Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders

Traumatic brain injury increases plasma astrocyte‐derived exosome levels of neurotoxic complement proteins

(2020) Edward J. Goetzl et al.   FASEB JOURNAL

Astrocyte-Derived Exosomal microRNA miR-200a-3p Prevents MPP+-Induced Apoptotic Cell Death Through Down-Regulation of MKK4

(2020) Norshalena Shakespear et al.   NEUROCHEMICAL RESEARCH

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

(2020) Cory M. Willis et al.   Scientific Reports

Glutaminase 1 Regulates Neuroinflammation After Cerebral Ischemia Through Enhancing Microglial Activation and Pro-Inflammatory Exosome Release

(2020) Ge Gao et al.   Frontiers in Immunology

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

(2020) Raghavendra Upadhya et al.   JOURNAL OF CONTROLLED RELEASE

Small-Medium Extracellular Vesicles and Their miRNA Cargo in Retinal Health and Degeneration: Mediators of Homeostasis, and Vehicles for Targeted Gene Therapy

(2020) Yvette Wooff et al.   Frontiers in Cellular Neuroscience

miR‐195 reduces age‐related blood–brain barrier leakage caused by thrombospondin‐1‐mediated selective autophagy

(2020) Chien‐Yuan Chen et al.   AGING CELL

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress

(2019) Raquel Pascua-Maestro et al.   Frontiers in Cellular Neuroscience

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

(2019) André Varcianna et al.   EBioMedicine

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes as a source of immunomodulatory extracellular vesicles

(2019) Victoria N. Neckles et al.   Scientific Reports

Astrocyte-derived exosomes suppress autophagy and ameliorate neuronal damage in experimental ischemic stroke

(2019) Xiaoxi Pei et al.   EXPERIMENTAL CELL RESEARCH

TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles

(2019) Francesc Ibáñez et al.   Journal of Neuroinflammation

Exosomes regulate neurogenesis and circuit assembly

(2019) Pranav Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutaminase C Regulates Microglial Activation and Pro-inflammatory Exosome Release: Relevance to the Pathogenesis of Alzheimer’s Disease

(2019) Ge Gao et al.   Frontiers in Cellular Neuroscience

Exosome-shuttled miR-92b-3p from ischemic preconditioned astrocytes protects neurons against oxygen and glucose deprivation

(2019) Lili Xu et al.   BRAIN RESEARCH

Stimulus-dependent modifications in astrocyte-derived extracellular vesicle cargo regulate neuronal excitability

(2019) Amrita Datta Chaudhuri et al.   GLIA

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

(2019) Xiaohuan Xia et al.   PROGRESS IN NEUROBIOLOGY

Increased Interleukin-6 Levels in the Astrocyte-Derived Exosomes of Sporadic Amyotrophic Lateral Sclerosis Patients

(2019) Yong Chen et al.   Frontiers in Neuroscience

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity

(2019) Charisse N. Winston et al.   Frontiers in Neuroscience

Astrocytes‐derived exosomes induce neuronal recovery after traumatic brain injury via delivering gap junction alpha 1‐20 k

(2019) Wei Chen et al.   Journal of Tissue Engineering and Regenerative Medicine

Exosomes From Astrocyte Processes: Signaling to Neurons

(2019) Arianna Venturini et al.   Frontiers in Pharmacology

Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing

(2019) Yang You et al.   Journal of Extracellular Vesicles

Understanding the impact of sex and gender in Alzheimer's disease: A call to action

(2018) Rebecca A. Nebel et al.   Alzheimers & Dementia

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Microglia-derived extracellular vesicles in Alzheimer’s Disease: A double-edged sword

(2018) Teresa Trotta et al.   BIOCHEMICAL PHARMACOLOGY

Delivery of MGMT mRNA to glioma cells by reactive astrocyte-derived exosomes confers a temozolomide resistance phenotype

(2018) Tianfu Yu et al.   CANCER LETTERS

Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration

(2018) Lu Yang et al.   Journal of Neuroimmune Pharmacology

Astrocyte pathology in the ventral prefrontal white matter in depression

(2018) Grazyna Rajkowska et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Cell-to-cell Communication by Extracellular Vesicles: Focus on Microglia

(2018) Rosa C. Paolicelli et al.   NEUROSCIENCE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

(2018) Amrita Datta Chaudhuri et al.   Cell Death & Disease

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869

(2018) Yunlong Huang et al.   Cell Discovery

JHU-083 selectively blocks glutaminase activity in brain CD11b+ cells and prevents depression-associated behaviors induced by chronic social defeat stress

(2018) Xiaolei Zhu et al.   NEUROPSYCHOPHARMACOLOGY

Astrocyte-Derived Exosomes Treated With a Semaphorin 3A Inhibitor Enhance Stroke Recovery via Prostaglandin D 2 Synthase

(2018) Kenichiro Hira et al.   STROKE

Astrocyte EV-induced lincRNA-Cox2 regulates microglial phagocytosis: Implications for morphine-mediated potentiation of neurodegeneration

(2018) Guoku Hu et al.   Molecular Therapy-Nucleic Acids

Extracellular αB-crystallin modulates the inflammatory responses

(2018) Yong-shun Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutral Sphingomyelinase Inhibition Alleviates LPS Induced Microglia Activation and Neuroinflammation after Experimental Traumatic Brain Injury

(2018) Asit Kumar et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Preservation of neuronal functions by exosomes derived from different human neural cell types under ischemic conditions

(2017) Mingyang Deng et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Potential Modes of Intercellular α-Synuclein Transmission

(2017) Dario Valdinocci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases

(2017) David Rufino-Ramos et al.   JOURNAL OF CONTROLLED RELEASE

Screening the expression characteristics of several miRNAs in G93A-SOD1 transgenic mouse: altered expression of miRNA-124 is associated with astrocyte differentiation by targeting Sox2 and Sox9

(2017) Fenghua Zhou et al.   JOURNAL OF NEUROCHEMISTRY

TNF-α promotes extracellular vesicle release in mouse astrocytes through glutaminase

(2017) Kaizhe Wang et al.   Journal of Neuroinflammation

Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes

(2017) Yan Hong et al.   JOURNAL OF NEUROSCIENCE

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Tipping Points and Endogenous Determinants of Nigrostriatal Degeneration by MPTP

(2017) Stefan Schildknecht et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

HIV-1 Nef is released in extracellular vesicles derived from astrocytes: evidence for Nef-mediated neurotoxicity

(2017) A Sami Saribas et al.   Cell Death & Disease

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

(2017) Alex M. Dickens et al.   Science Signaling

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

(2017) Anna Chiarini et al.   Frontiers in Neuroscience

α-Synuclein-carrying extracellular vesicles in Parkinson’s disease: deadly transmitters

(2016) Dimitry A. Chistiakov et al.   ACTA NEUROLOGICA BELGICA

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation

(2016) Kae M. Pusic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Complex and Differential Glial Responses in Alzheimers Disease and Ageing

(2016) José J. Rodríguez et al.   Current Alzheimer Research

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

(2016) A. Verkhratsky et al.   EMBO JOURNAL

Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles

(2016) David W. Greening et al.   Expert Review of Proteomics

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease

(2016) Brian Spencer et al.   HUMAN MOLECULAR GENETICS

Stimulating the Release of Exosomes Increases the Intercellular Transfer of Prions

(2016) Belinda B. Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicle isolation and characterization: toward clinical application

(2016) Rong Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity

(2016) Clemens Falker et al.   JOURNAL OF NEUROCHEMISTRY

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

(2016) Sofia Söllvander et al.   Molecular Neurodegeneration

Transfer of mitochondria from astrocytes to neurons after stroke

(2016) Kazuhide Hayakawa et al.   NATURE

Extracellular vesicles round off communication in the nervous system

(2016) Vivian Budnik et al.   NATURE REVIEWS NEUROSCIENCE

Decoding astrocyte heterogeneity: New tools for clonal analysis

(2016) A. Bribián et al.   NEUROSCIENCE

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

The contribution of astrocytes and microglia to traumatic brain injury

(2015) Ila P Karve et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cerebral Ischemic Preconditioning: the Road So Far…

(2015) Thushara Vijayakumar N et al.   MOLECULAR NEUROBIOLOGY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure

(2015) Georgia K. Atkin-Smith et al.   Nature Communications

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

(2015) Valentina R. Minciacchi et al.   Oncotarget

Glia in the pathogenesis of neurodegenerative diseases

(2014) Alexei Verkhratsky et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination

(2013) Aya D. Pusic et al.   GLIA

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

(2013) Manuela Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Intracellular Interactome of Tetraspanin-enriched Microdomains Reveals Their Function as Sorting Machineries toward Exosomes

(2013) Daniel Perez-Hernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells

(2013) Nicolas Pallet et al.   PROTEOMICS

Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms

(2013) James W. Smyth et al.   Cell Reports

Microglia are required for astroglial toll-like receptor 4 response and for optimal TLR2 and TLR3 response

(2012) Thomas H. Holm et al.   GLIA

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

(2012) Guanghu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Ectosomes

(2011) Emanuele Cocucci et al.   CURRENT BIOLOGY

Calcium Triggers Exocytosis from Two Types of Organelles in a Single Astrocyte

(2011) T. Liu et al.   JOURNAL OF NEUROSCIENCE

Synapsin I Is an Oligomannose-Carrying Glycoprotein, Acts As an Oligomannose-Binding Lectin, and Promotes Neurite Outgrowth and Neuronal Survival When Released via Glia-Derived Exosomes

(2011) S. Wang et al.   JOURNAL OF NEUROSCIENCE

Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein

(2010) Keiichi Tamai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microparticles

(2010) Sebastian F. Mause et al.   CIRCULATION RESEARCH

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Exosome Secretion Ameliorates Lysosomal Storage of Cholesterol in Niemann-Pick Type C Disease

(2010) Katrin Strauss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

What has inflammation to do with traumatic brain injury?

(2009) David Cederberg et al.   CHILDS NERVOUS SYSTEM

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Trafficking and Fusion of Neuropeptide Y-Containing Dense-Core Granules in Astrocytes

(2008) P. Ramamoorthy et al.   JOURNAL OF NEUROSCIENCE

Stroke

(2008) Geoffrey A Donnan et al.   LANCET

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE

White matter in learning, cognition and psychiatric disorders

(2008) R. Douglas Fields   TRENDS IN NEUROSCIENCES