Extracellular vesicle drug occupancy enables real-time monitoring of targeted cancer therapy

Exosome-templated nanoplasmonics for multiparametric molecular profiling

(2020) Xingjie Wu et al.   Science Advances

Subtyping of circulating exosome-bound amyloid β reflects brain plaque deposition

(2019) Carine Z. J. Lim et al.   Nature Communications

Mobile platform for rapid sub–picogram-per-milliliter, multiplexed, digital droplet detection of proteins

(2019) Venkata Yelleswarapu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular conjugation using non-covalent click chemistry

(2019) Cynthia L. Schreiber et al.   Nature Reviews Chemistry

Lighting Up Biosensors: Now and the Decade To Come

(2019) Frances S. Ligler et al.   ANALYTICAL CHEMISTRY

Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution

(2019) Noah R. Sundah et al.   Nature Biomedical Engineering

New Sensors for Extracellular Vesicles: Insights on Constituent and Associated Biomarkers

(2019) Carine Z. J. Lim et al.   ACS Sensors

New Technologies for Analysis of Extracellular Vesicles

(2018) Huilin Shao et al.   CHEMICAL REVIEWS

Chemical probes and drug leads from advances in synthetic planning and methodology

(2018) Christopher J. Gerry et al.   NATURE REVIEWS DRUG DISCOVERY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nanoplasmonic optical antennas for life sciences and medicine

(2018) Hongbao Xin et al.   Nature Reviews Materials

Visual and modular detection of pathogen nucleic acids with enzyme–DNA molecular complexes

(2018) Nicholas R. Y. Ho et al.   Nature Communications

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Lung cancer: current therapies and new targeted treatments

(2017) Fred R Hirsch et al.   LANCET

The evidence framework for precision cancer medicine

(2017) Jeffrey A. Moscow et al.   Nature Reviews Clinical Oncology

Clinical chemoproteomics—Opportunities and obstacles

(2017) Lyn H. Jones et al.   Science Translational Medicine

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip

(2017) Erh-Chia Yeh et al.   Science Advances

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

(2016) Anna Rutkowska et al.   ACS Chemical Biology

Single-Molecule Sensors: Challenges and Opportunities for Quantitative Analysis

(2016) J. Justin Gooding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exosomal proteins as prognostic biomarkers in non-small cell lung cancer

(2016) B. Sandfeld-Paulsen et al.   Molecular Oncology

RECIST — learning from the past to build the future

(2016) Saskia Litière et al.   Nature Reviews Clinical Oncology

Stress-Induced EGFR Trafficking: Mechanisms, Functions, and Therapeutic Implications

(2016) Xiaojun Tan et al.   TRENDS IN CELL BIOLOGY

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Covalent docking using autodock: Two-point attractor and flexible side chain methods

(2015) Giulia Bianco et al.   PROTEIN SCIENCE

An implantable microdevice to perform high-throughput in vivo drug sensitivity testing in tumors

(2015) Oliver Jonas et al.   Science Translational Medicine

Extracellular Vesicles in Cancer: Exosomes, Microvesicles and the Emerging Role of Large Oncosomes

(2015) Valentina R. Minciacchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

(2015) Huilin Shao et al.   Nature Communications

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Proteomics of extracellular vesicles: Exosomes and ectosomes

(2014) Dong-Sic Choi et al.   MASS SPECTROMETRY REVIEWS

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

(2014) Hyungsoon Im et al.   NATURE BIOTECHNOLOGY

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

(2014) Bryan R Lanning et al.   Nature Chemical Biology

AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer

(2014) D. A. E. Cross et al.   Cancer Discovery

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research

(2014) Tove Tuntland et al.   Frontiers in Pharmacology

An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules

(2013) Amrita Basu et al.   CELL

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy

(2012) Huilin Shao et al.   NATURE MEDICINE

Cu-free click cycloaddition reactions in chemical biology

(2010) John C. Jewett et al.   CHEMICAL SOCIETY REVIEWS

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE

Strategic Approach to Fit-for-Purpose Biomarkers in Drug Development

(2007) John A. Wagner   Annual Review of Pharmacology and Toxicology