Metabolic requirements of human pro-inflammatory B cells in aging and obesity

Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses

(2018) Daniela Frasca   EXPERIMENTAL GERONTOLOGY

Erythropoietin alleviates hyperglycaemia-associated inflammation by regulating macrophage polarization via the JAK2/STAT3 signalling pathway

(2018) Jinjin Cui et al.   MOLECULAR IMMUNOLOGY

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

(2018) Munir Akkaya et al.   NATURE IMMUNOLOGY

Secretion of autoimmune antibodies in the human subcutaneous adipose tissue

(2018) Daniela Frasca et al.   PLoS One

Regulatory role of vitamin E in the immune system and inflammation

(2018) Erin Diane Lewis et al.   IUBMB LIFE

Human peripheral late/exhausted memory B cells express a senescent-associated secretory phenotype and preferentially utilize metabolic signaling pathways

(2017) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

B Cell–Specific Biomarkers for Optimal Antibody Responses to Influenza Vaccination and Molecular Pathways That Reduce B Cell Function with Aging

(2016) Daniela Frasca et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Killer Cell Lectin-like Receptor G1 Inhibits NK Cell Function through Activation of Adenosine 5′-Monophosphate–Activated Protein Kinase

(2016) Bojana Müller-Durovic et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-4, IL-21, and IFN-γ Interact To Govern T-bet and CD11c Expression in TLR-Activated B Cells

(2016) Martin S. Naradikian et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

(2016) Nele Claes et al.   JOURNAL OF IMMUNOLOGY

Obesity decreases B cell responses in young and elderly individuals

(2016) Daniela Frasca et al.   Obesity

Inflammaging decreases adaptive and innate immune responses in mice and humans

(2015) Daniela Frasca et al.   BIOGERONTOLOGY

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

(2015) Diana G. Adlowitz et al.   PLoS One

High TNF-α levels in resting B cells negatively correlate with their response

(2014) Daniela Frasca et al.   EXPERIMENTAL GERONTOLOGY

Trafficking phenotype and production of granzyme B by double negative B cells (IgG+IgD−CD27−) in the elderly

(2014) Matteo Bulati et al.   EXPERIMENTAL GERONTOLOGY

Double negative (CD19+IgG+IgD−CD27−) B lymphocytes: A new insight from telomerase in healthy elderly, in centenarian offspring and in Alzheimer's disease patients

(2014) Adriana Martorana et al.   IMMUNOLOGY LETTERS

Metabolic Reprogramming of Macrophages

(2014) Alex J. Freemerman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Aging Down-Regulates the Transcription Factor E2A, Activation-Induced Cytidine Deaminase, and Ig Class Switch in Human B Cells

(2014) D. Frasca et al.   JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Is Required for Antibody Production That Is Suppressed in Anergic but Exaggerated in Chronically BAFF-Exposed B Cells

(2014) A. Caro-Maldonado et al.   JOURNAL OF IMMUNOLOGY

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Adipose tissue, diet and aging

(2013) Mauro Zamboni et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sestrin 2 and AMPK Connect Hyperglycemia to Nox4-Dependent Endothelial Nitric Oxide Synthase Uncoupling and Matrix Protein Expression

(2013) Assaad A. Eid et al.   MOLECULAR AND CELLULAR BIOLOGY

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

(2013) Kira Rubtsova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling

(2012) Fabiola Olivieri et al.   AGE

Expansion of Autoreactive Unresponsive CD21−/lowB Cells in Sjögren's Syndrome-Associated Lymphoproliferation

(2012) D. Saadoun et al.   ARTHRITIS AND RHEUMATISM

Boesenbergia pandurata Attenuates Diet-Induced Obesity by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism

(2012) Dae-Young Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion

(2012) J. Illingworth et al.   JOURNAL OF IMMUNOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

Breaking the NF- B and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis

(2010) Y.-J. Surh et al.   Cancer Prevention Research

Cellular senescence: putting the paradoxes in perspective

(2010) Judith Campisi   CURRENT OPINION IN GENETICS & DEVELOPMENT

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Therapeutic agents for patients with rheumatoid arthritis and an inadequate response to tumour necrosis factor-α antagonists

(2009) John D Isaacs   EXPERT OPINION ON BIOLOGICAL THERAPY

A double-negative (IgD−CD27−) B cell population is increased in the peripheral blood of elderly people

(2009) Giuseppina Colonna-Romano et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Minireview: Adenosine 5′-Monophosphate-Activated Protein Kinase Regulation of Fatty Acid Oxidation in Skeletal Muscle

(2008) Megan E. Osler et al.   ENDOCRINOLOGY

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association between LTA, TNF and AGER Polymorphisms and Late Diabetic Complications

(2008) Eero Lindholm et al.   PLoS One

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY