Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice

Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators

(2020) Li Wang et al.   Frontiers in Immunology

Gene editing and elimination of latent herpes simplex virus in vivo

(2020) Martine Aubert et al.   Nature Communications

Development of a gene-editing approach to restore vision loss in Leber congenital amaurosis type 10

(2019) Morgan L. Maeder et al.   NATURE MEDICINE

Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication

(2019) Savithri Weerasooriya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycotic Antimicrobial Localized Injection (MALIN): A Randomized Clinical Trial Evaluating Intrastromal Injection of Voriconazole

(2019) Shivananda Narayana et al.   OPHTHALMOLOGY

Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy

(2019) Christopher E. Nelson et al.   NATURE MEDICINE

Development of a CRISPR/Cas9-based therapy for Hutchinson–Gilford progeria syndrome

(2019) Olaya Santiago-Fernández et al.   NATURE MEDICINE

Single-dose CRISPR–Cas9 therapy extends lifespan of mice with Hutchinson–Gilford progeria syndrome

(2019) Ergin Beyret et al.   NATURE MEDICINE

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

(2019) Prasanta K. Dash et al.   Nature Communications

Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections

(2019) Raghuram Koganti et al.   Microorganisms

Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9

(2019) Hyung Suk Oh et al.   eLife

PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1–Infected Corneas

(2018) Sohyun Jeon et al.   JOURNAL OF IMMUNOLOGY

An off-target effect of BX795 blocks herpes simplex virus type 1 infection of the eye

(2018) Dinesh Jaishankar et al.   Science Translational Medicine

Nanoparticle delivery of CRISPR into the brain rescues a mouse model of fragile X syndrome from exaggerated repetitive behaviours

(2018) Bumwhee Lee et al.   Nature Biomedical Engineering

Harnessing CRISPR to combat human viral infections

(2018) Hendrik de Buhr et al.   CURRENT OPINION IN IMMUNOLOGY

Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E

(2018) Shigeki Kato et al.   JOURNAL OF NEUROSCIENCE METHODS

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

(2017) Xue Gao et al.   NATURE

Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions

(2017) Kenta Kobayashi et al.   Frontiers in Neuroanatomy

Herpes Simplex Virus-1 Encephalitis in Adults: Pathophysiology, Diagnosis, and Management

(2016) Michael J. Bradshaw et al.   Neurotherapeutics

Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

(2016) Line S. Reinert et al.   Nature Communications

Intrastromal Injection of Bevacizumab in the Management of Corneal Neovascularization: About 25 Eyes

(2016) Belghmaidi Sarah et al.   Journal of Ophthalmology

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

(2016) Ferdy R. van Diemen et al.   PLoS Pathogens

Intrastromal bevacizumab injection for corneal neovascularization in herpetic stromal keratitis

(2015) C. Berrozpe-Villabona et al.   JOURNAL FRANCAIS D OPHTALMOLOGIE

Ups and downs in the search for a Herpes simplex virus vaccine

(2015) Silvia Bolland et al.   eLife

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

(2014) S. Bae et al.   BIOINFORMATICS

Herpes Simplex Epithelial and Stromal Keratitis: An Epidemiologic Update

(2012) Asim V. Farooq et al.   SURVEY OF OPHTHALMOLOGY

Herpes Simplex Viruses: Mechanisms of DNA Replication

(2012) S. K. Weller et al.   Cold Spring Harbor Perspectives in Biology

Ocular Herpes Simplex Virus Type 1: Is the Cornea a Reservoir for Viral Latency or a Fast Pit Stop?

(2010) David P Kennedy et al.   CORNEA

Prevalence and Clinical Consequences of Herpes Simplex Virus Type 1 DNA in Human Cornea Tissues

(2009) Lies Remeijer et al.   JOURNAL OF INFECTIOUS DISEASES