Organs-on-a-chip models for biological research

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

(2020) David B. Chou et al.   Nature Biomedical Engineering

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

(2020) Trevor Sasserath et al.   Advanced Science

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

(2020) Martin Trapecar et al.   Cell Systems

h-FIBER: Microfluidic Topographical Hollow Fiber for Studies of Glomerular Filtration Barrier

(2020) Ruoxiao Xie et al.   ACS Central Science

Recapitulating Pancreatic Tumor Microenvironment through Synergistic Use of Patient Organoids and Organ‐on‐a‐Chip Vasculature

(2020) Benjamin Fook Lun Lai et al.   ADVANCED FUNCTIONAL MATERIALS

Human Organs-on-Chips for Virology

(2020) Huaqi Tang et al.   TRENDS IN MICROBIOLOGY

Toward Brain-on-a-Chip: Human Induced Pluripotent Stem Cell-Derived Guided Neuronal Networks in Tailor-Made 3D Nanoprinted Microscaffolds

(2020) Jann Harberts et al.   ACS Nano

IFlowPlate—A Customized 384‐Well Plate for the Culture of Perfusable Vascularized Colon Organoids

(2020) Shravanthi Rajasekar et al.   ADVANCED MATERIALS

COVID-19 can affect the heart

(2020) Eric J. Topol   SCIENCE

3D curvature-instructed endothelial flow response and tissue vascularization

(2020) Christian Mandrycky et al.   Science Advances

Organ-on-a-Chip Systems for Modeling Pathological Tissue Morphogenesis Associated with Fibrosis and Cancer

(2020) Kristen L. Hayward et al.   ACS Biomaterials-Science & Engineering

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

(2019) Leah M. Norona et al.   PLoS One

Bioengineered human acellular vessels recellularize and evolve into living blood vessels after human implantation

(2019) Robert D. Kirkton et al.   Science Translational Medicine

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

(2019) Idit Goldfracht et al.   Acta Biomaterialia

Multivascular networks and functional intravascular topologies within biocompatible hydrogels

(2019) Bagrat Grigoryan et al.   SCIENCE

A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

(2019) Mohsen Afshar Bakooshli et al.   eLife

Colorectal tumor-on-a-chip system: A 3D tool for precision onco-nanomedicine

(2019) M. R. Carvalho et al.   Science Advances

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

Engineering a 3D functional human peripheral nerve in vitro using the Nerve-on-a-Chip platform

(2019) Anup D. Sharma et al.   Scientific Reports

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection

(2019) Alexandre Grassart et al.   Cell Host & Microbe

Multiscale reverse engineering of the human ocular surface

(2019) Jeongyun Seo et al.   NATURE MEDICINE

Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype

(2019) Kacey Ronaldson-Bouchard et al.   Nature Protocols

Deconstructed Microfluidic Bone Marrow On‐A‐Chip to Study Normal and Malignant Hemopoietic Cell–Niche Interactions

(2019) Julio Aleman et al.   Small

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

(2019) Kevin Achberger et al.   eLife

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs

(2019) Zixuan Lin et al.   Frontiers in Bioengineering and Biotechnology

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

(2018) T. Satoh et al.   LAB ON A CHIP

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

(2018) Kacey Ronaldson-Bouchard et al.   NATURE

Engineering human pluripotent stem cells into a functional skeletal muscle tissue

(2018) Lingjun Rao et al.   Nature Communications

Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease

(2018) Yongzhi Qiu et al.   Nature Biomedical Engineering

Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle

(2018) Alastair Khodabukus et al.   BIOMATERIALS

A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX

(2018) Xiang Li et al.   LAB ON A CHIP

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

(2018) Collin D. Edington et al.   Scientific Reports

Advances in organ-on-a-chip engineering

(2018) Boyang Zhang et al.   Nature Reviews Materials

Tissue engineering of human hair follicles using a biomimetic developmental approach

(2018) Hasan Erbil Abaci et al.   Nature Communications

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, andN-cadherin balance in mural cell–endothelial cell-regulated barrier function

(2017) Stella Alimperti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

(2017) Shuo Xiao et al.   Nature Communications

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

(2017) Sophie Bauer et al.   Scientific Reports

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

(2016) Zhiyun Xu et al.   ACS Applied Materials & Interfaces

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Engineering a perfusable 3D human liver platform from iPS cells

(2016) Arnout Schepers et al.   LAB ON A CHIP

The intercell dynamics of T cells and dendritic cells in a lymph node-on-a-chip flow device

(2016) Patrícia Moura Rosa et al.   LAB ON A CHIP

A microphysiological model of the human placental barrier

(2016) Cassidy Blundell et al.   LAB ON A CHIP

Biodegradable scaffold with built-in vasculature for organ-on-a-chip engineering and direct surgical anastomosis

(2016) Boyang Zhang et al.   NATURE MATERIALS

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

(2016) Mengying Zhou et al.   Scientific Reports

Human gut microbiota: the links with dementia development

(2016) Rashad Alkasir et al.   Protein & Cell

Human Engineered Heart Tissue: Analysis of Contractile Force

(2016) Ingra Mannhardt et al.   Stem Cell Reports

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Bioprinting of 3D Convoluted Renal Proximal Tubules on Perfusable Chips

(2016) Kimberly A. Homan et al.   Scientific Reports

Microfluidic vascularized bone tissue model with hydroxyapatite-incorporated extracellular matrix

(2015) Norhana Jusoh et al.   LAB ON A CHIP

Personalized medicine: Time for one-person trials

(2015) Nicholas J. Schork   NATURE

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

(2015) J. T. Hinson et al.   SCIENCE

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

(2015) Anurag Mathur et al.   Scientific Reports

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies

(2014) Gang Wang et al.   NATURE MEDICINE

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concerns about the widespread use of rodent models for human risk assessments of endocrine disruptors

(2014) René Habert et al.   REPRODUCTION

Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes

(2014) Wendy Keung et al.   Stem Cell Research & Therapy

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes

(2013) Sara S Nunes et al.   NATURE METHODS

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The n-of-1 clinical trial: the ultimate strategy for individualizing medicine?

(2011) Elizabeth O Lillie et al.   Personalized Medicine

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Current challenges in the evaluation of cardiac safety during drug development: Translational medicine meets the Critical Path Initiative

(2009) Jonathan P. Piccini et al.   AMERICAN HEART JOURNAL

Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix

(2009) Farshid Guilak et al.   Cell Stem Cell

A micro cell culture analog (µCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs

(2009) Jong Hwan Sung et al.   LAB ON A CHIP

Development of a Microscale Cell Culture Analog To Probe Naphthalene Toxicity

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS