Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models

(2020) Yohei Tomita et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcytosis at the blood–brain barrier

(2019) Swathi Ayloo et al.   CURRENT OPINION IN NEUROBIOLOGY

Suppression of transcytosis regulates zebrafish blood-brain barrier function

(2019) Natasha M O'Brown et al.   eLife

Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction

(2019) Ekaterina S. Lobanova et al.   JOURNAL OF NEUROSCIENCE

Zika virus degrades the ω-3 fatty acid transporter Mfsd2a in brain microvascular endothelial cells and impairs lipid homeostasis

(2019) Jia Zhou et al.   Science Advances

Interplay of the Norrin and Wnt7a/Wnt7b signaling systems in blood–brain barrier and blood–retina barrier development and maintenance

(2018) Yanshu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in vascular eye diseases

(2018) Zhongxiao Wang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels

(2017) Jenna Mazzoni et al.   NEURON

Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-Specific Signaling in Mammalian CNS Angiogenesis and Blood-Brain Barrier Regulation

(2017) Chris Cho et al.   NEURON

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation

(2017) Brian Wai Chow et al.   NEURON

Targeting blood-brain-barrier transcytosis – perspectives for drug delivery

(2017) Imre Mäger et al.   NEUROPHARMACOLOGY

The inner blood-retinal barrier: Cellular basis and development

(2017) Mónica Díaz-Coránguez et al.   VISION RESEARCH

Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy

(2016) Zhongxiao Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development

(2016) Bernice H. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mfsd2a-based pharmacological strategies for drug delivery across the blood–brain barrier

(2016) Jing-Zhang Wang et al.   PHARMACOLOGICAL RESEARCH

Critical Endothelial Regulation by LRP5 during Retinal Vascular Development

(2016) Wei Huang et al.   PLoS One

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

(2015) Alicia Guemez-Gamboa et al.   NATURE GENETICS

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

(2015) Chuck T. Chen et al.   Scientific Reports

Novel insights into the development and maintenance of the blood–brain barrier

(2014) Britta Engelhardt et al.   CELL AND TISSUE RESEARCH

Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling

(2014) Yulian Zhou et al.   DEVELOPMENTAL CELL

The Role of the Hypoxia Response in Shaping Retinal Vascular * Development in the Absence of Norrin/Frizzled4 Signaling

(2014) A. Rattner et al.   INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants

(2014) Nga Bien-Ly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

(2014) Long N. Nguyen et al.   NATURE

Double function at the blood–brain barrier

(2014) Christer Betsholtz   NATURE

Stepwise Recruitment of Transcellular and Paracellular Pathways Underlies Blood-Brain Barrier Breakdown in Stroke

(2014) Daniel Knowland et al.   NEURON

XAV939: From a Small Inhibitor to a Potent Drug Bioconjugate When Delivered by Gold Nanoparticles

(2013) Marwa M. Afifi et al.   BIOCONJUGATE CHEMISTRY

Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions

(2013) Ingeborg Klaassen et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

Diabetic Retinopathy

(2012) David A. Antonetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Retinal Expression of Wnt-Pathway Mediated Genes in Low-Density Lipoprotein Receptor-Related Protein 5 (Lrp5) Knockout Mice

(2012) Jing Chen et al.   PLoS One

Wnt Signaling Mediates Pathological Vascular Growth in Proliferative Retinopathy

(2011) Jing Chen et al.   CIRCULATION

Caveolae at a glance

(2010) M. Bastiani et al.   JOURNAL OF CELL SCIENCE

The Norrin/Frizzled4 signaling pathway in retinal vascular development and disease

(2010) Xin Ye et al.   TRENDS IN MOLECULAR MEDICINE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt/β-catenin signaling controls development of the blood–brain barrier

(2008) Stefan Liebner et al.   JOURNAL OF CELL BIOLOGY

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE