The Combined Influence of Viscoelastic and Adhesive Cues on Fibroblast Spreading and Focal Adhesion Organization

Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue

(2020) Roderick Harold Jan de Hilster et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Spatial mapping of tissue properties in vivo reveals a 3D stiffness gradient in the mouse limb bud

(2020) Min Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Micromechanical poroelastic and viscoelastic properties of ex-vivo soft tissues

(2020) Mohammad R. Islam et al.   JOURNAL OF BIOMECHANICS

Fibrosis: from mechanisms to medicines

(2020) Neil C. Henderson et al.   NATURE

Actin flow-dependent and -independent force transmission through integrins

(2020) Tristan P. Driscoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrins as biomechanical sensors of the microenvironment

(2019) Jenny Z. Kechagia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatiotemporal Control of Viscoelasticity in Phototunable Hyaluronic Acid Hydrogels

(2019) Erica Hui et al.   BIOMACROMOLECULES

Influence of hyaluronic acid modification on CD44 binding towards the design of hydrogel biomaterials

(2019) Mi Y. Kwon et al.   BIOMATERIALS

Adaptable boronate ester hydrogels with tunable viscoelastic spectra to probe timescale dependent mechanotransduction

(2019) Ian A. Marozas et al.   BIOMATERIALS

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

(2018) Ze Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

(2018) Elisabeth E. Charrier et al.   Nature Communications

Adaptable Fast Relaxing Boronate-Based Hydrogels for Probing Cell-Matrix Interactions

(2018) Shengchang Tang et al.   Advanced Science

Mechanosensing at Cellular Interfaces

(2018) Ryan J. Leiphart et al.   LANGMUIR

Paxillin: a crossroad in pathological cell migration

(2017) Ana María López-Colomé et al.   Journal of Hematology & Oncology

Hydrogels with precisely controlled integrin activation dictate vascular patterning and permeability

(2017) Shuoran Li et al.   NATURE MATERIALS

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at the cell-matrix interface

(2017) K.A. Jansen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Idiopathic pulmonary fibrosis

(2017) Fernando J. Martinez et al.   Nature Reviews Disease Primers

Injectable and Cytocompatible Tough Double-Network Hydrogels through Tandem Supramolecular and Covalent Crosslinking

(2016) Christopher B. Rodell et al.   ADVANCED MATERIALS

Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments

(2016) Steven R. Caliari et al.   BIOMATERIALS

αv integrins: key regulators of tissue fibrosis

(2016) Kylie P. Conroy et al.   CELL AND TISSUE RESEARCH

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression

(2016) Steven R. Caliari et al.   Integrative Biology

A practical guide to hydrogels for cell culture

(2016) Steven R Caliari et al.   NATURE METHODS

In This Issue

(2016)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity

(2016) Takayuki Kishi et al.   Oncotarget

Normal and Fibrotic Rat Livers Demonstrate Shear Strain Softening and Compression Stiffening: A Model for Soft Tissue Mechanics

(2016) Maryna Perepelyuk et al.   PLoS One

Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation

(2016) Steven R. Caliari et al.   Scientific Reports

Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways

(2015) Xingqi Deng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Shear-Thinning Supramolecular Hydrogels with Secondary Autonomous Covalent Crosslinking to Modulate Viscoelastic Properties In Vivo

(2014) Christopher B. Rodell et al.   ADVANCED FUNCTIONAL MATERIALS

Mechanotransduction and fibrosis

(2014) Dominik Duscher et al.   JOURNAL OF BIOMECHANICS

Inelastic behaviour of collagen networks in cell-matrix interactions and mechanosensation

(2014) H. Mohammadi et al.   Journal of the Royal Society Interface

Interplay of matrix stiffness and protein tethering in stem cell differentiation

(2014) Jessica H. Wen et al.   NATURE MATERIALS

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyaluronan: A simple polysaccharide with diverse biological functions

(2013) Kevin T. Dicker et al.   Acta Biomaterialia

Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems

(2013) Daniel D. McKinnon et al.   ADVANCED MATERIALS

Rational Design of Network Properties in Guest–Host Assembled and Shear-Thinning Hyaluronic Acid Hydrogels

(2013) Christopher B. Rodell et al.   BIOMACROMOLECULES

Synthesis and orthogonal photopatterning of hyaluronic acid hydrogels with thiol-norbornene chemistry

(2013) William M. Gramlich et al.   BIOMATERIALS

The role of focal adhesion complexes in fibroblast mechanotransduction during scar formation

(2013) Kristine C. Rustad et al.   DIFFERENTIATION

Mechanotransduction at focal adhesions: from physiology to cancer development

(2013) Jihye Seong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Hydrogels with differential and patterned mechanics to study stiffness-mediated myofibroblastic differentiation of hepatic stellate cells

(2013) Murat Guvendiren et al.   Journal of the Mechanical Behavior of Biomedical Materials

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Paxillin controls directional cell motility in response to physical cues

(2013) Julia E. Sero et al.   Cell Adhesion & Migration

Acellular Normal and Fibrotic Human Lung Matrices as a Culture System forIn VitroInvestigation

(2012) Adam J. Booth et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased fibroblast telomerase expression precedes myofibroblast α-smooth muscle actin expression in idiopathic pulmonary fibrosis

(2012) DR Waisberg et al.   Clinics

The mechanical memory of lung myofibroblasts

(2012) Jenna L. Balestrini et al.   Integrative Biology

Directing epithelial to mesenchymal transition through engineered microenvironments displaying orthogonal adhesive and mechanical cues

(2012) Marilyn C. Markowski et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Functional Supramolecular Polymers

(2012) T. Aida et al.   SCIENCE

Hyaluronic Acid Hydrogels for Biomedical Applications

(2011) Jason A. Burdick et al.   ADVANCED MATERIALS

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications

(2011) Carole E. Schanté et al.   CARBOHYDRATE POLYMERS

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration

(2010) Margaret L. Gardel et al.   Annual Review of Cell and Developmental Biology

Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression

(2010) Fei Liu et al.   JOURNAL OF CELL BIOLOGY

Guiding Epithelial Cell Phenotypes with Engineered Integrin-Specific Recombinant Fibronectin Fragments

(2010) Ashley C. Brown et al.   TISSUE ENGINEERING PART A

In situ elasticity modulation with dynamic substrates to direct cell phenotype

(2009) April M. Kloxin et al.   BIOMATERIALS

Matrix mechanics and receptor–ligand interactions in cell adhesion

(2009) Dewi Harjanto et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Supramolecular hydrogels formed by β-cyclodextrin self-association and host–guest inclusion complexes

(2009) Frank van de Manakker et al.   Soft Matter

Integrin Clustering Is Driven by Mechanical Resistance from the Glycocalyx and the Substrate

(2009) Matthew J. Paszek et al.   PLoS Computational Biology

Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability

(2008) Mikaël M. Martino et al.   BIOMATERIALS

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY