Intracellular transport and regulation of transcytosis across the blood–brain barrier

Transcytosis of payloads that are non-covalently complexed to bispecific antibodies across the hCMEC/D3 blood-brain barrier model

(2018) Daniela Schmid et al.   BIOLOGICAL CHEMISTRY

HRS–WASH axis governs actin-mediated endosomal recycling and cell invasion

(2018) Ewan MacDonald et al.   JOURNAL OF CELL BIOLOGY

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

(2018) Justin R. Piro et al.   Journal of Neuroinflammation

Brain uptake of multivalent and multi-specific DVD-Ig proteins after systemic administration

(2018) Denise Karaoglu Hanzatian et al.   mAbs

The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro

(2018) Andrea E. Toth et al.   MOLECULAR NEUROBIOLOGY

Mechanisms of clathrin-mediated endocytosis

(2018) Marko Kaksonen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

(2018) Mark A. Petersen et al.   NATURE REVIEWS NEUROSCIENCE

Microglia in the Neurovascular Unit: Blood–Brain Barrier–microglia Interactions After Central Nervous System Disorders

(2018) Hannah Thurgur et al.   NEUROSCIENCE

Mechanisms of Carrier Formation during Clathrin-Independent Endocytosis

(2018) Antonio P.A. Ferreira et al.   TRENDS IN CELL BIOLOGY

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis

(2018) Maria Ribecco-Lutkiewicz et al.   Scientific Reports

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

(2018) Kasper Bendix Johnsen et al.   Theranostics

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

(2018) Andrée-Anne Berthiaume et al.   Cell Reports

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

(2018) Maria Daniela Garcia-Castillo et al.   eLife

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR

(2017) Boris Simonetti et al.   JOURNAL OF CELL BIOLOGY

Endosomal trafficking regulates receptor-mediated transcytosis of antibodies across the blood brain barrier

(2017) Arsalan S Haqqani et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Region-specific permeability of the blood–brain barrier upon pericyte loss

(2017) Roberto Villaseñor et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Bidirectional apical–basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

(2017) Piotr Siupka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?

(2017) Axel Montagne et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An isogenic blood-brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

(2017) Scott G. Canfield et al.   JOURNAL OF NEUROCHEMISTRY

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Endothelial Wnt/β-catenin signaling reduces immune cell infiltration in multiple sclerosis

(2017) Justin E. Lengfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcellular vesicular transport in epithelial and endothelial cells: Challenges and opportunities

(2017) Karen Y. Y. Fung et al.   TRAFFIC

Membrane Transport across Polarized Epithelia

(2017) Maria Daniela Garcia-Castillo et al.   Cold Spring Harbor Perspectives in Biology

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

Sorting Tubules Regulate Blood-Brain Barrier Transcytosis

(2017) Roberto Villaseñor et al.   Cell Reports

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

(2017) Sarah E. Lutz et al.   Cell Reports

Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner

(2017) Dimitris Basagiannis et al.   Scientific Reports

Involvement of the Blood-Brain Barrier in Metabolic Regulation

(2016) Abba J. Kastin et al.   CNS & Neurological Disorders-Drug Targets

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease

(2016) Claudio Villegas-Llerena et al.   CURRENT OPINION IN NEUROBIOLOGY

Glial-endothelial crosstalk regulates blood–brain barrier function

(2016) Lara Cheslow et al.   CURRENT OPINION IN PHARMACOLOGY

Into rather unexplored terrain-transcellular transport across the blood-brain barrier

(2016) Marijke De Bock et al.   GLIA

The blood–brain barrier after stroke: Structural studies and the role of transcytotic vesicles

(2016) Michael J Haley et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

(2016) Justin Rustenhoven et al.   Journal of Neuroinflammation

Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2016) Hao Wu et al.   JOURNAL OF NEUROSCIENCE

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Cerebrovascular pathology during the progression of experimental Alzheimer's disease

(2016) Patrizia Giannoni et al.   NEUROBIOLOGY OF DISEASE

Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies

(2016) Y. Joy Yu Zuchero et al.   NEURON

Caveolae: One Function or Many?

(2016) Jade P.X. Cheng et al.   TRENDS IN CELL BIOLOGY

Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier

(2016) Roberto Villaseñor et al.   Scientific Reports

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

(2016) Rocío Navarro et al.   Frontiers in Immunology

A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis

(2015) Susan M. Armstrong et al.   CARDIOVASCULAR RESEARCH

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

The Alzheimer's disease risk factor CD2AP maintains blood–brain barrier integrity

(2015) J. Nicholas Cochran et al.   HUMAN MOLECULAR GENETICS

Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation

(2015) Gernot F. Grabner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is a pericyte?

(2015) David Attwell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ultrastructural analysis of blood–brain barrier breakdown in the peri-infarct zone in young adult and aged mice

(2015) Patrick C Nahirney et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

(2015) Steffen E. Storck et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells

(2015) Paymon M. Azizi et al.   MOLECULAR BIOLOGY OF THE CELL

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

(2015) Zhen Zhao et al.   NATURE NEUROSCIENCE

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

(2015) Axel Montagne et al.   NEURON

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

(2015) Robert A. Hill et al.   NEURON

The Molecular Constituents of the Blood–Brain Barrier

(2015) Brian Wai Chow et al.   TRENDS IN NEUROSCIENCES

Lipopolysaccharide-induced caveolin-1 phosphorylation-dependent increase in transcellular permeability precedes the increase in paracellular permeability

(2015) Gengyun Sun et al.   Drug Design Development and Therapy

Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex

(2015) Christoph M. Zehendner et al.   Scientific Reports

Cargo Delivery into the Brain by in vivo identified Transport Peptides

(2015) Eduard Urich et al.   Scientific Reports

Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action

(2015) Andreu Viader et al.   Cell Reports

Clinical evidence of inflammation driving secondary brain injury

(2015) Holly E. Hinson et al.   Journal of Trauma and Acute Care Surgery

Inflammation and Neuroprotection in Traumatic Brain Injury

(2015) Kara N. Corps et al.   JAMA Neurology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer‘s disease

(2014) Ludovic Collin et al.   BRAIN

A novel platform for engineering blood-brain barrier-crossing bispecific biologics

(2014) Graham K. Farrington et al.   FASEB JOURNAL

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Endophilin marks and controls a clathrin-independent endocytic pathway

(2014) Emmanuel Boucrot et al.   NATURE

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

(2014) Junichi Matsumoto et al.   NEUROSCIENCE LETTERS

Lattice light-sheet microscopy: Imaging molecules to embryos at high spatiotemporal resolution

(2014) Bi-Chang Chen et al.   SCIENCE

Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates

(2014) Y. J. Yu et al.   Science Translational Medicine

Membrane-associated cargo recycling by tubule-based endosomal sorting

(2014) Jan R.T. van Weering et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The impact of microglial activation on blood-brain barrier in brain diseases

(2014) Anna Carolina Carvalho da Fonseca et al.   Frontiers in Cellular Neuroscience

Clathrin-Independent Pathways of Endocytosis

(2014) S. Mayor et al.   Cold Spring Harbor Perspectives in Biology

Endocytic Crosstalk: Cavins, Caveolins, and Caveolae Regulate Clathrin-Independent Endocytosis

(2014) Natasha Chaudhary et al.   PLOS BIOLOGY

Clathrin-independent pathways do not contribute significantly to endocytic flux

(2014) Vassilis Bitsikas et al.   eLife

Glial influence on the blood brain barrier

(2013) Jorge Ivan Alvarez et al.   GLIA

Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules

(2013) Andrew W. Weflen et al.   MOLECULAR BIOLOGY OF THE CELL

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins

(2012) David B. Thompson et al.   CHEMISTRY & BIOLOGY

Early Loss of Pericytes and Perivascular Stromal Cell-Induced Scar Formation after Stroke

(2012) Francisco Fernández-Klett et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Insulin in the brain: There and back again

(2012) William A. Banks et al.   PHARMACOLOGY & THERAPEUTICS

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Sequence-Dependent Sorting of Recycling Proteins by Actin-Stabilized Endosomal Microdomains

(2010) Manojkumar A. Puthenveedu et al.   CELL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS