Article
Pediatrics
Aleksandra Stasiak, Ewelina Perdas, Elzbieta Smolewska
Summary: Pediatric multi-system inflammatory syndrome temporally associated with COVID-19 (PIMS-TS) is a serious complication of previous SARS-CoV-2 infection. This retrospective study identified laboratory risk factors that affect the severity and resistance to standard therapy of PIMS-TS. The study found that certain laboratory parameters can be used as predictors of disease severity.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Infectious Diseases
Hua Zou, Juan Lu, Jingjing Liu, Josiah Hiu-yuen Wong, Si Cheng, Qiuhong Li, Yan Shen, Chunli Li, Xiaojiong Jia
Summary: Pediatric multisystem inflammation syndrome (PMIS) may be associated with SARS-CoV-2 infection, with common symptoms including persistent fever, gastrointestinal symptoms, and heart dysfunction. Treatment typically involves intravenous immunoglobulin and mechanical ventilation.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Pediatrics
Carlos Mauricio Jaramillo-Esparza, Rodrigo Vazquez-Frias
Summary: There is an increased risk of developing multisystem inflammatory syndrome when pediatric patients with COVID-19 have gastrointestinal symptoms.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Devika Subramanian, Aadith Vittala, Xinpu Chen, Christopher Julien, Sebastian Acosta, Craig Rusin, Carl Allen, Nicholas Rider, Zbigniew Starosolski, Ananth Annapragada, Sridevi Devaraj, Laura Franza, Rossella Cianci
Summary: The study aims to find an objective method to identify MIS-C in children infected with SARS-CoV-2. By analyzing blood samples from patients with different variants, it was found that the cytokine/chemokine panel can predict MIS-C accurately and only a few indicators are needed to achieve high precision.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
R. Castagnoli, I. Brambilla, M. De Filippo, M. Votto, D. Montagna, L. Montagna, A. Licari, G. L. Marseglia
Summary: This review provides a comprehensive overview of COVID-19 in children until July 2021, including global infection and mortality data, as well as age-specific statistics.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Junyi Zhao, Xiafan Xu, Yifei Gao, Yijing Yu, Conglei Li
Summary: This review discusses the potential mechanisms underlying the increased thrombotic events and altered platelet count and activity in COVID-19. The researchers propose several potential antiviral strategies that platelets might undertake and discuss platelet-targeted therapeutic strategies in controlling COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Abby Basalely, Shari Gurusinghe, James Schneider, Sareen S. Shah, Linda B. Siegel, Gabrielle Pollack, Pamela Singer, Laura J. Castellanos-Reyes, Steven Fishbane, Kenar D. Jhaveri, Elizabeth Mitchell, Kumail Merchant, Christine Capone, Ashley M. Gefen, Julie Steinberg, Christine B. Sethna
Summary: This study found a high incidence of acute kidney injury in patients with COVID-19 and MIS-C, with associations to lower serum albumin levels and higher white blood cell counts, suggesting a link to inflammation and dehydration.
KIDNEY INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Aleksandra Stasiak, Piotr Kedziora, Beata Kierzkowska, Katarzyna Niewiadomska-Jarosik, Ewelina Perdas, Elzbieta Smolewska
Summary: Pediatric multisystem inflammatory syndrome temporally associated with COVID-19 (PIMS-TS) is a serious complication in pediatric patients. This study retrospectively analyzed demographic data, clinical course, laboratory tests, and cardiovascular system assessment of 51 patients with PIMS-TS. Results showed that changes in the cardiovascular system in PIMS-TS are diverse, and most patients require close cardiac supervision and long-term follow-up.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cell Biology
Brittany P. Boribong, Thomas J. LaSalle, Yannic C. Bartsch, Felix Ellett, Maggie E. Loiselle, Jameson P. Davis, Anna L. K. Gonye, David B. Sykes, Soroush Hajizadeh, Johannes Kreuzer, Shiv Pillai, Wilhelm Haas, Andrea G. Edlow, Alessio Fasano, Galit Alter, Daniel Irimia, Moshe Sade-Feldman, Lael M. Yonker
Summary: Multisystem inflammatory syndrome in children (MIS-C) is a hyperinflammatory disease characterized by SARS-CoV-2 antigenemia, cytokine storm, and immune dysregulation. Neutrophils in MIS-C display a distinct signature of granulocytic myeloid-derived suppressor cells (G-MDSC) and altered metabolism. Extensive neutrophil extracellular trap (NET) formation is observed in MIS-C.
CELL REPORTS MEDICINE
(2022)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Federica Di Spirito, Mario Caggiano, Maria Pia Di Palo, Maria Contaldo, Francesco D'Ambrosio, Stefano Martina, Alessandra Amato
Summary: This study aimed to assess the prevalence, characteristics, and epidemiology of oral lesions following pediatric SARS-CoV-2 infection and COVID-19 vaccine administration, revealing limited information.
APPLIED SCIENCES-BASEL
(2022)
Review
Biochemistry & Molecular Biology
Jozica Sikic, Zrinka Planinic, Vid Matisic, Tea Friscic, Vilim Molnar, Dorijan Jagacic, Lovro Vujicic, Neven Tudoric, Lana Postruzin Grsic, Divo Ljubicic, Dragan Primorac
Summary: SARS-CoV-2 has been circulating worldwide for a year and a half, leading to a vast amount of scientific literature. The cardiovascular system plays a crucial role in infection, and thorough diagnostics and patient monitoring are beneficial for patient recovery.
Article
Immunology
Mark B. Salzman, Cheng-Wei Huang, Christopher M. O'Brien, Rhina D. Castillo
Summary: This report discusses 3 cases of patients in California who experienced multisystem inflammatory syndrome (MIS) after receiving vaccination and being infected with SARS-CoV-2. It also mentions 3 cases of adults who were not vaccinated developing MIS during a period when around 7% of the adult population had received at least one vaccine.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Gastroenterology & Hepatology
Paulina Delgado-Gonzalez, Carlos A. Gonzalez-Villarreal, Jorge A. Roacho-Perez, Adriana G. Quiroz-Reyes, Jose Francisco Islas, Juan Luis Delgado-Gallegos, Daniel Arellanos-Soto, Kame A. Galan-Huerta, Elsa N. Garza-Trevino
Summary: Infection by SARS-CoV-2 can lead to GI symptoms and affect the progression of COVID-19, with dysbiosis of intestinal microbiota observed in severe cases.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Allergy
Le Duc Huy Ta, James Chun Yip Chan, Gaik Chin Yap, Chiung-Hui Huang, Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Noor H. A. Suaini, Lynette P. Shek, Neerja Karnani, Anne Eng Neo Goh, Hugo P. S. Van Bever, Oon Hoe Teoh, Yiong Huak Chan, Christophe Lay, Jan Knol, Fabian Yap, Kok Hian Tan, Yap-Seng Chong, Mary Foong-Fong Chong, Shiao Yng Chan, Johan Gunnar Eriksson, Keith M. Godfrey, Eric Chun Yong Chan, Bee Wah Lee
Letter
Infectious Diseases
Lydia Su Yin Wong, Evelyn Xiu Ling Loo, Chiung-Hui Huang, Gaik Chin Yap, Michelle Jia Yu Tay, Regena Xin, Liangjian Lu, Bee Wah Lee, Lynette Pei-Chi Shek, Jinyan Zhang, Wan Ni Chia, Lin-Fa Wang, Elizabeth Huiwen Tham, Paul Anantharajah Tambyah
JOURNAL OF INFECTION
(2023)
Review
Allergy
Harris Jun Jie Muhammad Danial Song, Charlotte Tze Min Lee, Faye Yu Ci Ng, Benjamin Kye Jyn Tan, Kewin Tien Ho Siah, Elizabeth Huiwen Tham
Summary: Recent studies indicate that the use of acid suppressants in early childhood may elevate the risk of allergic diseases. This systematic review examined the associations between childhood acid suppressant use and the development of allergic diseases. The findings suggest that childhood use of acid suppressants is significantly associated with an increased risk of asthma, atopic dermatitis, and allergic rhinitis. However, larger studies are needed to establish causality, and more stringent guidelines should be implemented for the judicious use of these drugs in pediatric patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Infectious Diseases
Jinghao Nicholas Ngiam, Srishti Chhabra, Wilson Goh, Meng Ying Sim, Nicholas W. S. Chew, Ching-Hui Sia, Gail Brenda Cross, Paul Anantharajah Tambyah
Summary: In the early months of the COVID-19 pandemic, migrant workers in Singapore's dormitories were the majority of infected persons. However, with the emergence of Delta and Omicron variants, the elderly population in the local community became more vulnerable. A comparison of hospitalized COVID-19 cases in 2020 and 2021 showed that the 2021 cases had more severe disease and worse outcomes.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Kai Sen Tan, Alicia Xin Yu Ang, Douglas Jie Wen Tay, Jyoti Somani, Alexander Jet Yue Ng, Li Lee Peng, Justin Jang Hann Chu, Paul Anantharajah Tambyah, David Michael Allen
Summary: This study evaluated the effectiveness of an active air sampling device as a potential surveillance system for detecting hospital pathogens, using SARS-CoV-2 as a surrogate. The results showed that the device provided consistent detection of SARS-CoV-2 in as little as 2 hours of sampling time, demonstrating its good surveillance capacity and sensitivity in hospital settings.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Pediatrics
Elizabeth Huiwen Tham
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Letter
Allergy
Zhao Xiang Choa, Gaik Chin Yap, Ruochen Du, Evelyn Xiu Ling Loo, Anne Eng Neo Goh, Oon Hoe Teoh, Hugo P. S. Van Bever, Lynette Pei-Chi Shek, Bee Wah Lee, Kok Hian Tan, Keith M. Godfrey, Johan Gunnar Eriksson, Yap Seng Chong, Shiao Yng Chan, Elizabeth Huiwen Tham
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Letter
Allergy
Carmen Riggioni, Kee Fong Phang, Sen Hee Tay, Hugo Van Bever, Serene Xu, Sylvia Oh, Angela Bueno, Ruth Chua, Si Hui Goh, Kok Wee Chong, Elizabeth Huiwen Tham, Amelia Santosa
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Lian Chye Winston Koh, Yiqi Seow, Kiat Whye Kong, Ming Li Lalita Lau, Shoban Krishna Kumar, Gabriel Yan, Chun Kiat Lee, Benedict Yan, Paul Anantharajah Tambyah, Shawn Hoon
Summary: This report presents a modified sequencing workflow using short tiling (280bp) amplicons library preparation method with Illumina's iSeq100 desktop sequencer, which can identify gapped reads capturing characteristics of subgenomic RNA junctions within a patient cohort. These approaches allow flexible, small footprint and decentralized deployment for comprehensive genetics characterizations during outbreaks. Taqman assays based on sequencing data accurately capture the quantity of subgenomic ORF5 and ORF7a RNA in patient samples and demonstrate utility in tracking subgenomic titres in combination with a standard COVID-19 qRT-PCR assay.
FRONTIERS IN GENETICS
(2023)
Review
Allergy
Elizabeth Huiwen Tham, Agnes Sze Yin Leung, Kiwako Yamamoto-Hanada, Lamia Dahdah, Thulja Trikamjee, Vrushali Vijay Warad, Matthew Norris, Elsy Navarrete, Daria Levina, Miny Samuel, Andre van Niekerk, Santiago Martinez, Anne K. Ellis, Leonard Bielory, Hugo van Bever, Dana Wallace, Derek K. Chu, Daniel Munblit, Mimi L. K. Tang, James Sublett, Gary Wing Kin Wong
Summary: This study conducted a comprehensive assessment of Clinical Practice Guidelines (CPGs) for primary prevention of food allergy and atopic dermatitis. It found that although some guidelines had high quality, they performed poorly in terms of global applicability. The study calls for guideline developers to consider stakeholders' preferences, local applicability, and adapt existing recommendations to different geographical settings.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Article
Allergy
Hui Xing Lau, Zhaojin Chen, Hugo Van Bever, Elizabeth Huiwen Tham, Yiong Huak Chan, Qai Ven Yap, Anne Eng Neo Goh, Oon Hoe Teoh, Kok Hian Tan, Fabian Kok Peng Yap, Keith M. Godfrey, Johan G. Eriksson, Yap Seng Chong, Bee Wah Lee, Lynette Pei-Chi Shek, Evelyn Xiu Ling Loo
Summary: Childhood wheezing is a highly heterogeneous condition, and wheeze trajectories vary. This study found that early-onset wheezing is associated with nonallergic rhinitis, while late-onset and persistent wheezing have similar origins characterized by parent-reported viral infections. However, persistent wheezing is generally more strongly associated with a family history of allergy, parent-reported viral infections, and allergic comorbidities compared to late-onset wheezing.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Review
Allergy
Hui Xing Lau, Jia Wei Lee, Qai Ven Yap, Yiong Huak Chan, Miny Samuel, Evelyn Xiu Ling Loo
Summary: This study investigated the effects of smoke exposure on the development of early eczema or food allergy/hypersensitivity in children. The results showed that parental smoking during critical development periods was generally not associated with the risk of these allergies. However, maternal active smoking during pregnancy was negatively associated with doctor-diagnosed eczema, while maternal passive smoking during pregnancy was positively associated with clinician-assessed eczema in one study.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Review
Allergy
Pauline Poh-Lin Chan Ng, Elizabeth Huiwen Tham, Bee-Wah Lee
Summary: The allergy epidemic is linked to urbanization and the modern lifestyle. Different theories, relating to microbes and the epithelial barrier, have been proposed to explain the causes. Clinical studies have led to intervention strategies during the first thousand days, with the most significant being the early introduction of allergenic foods. Other strategies include a healthy diet during pregnancy, continuing allergenic food intake, and vitamin D supplementation. The translation of these strategies into public health and clinical practice is still a work in progress, and long-term population studies are crucial for assessing their feasibility.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)