AID-Driven Deletion Causes Immunoglobulin Heavy Chain Locus Suicide Recombination in B Cells

Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, and hs4) dramatically affects class switch recombination and Ig secretion to all isotypes

(2010) C. Vincent-Fabert et al.   BLOOD

High-resolution profiling of γH2AX around DNA double strand breaks in the mammalian genome

(2010) Jason S Iacovoni et al.   EMBO JOURNAL

In Vivo Redundant Function of the 3' IgH Regulatory Element HS3b in the Mouse

(2010) A.-G. Bebin et al.   JOURNAL OF IMMUNOLOGY

Widespread transcription at neuronal activity-regulated enhancers

(2010) Tae-Kyung Kim et al.   NATURE

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

(2010) Arito Yamane et al.   NATURE IMMUNOLOGY

Control systems and decision making for antibody production

(2010) Christopher C Goodnow et al.   NATURE IMMUNOLOGY

Premature replacement of   with   immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation

(2010) S. Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region

(2009) Wesley A. Dunnick et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region

(2009) Monica Gostissa et al.   NATURE

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

Pax5 and Linker Histone H1 Coordinate DNA Methylation and Histone Modifications in the 3' Regulatory Region of the Immunoglobulin Heavy Chain Locus

(2008) V. Giambra et al.   MOLECULAR AND CELLULAR BIOLOGY

Two levels of protection for the B cell genome during somatic hypermutation

(2008) Man Liu et al.   NATURE

Functional long-range interactions of the IgH 3′ enhancers with the bcl-2 promoter region in t(14;18) lymphoma cells

(2008) H Duan et al.   ONCOGENE