Article
Cardiac & Cardiovascular Systems
Carmen Hannemann, Johannes H. Schecker, Alica Brettschneider, Jana Grune, Nicole Roesener, Andrea Weller, Verena Stangl, Edward A. Fisher, Karl Stangl, Antje Ludwig, Bernd Hewing
Summary: The study demonstrated that deficiency of iRhom2 can reduce the development of atherosclerosis, particularly in early stages. Additionally, iRhom2 deficiency was found to lower serum levels of TNF-alpha, as well as circulating and hepatic levels of cholesterol and triglycerides.
CARDIOVASCULAR RESEARCH
(2022)
Article
Immunology
Yuheng Luo, Cong Lan, Kunhong Xie, Hua Li, Estelle Devillard, Jun He, Li Liu, Jingyi Cai, Gang Tian, Aimin Wu, Zhihua Ren, Daiwen Chen, Bing Yu, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Hui Yan, Quyuan Wang, Huifen Wang, Jiayong Tang
Summary: Akkermansia muciniphila has shown potential in alleviating intestinal inflammation by reducing proinflammatory cytokines and increasing tight junction protein gene levels in porcine enterocytes, indicating its promise as a next-generation probiotics in targeting intestinal inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hui-yun Ye, Ya-li Song, Wen-ting Ye, Chong-xiang Xiong, Jie-mei Li, Jin-hua Miao, Wei-wei Shen, Xiao-long Li, Li-li Zhou
Summary: This study investigated the mediators responsible for PCOS-related kidney injury and found that TNF-alpha plays a key role in mediating inflammation and apoptosis in renal tubular cells associated with PCOS-related kidney injury. Increased levels of TNF-alpha were observed in serum and ovarian tissue of PCOS patients, and these levels were positively correlated with the severity of PCOS and markers of renal tubular cell-derived proteinuria.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Plant Sciences
Yali Zhao, Chongyu Shao, Huifen Zhou, Li Yu, Yida Bao, Qianping Mao, Jiehong Yang, Haitong Wan
Summary: Salvianolic acid B (Sal B) has a protective effect against atherosclerosis (AS) and TNF-alpha-induced damage in human umbilical vein endothelial cells (HUVECs) by modulating the NF-kappa B/NLRP3 pathway. In vivo studies showed that Sal B reduced serum lipid levels and improved pathological abnormalities in AS model mice. In vitro studies demonstrated that Sal B increased cell viability, reduced LDH release, and inhibited NLRP3 inflammasome activation.
Article
Biochemistry & Molecular Biology
Marco Gasparella, Carola Cenzi, Monica Piccione, Valentina Noemi Madia, Roberto Di Santo, Valeria Tudino, Marco Artico, Samanta Taurone, Chiara De Ponte, Roberta Costi, Rosa Di Liddo
Summary: This study investigated the effects of a derivative of glucosamine called DCF001 on the proliferation and chondrogenic induction of stem cells under inflammatory stimuli. The results showed that DCF001 could regulate the expression of CD39, CD73, and TNF receptors, modulate the release of growth factors, and enhance the chondrogenic potential of stem cells. These findings suggest that DCF001 could be a valuable supplement for improving the outcome of cartilage repair using stem cells under inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Burak Onal, Merve Alaylioglu, Erdinc Dursun, Duygu Gezen-Ak
Summary: In a cell line model of inflammation, vitamin D was found to decrease the expression of pro-atherosclerotic cytokines and increase the expression of anti-atherosclerotic cytokines, potentially reducing cardiovascular risks. Further verification through in vivo studies is needed.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Cell Biology
Aliya Sekenova, Yelena Li, Assel Issabekova, Arman Saparov, Vyacheslav Ogay
Summary: This study found that TNF-a preconditioning of mesenchymal stem cells (MSCs) is more effective in treating atherosclerosis (AS) than untreated MSCs. TNF-a-MSCs reduced the size of atherosclerotic lesions, decreased proinflammatory cytokine levels, increased immunosuppressive factor levels, and regulated serum lipid levels.
Article
Multidisciplinary Sciences
Rosalind L. Ang, Mark Chan, Diana Legarda, John P. Sundberg, Shao-Cong Sun, Virginia L. Gillespie, Nicholas Chun, Peter S. Heeger, Huabao Xiong, Sergio A. Lira, Adrian T. Ting
Summary: The study found that the phenotype of Sharpin(cpdm/cpdm) mice is dependent on CYLD, which suppresses TNF- and RIPK1-dependent cell death. Regulation of CYLD can ameliorate inflammatory symptoms such as dermatitis in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Andrea Sanchez-Medina, Monica Redondo-Puente, Rudolf Dupak, Laura Bravo-Clemente, Luis Goya, Beatriz Sarria
Summary: Coffee contains hydroxycinnamic acids, which are the main bioactive compounds with potential anti-inflammatory effects. In this study, the researchers tested three of these compounds and found that they have a protective effect against inflammation and oxidative stress in liver cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chan Woo Kim, Eun-Taex Oh, Heon Joo Park
Summary: This study demonstrates that brusatol prevents atherosclerosis development by inhibiting TNFR1 protein synthesis, supporting the potential of downregulating cell surface TNFR1 as an effective therapeutic approach to inhibit atherosclerosis development.
Article
Food Science & Technology
Lijuan Fu, Lujuan Xing, Yuejing Hao, Ziyi Yang, Shuang Teng, Lanlan Wei, Wangang Zhang
Summary: Xuanwei ham crude peptides (XHP) exhibited anti-inflammatory effects by inhibiting the secretion of inflammatory mediators through regulating inflammation-related signaling pathways, with specific peptide sequences showing higher anti-inflammatory capacity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Wenxiang Cai, Yubiao Zhang, Wenyi Jin, Sixing Wei, Junwen Chen, Changheng Zhong, Yujian Zhong, Chang Tu, Hao Peng
Summary: The study suggests that PCB2 may be used as a therapeutic agent for osteoarthritis (OA) due to its anti-inflammatory, anti-senescence, and anti-apoptotic effects. PCB2 attenuates chondrocyte senescence and apoptosis, reduces the destruction of the extracellular matrix, and alleviates knee cartilage degeneration in an OA rat model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuyo Maeda, Takashi Otsuka, Masaaki Takeda, Takahito Okazaki, Kiyoharu Shimizu, Masashi Kuwabara, Masahiro Hosogai, Louis Yuge, Takafumi Mitsuhara
Summary: This study demonstrated the efficacy of rat cranial bone-derived MSCs transplantation in improving motor function and electrophysiology recovery in rat spinal cord injury models, as well as reducing cavity ratio and suppressing proinflammatory cytokine expression in spinal cord tissues.
SCIENTIFIC REPORTS
(2021)
Review
Cardiac & Cardiovascular Systems
Mark Colin Gissler, Peter Stachon, Dennis Wolf, Timoteo Marchini
Summary: TNF receptor associated factors (TRAFs) are a family of cytoplasmic signaling adaptor proteins that regulate inflammatory signals downstream of various receptors. TRAFs play a crucial role in cell survival and immune cell function, and are important regulators of inflammation. Inhibition of specific TRAFs may be beneficial or harmful depending on the condition. TRAFs have been suggested as potential modulators of inflammation in atherosclerosis and vascular inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Zhi-wei Liu, Yi-ming Zhang, Li-ying Zhang, Ting Zhou, Yang-yang Li, Gu-cheng Zhou, Zhi-ming Miao, Ming Shang, Jin-peng He, Nan- Ding, Yong-qi Liu
Summary: The tumor microenvironment plays a crucial role in the formation and development of tumors. Cytokines, such as TGF-beta and TNF-alpha, have different effects on tumor growth, metastasis, and prognosis at different stages. Inhibiting TGF-beta can promote tumor formation, while TGF-beta can contribute to tumor malignancy. TNF-alpha, initially identified as a natural immune serum mediator for tumor hemorrhagic necrosis, has broad biological activities and can be targeted for immune diseases and tumors. However, there is limited research on the interaction between these two cytokines in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)