In vitro modeling of the neurovascular unit: advances in the field

Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications

(2019) Zulema Vargas-Osorio et al.   Nanomaterials

Permeability analyses and three dimensional imaging of interferon gamma-induced barrier disintegration in intestinal organoids

(2019) Marco Bardenbacher et al.   Stem Cell Research

Organs to Cells and Cells to Organoids: The Evolution of in vitro Central Nervous System Modelling

(2019) Dario Pacitti et al.   Frontiers in Cellular Neuroscience

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

(2019) Gad D. Vatine et al.   Cell Stem Cell

Cerebrovascular and Neurological Disorders: Protective Role of NRF2

(2019) Farzane Sivandzade et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D

(2019) John J. Jamieson et al.   Fluids and Barriers of the CNS

Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

(2019) Yoojin Shin et al.   Advanced Science

A Reconfigurable In Vitro Model for Studying the Blood–Brain Barrier

(2019) Monica L. Moya et al.   ANNALS OF BIOMEDICAL ENGINEERING

In-vitro blood-brain barrier models for drug screening and permeation studies: an overview

(2019) Sounak Bagchi et al.   Drug Design Development and Therapy

Proof-of-Concept Study of Drug Brain Permeability Between in Vivo Human Brain and an in Vitro iPSCs-Human Blood-Brain Barrier Model

(2019) Gwenaëlle Le Roux et al.   Scientific Reports

Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells

(2019) Gabrielle N. Grifno et al.   Scientific Reports

3D-printed gelatin scaffolds of differing pore geometry modulate hepatocyte function and gene expression

(2018) Phillip L. Lewis et al.   Acta Biomaterialia

Blood-Brain Barrier Dysfunction in Ischemic Stroke: Targeting Tight Junctions and Transporters for Vascular Protection

(2018) Wazir Abdullahi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fabricating smooth PDMS microfluidic channels from low-resolution 3D printed molds using an omniphobic lubricant-infused coating

(2018) Martin Villegas et al.   ANALYTICA CHIMICA ACTA

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Computational modeling in glioblastoma: from the prediction of blood–brain barrier permeability to the simulation of tumor behavior

(2018) Ana Miranda et al.   Future Medicinal Chemistry

Role of Blood-Brain Barrier in Alzheimer’s Disease

(2018) Zhiyou Cai et al.   JOURNAL OF ALZHEIMERS DISEASE

In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain

(2018) Hassan Pezeshgi Modarres et al.   JOURNAL OF CONTROLLED RELEASE

Monocultures of primary porcine brain capillary endothelial cells: Still a functional in vitro model for the blood-brain-barrier

(2018) Hans-Joachim Galla   JOURNAL OF CONTROLLED RELEASE

3D-printed thick structured gelatin membrane for engineering of heterogeneous tissues

(2018) Lobat Tayebi et al.   MATERIALS LETTERS

3D printed microfluidics and microelectronics

(2018) Ryan D. Sochol et al.   MICROELECTRONIC ENGINEERING

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

3D printed microfluidic device with integrated optical sensing for particle analysis

(2018) S.M. Hampson et al.   SENSORS AND ACTUATORS B-CHEMICAL

Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling

(2018) Goodwell Nzou et al.   Scientific Reports

Rate of small-molecular drug transport across the blood-brain barrier in a pericyte-deficient state

(2018) Nebojsa Mihajlica et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Diabetes and Hypercholesterolemia Increase Blood-Brain Barrier Permeability and Brain Amyloid Deposition: Beneficial Effects of the LpPLA2 Inhibitor Darapladib

(2018) Nimish K. Acharya et al.   JOURNAL OF ALZHEIMERS DISEASE

Human iPSC-derived blood-brain barrier microvessels: validation of barrier function and endothelial cell behavior

(2018) Raleigh M. Linville et al.   BIOMATERIALS

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

(2018) Sonja Bergmann et al.   Nature Protocols

Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier

(2018) Peter Van Dyken et al.   Frontiers in Neuroscience

Basement membrane and blood–brain barrier

(2018) Lingling Xu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Isogenic blood-brain barrier models based on patient-derived stem cells display inter-individual differences in cell maturation and functionality

(2017) Ronak Patel et al.   JOURNAL OF NEUROCHEMISTRY

A 3D neurovascular microfluidic model consisting of neurons, astrocytes and cerebral endothelial cells as a blood–brain barrier

(2017) Giulia Adriani et al.   LAB ON A CHIP

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia

(2017) C Greene et al.   MOLECULAR PSYCHIATRY

Human induced pluripotent stem cell based in vitro models of the blood-brain barrier: the future standard?

(2017) Winfried Neuhaus   Neural Regeneration Research

The blood-brain barrier in Alzheimer's disease

(2017) Elena Zenaro et al.   NEUROBIOLOGY OF DISEASE

Simplified fabrication of integrated microfluidic devices using fused deposition modeling 3D printing

(2017) Gabriel Gaal et al.   SENSORS AND ACTUATORS B-CHEMICAL

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

QSAR model for blood-brain barrier permeation

(2017) Andrey A. Toropov et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Mild hypothermia alleviates brain oedema and blood-brain barrier disruption by attenuating tight junction and adherens junction breakdown in a swine model of cardiopulmonary resuscitation

(2017) Jiebin Li et al.   PLoS One

Impairment of blood-brain barrier is an early event in R6/2 mouse model of Huntington Disease

(2017) Alba Di Pardo et al.   Scientific Reports

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

(2016) Axel Montagne et al.   ACTA NEUROPATHOLOGICA

Microfluidic blood-brain barrier model provides in vivo-like barrier properties for drug permeability screening

(2016) Ying I. Wang et al.   BIOTECHNOLOGY AND BIOENGINEERING

New experimental models of the blood-brain barrier for CNS drug discovery

(2016) Mohammad A. Kaisar et al.   Expert Opinion on Drug Discovery

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Organization of Endothelial Cells, Pericytes, and Astrocytes into a 3D Microfluidic in Vitro Model of the Blood–Brain Barrier

(2016) Jack D. Wang et al.   MOLECULAR PHARMACEUTICS

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Neurovascular unit impairment in early Alzheimer's disease measured with magnetic resonance imaging

(2016) Harm J. van de Haar et al.   NEUROBIOLOGY OF AGING

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

(2016) Harm J. van de Haar et al.   RADIOLOGY

A versatile lab-on-a-chip tool for modeling biological barriers

(2016) Fruzsina R. Walter et al.   SENSORS AND ACTUATORS B-CHEMICAL

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Cerebrovascular and blood-brain barrier impairments in Huntington's disease: Potential implications for its pathophysiology

(2015) Janelle Drouin-Ouellet et al.   ANNALS OF NEUROLOGY

Collagen-based brain microvasculature model in vitro using three-dimensional printed template

(2015) Jeong Ah Kim et al.   Biomicrofluidics

An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model

(2015) Katelyn L. Sellgren et al.   Biomicrofluidics

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor

(2015) Jacquelyn A. Brown et al.   Biomicrofluidics

The Blood-Brain Barrier in Multiple Sclerosis: microRNAs as Key Regulators

(2015) Wouter Kamphuis et al.   CNS & Neurological Disorders-Drug Targets

Conductive 3D microstructures by direct 3D printing of polymer/carbon nanotube nanocomposites via liquid deposition modeling

(2015) Giovanni Postiglione et al.   COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING

3D printed microfluidics for biological applications

(2015) Chee Meng Benjamin Ho et al.   LAB ON A CHIP

Inkjet printing for biosensor fabrication: combining chemistry and technology for advanced manufacturing

(2015) Jia Li et al.   LAB ON A CHIP

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

3D printed molds for non-planar PDMS microfluidic channels

(2015) Yongha Hwang et al.   SENSORS AND ACTUATORS A-PHYSICAL

Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice

(2015) Yun Jiao et al.   Journal of Parkinsons Disease

3D printing of porous structures by UV-curable O/W emulsion for fabrication of conductive objects

(2015) I. Cooperstein et al.   Journal of Materials Chemistry C

Bench-to-Bedside and Bedside Back to the Bench; Seeking a Better Understanding of the Acute Pathophysiological Process in Severe Traumatic Brain Injury

(2015) Denes V. Agoston   Frontiers in Neurology

Fiber Encapsulation Additive Manufacturing: An Enabling Technology for 3D Printing of Electromechanical Devices and Robotic Components

(2015) Matt Saari et al.   3D Printing and Additive Manufacturing

A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip

(2015) Sudhir P. Deosarkar et al.   PLoS One

3D Optical Printing of Piezoelectric Nanoparticle–Polymer Composite Materials

(2014) Kanguk Kim et al.   ACS Nano

Mechanical properties of components fabricated with open-source 3-D printers under realistic environmental conditions

(2014) B.M. Tymrak et al.   MATERIALS & DESIGN

In Vitro Models of the Blood–Brain Barrier for the Study of Drug Delivery to the Brain

(2014) Imola Wilhelm et al.   MOLECULAR PHARMACEUTICS

Mind the gap: Models in multiple species needed for therapeutic development in Huntington's disease

(2014) David S. Howland et al.   MOVEMENT DISORDERS

In Vitro Cerebrovascular Modeling in the 21st Century: Current and Prospective Technologies

(2014) Christopher A. Palmiotti et al.   PHARMACEUTICAL RESEARCH

Instruction of Circulating Endothelial Progenitors In Vitro towards Specialized Blood-Brain Barrier and Arterial Phenotypes

(2014) Julie Boyer-Di Ponio et al.   PLoS One

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

Active origami by 4D printing

(2014) Qi Ge et al.   Smart Materials and Structures

Efficient Differentiation of Human Pluripotent Stem Cells to Endothelial Progenitors via Small-Molecule Activation of WNT Signaling

(2014) Xiaojun Lian et al.   Stem Cell Reports

Phenotypic Spectrum of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

(2013) Toni S. Pearson et al.   Current Neurology and Neuroscience Reports

Quantification of Blood-Brain Barrier Solute Permeability and Brain Transport by Multiphoton Microscopy

(2013) Lingyan Shi et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Blood–brain barrier structure and function and the challenges for CNS drug delivery

(2013) N. Joan Abbott   JOURNAL OF INHERITED METABOLIC DISEASE

Vascular Physiology and Protein Disposition in a Preclinical Model of Neurodegeneration

(2013) C. Andrew Boswell et al.   MOLECULAR PHARMACEUTICS

Choosing an animal model for the study of Huntington's disease

(2013) Mahmoud A. Pouladi et al.   NATURE REVIEWS NEUROSCIENCE

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier

(2013) Eduard Urich et al.   Scientific Reports

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blood-Brain Barrier Permeability Is Increased After Acute Adult Stroke But Not Neonatal Stroke in the Rat

(2012) D. Fernandez-Lopez et al.   JOURNAL OF NEUROSCIENCE

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

SyM-BBB: a microfluidic blood brain barrier model

(2012) Balabhaskar Prabhakarpandian et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Vascular pathology of multiple sclerosis

(2012) Robert Zivadinov et al.   NEUROLOGICAL RESEARCH

Adult Neural Stem Cells: Response to Stroke Injury and Potential for Therapeutic Applications

(2012) Basam Z. Barkho et al.   Current Stem Cell Research & Therapy

Modern methods for delivery of drugs across the blood–brain barrier

(2011) Yan Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

In Vitro Blood–Brain Barrier Models: Current and Perspective Technologies

(2011) Pooja Naik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The biology of brain metastases—translation to new therapies

(2011) April F. Eichler et al.   Nature Reviews Clinical Oncology

Amyloid-β Contributes to Blood–Brain Barrier Leakage in Transgenic Human Amyloid Precursor Protein Mice and in Humans With Cerebral Amyloid Angiopathy

(2011) Anika M.S. Hartz et al.   STROKE

Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function

(2010) Yasuteru Sano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Dynamic in vitro BBB Model for the Study of Immune Cell Trafficking into the Central Nervous System

(2010) Luca Cucullo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Review of Three-Dimensional In Vitro Tissue Models for Drug Discovery and Transport Studies

(2010) Nelita T. Elliott et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nuclear reprogramming to a pluripotent state by three approaches

(2010) Shinya Yamanaka et al.   NATURE

The role of the organ microenvironment in brain metastasis

(2010) Isaiah J. Fidler   SEMINARS IN CANCER BIOLOGY

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

Launching invasive, first-in-human trials against Parkinson's disease: Ethical considerations

(2009) Jonathan Kimmelman et al.   MOVEMENT DISORDERS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Brain endothelial cells and the glio-vascular complex

(2008) Hartwig Wolburg et al.   CELL AND TISSUE RESEARCH

The Role of the Cell Surface LRP and Soluble LRP in Blood-Brain Barrier Aβ Clearance in Alzheimers Disease

(2008) R. Deane et al.   CURRENT PHARMACEUTICAL DESIGN

Early complications of ischemic stroke

(2008) H. Bart van der Worp et al.   Current Treatment Options in Neurology

Non-invasive measurement of solute permeability in cerebral microvessels of the rat

(2008) Wei Yuan et al.   MICROVASCULAR RESEARCH

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE