Advances in microphysiological blood-brain barrier (BBB) models towards drug delivery

Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood–Brain Barrier Model

(2020) Diána Hudecz et al.   ACS Nano

Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms

(2020) Song Ih Ahn et al.   Nature Communications

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Vascularized neural constructs for ex-vivo reconstitution of blood-brain barrier function

(2020) Haibing Yue et al.   BIOMATERIALS

Fluid flow rate dictates the efficacy of low intensity anti‐vascular ultrasound therapy in a microfluidic model

(2019) B. J DeOre et al.   MICROCIRCULATION

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Organoids-on-a-chip

(2019) Sunghee Estelle Park et al.   SCIENCE

An isogenic hiPSC-derived BBB-on-a-chip

(2019) Pedram Motallebnejad et al.   Biomicrofluidics

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Reversible Cavitation‐Induced Junctional Opening in an Artificial Endothelial Layer

(2019) Giulia Silvani et al.   Small

3D brain angiogenesis model to reconstitute functional human blood–brain barrier in vitro

(2019) Somin Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

Vascularized Microfluidics and the Blood–Endothelium Interface

(2019) Christopher A. Hesh et al.   Micromachines

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

(2018) Kacey Ronaldson-Bouchard et al.   Cell Stem Cell

Use of porous membranes in tissue barrier and co-culture models

(2018) Henry H. Chung et al.   LAB ON A CHIP

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling

(2018) Goodwell Nzou et al.   Scientific Reports

Current Strategies for Brain Drug Delivery

(2018) Xiaowei Dong   Theranostics

Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier

(2018) Iason Papademetriou et al.   PLoS One

Engineered 3D Microvascular Networks for the Study of Ultrasound-Microbubble-Mediated Drug Delivery

(2018) Eric K. Juang et al.   LANGMUIR

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

(2018) Sonja Bergmann et al.   Nature Protocols

Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

(2017) Duc TT Phan et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

A microfluidic model of the blood–brain barrier to study permeabilization by pulsed electric fields

(2017) M. Bonakdar et al.   RSC Advances

Microvessels-on-a-Chip to Assess Targeted Ultrasound-Assisted Drug Delivery

(2016) Yoonjee C. Park et al.   ACS Applied Materials & Interfaces

In vitro screening of nanomedicines through the blood brain barrier: A critical review

(2016) Juan Aparicio-Blanco et al.   BIOMATERIALS

Shuttle-mediated nanoparticle transport across an in vitro brain endothelium under flow conditions

(2016) Andrea P. Falanga et al.   BIOTECHNOLOGY AND BIOENGINEERING

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Minimum Transendothelial Electrical Resistance Thresholds for the Study of Small and Large Molecule Drug Transport in a Human in Vitro Blood–Brain Barrier Model

(2016) Jennifer L. Mantle et al.   MOLECULAR PHARMACEUTICS

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

(2016) S. Aday et al.   TRENDS IN BIOTECHNOLOGY

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

(2015) Jeong Ah Kim et al.   Biomicrofluidics

Microcirculation-on-a-Chip: A Microfluidic Platform for Assaying Blood- and Lymphatic-Vessel Permeability

(2015) Miwa Sato et al.   PLoS One

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

The Cost of Brain Diseases: A Burden or a Challenge?

(2014) Monica DiLuca et al.   NEURON

Inhibiting drug efflux transporters improves efficacy of ALS therapeutics

(2014) Michael R. Jablonski et al.   Annals of Clinical and Translational Neurology

Quantification of Blood-Brain Barrier Solute Permeability and Brain Transport by Multiphoton Microscopy

(2013) Lingyan Shi et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP