Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease

Chromatin accessibility dynamics in a model of human forebrain development

(2020) Alexandro E. Trevino et al.   SCIENCE

Potassium channel dysfunction in human neuronal models of Angelman syndrome

(2020) Alfred Xuyang Sun et al.   SCIENCE

Synthetic Analyses of Single-Cell Transcriptomes from Multiple Brain Organoids and Fetal Brain

(2020) Yoshiaki Tanaka et al.   Cell Reports

Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation

(2020) Xuyu Qian et al.   Cell Stem Cell

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

(2019) Simon T. Schafer et al.   NATURE NEUROSCIENCE

Modeling G2019S-LRRK2 Sporadic Parkinson's Disease in 3D Midbrain Organoids

(2019) Hongwon Kim et al.   Stem Cell Reports

Modeling Patient-Derived Glioblastoma with Cerebral Organoids

(2019) Amanda Linkous et al.   Cell Reports

Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis

(2019) Carla G. Silva et al.   NATURE REVIEWS NEUROSCIENCE

Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output

(2019) Stefano L. Giandomenico et al.   NATURE NEUROSCIENCE

Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia

(2019) Johannes Klaus et al.   NATURE MEDICINE

Zika virus infection induces RNAi-mediated antiviral immunity in human neural progenitors and brain organoids

(2019) Yan-Peng Xu et al.   CELL RESEARCH

Defining the Genetic, Genomic, Cellular, and Diagnostic Architectures of Psychiatric Disorders

(2019) Patrick F. Sullivan et al.   CELL

Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution

(2019) Alex A. Pollen et al.   CELL

Brain organoids: advances, applications and challenges

(2019) Xuyu Qian et al.   DEVELOPMENT

Specification of positional identity in forebrain organoids

(2019) Gustav Y. Cederquist et al.   NATURE BIOTECHNOLOGY

Human 3D cellular model of hypoxic brain injury of prematurity

(2019) Anca M. Pașca et al.   NATURE MEDICINE

Minocycline mitigates the effect of neonatal hypoxic insult on human brain organoids

(2019) Erin M. Boisvert et al.   Cell Death & Disease

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors

(2019) Wei Zhang et al.   Nature Communications

Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells

(2019) Liqing Song et al.   Scientific Reports

New insights into the development of the human cerebral cortex

(2019) Zoltán Molnár et al.   JOURNAL OF ANATOMY

Mapping human cell phenotypes to genotypes with single-cell genomics

(2019) J. Gray Camp et al.   SCIENCE

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Brain Organoids: Human Neurodevelopment in a Dish

(2019) Silvia Benito-Kwiecinski et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of hyperexcitability in Alzheimer’s disease hiPSC-derived neurons and cerebral organoids vs isogenic controls

(2019) Swagata Ghatak et al.   eLife

The Genetics of Primary Microcephaly

(2018) Divya Jayaraman et al.   Annual Review of Genomics and Human Genetics

Evolutionary Changes in Transcriptional Regulation: Insights into Human Behavior and Neurological Conditions

(2018) Ryan N. Doan et al.   Annual Review of Neuroscience

Brain organoids as models to study human neocortex development and evolution

(2018) Michael Heide et al.   CURRENT OPINION IN CELL BIOLOGY

Endoplasmic Reticulum Stress signalling - from basic mechanisms to clinical applications

(2018) Aitor Almanza et al.   FEBS Journal

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation

(2018) Maria L. Allende et al.   JOURNAL OF LIPID RESEARCH

Human brain organoid-on-a-chip to model prenatal nicotine exposure

(2018) Yaqing Wang et al.   LAB ON A CHIP

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Genetically engineered cerebral organoids model brain tumor formation

(2018) Shan Bian et al.   NATURE METHODS

Building three-dimensional human brain organoids

(2018) Sergiu Paşca   NATURE NEUROSCIENCE

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Charting the protomap of the human telencephalon

(2018) Gavin J. Clowry et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Glioblastoma Model Using Human Cerebral Organoids

(2018) Junko Ogawa et al.   Cell Reports

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids

(2018) Priya Srikanth et al.   Translational Psychiatry

Modeling amyloid beta and tau pathology in human cerebral organoids

(2018) Cesar Gonzalez et al.   MOLECULAR PSYCHIATRY

Genetically engineered human cortical spheroid models of tuberous sclerosis

(2018) John D. Blair et al.   NATURE MEDICINE

Human Models Are Needed for Studying Human Neurodevelopmental Disorders

(2018) Xinyu Zhao et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Reliability of human cortical organoid generation

(2018) Se-Jin Yoon et al.   NATURE METHODS

Building Models of Brain Disorders with Three-Dimensional Organoids

(2018) Neal D. Amin et al.   NEURON

Integrative functional genomic analysis of human brain development and neuropsychiatric risks

(2018) Mingfeng Li et al.   SCIENCE

Transcriptome and epigenome landscape of human cortical development modeled in organoids

(2018) Anahita Amiri et al.   SCIENCE

Microglia innately develop within cerebral organoids

(2018) Paul R. Ormel et al.   Nature Communications

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

(2017) Jinsoo Seo et al.   JOURNAL OF NEUROSCIENCE

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling

(2017) N Mellios et al.   MOLECULAR PSYCHIATRY

Assembly of functionally integrated human forebrain spheroids

(2017) Fikri Birey et al.   NATURE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Guided self-organization and cortical plate formation in human brain organoids

(2017) Madeline A Lancaster et al.   NATURE BIOTECHNOLOGY

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Fused cerebral organoids model interactions between brain regions

(2017) Joshua A Bagley et al.   NATURE METHODS

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

Genetic insights into the neurodevelopmental origins of schizophrenia

(2017) Rebecca Birnbaum et al.   NATURE REVIEWS NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis

(2017) Fei Ye et al.   NEURON

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

(2017) Momoko Watanabe et al.   Cell Reports

An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

(2017) Vira Iefremova et al.   Cell Reports

Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease

(2017) Rui Li et al.   Protein & Cell

Evolution of Gene Regulation in Humans

(2016) Steven K. Reilly et al.   Annual Review of Genomics and Human Genetics

SnapShot: Microglia in Disease

(2016) Simon Beggs et al.   CELL

Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior

(2016) Ryan N. Doan et al.   CELL

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

(2016) Xuyu Qian et al.   CELL

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Encoding and decoding time in neural development

(2016) Kenichi Toma et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

CPAP promotes timely cilium disassembly to maintain neural progenitor pool

(2016) Elke Gabriel et al.   EMBO JOURNAL

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

The Brazilian Zika virus strain causes birth defects in experimental models

(2016) Fernanda R. Cugola et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Pluripotent stem cells in disease modelling and drug discovery

(2016) Yishai Avior et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Cellular and Molecular Landscapes of the Developing Human Central Nervous System

(2016) John C. Silbereis et al.   NEURON

CYP3A5 Mediates Effects of Cocaine on Human Neocorticogenesis: Studies using an In Vitro 3D Self-Organized hPSC Model with a Single Cortex-Like Unit

(2016) Chun-Ting Lee et al.   NEUROPSYCHOPHARMACOLOGY

Zika virus impairs growth in human neurospheres and brain organoids

(2016) P. P. Garcez et al.   SCIENCE

Cerebral Organoids Recapitulate Epigenomic Signatures of the Human Fetal Brain

(2016) Chongyuan Luo et al.   Cell Reports

Mouse Genetic Models of Human Brain Disorders

(2016) Celeste Leung et al.   Frontiers in Genetics

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Viral Infections During Pregnancy

(2015) Michelle Silasi et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing

(2015) Akitsu Hotta et al.   Annual Review of Genetics

FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders

(2015) Jessica Mariani et al.   CELL

Is this a brain which I see before me? Modeling human neural development with pluripotent stem cells

(2015) I. K. Suzuki et al.   DEVELOPMENT

Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture

(2015) Anca M Paşca et al.   NATURE METHODS

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

Human cerebral organoids recapitulate gene expression programs of fetal neocortex development

(2015) J. Gray Camp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary changes in promoter and enhancer activity during human corticogenesis

(2015) S. K. Reilly et al.   SCIENCE

Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

(2015) Hideya Sakaguchi et al.   Nature Communications

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

(2015) Keiko Muguruma et al.   Cell Reports

The Cell Biology of Neurogenesis: Toward an Understanding of the Development and Evolution of the Neocortex

(2014) Elena Taverna et al.   Annual Review of Cell and Developmental Biology

The Diverse Genetic Landscape of Neurodevelopmental Disorders

(2014) Wen F. Hu et al.   Annual Review of Genomics and Human Genetics

Autism-epilepsy phenotype with macrocephaly suggests PTEN, but not GLIALCAM, genetic screening

(2014) Maria Marchese et al.   BMC Medical Genetics

Neural progenitors, neurogenesis and the evolution of the neocortex

(2014) M. Florio et al.   DEVELOPMENT

Generation of cerebral organoids from human pluripotent stem cells

(2014) Madeline A Lancaster et al.   Nature Protocols

Investigating human disease using stem cell models

(2014) Jared L. Sterneckert et al.   NATURE REVIEWS GENETICS

Growth and folding of the mammalian cerebral cortex: from molecules to malformations

(2014) Tao Sun et al.   NATURE REVIEWS NEUROSCIENCE

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

The impact of environmental factors in severe psychiatric disorders

(2014) Andrea Schmitt et al.   Frontiers in Neuroscience

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Many human accelerated regions are developmental enhancers

(2013) J. A. Capra et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

(2013) T. Kadoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro recapitulation of neural development using embryonic stem cells: From neurogenesis to histogenesis

(2012) Keiko Muguruma et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Genetic architectures of psychiatric disorders: the emerging picture and its implications

(2012) Patrick F. Sullivan et al.   NATURE REVIEWS GENETICS

Human Mutations in NDE1 Cause Extreme Microcephaly with Lissencephaly

(2011) Fowzan S. Alkuraya et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular modulation of prefrontal cortex: Rational development of treatments for psychiatric disorders.

(2011) Nao J. Gamo et al.   BEHAVIORAL NEUROSCIENCE

Trisomy 21 and early brain development

(2011) Tarik F. Haydar et al.   TRENDS IN NEUROSCIENCES

Human Genetic Disorders of Axon Guidance

(2010) E. C. Engle   Cold Spring Harbor Perspectives in Biology

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY