The Dynamics of B Cell Aging in Health and Disease

Hallmarks of T cell aging

(2021) Maria Mittelbrunn et al.   NATURE IMMUNOLOGY

Hallmarks of aging and immunosenescence: Connecting the dots

(2021) Leane Perim Rodrigues et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

(2020) John L. Johnson et al.   IMMUNITY

The role of B cell antigen presentation in the initiation of CD4+ T cell response

(2020) Zhaolin Hua et al.   IMMUNOLOGICAL REVIEWS

Rituximab in the treatment of multiple sclerosis in the Hospital District of Southwest Finland

(2020) Laura Airas et al.   Multiple Sclerosis and Related Disorders

B Cell Development and T-Dependent Antibody Response Are Regulated by p38γ and p38δ

(2020) Laura Barrio et al.   Frontiers in Cell and Developmental Biology

A human circulating immune cell landscape in aging and COVID-19

(2020) Yingfeng Zheng et al.   Protein & Cell

Microanatomy of the Human Atherosclerotic Plaque by Single-Cell Transcriptomics

(2020) Marie AC Depuydt et al.   CIRCULATION RESEARCH

Age-Related Differences in Immunological Responses to SARS-CoV-2

(2020) Lydia Su Yin Wong et al.   Journal of Allergy and Clinical Immunology-In Practice

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination

(2020) Daniela Frasca et al.   Immunity & Ageing

B Cell Subsets as Severity-Associated Signatures in COVID-19 Patients

(2020) Víctor A. Sosa-Hernández et al.   Frontiers in Immunology

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

The continuing story of T‐cell independent antibodies

(2019) David Allman et al.   IMMUNOLOGICAL REVIEWS

Epigenetic regulation of B cell fate and function during an immune response

(2019) Yan Zhang et al.   IMMUNOLOGICAL REVIEWS

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals

(2019) Carole Henry et al.   Cell Host & Microbe

B- and T-lymphocyte attenuator stimulation protects against atherosclerosis by regulating follicular B cells

(2019) Hidde Douna et al.   CARDIOVASCULAR RESEARCH

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

(2019) Robert C. Wirka et al.   NATURE MEDICINE

Metabolic requirements of human pro-inflammatory B cells in aging and obesity

(2019) Daniela Frasca et al.   PLoS One

Regulatory B cells: Development, phenotypes, functions, and role in transplantation

(2019) Rowa Y. Alhabbab et al.   IMMUNOLOGICAL REVIEWS

Age-Associated Myeloid Biased Hematopoiesis Depends on Relative Decrease of Short-Term Hematopoietic Stem Cell

(2019) Katsuyuki Nishi et al.   BLOOD

Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells

(2019) Joanne Boldison et al.   Cellular & Molecular Immunology

Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells

(2019) Samuel W. Du et al.   JOURNAL OF IMMUNOLOGY

Single-cell immune landscape of human atherosclerotic plaques

(2019) Dawn M. Fernandez et al.   NATURE MEDICINE

B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage

(2019) Jason B. Wong et al.   Nature Communications

Adipose Tissue B Cells Come of Age: The AABs of Fat Inflammation

(2019) Saad Khan et al.   Cell Metabolism

Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis

(2019) Christina D. Camell et al.   Cell Metabolism

Follicular B Cells Promote Atherosclerosis via T Cell–Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin GHighlights

(2018) Christopher Tay et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aged murine hematopoietic stem cells drive aging-associated immune remodeling

(2018) Hanna Leins et al.   BLOOD

BAFF Neutralization Aggravates Atherosclerosis

(2018) Dimitrios Tsiantoulas et al.   CIRCULATION

Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass CytometryNovelty and Significance

(2018) Holger Winkels et al.   CIRCULATION RESEARCH

Diminished antibody response to influenza vaccination is characterized by expansion of an age-associated B-cell population with low PAX5

(2018) Allison J. Nipper et al.   CLINICAL IMMUNOLOGY

Responders and non-responders to influenza vaccination: A DNA methylation approach on blood cells

(2018) Noémie Gensous et al.   EXPERIMENTAL GERONTOLOGY

B lymphocytes can be activated to act as antigen presenting cells to promote anti-tumor responses

(2018) Renata Ariza Marques Rossetti et al.   PLoS One

Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation

(2018) Bo Peng et al.   Cell Death & Disease

IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE

(2018) Shu Wang et al.   Nature Communications

Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study

(2018) Danielle M Gerlag et al.   ANNALS OF THE RHEUMATIC DISEASES

Bidirectional effects of IL-10+ regulatory B cells in Ldlr mice

(2018) Hidde Douna et al.   ATHEROSCLEROSIS

Transcriptome Analysis Reveals Nonfoamy Rather Than Foamy Plaque Macrophages Are Proinflammatory in Atherosclerotic Murine Models

(2018) Kyeongdae Kim et al.   CIRCULATION RESEARCH

Generation of functional murine CD11c+ age-associated B cells in the absence of B cell T-bet expression

(2018) Samuel W. Du et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

PD-L1+ Regulatory B Cells Are Significantly Decreased in Rheumatoid Arthritis Patients and Increase After Successful Treatment

(2018) Estefanía R. Zacca et al.   Frontiers in Immunology

BAFF and BAFF-Receptor in B Cell Selection and Survival

(2018) Cristian R. Smulski et al.   Frontiers in Immunology

Regulation of NLRP3 Inflammasome by Phosphorylation

(2018) Nan Song et al.   Frontiers in Immunology

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

(2017) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

(2017) Sezin Dagdeviren et al.   FASEB JOURNAL

Ageing adversely affects the migration and function of marginal zone B cells

(2017) Vivian M. Turner et al.   IMMUNOLOGY

Age-Associated B Cells Express a Diverse Repertoire of VHand Vκ Genes with Somatic Hypermutation

(2017) Lisa M. Russell Knode et al.   JOURNAL OF IMMUNOLOGY

Obesity induces pro-inflammatory B cells and impairs B cell function in old mice

(2017) Daniela Frasca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Marginal zone B cells control the response of follicular helper T cells to a high-cholesterol diet

(2017) Meritxell Nus et al.   NATURE MEDICINE

Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses

(2017) Isabel Cortegano et al.   Cell Death & Disease

Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help

(2017) Ting-ting Zhang et al.   eLife

Perivascular Adipose Tissue Harbors Atheroprotective IgM-Producing B Cells

(2017) Prasad Srikakulapu et al.   Frontiers in Physiology

The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome

(2017) Carlene Petes et al.   Frontiers in Immunology

Defining Natural Antibodies

(2017) Nichol E. Holodick et al.   Frontiers in Immunology

Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in AgedApoE−/−MiceHighlights

(2016) Prasad Srikakulapu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

B-cell-specific depletion of tumour necrosis factor alpha inhibits atherosclerosis development and plaque vulnerability to rupture by reducing cell death and inflammation

(2016) Christopher Tay et al.   CARDIOVASCULAR RESEARCH

Novel B-cell subsets in atherosclerosis

(2016) Hidde Douna et al.   CURRENT OPINION IN LIPIDOLOGY

Infection in an aging population

(2016) Kimberly A Kline et al.   CURRENT OPINION IN MICROBIOLOGY

Distinct Genetic Networks Orchestrate the Emergence of Specific Waves of Fetal and Adult B-1 and B-2 Development

(2016) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis

(2016) Alexander S. Kim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells

(2016) Charlotte Hua et al.   JOURNAL OF AUTOIMMUNITY

Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood

(2016) Tâm D. Quách et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: B Cell–Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection

(2016) Burton E. Barnett et al.   JOURNAL OF IMMUNOLOGY

Aging Converts Innate B1a Cells into Potent CD8+T Cell Inducers

(2016) Catalina Lee-Chang et al.   JOURNAL OF IMMUNOLOGY

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Haidong Wang et al.   LANCET

Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response

(2016) Julie Tellier et al.   NATURE IMMUNOLOGY

Defining antigen-specific plasmablast and memory B cell subsets in human blood after viral infection or vaccination

(2016) Ali H Ellebedy et al.   NATURE IMMUNOLOGY

System-Wide Associations between DNA-Methylation, Gene Expression, and Humoral Immune Response to Influenza Vaccination

(2016) Michael T. Zimmermann et al.   PLoS One

Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells

(2016) Shailaja Akunuru et al.   TRENDS IN MOLECULAR MEDICINE

Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis

(2016) Natalia Di Pietro et al.   VASCULAR PHARMACOLOGY

Sialic Acid-Binding Immunoglobulin-like Lectin G Promotes Atherosclerosis and Liver Inflammation by Suppressing the Protective Functions of B-1 Cells

(2016) Sabrina Gruber et al.   Cell Reports

Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment

(2016) Eliver Eid Bou Ghosn et al.   Stem Cell Reports

Editorial: Epigenetics of B Cells and Antibody Responses

(2016) Hong Zan et al.   Frontiers in Immunology

An Overview of B-1 Cells as Antigen-Presenting Cells

(2016) Ana F. Popi et al.   Frontiers in Immunology

Transitional B Cells in Early Human B Cell Development – Time to Revisit the Paradigm?

(2016) Victoria G. Martin et al.   Frontiers in Immunology

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

(2015) Rute Martins et al.   AGING CELL

B-1b Cells Secrete Atheroprotective IgM and Attenuate AtherosclerosisNovelty and Significance

(2015) Sam M. Rosenfeld et al.   CIRCULATION RESEARCH

The ageing human B cell repertoire: a failure of selection?

(2015) D. K. Dunn-Walters   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin β Receptors

(2015) Desheng Hu et al.   IMMUNITY

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

Tim-1 Is Essential for Induction and Maintenance of IL-10 in Regulatory B Cells and Their Regulation of Tissue Inflammation

(2015) Sheng Xiao et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs miR-155 and miR-16 Decrease AID and E47 in B Cells from Elderly Individuals

(2015) Daniela Frasca et al.   JOURNAL OF IMMUNOLOGY

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

(2015) Anatoly V. Rubtsov et al.   JOURNAL OF IMMUNOLOGY

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

(2015) G. F. Weber et al.   SCIENCE

B regulatory cells are increased in hypercholesterolaemic mice and protect from lesion development via IL-10

(2015) Paul Blair et al.   THROMBOSIS AND HAEMOSTASIS

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

(2015) Peter T. Sage et al.   Cell Reports

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

(2015) Diana G. Adlowitz et al.   PLoS One

Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency

(2014) Mi Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Accumulation of 4-1BBL+ B cells in the elderly induces the generation of granzyme-B+ CD8+ T cells with potential antitumor activity

(2014) C. Lee-Chang et al.   BLOOD

Innate Response Activator B Cells Aggravate Atherosclerosis by Stimulating T Helper-1 Adaptive Immunity

(2014) Ingo Hilgendorf et al.   CIRCULATION

Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis

(2014) Sarajo Kumar Mohanta et al.   CIRCULATION RESEARCH

TGF-β-producing regulatory B cells induce regulatory T cells and promote transplantation tolerance

(2014) Kang Mi Lee et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Deviation of the B Cell Pathway in Senescent Mice Is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression

(2014) S. Alter-Wolf et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

(2014) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Differences in Mouse and Human Nonmemory B Cell Pools

(2014) A. Benitez et al.   JOURNAL OF IMMUNOLOGY

A Novel Mechanism of B Cell–Mediated Immune Suppression through CD73 Expression and Adenosine Production

(2014) Hiroaki Kaku et al.   JOURNAL OF IMMUNOLOGY

IgH Chain Class Switch Recombination: Mechanism and Regulation

(2014) Janet Stavnezer et al.   JOURNAL OF IMMUNOLOGY

Interleukin-35 takes the 'B' line

(2014) Claudia Mauri et al.   NATURE MEDICINE

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

Regulatory B10 Cells Are Decreased in Patients With Rheumatoid Arthritis and Are Inversely Correlated With Disease Activity

(2014) Claire I. Daien et al.   Arthritis & Rheumatology

MicroRNAs, Major Players in B Cells Homeostasis and Function

(2014) Richard Danger et al.   Frontiers in Immunology

In senescence, age-associated B cells secrete TNFα and inhibit survival of B-cell precursors*

(2013) Michelle Ratliff et al.   AGING CELL

Aging is associated with increased regulatory T-cell function

(2013) Sanjay K. Garg et al.   AGING CELL

Age-related autoimmunity

(2013) Zahava Vadasz et al.   BMC Medicine

Epidemiology and Long-term Clinical and Biologic Risk Factors for Pneumonia in Community-Dwelling Older Americans

(2013) Sachin Yende et al.   CHEST

Peritoneal cavity B-1a cells promote peripheral CD4+T-cell activation

(2013) Bram Margry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Increased Th17 differentiation in aged mice is significantly associated with high IL-1β level and low IL-2 expression

(2013) Mi-Ae Lim et al.   EXPERIMENTAL GERONTOLOGY

Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans

(2013) Peter Libby et al.   IMMUNITY

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR9 Promotes Tolerance by Restricting Survival of Anergic Anti-DNA B Cells, Yet Is Also Required for Their Activation

(2013) K. M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

BAFF Receptor mAb Treatment Ameliorates Development and Progression of Atherosclerosis in Hyperlipidemic ApoE−/− Mice

(2013) Tin Kyaw et al.   PLoS One

B-1 Cell Immunoglobulin Directed Against Oxidation-Specific Epitopes

(2013) Dimitrios Tsiantoulas et al.   Frontiers in Immunology

BAFF Receptor Deficiency Reduces the Development of Atherosclerosis in Mice—Brief Report

(2012) Andrew P. Sage et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Apoptotic Cell Death and Efferocytosis in Atherosclerosis

(2012) Emily A. Van Vré et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stem cell heterogeneity: implications for aging and regenerative medicine

(2012) C. E. Muller-Sieburg et al.   BLOOD

Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation

(2012) Maria Carolina Florian et al.   Cell Stem Cell

IgM memory B cells: a mouse/human paradox

(2012) Claude-Agnès Reynaud et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Effect of Anti-B-cell Therapy on the Development of Atherosclerosis in Patients with Rheumatoid Arthritis

(2012) Diana S. Novikova et al.   CURRENT PHARMACEUTICAL DESIGN

B-1 B Cell Development in the Fetus and Adult

(2012) Encarnacion Montecino-Rodriguez et al.   IMMUNITY

High Rate of Antibody Secretion Is not Integral to Plasma Cell Differentiation as Revealed by XBP-1 Deficiency

(2012) N. Taubenheim et al.   JOURNAL OF IMMUNOLOGY

IL-17 and TNF-  Sustain Neutrophil Recruitment during Inflammation through Synergistic Effects on Endothelial Activation

(2012) G. K. Griffin et al.   JOURNAL OF IMMUNOLOGY

In Vivo Detection of Oxidation-Specific Epitopes in Atherosclerotic Lesions Using Biocompatible Manganese Molecular Magnetic Imaging Probes

(2012) Karen C. Briley-Saebo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

B Lymphocytes in Human Subcutaneous Adipose Crown-Like Structures

(2012) Marie E. McDonnell et al.   Obesity

Depletion of B2 but Not B1a B Cells in BAFF Receptor-Deficient ApoE−/− Mice Attenuates Atherosclerosis by Potently Ameliorating Arterial Inflammation

(2012) Tin Kyaw et al.   PLoS One

AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells

(2012) S. Peron et al.   SCIENCE

Lin28b Reprograms Adult Bone Marrow Hematopoietic Progenitors to Mediate Fetal-Like Lymphopoiesis

(2012) Joan Yuan et al.   SCIENCE

Innate Response Activator B Cells Protect Against Microbial Sepsis

(2012) P. J. Rauch et al.   SCIENCE

B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging

(2011) Z. Keren et al.   BLOOD

A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice

(2011) Y. Hao et al.   BLOOD

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity

(2011) A. V. Rubtsov et al.   BLOOD

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

B1a B Lymphocytes Are Atheroprotective by Secreting Natural IgM That Increases IgM Deposits and Reduces Necrotic Cores in Atherosclerotic Lesions

(2011) Tin Kyaw et al.   CIRCULATION RESEARCH

Alterations in Marginal Zone Macrophages and Marginal Zone B Cells in Old Mice

(2011) S. Z. Birjandi et al.   JOURNAL OF IMMUNOLOGY

Pivotal Advance: Peritoneal cavity B-1 B cells have phagocytic and microbicidal capacities and present phagocytosed antigen to CD4+ T cells

(2011) D. Parra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Reduced production of B-1-specified common lymphoid progenitors results in diminished potential of adult marrow to generate B-1 cells

(2011) C. L. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunosenescence of Polymorphonuclear Neutrophils

(2011) Inga Wessels et al.   TheScientificWorldJOURNAL

Marginal Zone B-Cells, a Gatekeeper of Innate Immunity

(2011) Moncef Zouali et al.   Frontiers in Immunology

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

(2010) Matteo Bulati et al.   AGEING RESEARCH REVIEWS

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Potentiation of Th17 cytokines in aging process contributes to the development of colitis

(2010) Xinshou Ouyang et al.   CELLULAR IMMUNOLOGY

B cell depletion reduces the development of atherosclerosis in mice

(2010) Hafid Ait-Oufella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

(2010) T. Kyaw et al.   JOURNAL OF IMMUNOLOGY

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

(2010) Kevin M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Antigen-loaded exosomes alone induce Th1-type memory through a B cell-dependent mechanism

(2009) K. R. Qazi et al.   BLOOD

Specific immune responses but not basal functions of B and T cells are impaired in aged mice

(2009) E. Speziali et al.   CELLULAR IMMUNOLOGY

Adult BM generates CD5+ B1 cells containing abundant N-region additions

(2009) Nichol E. Holodick et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

(2009) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

Generation of B Cell Memory to the Bacterial Polysaccharide  -1,3 Dextran

(2009) J. B. Foote et al.   JOURNAL OF IMMUNOLOGY

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

Old mice retain bone marrow B1 progenitors, but lose B2 precursors, and exhibit altered immature B cell phenotype and light chain usage

(2009) Sarah Alter-Wolf et al.   MECHANISMS OF AGEING AND DEVELOPMENT

A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people

(2009) Giuseppina Colonna-Romano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Crucial Role for BAFF-BAFF-R Signaling in the Survival and Maintenance of Mature B Cells

(2009) Melanie Rauch et al.   PLoS One

Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells

(2009) M. Rakhmanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis

(2009) Steven K Lundy et al.   ARTHRITIS RESEARCH & THERAPY

The role of B lymphocytes as antigen-presenting cells

(2008) Xinjian Chen et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging

(2008) L. M. Guerrettaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA