Function

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Mitochondrial enzymes are protected from stress-induced aggregation by mitochondrial chaperones and the Pim1/LON protease

(2011) Tom Bender et al.   MOLECULAR BIOLOGY OF THE CELL

Morphological Changes of the Human Purkinje Cells and Deposition of Neuritic Plaques and Neurofibrillary Tangles on the Cerebellar Cortex of Alzheimer’s Disease

(2010) Ioannis A. Mavroudis et al.   American Journal of Alzheimers Disease and Other Dementias

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

(2010) H. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA