The in vivo fate and targeting engineering of crossover vesicle-based gene delivery system

Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis

(2022) Chengqi Yan et al.   DRUG DELIVERY

Immunogenic Hybrid Nanovesicles of Liposomes and Tumor-Derived Nanovesicles for Cancer Immunochemotherapy

(2021) Mei Hu et al.   ACS Nano

Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol

(2021) Juan Carlos Polanco et al.   ACTA NEUROPATHOLOGICA

Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy

(2021) Lorena del Pozo-Acebo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

(2021) Di Yin et al.   NATURE BIOTECHNOLOGY

Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models

(2021) Samantha Sheller-Miller et al.   Science Advances

Lentiviral delivery of co-packaged Cas9 mRNA and a Vegfa-targeting guide RNA prevents wet age-related macular degeneration in mice

(2021) Sikai Ling et al.   Nature Biomedical Engineering

Overcoming barriers by local drug delivery with liposomes

(2021) S.G. Antimisiaris et al.   ADVANCED DRUG DELIVERY REVIEWS

A Novel Targeted Therapy System for Cervical Cancer:  Co-Delivery System  of  Antisense LncRNA of MDC1 and Oxaliplatin Magnetic Thermosensitive Cationic Liposome Drug Carrier

(2021) Hui Ye et al.   International Journal of Nanomedicine

Treatment for Hepatocellular Carcinoma Is Enhanced When Norcantharidin Is Encapsulated in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells

(2021) Leyi Liang et al.   MOLECULAR PHARMACEUTICS

Nanomaterial Biointerfacing via Mitochondrial Membrane Coating for Targeted Detoxification and Molecular Detection

(2021) Hua Gong et al.   NANO LETTERS

Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR–Cas gene editing

(2021) Shuai Liu et al.   NATURE MATERIALS

Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy

(2021) Sijun Pan et al.   Nature Nanotechnology

Role of extracellular vesicles in neurodegenerative diseases

(2021) Yun Xiao et al.   PROGRESS IN NEUROBIOLOGY

New approaches in extracellular vesicle engineering for improving the efficacy of anti-cancer therapies

(2021) Migara Kavishka Jayasinghe et al.   SEMINARS IN CANCER BIOLOGY

Multifunctional Liposomes Enable Active Targeting and Twinfilin 1 Silencing to Reverse Paclitaxel Resistance in Brain Metastatic Breast Cancer

(2021) Jiawei Du et al.   ACS Applied Materials & Interfaces

Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke

(2021) Yuguo Xia et al.   ACS Nano

Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis

(2021) Lingna Sun et al.   BIOMATERIALS

Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor

(2021) Changguo Gong et al.   Advanced Science

Mesenchymal stromal exosome–functionalized scaffolds induce innate and adaptive immunomodulatory responses toward tissue repair

(2021) Ni Su et al.   Science Advances

Engineered extracellular vesicles as versatile ribonucleoprotein delivery vehicles for efficient and safe CRISPR genome editing

(2021) Xingang Yao et al.   Journal of Extracellular Vesicles

Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy

(2021) Lili Cheng et al.   BIOMATERIALS

Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy

(2021) Jun Wang et al.   BIOMATERIALS

Designer exosomes enabling tumor targeted efficient chemo/gene/photothermal therapy

(2021) Jie Wang et al.   BIOMATERIALS

Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison

(2021) Jun-Yong Wu et al.   JOURNAL OF CONTROLLED RELEASE

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury

(2021) Shiqi Hu et al.   Nano Today

Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders

(2021) Shu Zhao et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery

(2021) Michael Segel et al.   SCIENCE

Exosomal miR-19a and IBSP cooperate to induce osteolytic bone metastasis of estrogen receptor-positive breast cancer

(2021) Kerui Wu et al.   Nature Communications

Artificial exosomes for translational nanomedicine

(2021) Yong-Jiang Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Preclinical efficacy and clinical safety of clinical‐grade nebulized allogenic adipose mesenchymal stromal cells‐derived extracellular vesicles

(2021) Meng‐meng Shi et al.   Journal of Extracellular Vesicles

‘Green’ nanotherapeutics from tea leaves for orally targeted prevention and alleviation of colon diseases

(2021) Menghang Zu et al.   BIOMATERIALS

M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization

(2021) Hui Li et al.   JOURNAL OF CONTROLLED RELEASE

Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor

(2020) Huiying Chen et al.   ACS Applied Materials & Interfaces

Liver‐Target and Glucose‐Responsive Polymersomes toward Mimicking Endogenous Insulin Secretion with Improved Hepatic Glucose Utilization

(2020) Aohua Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Nanosponges of circulating tumor-derived exosomes for breast cancer metastasis inhibition

(2020) Hao Ye et al.   BIOMATERIALS

Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke

(2020) Han Young Kim et al.   BIOMATERIALS

Theranostic MRI liposomes for magnetic targeting and ultrasound triggered release of the antivascular CA4P

(2020) Caroline J. Thébault et al.   JOURNAL OF CONTROLLED RELEASE

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

(2020) Wei Liu et al.   Journal of Neuroinflammation

LincRNA-EPS in biomimetic vesicles targeting cerebral infarction promotes inflammatory resolution and neurogenesis

(2020) Benping Zhang et al.   Journal of Translational Medicine

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

Cow Milk and Intestinal Epithelial Cell-derived Extracellular Vesicles as Systems for Enhancing Oral Drug Delivery

(2020) Greta Carobolante et al.   Pharmaceutics

Small extracellular vesicles derived from human mesenchymal stromal cells prevent group 2 innate lymphoid cell-dominant allergic airway inflammation through delivery of miR-146a-5p

(2020) Shu-Bin Fang et al.   Journal of Extracellular Vesicles

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

Extracellular Vesicle-Mediated Delivery of CircSCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models

(2020) Li Yang et al.   CIRCULATION

Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer

(2020) Qiumo Zhang et al.   International Journal of Nanomedicine

Transplantation of Human Mesenchymal Stem-Cell-Derived Exosomes Immobilized in an Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury

(2020) Liming Li et al.   NANO LETTERS

RNA therapeutics on the rise

(2020) Feng Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

(2020) Peter Gee et al.   Nature Communications

Cartilage Tissue-Mimetic Pellets with Multifunctional Magnetic Hyaluronic Acid-Graft-Amphiphilic Gelatin Microcapsules for Chondrogenic Stimulation

(2020) Kai-Ting Hou et al.   Polymers

Engineered Cell‐Membrane‐Coated Nanoparticles Directly Present Tumor Antigens to Promote Anticancer Immunity

(2020) Yao Jiang et al.   ADVANCED MATERIALS

Light-triggered switching of liposome surface charge directs delivery of membrane impermeable payloads in vivo

(2020) Gabriela Arias-Alpizar et al.   Nature Communications

Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy

(2020) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ultrasound Assisted Exosomal Delivery of Tissue Responsive mRNA for Enhanced Efficacy and Minimized Off-Target Effects

(2020) Wenqi Sun et al.   Molecular Therapy-Nucleic Acids

Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma

(2020) Yunfeng Gao et al.   Nature Biomedical Engineering

Mimovirus Vesicle‐Based Biological Orthogonal Reaction for Cancer Diagnosis

(2020) En Ren et al.   Small Methods

Generation of Small RNA-Modulated Exosome Mimetics for Bone Regeneration

(2020) Jiabing Fan et al.   ACS Nano

Engineering Stem Cell Derived Biomimetic Vesicles for Versatility and Effective Targeted Delivery

(2020) Honghui Wu et al.   ADVANCED FUNCTIONAL MATERIALS

Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo

(2020) Hongyu Tao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Tropism-facilitated delivery of CRISPR/Cas9 system with chimeric antigen receptor-extracellular vesicles against B-cell malignancies

(2020) Qian Xu et al.   JOURNAL OF CONTROLLED RELEASE

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

(2020) Lang Rao et al.   Nature Communications

Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Protect Liver Ischemia/Reperfusion Injury by Reducing CD154 Expression on CD4+ T Cells via CCT2

(2020) Jun Zheng et al.   Advanced Science

Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality

(2020) Axel Rosell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment

(2020) Lizhou Xu et al.   BIOMATERIALS

Targeted exosome coating gene-chem nanocomplex as “nanoscavenger” for clearing α-synuclein and immune activation of Parkinson’s disease

(2020) Linying Liu et al.   Science Advances

Extracellular vesicles: Natural liver‐accumulating drug delivery vehicles for the treatment of liver diseases

(2020) Gensheng Zhang et al.   Journal of Extracellular Vesicles

Macrophage membrane-coated nanocarriers Co-Modified by RVG29 and TPP improve brain neuronal mitochondria-targeting and therapeutic efficacy in Alzheimer's disease mice

(2020) Yang Han et al.   Bioactive Materials

Effect of physicochemical and surface properties on in vivo fate of drug nanocarriers

(2019) Zongmin Zhao et al.   ADVANCED DRUG DELIVERY REVIEWS

Neural Stem Cells Transfected with Reactive Oxygen Species-Responsive Polyplexes for Effective Treatment of Ischemic Stroke

(2019) Xin-Chi Jiang et al.   ADVANCED MATERIALS

Exosome-mimetic nanovesicles contain distinct proteome and post-translational modified protein cargo, in comparison to exosomes

(2019) Amirmohammad Nasiri Kenari et al.   PROTEOMICS

Golden Exosomes Selectively Target Brain Pathologies in Neurodegenerative and Neurodevelopmental Disorders

(2019) Nisim Perets et al.   NANO LETTERS

Erythroliposomes: Integrated Hybrid Nanovesicles Composed of Erythrocyte Membranes and Artificial Lipid Membranes for Pore-Forming Toxin Clearance

(2019) Yuwei He et al.   ACS Nano

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

(2019) Guang Yang et al.   ACS Nano

Ferrimagnetic Nanochains‐Based Mesenchymal Stem Cell Engineering for Highly Efficient Post‐Stroke Recovery

(2019) Tianyuan Zhang et al.   ADVANCED FUNCTIONAL MATERIALS

Milk exosomes - Natural nanoparticles for siRNA delivery

(2019) Farrukh Aqil et al.   CANCER LETTERS

Reversal of Osteoporotic Activity by Endothelial Cell-Secreted Bone Targeting and Biocompatible Exosomes

(2019) Hongyuan Song et al.   NANO LETTERS

Content release of extracellular vesicles in a cell‐free extract

(2019) Emeline Bonsergent et al.   FEBS LETTERS

Knockdown of hypoxia-inducible factor-1 alpha by tumor targeted delivery of CRISPR/Cas9 system suppressed the metastasis of pancreatic cancer

(2019) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

Mesenchymal stromal cell-derived nanovesicles ameliorate bacterial outer membrane vesicle-induced sepsis via IL-10

(2019) Kyong-Su Park et al.   Stem Cell Research & Therapy

Exosome-mimetic nanoplatforms for targeted cancer drug delivery

(2019) Abi J. Vázquez-Ríos et al.   JOURNAL OF NANOBIOTECHNOLOGY

Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties

(2019) Qiaoling Liu et al.   Research

Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release

(2019) Min Wang et al.   ACS Nano

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability

(2019) Amrita Datta Chaudhuri et al.   GLIA

Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

(2019) Chunai Gong et al.   JOURNAL OF NANOBIOTECHNOLOGY

Sustained delivery and molecular targeting of a therapeutic monoclonal antibody to metastases in the central nervous system of mice

(2019) Jing Wen et al.   Nature Biomedical Engineering

Cell-Selective Messenger RNA Delivery and CRISPR/Cas9 Genome Editing by Modulating the Interface of Phenylboronic Acid-Derived Lipid Nanoparticles and Cellular Surface Sialic Acid

(2019) Qiao Tang et al.   ACS Applied Materials & Interfaces

Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping

(2019) Zhen Zheng et al.   JOURNAL OF CONTROLLED RELEASE

Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy

(2019) Tuying Yong et al.   Nature Communications

Anionic nanoparticles enable the oral delivery of proteins by enhancing intestinal permeability

(2019) Nicholas G. Lamson et al.   Nature Biomedical Engineering

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

(2019) Weidong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineered nanomedicines with enhanced tumor penetration

(2019) Jianxun Ding et al.   Nano Today

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Modification of Extracellular Vesicles by Fusion with Liposomes for the Design of Personalized Biogenic Drug Delivery Systems

(2018) Max Piffoux et al.   ACS Nano

Strategic design of extracellular vesicle drug delivery systems

(2018) James P.K. Armstrong et al.   ADVANCED DRUG DELIVERY REVIEWS

Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes

(2018) Hyoeun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

(2018) Tian Tian et al.   BIOMATERIALS

Targeted shRNA-loaded liposome complex combined with focused ultrasound for blood brain barrier disruption and suppressing glioma growth

(2018) Guanjian Zhao et al.   CANCER LETTERS

Intravenously Administered Novel Liposomes, DCL64, Deliver Oligonucleotides to Cerebellar Purkinje Cells

(2018) Ana Tari Ashizawa et al.   CEREBELLUM

Calcium phosphate particles stimulate exosome secretion from phagocytes for the enhancement of drug delivery

(2018) Yan-Jye Shyong et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

(2018) Gaofeng Liang et al.   International Journal of Nanomedicine

Exosome-Mediated Small RNA Delivery: A Novel Therapeutic Approach for Inflammatory Lung Responses

(2018) Duo Zhang et al.   MOLECULAR THERAPY

Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis

(2018) Giacomo Casella et al.   MOLECULAR THERAPY

Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment

(2018) Han Young Kim et al.   NANO LETTERS

High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles

(2018) Andrea Longatti et al.   Nanoscale

Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol

(2018) Lili Wang et al.   NATURE BIOTECHNOLOGY

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

(2018) Amrita Datta Chaudhuri et al.   Cell Death & Disease

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Hypoxia-induced exosome secretion promotes survival of African-American and Caucasian prostate cancer cells

(2018) Gati K. Panigrahi et al.   Scientific Reports

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

(2018) Yao Lin et al.   Advanced Science

Bioinspired Artificial Nanodecoys for Hepatitis B Virus

(2018) Xuan Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioengineered stem cell membrane functionalized nanocarriers for therapeutic targeting of severe hindlimb ischemia

(2018) Rajendran JC. Bose et al.   BIOMATERIALS

pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery

(2018) Hyuk Lee et al.   CARBOHYDRATE POLYMERS

Effects of mesenchymal stem cells and their exosomes on the healing of large and refractory macular holes

(2018) Xiaomin Zhang et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection

(2018) Bruna dos Santos Rodrigues et al.   JOURNAL OF CONTROLLED RELEASE

Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease

(2018) Mengke Qu et al.   JOURNAL OF CONTROLLED RELEASE

Sensitive and rapid quantification of exosomes by fusing luciferase to exosome marker proteins

(2018) Tomoya Hikita et al.   Scientific Reports

A New Approach for Loading Anticancer Drugs Into Mesenchymal Stem Cell-Derived Exosome Mimetics for Cancer Therapy

(2018) Senthilkumar Kalimuthu et al.   Frontiers in Pharmacology

Apoptosis and apoptotic body: disease message and therapeutic target potentials

(2018) Xuebo Xu et al.   BIOSCIENCE REPORTS

Highly efficient siRNA transfection in macrophages using apoptotic body-mimic Ca-PS lipopolyplex

(2018) Yueyang Lai et al.   International Journal of Nanomedicine

Preservation of exosomes at room temperature using lyophilization

(2018) Chonlada Charoenviriyakul et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Route to Rheumatoid Arthritis by Macrophage-Derived Microvesicle-Coated Nanoparticles

(2018) Ruixiang Li et al.   NANO LETTERS

In Vitro and in Vivo RNA Inhibition by CD9-HuR Functionalized Exosomes Encapsulated with miRNA or CRISPR/dCas9

(2018) Zhelong Li et al.   NANO LETTERS

Development of a novel drug targeting delivery system for cervical cancer therapy

(2018) Li Xiao et al.   NANOTECHNOLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Worm-Like Biomimetic Nanoerythrocyte Carrying siRNA for Melanoma Gene Therapy

(2018) Yanming Wang et al.   Small

Peptide modified mesenchymal stem cells as targeting delivery system transfected with miR-133b for the treatment of cerebral ischemia

(2017) Bing Huang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Small Interfering RNA in Milk Exosomes Is Resistant to Digestion and Crosses the Intestinal Barrier In Vitro

(2017) Shruti Shandilya et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

(2017) Seung Min Kim et al.   JOURNAL OF CONTROLLED RELEASE

Modality of tumor endothelial VEGFR2 silencing-mediated improvement in intratumoral distribution of lipid nanoparticles

(2017) Shoshiro Yamamoto et al.   JOURNAL OF CONTROLLED RELEASE

TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase

(2017) Kaizhe Wang et al.   Journal of Neuroinflammation

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

(2017) Akihiro Matsumoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Human milk exosomes and their microRNAs survive digestion in vitro and are taken up by human intestinal cells

(2017) Yalin Liao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Higher functionality of extracellular vesicles isolated using size-exclusion chromatography compared to ultracentrifugation

(2017) Emma A. Mol et al.   Nanomedicine-Nanotechnology Biology and Medicine

Fluorescence labelling of extracellular vesicles using a novel thiol-based strategy for quantitative analysis of cellular delivery and intracellular traffic

(2017) H. D. Roberts-Dalton et al.   Nanoscale

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Genome Editing for Cancer Therapy: Delivery of Cas9 Protein/sgRNA Plasmid via a Gold Nanocluster/Lipid Core-Shell Nanocarrier

(2017) Peng Wang et al.   Advanced Science

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

(2017) Aizea Morales-Kastresana et al.   Scientific Reports

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

(2017) Wei Jiang Goh et al.   Scientific Reports

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Human vascular endothelial cells transport foreign exosomes from cow's milk by endocytosis

(2016) Rio Jati Kusuma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer

(2016) Taral R. Lunavat et al.   BIOMATERIALS

Efficient production and enhanced tumor delivery of engineered extracellular vesicles

(2016) Dionysios C. Watson et al.   BIOMATERIALS

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles

(2016) Jingwei Ma et al.   CELL RESEARCH

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Circulating melanoma exosomes as diagnostic and prognosis biomarkers

(2016) Estibaliz Alegre et al.   CLINICA CHIMICA ACTA

Microvesicle Tissue Factor Activity and Interleukin-8 Levels are Associated with Mortality in Patients with Influenza A/H1N1 Infection

(2016) Matthew T. Rondina et al.   CRITICAL CARE MEDICINE

In Vivo Delivery Systems for Therapeutic Genome Editing

(2016) Luyao Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosisviamembrane TNF-α mediated NF-κB pathway

(2016) Wei Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery

(2016) Dominique Ingato et al.   JOURNAL OF CONTROLLED RELEASE

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

(2016) Zhaogang Yang et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

The impact of various preanalytical treatments on the phenotype of small extracellular vesicles in blood analyzed by protein microarray

(2016) Rikke Bæk et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Ultrasmall Magnetically Engineered Ag2Se Quantum Dots for Instant Efficient Labeling and Whole-Body High-Resolution Multimodal Real-Time Tracking of Cell-Derived Microvesicles

(2016) Jing-Ya Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transferrin-modified liposome promotes α-mangostin to penetrate the blood–brain barrier

(2016) Zhi-Lan Chen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Macrophage Exosomes Induce Placental Inflammatory Cytokines: A Novel Mode of Maternal-Placental Messaging

(2016) Beth Holder et al.   TRAFFIC

Onivyde for the therapy of multiple solid tumors

(2016) Haijun Zhang   OncoTargets and Therapy

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes

(2016) Andrew J. McKenzie et al.   Cell Reports

Tumor-homing peptides as tools for targeted delivery of payloads to the placenta

(2016) A. King et al.   Science Advances

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Trehalose prevents aggregation of exosomes and cryodamage

(2016) Steffi Bosch et al.   Scientific Reports

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers

(2015) Yueting Wu et al.   ANALYST

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

(2015) Jaewoong Yoon et al.   BIOMATERIALS

Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice

(2015) Tian-Yuan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

The Intestinal Transport of Bovine Milk Exosomes Is Mediated by Endocytosis in Human Colon Carcinoma Caco-2 Cells and Rat Small Intestinal IEC-6 Cells

(2015) Tovah Wolf et al.   JOURNAL OF NUTRITION

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Oral administration of bovine milk derived extracellular vesicles attenuates arthritis in two mouse models

(2015) Onno J. Arntz et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

(2015) Sarah E. Headland et al.   Science Translational Medicine

Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters

(2015) Charles P. Lai et al.   Nature Communications

Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche

(2015) Catherine A. Sánchez et al.   Oncotarget

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

(2015) Do Won Hwang et al.   Scientific Reports

Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

(2015) Yuchen Liu et al.   Scientific Reports

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling

(2014) Randall J. Platt et al.   CELL

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

(2014) Wonju Jo et al.   LAB ON A CHIP

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

(2014) J. Mark Cooper et al.   MOVEMENT DISORDERS

Large-scale generation of cell-derived nanovesicles

(2014) W. Jo et al.   Nanoscale

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Magnetic and Photoresponsive Theranosomes: Translating Cell-Released Vesicles into Smart Nanovectors for Cancer Therapy

(2013) Amanda K. A. Silva et al.   ACS Nano

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

(2013) Su Chul Jang et al.   ACS Nano

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Quantification of human urinary exosomes by nanoparticle tracking analysis

(2013) Wilna Oosthuyzen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Exosomes Derived from Epstein-Barr Virus-Infected Cells Are Internalized via Caveola-Dependent Endocytosis and Promote Phenotypic Modulation in Target Cells

(2013) A. Nanbo et al.   JOURNAL OF VIROLOGY

Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials

(2013) Amanda K. Andriola Silva et al.   Nanoscale

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Exosomes for drug delivery — a novel application for the mesenchymal stem cell

(2012) Ruenn Chai Lai et al.   BIOTECHNOLOGY ADVANCES

Hypoxic enhancement of exosome release by breast cancer cells

(2012) Hamish W King et al.   BMC CANCER

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Dynamics of exosome internalization and trafficking

(2012) Tian Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Doxil® — The first FDA-approved nano-drug: Lessons learned

(2012) Yechezkel (Chezy) Barenholz   JOURNAL OF CONTROLLED RELEASE

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes

(2011) A. Montecalvo et al.   BLOOD

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes

(2011) S. Wang et al.   JOURNAL OF NEUROSCIENCE

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

In vivo genome editing restores haemostasis in a mouse model of haemophilia

(2011) Hojun Li et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Cell Surface Tetraspanin Tspan8 Contributes to Molecular Pathways of Exosome-Induced Endothelial Cell Activation

(2010) I. Nazarenko et al.   CANCER RESEARCH

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Size and shape effects in the biodistribution of intravascularly injected particles

(2009) P. Decuzzi et al.   JOURNAL OF CONTROLLED RELEASE

Effect of Genome Size on AAV Vector Packaging

(2009) Zhijian Wu et al.   MOLECULAR THERAPY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer

(2008) E Wisse et al.   GENE THERAPY

Increased exosome production from tumour cell cultures using the Integra CELLine Culture System

(2008) J. Paul Mitchell et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY