Review
Biochemistry & Molecular Biology
Jin Kyeong Choi, Charles E. Egwuagu
Summary: B lymphocytes play a central role in host immunity by orchestrating humoral immune responses and producing neutralizing antibodies. Recent recognition shows that B cells also help maintain peripheral tolerance and suppress autoimmune diseases, with rare populations of regulatory B cells producing anti-inflammatory cytokines. The newly discovered i35-Bregs can suppress autoimmune diseases by inducing infectious tolerance in conventional B cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Immunology
Siqi Liu, Lanlan Yang, Shengnan Jia, Rui Zhao, Zhenjing Jin
Summary: In patients with hepatocellular carcinoma (HCC), the levels of NKB cells and IL-18 secretion were decreased in both peripheral blood and liver-infiltrating sites. Elevated IL-35 levels were negatively correlated with the percentage of NKB cells and IL-18 production in HCC, suggesting a suppressive role of IL-35 on NKB cell activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Qian Zhang, Lanlan Yang, Siqi Liu, Mengyao Zhang, Zhenjing Jin
Summary: This study found that in HBV-related HCC patients, IL-35 may attenuate the activity of Th9 cells, resulting in the suppression of cytotoxicity of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Weixi Feng, Yanli Zhang, Shixin Ding, Sijia Chen, Tianqi Wang, Ze Wang, Ying Zou, Chengyu Sheng, Yan Chen, Yingting Pang, Charles Marshall, Jingping Shi, Maiken Nedergaard, Qian Li, Ming Xiao
Summary: This study found that B lymphocytes could alleviate beta-Amyloid (Aβ) pathology and memory impairments in a transgenic AD mouse model. The depletion of mature B cells aggravated Aβ load and memory deficits in the mice.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Meng Feng, Shuping Zhou, Tong Liu, Yong Yu, Qinghong Su, Xiaofan Li, Min Zhang, Xiao Xie, Tingting Liu, Wei Lin
Summary: IL-35 is an essential regulatory factor in autoimmune uveitis, and its specific SNP sites change may be correlated to disease susceptibility and clinical symptoms, especially in patients with Vogt-Koyanagi-Harada syndrome.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Xuefen Li, Xia Liu, Weilin Wang
Summary: IL-35, a newly discovered cytokine, plays a crucial role in the progression of chronic HBV infection, liver cirrhosis, and hepatocellular carcinoma by inhibiting immune cell activity to regulate immune responses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shiyi Li, Li Su, Qingxian Luan, Guojing Liu, Wenmin Zeng, Xiaoqian Yu
Summary: This study investigated the role of IL-35-induced Bregs in periodontitis. The results showed that IL-35 could expand CD1d(hi)CD5(+) B10 cells and increase the production of IL-10 and IL-35. Administration of IL-35 also reduced alveolar bone loss and inhibited inflammatory responses.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Rheumatology
Yu Zhang, Sixi Wei, Qingqing Wu, Xue Shen, Wanrong Dai, Zhiqi Zhang, Man Chen, Hai Huang, Li Ma
Summary: IL-35 is a potent cytokine that suppresses CD4(+) effector T cell proliferation and promotes Treg expansion. This study investigates the effects of IL-35 on Bregs in AS patients and finds that reduced IL-35 production may be associated with Bregs defects in AS patients. Furthermore, IL-35 can induce the proliferation of CD19(+)CD24(hi)CD38(hi) Bregs and IL-10 production, suggesting its potential as a therapeutic target for AS.
CLINICAL RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Weronika Zysk, Jolanta Glen, Magdalena Trzeciak
Summary: IL-35, a cytokine that can induce regulatory cells, may play an important role in various diseases. Dysregulation of IL-35 has been observed in autoimmune, inflammatory, and allergic diseases. IL-35 may serve as a novel therapeutic strategy for atopic dermatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
YaYun Liu, Ying Luo, Tong Zhu, Meng Jiang, ZhaoFeng Tian, GuSheng Tang, XueSong Liang
Summary: IL-35+ B cells are increased in chronic HBV infection and enriched in the CD19+CD24hiCD38hi B cell subset, with a moderate correlation with alanine aminotransferase levels and a mild correlation with HBV DNA levels. IL-35+ B cells negatively correlate with IFN-gamma-producing CD4+ and CD8+ cells, but positively correlate with IL-4-producing T cells. Breg cells dysregulate T cell function through an IL-35-dependent mechanism and require cell-to-cell contact.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anna Slawek, Daria Lorek, Anna Ewa Kedzierska, Paulina Kubik, Jaroslaw Pajak, Agnieszka Chrobak, Anna Chelmonska-Soyta
Summary: This study reveals for the first time the frequencies of different subpopulations of Bregs producing IL-35 in women with endometriosis. The results suggest that IL-35 expression in B lymphocytes could be used as a peripheral marker of endometriosis, but further studies are needed.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ying Tang, Tianyi Ma, Shengnan Jia, Qian Zhang, Siqi Liu, Ling Qi, Lanlan Yang
Summary: IL-35 is a newly identified cytokine that plays a crucial role in chronic hepatitis B disease, affecting immune mechanisms and controlling inflammation. Its contradictory effects on the development of the disease warrant further research and discussion for potential therapeutic breakthroughs.
SEMINARS IN LIVER DISEASE
(2021)
Review
Pharmacology & Pharmacy
Shuang Hu, Pan-pan Lian, Ying Hu, Xing-yu Zhu, Shao-wei Jiang, Qiang Ma, Liang-yun Li, Jun-fa Yang, Li Yang, Hai-yue Guo, Hong Zhou, Chen-chen Yang, Xiao-ming Meng, Jun Li, Hai-wen Li, Tao Xu, Huan Zhou
Summary: IL-35 can protect the liver from environmental attack by increasing the ratio of Tregs, which has anti-inflammatory effects, and may play a crucial role in the progression of liver diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruben Osuna-Gomez, Ivan Castellvi, Maria Mulet, Ma Angels Ortiz, Douglas E. Brough, Helen Sabzevari, Roshanak T. Semnani, Silvia Vidal
Summary: This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production. The study found significantly lower plasma IL-35 concentrations in SSc patients, and the levels of IL-35 showed a negative correlation with TGF-beta and IL-17. Flow cytometry analysis revealed higher levels of IL-35 receptor expression on monocytes and lower levels on CD8+ T cells in SSc patients. The addition of recombinant IL-35 reduced the percentage of IL-17+CD4+ T cells and increased the percentage of IL-35+CD4+ T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Jie Feng, Yanqing Wu
Summary: The immune response plays a crucial role in the initiation and progression of cardiovascular diseases. IL-35, a novel anti-inflammatory and immunosuppressive cytokine, has been found to have a significant impact on the regulation of inflammation and immune homeostasis. It is closely associated with cardiovascular diseases, particularly in protecting against atherosclerosis and myocarditis. Although the specific molecular mechanisms of IL-35's protective effects are still unclear, targeted therapies with IL-35 have the potential to provide a promising and effective solution for preventing and treating cardiovascular diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Immunology
Claudia Mauri
IMMUNOLOGICAL REVIEWS
(2021)
Letter
Infectious Diseases
Luca Borghesi, Valentina Viaggi, Marco Franzetti, Matteo Montoli, Carola Mauri, Giovanni Moioli, Mauro Roberto Benvenuti, Stefania Piconi, Francesco Luzzaro
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Review
Infectious Diseases
Carola Mauri, Alberto Enrico Maraolo, Stefano Di Bella, Francesco Luzzaro, Luigi Principe
Summary: The combination of aztreonam + avibactam shows promise in treating infections caused by MBL-producing bacteria, especially Enterobacterales. Clinical resolution within 30 days was reported in 80% of infected patients, with a lower success rate for patients with bloodstream infections caused by Pseudomonas. Further research is needed to fully understand the effectiveness of this combination therapy.
Article
Hospitality, Leisure, Sport & Tourism
Chiara Mauri, Consuelo R. Nava
Summary: The study found that during winter mountain holidays, 21% of tourists perceive boredom, with a portion of them experiencing both excitement and boredom at the same time. Most of these bored tourists are mothers accompanying their relatives, staying in hotels, participating in many activities, and spending more than other tourists.
ANNALS OF TOURISM RESEARCH
(2021)
Editorial Material
Immunology
Christopher J. M. Piper, Claudia Mauri
Summary: This study reveals a novel mechanism showing how 25-hydroxycholesterol inhibits the differentiation of IgA plasma cells in the Peyer's patches by regulating SREBP2, independent of EBI2-mediated migration.
Article
Infectious Diseases
Aurora Piazza, Matteo Perini, Carola Mauri, Francesco Comandatore, Elisa Meroni, Francesco Luzzaro, Luigi Principe
Summary: This study reports a hypermucoviscous K. pneumoniae strain causing recurrent meningitis and investigates its genomic features using whole-genome sequencing analysis. The strain is susceptible to most antibiotics despite the presence of some resistance genes and exhibits several virulence factors related to pathogenicity. Phylogenetic analysis shows high similarity between this strain and a Chinese isolate, suggesting a hidden circulation of this lineage.
Article
Infectious Diseases
Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D'Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, Roberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla
Summary: MBLs are challenging bacterial enzymes, with ATM being the only beta-lactam not hydrolyzed by MBLs but often inactivated by ESBLs. In this study, the combination of ATM with various BLIs showed promising activity against MBL and ESBL co-producing Gram-negative clinical isolates, providing multiple treatment options. However, some non-fermentative bacilli were not inhibited by any ATM-BLI combination, indicating the presence of additional resistance mechanisms complicating therapy choices.
Article
Microbiology
Stefano Di Bella, Roberta Maria Antonello, Gianfranco Sanson, Alberto Enrico Maraolo, Daniele Roberto Giacobbe, Chiara Sepulcri, Simone Ambretti, Richard Aschbacher, Laura Bartolini, Mariano Bernardo, Alessandra Bielli, Marina Busetti, Davide Carcione, Giulio Camarlinghi, Edoardo Carretto, Tiziana Cassetti, Chiara Chilleri, Francesco Giuseppe De Rosa, Saveria Dodaro, Raffaele Gargiulo, Francesca Greco, Anna Knezevich, Jari Intra, Tommaso Lupia, Erika Concialdi, Gabriele Bianco, Francesco Luzzaro, Carola Mauri, Gianluca Morroni, Adriana Mosca, Elisabetta Pagani, Eva Maria Parisio, Claudio Ucciferri, Chiara Vismara, Roberto Luzzati, Luigi Principe
Summary: This study provides updated data on the burden and profile of anaerobic bloodstream infections (ABIs) in Italy. The findings show that the average age of ABIs patients is relatively high, with a majority being males. The susceptibility testing of antibiotics reveals a low resistance rate to metronidazole and a high resistance rate to penicillin among anaerobes. The resistance of Bacteroides spp. to clindamycin has increased over the study period. These results offer a comprehensive overview of the epidemiology of ABIs.
Editorial Material
Infectious Diseases
Edgar I. Campos-Madueno, Carola Mauri, Elisa Meroni, Pablo Porragas Paseiro, Alessandra Consonni, Francesco Luzzaro, Andrea Endimiani
Summary: This study reports two bla(KPC-3)-positive isolates identified as Klebsiella oxytoca and Escherichia coli in the same rectal swab. Whole-genome sequencing revealed that the K. oxytoca isolate was actually Klebsiella grimontii, while the E. coli isolate belonged to a different strain. The study also identified additional bla(KPC)-positive K. grimontii strains misidentified as K. oxytoca in public databases.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Correction
Infectious Diseases
Gianluca Morroni, Raffaela Bressan, Simona Fioriti, Gloria D'Achille, Marina Mingoia, Oscar Cirioni, Stefano Di Bella, Aurora Piazza, Francesco Comandatore, Carola Mauri, Roberta Migliavacca, Francesco Luzzaro, Luigi Principe, Cristina Lagatolla
Article
Multidisciplinary Sciences
Jeremiah Bernier-Latmani, Cristina Mauri, Rachel Marcone, Francois Renevey, Stephan Durot, Liqun He, Michael Vanlandewijck, Catherine Maclachlan, Suzel Davanture, Nicola Zamboni, Graham W. Knott, Sanjiv A. Luther, Christer Betsholtz, Mauro Delorenzi, Cathrin Brisken, Tatiana Petrova
Summary: The specialized structure of small intestinal villus tip blood vessels is maintained by ADAMTS18(+) telocytes, which regulate the level and location of VEGFA signaling to ensure the presence of endothelial fenestrae for nutrient absorption, while avoiding excessive leakiness and destabilization of villus tip epithelial structures.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Hannah F. Bradford, Liis Haljasmagi, Madhvi Menon, Thomas C. R. McDonnell, Karita Sarekannu, Martti Vanker, Part Peterson, Chris Wincup, Rym Abida, Raquel Fernandez Gonzalez, Vincent Bondet, Darragh Duffy, David A. Isenberg, Kai Kisand, Claudia Mauri
Summary: Systemic lupus erythematosus (SLE) patients often exhibit increased expression of type I interferon (IFN)-regulated genes. In our study of 501 SLE patients, we found that 73 (14%) had autoantibodies against IFN-alpha (anti-IFN-Abs). The presence of neutralizing anti-IFN-Abs in 4.2% of patients correlated with low IFN-alpha protein levels, inhibition of IFN-I downstream gene signatures, and inactive disease score. These neutralizing anti-IFN-Abs were found to play a role in controlling SLE pathogenesis, specifically in regulating B cell populations.
CELL REPORTS MEDICINE
(2023)
Article
Linguistics
Caterina Mauri, Andrea Sanso
Summary: This paper provides a diachronic typology of heterogeneous plurals, including associative plurals and similative plurals. Based on a 110-language sample, the most recurrent sources of these two types of plurals are identified. Associative plurals develop from elements that work as set constructors, while similative plurals comprise elements with vague reference. There are also some sources that may develop into both associative and similative plurals. These differences can be explained in terms of the referential properties of the nominal bases and the discourse contexts in which the plurals are used.
LINGUISTIC TYPOLOGY
(2023)
Letter
Infectious Diseases
Aline I. Moser, Valentina Viaggi, Carola Mauri, Alessandra Carattoli, Francesco Luzzaro, Andrea Endimiani
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Business
Chiara Mauri, Laura Grazzini, Aulona Ulqinaku, Erika Poletti
Summary: The research shows that sugar teaspoon labels on product packaging are more effective in helping consumers make healthier choices compared to traffic-light labels, especially for food categories with simpler ingredients. Processing fluency is proposed as the mechanism for the relation between sugar signals and product choices.
PSYCHOLOGY & MARKETING
(2021)
