New approaches in extracellular vesicle engineering for improving the efficacy of anti-cancer therapies

Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery

(2021) Tin Chanh Pham et al.   Journal of Extracellular Vesicles

Exosomes co‐expressing AQP5‐targeting miRNAs and IL‐4 receptor‐binding peptide inhibit the migration of human breast cancer cells

(2020) Eui‐Jung Park et al.   FASEB JOURNAL

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

(2020) Gaofeng Liang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Exosome-Delivered c-Met siRNA Could Reverse Chemoresistance to Cisplatin in Gastric Cancer

(2020) Qiumo Zhang et al.   International Journal of Nanomedicine

Tumor-Homing pH-Sensitive Extracellular Vesicles for Targeting Heterogeneous Tumors

(2020) Jaeduk Park et al.   Pharmaceutics

Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair

(2020) Chuyue Zhang et al.   ACS Nano

Anti-CTLA-4 Antibody-Functionalized Dendritic Cell-derived Exosomes Targeting Tumor-draining Lymph Nodes for Effective Induction of Antitumor T-cell Responses

(2020) Cao Dai Phung et al.   Acta Biomaterialia

Exosomes as drug carriers for cancer therapy and challenges regarding exosome uptake

(2020) Xiaoyin Zhao et al.   BIOMEDICINE & PHARMACOTHERAPY

Recent advances of aptasensors for exosomes detection

(2020) Chao Zhu et al.   BIOSENSORS & BIOELECTRONICS

Ultrasound Assisted Exosomal Delivery of Tissue Responsive mRNA for Enhanced Efficacy and Minimized Off-Target Effects

(2020) Wenqi Sun et al.   Molecular Therapy-Nucleic Acids

Extracellular vesicles as natural therapeutic agents and innate drug delivery systems for cancer treatment: Recent advances, current obstacles, and challenges for clinical translation

(2020) Marco Pirisinu et al.   SEMINARS IN CANCER BIOLOGY

Extracellular Vesicles as an Efficient and Versatile System for Drug Delivery

(2020) Xuan T. T. Dang et al.   Cells

Aptamer-Functionalized Exosomes: Elucidating the Cellular Uptake Mechanism and the Potential for Cancer-Targeted Chemotherapy

(2019) Jianmei Zou et al.   ANALYTICAL CHEMISTRY

Dendritic Cell-Targeted pH-Responsive Extracellular Vesicles for Anticancer Vaccination

(2019) Hyuk Lee et al.   Pharmaceutics

Rapid On-Demand Extracellular Vesicle Augmentation with Versatile Oligonucleotide Tethers

(2019) Saigopalakrishna S. Yerneni et al.   ACS Nano

Glycan-Modified Melanoma-Derived Apoptotic Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

(2019) Horrevorts et al.   Cancers

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

(2019) Sophie A. Dusoswa et al.   Journal of Extracellular Vesicles

Targeted Exosomes for Drug Delivery: Biomanufacturing, Surface Tagging, and Validation

(2019) Yingnan Si et al.   Biotechnology Journal

Genetically Engineered Cell-Derived Nanoparticles for Targeted Breast Cancer Immunotherapy

(2019) Xiaojing Shi et al.   MOLECULAR THERAPY

Profiling surface proteins on individual exosomes using a proximity barcoding assay

(2019) Di Wu et al.   Nature Communications

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity

(2019) Wenyan Fu et al.   Nature Communications

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

(2019) Weidong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systemic delivery of microRNA-21 antisense oligonucleotides to the brain using T7-peptide decorated exosomes

(2019) Gyeungyun Kim et al.   JOURNAL OF CONTROLLED RELEASE

Exosome redux

(2019) Mark Zipkin   NATURE BIOTECHNOLOGY

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Methotrexate-Loaded Extracellular Vesicles Functionalized with Therapeutic and Targeted Peptides for the Treatment of Glioblastoma Multiforme

(2018) Zhilan Ye et al.   ACS Applied Materials & Interfaces

Designer Exosomes for Active Targeted Chemo-Photothermal Synergistic Tumor Therapy

(2018) Jie Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells

(2018) Shabanali Khodashenas Limoni et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo

(2018) Gang Jia et al.   BIOMATERIALS

Cell-derived Exosomes as Promising Carriers for Drug Delivery and Targeted Therapy

(2018) Xinyi Wang et al.   CURRENT CANCER DRUG TARGETS

Engineered exosome-mediated delivery of functionally active miR-26a and its enhanced suppression effect in HepG2 cells

(2018) Gaofeng Liang et al.   International Journal of Nanomedicine

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

(2018) M. Garofalo et al.   JOURNAL OF CONTROLLED RELEASE

Anti-HER2 scFv-Directed Extracellular Vesicle-Mediated mRNA-Based Gene Delivery Inhibits Growth of HER2-Positive Human Breast Tumor Xenografts by Prodrug Activation

(2018) Jing-Hung Wang et al.   MOLECULAR CANCER THERAPEUTICS

A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer

(2018) Yan Li et al.   Nanomedicine-Nanotechnology Biology and Medicine

Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations

(2018) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles

(2018) Andrea Longatti et al.   Nanoscale

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

A System of Cytokines Encapsulated in ExtraCellular Vesicles

(2018) Wendy Fitzgerald et al.   Scientific Reports

pH-responsive hyaluronate-anchored extracellular vesicles to promote tumor-targeted drug delivery

(2018) Hyuk Lee et al.   CARBOHYDRATE POLYMERS

Recombinant phosphatidylserine-binding nanobodies for targeting of extracellular vesicles to tumor cells: a plug-and-play approach

(2018) Sander A. A. Kooijmans et al.   Nanoscale

Targeted cancer therapy using engineered exosome as a natural drug delivery vehicle

(2018) Hosna Gomari et al.   OncoTargets and Therapy

Targeting extracellular vesicles to injured tissue using membrane cloaking and surface display

(2018) Travis J. Antes et al.   JOURNAL OF NANOBIOTECHNOLOGY

Liposomes with cyclic RGD peptide motif triggers acute immune response in mice

(2018) Xiaoyi Wang et al.   JOURNAL OF CONTROLLED RELEASE

Reprogramming Exosomes as Nanoscale Controllers of Cellular Immunity

(2018) Qinqin Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

(2018) Mariangela Garofalo et al.   Viruses-Basel

Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy

(2017) Wei Jiang Goh et al.   International Journal of Nanomedicine

Role of Phosphatidylserine-Derived Negative Surface Charges in the Recognition and Uptake of Intravenously Injected B16BL6-Derived Exosomes by Macrophages

(2017) Akihiro Matsumoto et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Engineered Exosomes as Vehicles for Biologically Active Proteins

(2017) Ulrich Sterzenbach et al.   MOLECULAR THERAPY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression

(2017) Fengmei Pi et al.   Nature Nanotechnology

Achieving the Promise of Therapeutic Extracellular Vesicles: The Devil is in Details of Therapeutic Loading

(2017) Dhruvitkumar S. Sutaria et al.   PHARMACEUTICAL RESEARCH

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake

(2017) Kinsley C. French et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

(2017) Sybren L.N. Maas et al.   TRENDS IN CELL BIOLOGY

Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth

(2017) Daniele Bellavia et al.   Theranostics

Current Perspectives on In Vivo Noninvasive Tracking of Extracellular Vesicles with Molecular Imaging

(2017) Prakash Gangadaran et al.   Biomed Research International

Cellular Engineering with Membrane Fusogenic Liposomes to Produce Functionalized Extracellular Vesicles

(2016) Junsung Lee et al.   ACS Applied Materials & Interfaces

Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

(2016) Hongzhao Qi et al.   ACS Nano

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

(2016) Tek N. Lamichhane et al.   Cellular and Molecular Bioengineering

Aggregation of PEGylated liposomes driven by hydrophobic forces

(2016) Tamás Bozó et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Meta-analysis of clinical and preclinical studies comparing the anticancer efficacy of liposomal versus conventional non-liposomal doxorubicin

(2016) Grant H. Petersen et al.   JOURNAL OF CONTROLLED RELEASE

PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time

(2016) S.A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

(2016) Marie-Cécile Didiot et al.   MOLECULAR THERAPY

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Designed proteins induce the formation of nanocage-containing extracellular vesicles

(2016) Jörg Votteler et al.   NATURE

Engineering hybrid exosomes by membrane fusion with liposomes

(2016) Yuko T. Sato et al.   Scientific Reports

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

(2015) MikoŁaj P. Zaborowski et al.   BIOSCIENCE

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

(2015) Michelle E. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biodistribution and delivery efficiency of unmodified tumor-derived exosomes

(2015) Tyson Smyth et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

(2015) Heikki Saari et al.   JOURNAL OF CONTROLLED RELEASE

Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

(2015) Guohua Lou et al.   Journal of Hematology & Oncology

Quantitative Analysis of Tissue Distribution of the B16BL6-Derived Exosomes Using a Streptavidin-Lactadherin Fusion Protein and Iodine-125-Labeled Biotin Derivative After Intravenous Injection in Mice

(2015) Masaki Morishita et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

Liposome-Based Engineering of Cells To Package Hydrophobic Compounds in Membrane Vesicles for Tumor Penetration

(2015) Junsung Lee et al.   NANO LETTERS

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

(2014) Basant Kumar Thakur et al.   CELL RESEARCH

Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging

(2014) CRISTINA GRANGE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery

(2014) Luisa Pascucci et al.   JOURNAL OF CONTROLLED RELEASE

Maximizing exosome colloidal stability following electroporation

(2013) Joshua L. Hood et al.   ANALYTICAL BIOCHEMISTRY

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

(2013) Oleg V. Kovalenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human erythrocytes as drug carriers: Loading efficiency and side effects of hypotonic dialysis, chlorpromazine treatment and fusion with liposomes

(2013) M.E. Favretto et al.   JOURNAL OF CONTROLLED RELEASE

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

‘Marker-of-self’ functionalization of nanoscale particles through a top-down cellular membrane coating approach

(2013) Che-Ming J. Hu et al.   Nanoscale

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

(2013) Jessian L Munoz et al.   Molecular Therapy-Nucleic Acids

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

scFv Antibody: Principles and Clinical Application

(2012) Zuhaida Asra Ahmad et al.   Clinical & Developmental Immunology

Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

Toward tailored exosomes: The exosomal tetraspanin web contributes to target cell selection

(2012) Sanyukta Rana et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microvesicle-associated AAV Vector as a Novel Gene Delivery System

(2012) Casey A Maguire et al.   MOLECULAR THERAPY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Delivery of chemotherapeutic drugs in tumour cell-derived microparticles

(2012) Ke Tang et al.   Nature Communications

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Enhancing blood compatibility of biodegradable polymers by introducing sulfobetaine

(2011) Jun Cao et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

The journey of a drug-carrier in the body: An anatomo-physiological perspective

(2011) Nicolas Bertrand et al.   JOURNAL OF CONTROLLED RELEASE

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins

(2009) Charles Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH