Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
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Title
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
Authors
Keywords
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Journal
NATURE REVIEWS DRUG DISCOVERY
Volume 19, Issue 7, Pages 480-494
Publisher
Springer Science and Business Media LLC
Online
2020-06-18
DOI
10.1038/s41573-020-0070-z
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Note: Only part of the references are listed.- Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway
- (2020) Kari J. Kurppa et al. CANCER CELL
- Yap suppresses T-cell function and infiltration in the tumor microenvironment
- (2020) Eleni Stampouloglou et al. PLOS BIOLOGY
- Anti-proliferative and anti-migratory effects of a novel YAP-TEAD interaction inhibitor identified using in silico molecular docking
- (2019) Sarah Smith et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation
- (2019) Choong-kun Lee et al. SCIENCE
- Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes
- (2019) Masamichi Ito et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Yap/Taz regulate alveolar regeneration and resolution of lung inflammation
- (2019) Ryan LaCanna et al. JOURNAL OF CLINICAL INVESTIGATION
- Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell
- (2019) Arshad Ayyaz et al. NATURE
- Self-organization and symmetry breaking in intestinal organoid development
- (2019) Denise Serra et al. NATURE
- Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade
- (2019) Emily J Lodge et al. eLife
- Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer
- (2019) Avnish Kapoor et al. CELL
- A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
- (2018) Ashton C. Berger et al. CANCER CELL
- The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
- (2018) Helena J. Janse van Rensburg et al. CANCER RESEARCH
- Oncogenic Signaling Pathways in The Cancer Genome Atlas
- (2018) Francisco Sanchez-Vega et al. CELL
- YAP/TAZ-Dependent Reprogramming of Colonic Epithelium Links ECM Remodeling to Tissue Regeneration
- (2018) Shiro Yui et al. Cell Stem Cell
- α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart
- (2018) Alexia Vite et al. DEVELOPMENT
- Pathogenesis of non-alcoholic fatty liver disease mediated by YAP
- (2018) Ping Chen et al. Hepatology International
- Therapeutic Targeting of TAZ and YAP by Dimethyl Fumarate in Systemic Sclerosis Fibrosis
- (2018) Tetsuo Toyama et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway
- (2018) Ramón García-Escudero et al. ORAL ONCOLOGY
- YAP Is Essential for Treg-Mediated Suppression of Antitumor Immunity
- (2018) Xuhao Ni et al. Cancer Discovery
- YAP-Induced PD-L1 Expression Drives Immune Evasion in BRAFi-Resistant Melanoma
- (2018) Min Hwan Kim et al. Cancer Immunology Research
- Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells
- (2018) Xingrong Du et al. NATURE
- A comprehensive evaluation of Hippo pathway silencing in sarcomas
- (2018) Nicole M. Merritt et al. Oncotarget
- Integrative Molecular Characterization of Malignant Pleural Mesothelioma
- (2018) Julija Hmeljak et al. Cancer Discovery
- Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer
- (2018) Yumeng Wang et al. Cell Reports
- Single tumor-initiating cells evade immune clearance by recruiting type II macrophages
- (2017) Xiaocan Guo et al. GENES & DEVELOPMENT
- Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity
- (2017) Thomas Mindos et al. JOURNAL OF CELL BIOLOGY
- Epicardial YAP/TAZ orchestrate an immunosuppressive response following myocardial infarction
- (2017) Vimal Ramjee et al. JOURNAL OF CLINICAL INVESTIGATION
- Targeting Transcriptional Enhanced Associate Domains (TEADs)
- (2017) Floriane Gibault et al. JOURNAL OF MEDICINAL CHEMISTRY
- Muscle Yap Is a Regulator of Neuromuscular Junction Formation and Regeneration
- (2017) Kai Zhao et al. JOURNAL OF NEUROSCIENCE
- Yap/Taz Deletion in Gli+Cell-Derived Myofibroblasts Attenuates Fibrosis
- (2017) Ming Liang et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma
- (2017) Shumei Song et al. MOLECULAR CANCER THERAPEUTICS
- LATS1 suppresses proliferation and invasion of cervical cancer
- (2017) Jihong Deng et al. Molecular Medicine Reports
- The extracellular matrix protein agrin promotes heart regeneration in mice
- (2017) Elad Bassat et al. NATURE
- Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade
- (2017) Qian Zhang et al. NATURE CELL BIOLOGY
- Regulation of Hippo pathway transcription factor TEAD by p38 MAPK-induced cytoplasmic translocation
- (2017) Kimberly C. Lin et al. NATURE CELL BIOLOGY
- Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells
- (2017) J Feng et al. ONCOGENE
- Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ
- (2017) A Noto et al. ONCOGENE
- Hippo pathway mediates resistance to cytotoxic drugs
- (2017) Taranjit S. Gujral et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis
- (2017) David Lagares et al. Science Translational Medicine
- Verteporfin exhibits YAP-independent anti-proliferative and cytotoxic effects in endometrial cancer cells
- (2017) Venkata Ramesh Dasari et al. Oncotarget
- Clinical significance of YAP1 activation in head and neck squamous cell carcinoma
- (2017) Young-Gyu Eun et al. Oncotarget
- YAP regulates PD-L1 expression in human NSCLC cells
- (2017) Jinbai Miao et al. Oncotarget
- YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC
- (2017) Elena Ghiso et al. NEOPLASIA
- Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance
- (2016) Jeong Eun Lee et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- YAP/TAZ at the Roots of Cancer
- (2016) Francesca Zanconato et al. CANCER CELL
- A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis
- (2016) Bo Kyung A. Seong et al. CANCER RESEARCH
- The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
- (2016) Toshiro Moroishi et al. CELL
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- (2016) Xiaobo Wang et al. Cell Metabolism
- Integrin signalling regulates YAP and TAZ to control skin homeostasis
- (2016) Ahmed Elbediwy et al. DEVELOPMENT
- Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2
- (2016) Giulio Loforese et al. EMBO Molecular Medicine
- Mechanisms of Hippo pathway regulation
- (2016) Zhipeng Meng et al. GENES & DEVELOPMENT
- Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling
- (2016) Hui Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans with Autosomal Recessive MST1 Deficiency
- (2016) Tarana Singh Dang et al. JOURNAL OF CLINICAL IMMUNOLOGY
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- (2016) Xiaolu Xu et al. JOURNAL OF IMMUNOLOGY
- YAP/TAZ Are Mechanoregulators of TGF- -Smad Signaling and Renal Fibrogenesis
- (2016) S. G. Szeto et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway
- (2016) PuiYee Chan et al. Nature Chemical Biology
- Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
- (2016) Raphael Bueno et al. NATURE GENETICS
- Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration
- (2016) Fuqin Fan et al. Science Translational Medicine
- Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling
- (2016) Cameron L. Noland et al. STRUCTURE
- Experimental Model for Successful Liver Cell Therapy by Lenti TTR-YapERT2 Transduced Hepatocytes with Tamoxifen Control of Yap Subcellular Location
- (2016) Mladen Yovchev et al. Scientific Reports
- MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration
- (2016) Zhe Liu et al. Cell Reports
- Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair
- (2016) Yujie Deng et al. Cell Reports
- Stiffening hydrogels for investigating the dynamics of hepatic stellate cell mechanotransduction during myofibroblast activation
- (2016) Steven R. Caliari et al. Scientific Reports
- YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts
- (2015) Bram Piersma et al. AMERICAN JOURNAL OF PATHOLOGY
- Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
- (2015) Fei Liu et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer
- (2015) Frederick H. Wilson et al. CANCER CELL
- Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis
- (2015) Rafael Kramann et al. Cell Stem Cell
- The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer
- (2015) S. Song et al. CLINICAL CANCER RESEARCH
- Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
- (2015) R. Mateus et al. DEVELOPMENT
- A conserved MST1/2–YAP axis mediates Hippo signaling during lung growth
- (2015) Chuwen Lin et al. DEVELOPMENTAL BIOLOGY
- Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap
- (2015) Aleksander D. Szymaniak et al. DEVELOPMENTAL CELL
- The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
- (2015) Chunbo He et al. EMBO Molecular Medicine
- Nuclear TAZ expression associates with the triple-negative phenotype in breast cancer
- (2015) J. Diaz-Martin et al. ENDOCRINE-RELATED CANCER
- The Hippo pathway effector YAP controls mouse hepatic stellate cell activation
- (2015) Inge Mannaerts et al. JOURNAL OF HEPATOLOGY
- Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease
- (2015) Mariana Verdelho Machado et al. JOURNAL OF HEPATOLOGY
- The Hippo Pathway and YAP/TAZ–TEAD Protein–Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment
- (2015) Matteo Santucci et al. JOURNAL OF MEDICINAL CHEMISTRY
- Activation of Yes-Associated Protein in Low-Grade Meningiomas Is Regulated by Merlin, Cell Density, and Extracellular Matrix Stiffness
- (2015) Kuniaki Tanahashi et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- A YAP/TAZ-Regulated Molecular Signature Is Associated with Oral Squamous Cell Carcinoma
- (2015) S. E. Hiemer et al. MOLECULAR CANCER RESEARCH
- Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer
- (2015) Alex Gregorieff et al. NATURE
- Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction
- (2015) Craig S. Nowell et al. NATURE CELL BIOLOGY
- Mutational dynamics between primary and relapse neuroblastomas
- (2015) Alexander Schramm et al. NATURE GENETICS
- The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies
- (2015) Luping Lin et al. NATURE GENETICS
- Mechanism of action of a WWTR1(TAZ)-CAMTA1 fusion oncoprotein
- (2015) M R Tanas et al. ONCOGENE
- YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells
- (2015) G Hua et al. ONCOGENE
- Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis
- (2015) T. S. Karin Eisinger-Mathason et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
- (2015) Huabing Zhang et al. Science Signaling
- The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
- (2015) Fengyuan Tang et al. Science Signaling
- Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice
- (2015) Yuka Morikawa et al. Science Signaling
- Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy
- (2015) Ajaybabu V. Pobbati et al. STRUCTURE
- Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression
- (2015) G. Wang et al. Cancer Discovery
- Transcriptional co-activator TAZ sustains proliferation and tumorigenicity of neuroblastoma by targeting CTGF and PDGF-β
- (2015) Mei wang et al. Oncotarget
- YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression
- (2015) Julien Fitamant et al. Cell Reports
- Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1
- (2015) Huabing Zhang et al. Science Signaling
- The kinases NDR1/2 act downstream of the Hippo homolog MST1 to mediate both egress of thymocytes from the thymus and lymphocyte motility
- (2015) Fengyuan Tang et al. Science Signaling
- Actin cytoskeletal remodeling with protrusion formation is essential for heart regeneration in Hippo-deficient mice
- (2015) Yuka Morikawa et al. Science Signaling
- Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration
- (2014) James L. Grijalva et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP
- (2014) Fa-Xing Yu et al. CANCER CELL
- Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry
- (2014) Xiaodong Feng et al. CANCER CELL
- A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
- (2014) Shi Jiao et al. CANCER CELL
- Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties
- (2014) S. Song et al. CANCER RESEARCH
- YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response
- (2014) Luca Azzolin et al. CELL
- KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
- (2014) Diane D. Shao et al. CELL
- Hippo Pathway Activity Influences Liver Cell Fate
- (2014) Dean Yimlamai et al. CELL
- Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function
- (2014) Brigid L.M. Hogan et al. Cell Stem Cell
- Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model
- (2014) Zhiqiang Lin et al. CIRCULATION RESEARCH
- Significant Association of Oncogene YAP1 with Poor Prognosis and Cetuximab Resistance in Colorectal Cancer Patients
- (2014) K.-W. Lee et al. CLINICAL CANCER RESEARCH
- Planarian yorkie/YAP functions to integrate adult stem cell proliferation, organ homeostasis and maintenance of axial patterning
- (2014) A. Y. T. Lin et al. DEVELOPMENT
- Transcriptional regulators in the Hippo signaling pathway control organ growth in Xenopus tadpole tail regeneration
- (2014) Shinichi Hayashi et al. DEVELOPMENTAL BIOLOGY
- Yap1, transcription regulator in the Hippo signaling pathway, is required for Xenopus limb bud regeneration
- (2014) Shinichi Hayashi et al. DEVELOPMENTAL BIOLOGY
- The Hippo Pathway Effector Yap Controls Patterning and Differentiation of Airway Epithelial Progenitors
- (2014) John E. Mahoney et al. DEVELOPMENTAL CELL
- Yap Tunes Airway Epithelial Size and Architecture by Regulating the Identity, Maintenance, and Self-Renewal of Stem Cells
- (2014) Rui Zhao et al. DEVELOPMENTAL CELL
- The Transcriptional Regulators TAZ and YAP Direct Transforming Growth Factor β-induced Tumorigenic Phenotypes in Breast Cancer Cells
- (2014) Samantha E. Hiemer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mst1/Mst2 Regulate Development and Function of Regulatory T Cells through Modulation of Foxo1/Foxo3 Stability in Autoimmune Disease
- (2014) X. Du et al. JOURNAL OF IMMUNOLOGY
- Identification, Mechanism of Action, and Antitumor Activity of a Small Molecule Inhibitor of Hippo, TGF- , and Wnt Signaling Pathways
- (2014) D. Basu et al. MOLECULAR CANCER THERAPEUTICS
- Dual role of YAP and TAZ in renewal of the intestinal epithelium
- (2014) Masamichi Imajo et al. NATURE CELL BIOLOGY
- Structure-Based Design and Synthesis of Potent Cyclic Peptides Inhibiting the YAP–TEAD Protein–Protein Interaction
- (2014) Zhisen Zhang et al. ACS Medicinal Chemistry Letters
- Transcriptome meta-analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes
- (2014) Saravana M. Dhanasekaran et al. Nature Communications
- NovelYAP1-TFE3fusion defines a distinct subset of epithelioid hemangioendothelioma
- (2013) Cristina R. Antonescu et al. GENES CHROMOSOMES & CANCER
- Clinical Significance of Yes-Associated Protein Overexpression in Cervical Carcinoma
- (2013) Tianbo Liu et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- YAP and TAZ Regulate Skin Wound Healing
- (2013) Min-Jung Lee et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Hippo pathway effector Yap promotes cardiac regeneration
- (2013) Mei Xin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1
- (2013) R. Fan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Clinical and prognostic significance of Yes-associated protein in colorectal cancer
- (2013) Yan Wang et al. TUMOR BIOLOGY
- The phenotype of human STK4 deficiency
- (2012) H. Abdollahpour et al. BLOOD
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- (2012) Y. Liu-Chittenden et al. GENES & DEVELOPMENT
- Yes-associated protein regulates the hepatic response after bile duct ligation
- (2012) Haibo Bai et al. HEPATOLOGY
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- (2012) Fan Mou et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Yap Controls Stem/Progenitor Cell Proliferation in the Mouse Postnatal Epidermis
- (2012) Annemiek Beverdam et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer
- (2012) Mian Xie et al. Journal of Thoracic Oncology
- Yes-Associated Protein 1 Is Activated and Functions as an Oncogene in Meningiomas
- (2012) G. S. Baia et al. MOLECULAR CANCER RESEARCH
- Lymphangiogenesis and biological behavior in pancreatic carcinoma and other pancreatic tumors
- (2012) ZHONGQIU WANG et al. Molecular Medicine Reports
- Restriction of intestinal stem cell expansion and the regenerative response by YAP
- (2012) Evan R. Barry et al. NATURE
- YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes
- (2012) T Mizuno et al. ONCOGENE
- Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8+ T cell
- (2012) J. E. D. Thaventhiran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
- (2012) J. M. Lamar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
- (2012) A. von Gise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and Functional Similarity between the Vgll1-TEAD and the YAP-TEAD Complexes
- (2012) Ajaybabu V. Pobbati et al. STRUCTURE
- Therapeutic Value of Small Molecule Inhibitor to Plasminogen Activator Inhibitor–1 for Lung Fibrosis
- (2011) Wen-Tan Huang et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- MST1 mutations in autosomal recessive primary immunodeficiency characterized by defective naive T-cell survival
- (2011) N. T. Nehme et al. BLOOD
- LATS2 Is a Tumor Suppressor Gene of Malignant Mesothelioma
- (2011) H. Murakami et al. CANCER RESEARCH
- The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
- (2011) Michelangelo Cordenonsi et al. CELL
- Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
- (2011) Karin Schlegelmilch et al. CELL
- Role of YAP/TAZ in mechanotransduction
- (2011) Sirio Dupont et al. NATURE
- The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
- (2011) X Zhang et al. ONCOGENE
- Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
- (2011) Yoshitaka Sekido PATHOLOGY INTERNATIONAL
- Identification of a Classical Bipartite Nuclear Localization Signal in the Drosophila TEA/ATTS Protein Scalloped
- (2011) Adam C. Magico et al. PLoS One
- Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance
- (2011) D. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin
- (2011) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1
- (2011) M. R. Silvis et al. Science Signaling
- Identification of a Disease-Defining Gene Fusion in Epithelioid Hemangioendothelioma
- (2011) M. R. Tanas et al. Science Translational Medicine
- YAP is a candidate oncogene for esophageal squamous cell carcinoma
- (2010) Tomoki Muramatsu et al. CARCINOGENESIS
- Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation
- (2010) Binnaz Kucuk Staley et al. CURRENT BIOLOGY
- The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration
- (2010) R. L. Shaw et al. DEVELOPMENT
- The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
- (2010) P. Karpowicz et al. DEVELOPMENT
- The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
- (2010) Nailing Zhang et al. DEVELOPMENTAL CELL
- The Hippo Pathway Regulates Wnt/β-Catenin Signaling
- (2010) Xaralabos Varelas et al. DEVELOPMENTAL CELL
- The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
- (2010) J. Cai et al. GENES & DEVELOPMENT
- Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver
- (2010) S. Benhamouche et al. GENES & DEVELOPMENT
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
- (2010) H. Song et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
- (2010) L. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis
- (2010) K.-P. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcriptional Coactivator with PDZ-binding Motif Is Essential for Normal Alveolarization in Mice
- (2009) Akihisa Mitani et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
- (2009) Dawang Zhou et al. CANCER CELL
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- (2008) S. W. Chan et al. CANCER RESEARCH
- TEAD mediates YAP-dependent gene induction and growth control
- (2008) B. Zhao et al. GENES & DEVELOPMENT
- TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal
- (2008) Xaralabos Varelas et al. NATURE CELL BIOLOGY
- The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells
- (2008) D. Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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