Mechanical communication in fibrosis progression

The quiescent endothelium: signalling pathways regulating organ-specific endothelial normalcy

(2021) Nicolas Ricard et al.   Nature Reviews Cardiology

Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

(2021) Begoña López et al.   Nature Reviews Cardiology

Mechanical Regulation of Transcription: Recent Advances

(2021) Kaustubh Wagh et al.   TRENDS IN CELL BIOLOGY

3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels

(2021) Andrew C. Daly et al.   Nature Communications

Viscoelastic Cell Microenvironment: Hydrogel‐Based Strategy for Recapitulating Dynamic ECM Mechanics

(2021) Yufei Ma et al.   ADVANCED FUNCTIONAL MATERIALS

Enhanced substrate stress relaxation promotes filopodia-mediated cell migration

(2021) Kolade Adebowale et al.   NATURE MATERIALS

Mechanosensitive Regulation of Fibrosis

(2021) Shuying Yang et al.   Cells

NLRP3-mediated pyroptosis aggravates pressure overload-induced cardiac hypertrophy, fibrosis, and dysfunction in mice: cardioprotective role of irisin

(2021) Rongchuan Yue et al.   Cell Death Discovery

A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids

(2021) Yao Teng et al.   BIOMATERIALS

The Combined Influence of Viscoelastic and Adhesive Cues on Fibroblast Spreading and Focal Adhesion Organization

(2021) Erica Hui et al.   Cellular and Molecular Bioengineering

Pulmonary Stretch and Lung Mechanotransduction: Implications for Progression in the Fibrotic Lung

(2021) Alessandro Marchioni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced mechanosensing of cells in synthetic 3D matrix with controlled biophysical dynamics

(2021) Boguang Yang et al.   Nature Communications

Presence of Left Atrial Fibrosis May Contribute to Aberrant Hemodynamics and Increased Risk of Stroke in Atrial Fibrillation Patients

(2021) Nikhil Paliwal et al.   Frontiers in Physiology

Post-COVID-19 Pulmonary Fibrosis: Novel Sequelae of the Current Pandemic

(2021) Shiva Rattan Ambardar et al.   Journal of Clinical Medicine

Remodeling of an in vitro microvessel exposed to cyclic mechanical stretch

(2021) Soheila Zeinali et al.   APL Bioengineering

Collagen crosslinking: effect on structure, mechanics and fibrosis progression

(2021) Wenyu Kong et al.   Biomedical Materials

Ventilatory support and mechanical properties of the fibrotic lung acting as a “squishy ball”

(2020) Alessandro Marchioni et al.   Annals of Intensive Care

The stiffness of living tissues and its implications for tissue engineering

(2020) Carlos F. Guimarães et al.   Nature Reviews Materials

Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway

(2020) Lewis Burton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lung transplantation as therapeutic option in acute respiratory distress syndrome for COVID-19-related pulmonary fibrosis

(2020) Jing-Yu Chen et al.   CHINESE MEDICAL JOURNAL

Matrix-transmitted paratensile signaling enables myofibroblast–fibroblast cross talk in fibrosis expansion

(2020) Longwei Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Influence of Chronic Liver Diseases on Hepatic Vasculature: A Liver-on-a-chip Review

(2020) Alican Özkan et al.   Micromachines

Intestine-Liver Axis On-Chip Reveals the Intestinal Protective Role on Hepatic Damage by Emulating Ethanol First-Pass Metabolism

(2020) Vincenza De Gregorio et al.   Frontiers in Bioengineering and Biotechnology

Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

(2020) Anwesha Dey et al.   NATURE REVIEWS DRUG DISCOVERY

Mechano-therapeutics: Targeting Mechanical Signaling in Fibrosis and Tumor Stroma

(2020) Daniel J. Tschumperlin et al.   PHARMACOLOGY & THERAPEUTICS

Myocardial Fibrosis in a 3D Model: Effect of Texture on Wave Propagation

(2020) Arsenii Dokuchaev et al.   Mathematics

Mechanical feed-forward loops contribute to Idiopathic Pulmonary Fibrosis

(2020) Margaret A.T. Freeberg et al.   AMERICAN JOURNAL OF PATHOLOGY

Single-Cell RNA-seq Analysis Reveals a Crucial Role for Collagen Triple Helix Repeat Containing 1 (CTHRC1) Cardiac Fibroblasts after Myocardial Infarction

(2020) Adrian Ruiz-Villalba et al.   CIRCULATION

Calcium Signaling Regulates Valvular Interstitial Cell Alignment and Myofibroblast Activation in Fast‐Relaxing Boronate Hydrogels

(2020) Hao Ma et al.   MACROMOLECULAR BIOSCIENCE

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

(2020) Juntang Yang et al.   MOLECULAR MEDICINE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Microengineered 3D pulmonary interstitial mimetics highlight a critical role for matrix degradation in myofibroblast differentiation

(2020) Daniel L. Matera et al.   Science Advances

Fully automated prediction of liver fibrosis using deep learning analysis of gadoxetic acid–enhanced MRI

(2020) Stefanie J. Hectors et al.   EUROPEAN RADIOLOGY

Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro

(2020) Monika Szepes et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tgfb3 and Mmp13 regulated the initiation of liver fibrosis progression as dynamic network biomarkers

(2020) Jinsheng Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization

(2020) Nan Wu et al.   MOLECULAR THERAPY

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Human biomimetic liver microphysiology systems in drug development and precision medicine

(2020) Albert Gough et al.   Nature Reviews Gastroenterology & Hepatology

Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

(2020) Xueke Shi et al.   Biomolecules

Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension

(2019) Moira B. Hilscher et al.   GASTROENTEROLOGY

Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies

(2019) Sungmin Nam et al.   BIOMATERIALS

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

(2019) Hannah L. Paish et al.   HEPATOLOGY

Bioengineered in Vitro Tissue Model of Fibroblast Activation for Modeling Pulmonary Fibrosis

(2019) Aswin Sundarakrishnan et al.   ACS Biomaterials-Science & Engineering

Endothelial cell Piezo1 mediates pressure-induced lung vascular hyperpermeability via disruption of adherens junctions

(2019) Emily E. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Prediction of idiopathic pulmonary fibrosis progression using early quantitative changes on CT imaging for a short term of clinical 18–24-month follow-ups

(2019) Grace Hyun J. Kim et al.   EUROPEAN RADIOLOGY

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Pamrevlumab, an anti-connective tissue growth factor therapy, for idiopathic pulmonary fibrosis (PRAISE): a phase 2, randomised, double-blind, placebo-controlled trial

(2019) Luca Richeldi et al.   Lancet Respiratory Medicine

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

(2019) Andrew J. Haak et al.   Science Translational Medicine

Reproducing human and cross-species drug toxicities using a Liver-Chip

(2019) Kyung-Jin Jang et al.   Science Translational Medicine

Mechanotransduction in Liver Diseases

(2019) Ningling Kang   SEMINARS IN LIVER DISEASE

Adaptable boronate ester hydrogels with tunable viscoelastic spectra to probe timescale dependent mechanotransduction

(2019) Ian A. Marozas et al.   BIOMATERIALS

Extracellular Matrix Cross-Linking Enhances Fibroblast Growth and Protects against Matrix Proteolysis in Lung Fibrosis

(2018) Christopher J. Philp et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation

(2018) Elizabeth L Evans et al.   BRITISH JOURNAL OF PHARMACOLOGY

NLRP3 Inflammasome Activation Contributes to Mechanical Stretch–Induced Endothelial-Mesenchymal Transition and Pulmonary Fibrosis

(2018) Zhou Lv et al.   CRITICAL CARE MEDICINE

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver fibrosis: Direct antifibrotic agents and targeted therapies

(2018) Detlef Schuppan et al.   MATRIX BIOLOGY

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

(2018) Ze Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

(2018) Elisabeth E. Charrier et al.   Nature Communications

Matrix Stiffness: the Conductor of Organ Fibrosis

(2018) Alba Santos et al.   Current Rheumatology Reports

Cardiac Remodeling: Endothelial Cells Have More to Say Than Just NO

(2018) Vincent F. M. Segers et al.   Frontiers in Physiology

Tensile forces drive a reversible fibroblast-to-myofibroblast transition during tissue growth in engineered clefts

(2018) Philip Kollmannsberger et al.   Science Advances

Viscoelastic properties of microgel thin films control fibroblast modes of migration and pro-fibrotic responses

(2018) Daniel Chester et al.   BIOMATERIALS

Investigation of the effect of hepatic metabolism on off-target cardiotoxicity in a multi-organ human-on-a-chip system

(2018) Carlota Oleaga et al.   BIOMATERIALS

A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX

(2018) Xiang Li et al.   LAB ON A CHIP

A model for positive feedback control of the transformation of fibroblasts to myofibroblasts

(2018) Elliot L. Elson et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Computational models in cardiology

(2018) Steven A. Niederer et al.   Nature Reviews Cardiology

Hepatic microcirculation and mechanisms of portal hypertension

(2018) Jordi Gracia-Sancho et al.   Nature Reviews Gastroenterology & Hepatology

Neutrophil adhesion and crawling dynamics on liver sinusoidal endothelial cells under shear flow

(2017) Hao Yang et al.   EXPERIMENTAL CELL RESEARCH

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

Fibronectin, the extracellular glue

(2017) Alicia J. Zollinger et al.   MATRIX BIOLOGY

Mechanical regulation of cardiac fibroblast profibrotic phenotypes

(2017) Kate M. Herum et al.   MOLECULAR BIOLOGY OF THE CELL

Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation

(2017) Irena L. Ivanovska et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanotransduction-modulated fibrotic microniches reveal the contribution of angiogenesis in liver fibrosis

(2017) Longwei Liu et al.   NATURE MATERIALS

Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography

(2017) Meng Yin et al.   RADIOLOGY

Mechanoresponsive stem cells to target cancer metastases through biophysical cues

(2017) Linan Liu et al.   Science Translational Medicine

Vascular endothelial cell mechanosensing: New insights gained from biomimetic microfluidic models

(2017) Kelsey M. Gray et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Non-additive impacts of covalent cross-linking on the viscoelastic nanomechanics of ionic polyelectrolyte complexes

(2017) Biao Han et al.   RSC Advances

Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail

(2017) Marwa M. Mahmoud et al.   Scientific Reports

Predictive model identifies key network regulators of cardiomyocyte mechano-signaling

(2017) Philip M. Tan et al.   PLoS Computational Biology

Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial

(2017) Ganesh Raghu et al.   Lancet Respiratory Medicine

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule

(2017) Kirstin Meyer et al.   Cell Systems

The Soft- and Hard-Heartedness of Cardiac Fibroblasts: Mechanotransduction Signaling Pathways in Fibrosis of the Heart

(2017) Kate Herum et al.   Journal of Clinical Medicine

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

(2016) Yu Shrike Zhang et al.   BIOMATERIALS

A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation

(2016) A.C. Zeigler et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease

(2016) FuiBoon Kai et al.   TRENDS IN CELL BIOLOGY

Designing a fibrotic microenvironment to investigate changes in human liver sinusoidal endothelial cell function

(2015) Andrew J. Ford et al.   Acta Biomaterialia

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

(2015) Fei Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

(2015) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Cardiac Tissue Engineering

(2014) Marc N. Hirt et al.   CIRCULATION RESEARCH

Systems Level Analysis and Identification of Pathways and Networks Associated with Liver Fibrosis

(2014) Mohamed Diwan M. AbdulHameed et al.   PLoS One

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

(2013) Clay W Scott et al.   TOXICOLOGY LETTERS

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Assessment of Liver Viscoelasticity by Using Shear Waves Induced by Ultrasound Radiation Force

(2012) Shigao Chen et al.   RADIOLOGY

Angiotensin II Infusion–Induced Inflammation, Monocytic Fibroblast Precursor Infiltration, and Cardiac Fibrosis are Pressure Dependent

(2011) Guanming Qi et al.   Cardiovascular Toxicology

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE