Collagen crosslinking: effect on structure, mechanics and fibrosis progression

The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis

(2021) Yuanbo Jia et al.   Advanced Healthcare Materials

Engineering self-assembled neomenisci through combination of matrix augmentation and directional remodeling

(2020) Erik A. Gonzalez-Leon et al.   Acta Biomaterialia

Transglutaminase-2 regulates Wnt and FoxO3a signaling to determine the severity of osteoarthritis

(2020) Min-Su Han et al.   Scientific Reports

Tunable bioactivity and mechanics of collagen-based tissue engineering constructs: A comparison of EDC-NHS, genipin and TG2 crosslinkers

(2020) Malavika Nair et al.   BIOMATERIALS

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact

(2019) David R. Eyre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent cross-linking of basement membrane-like matrices physically restricts invasive protrusions in breast cancer cells

(2019) Katrina M. Wisdom et al.   MATRIX BIOLOGY

Development and Progression of Non-Alcoholic Fatty Liver Disease: The Role of Advanced Glycation End Products

(2019) Dinali H. Fernando et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact

(2019) Mitsuo Yamauchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety profile of autologous macrophage therapy for liver cirrhosis

(2019) Francesca Moroni et al.   NATURE MEDICINE

Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload

(2018) Elia C El Hajj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis

(2018) Stephen A. Harrison et al.   GASTROENTEROLOGY

Lysyl oxidase like-2 contributes to renal fibrosis in Col4α3/Alport mice

(2018) Dominic Cosgrove et al.   KIDNEY INTERNATIONAL

Cell contraction induces long-ranged stress stiffening in the extracellular matrix

(2018) Yu Long Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting extracellular matrix stiffness to attenuate disease: From molecular mechanisms to clinical trials

(2018) Marsha C. Lampi et al.   Science Translational Medicine

Friction Determination by Atomic Force Microscopy in Field of Biochemical Science

(2018) Yan Wang et al.   Micromachines

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

(2018) Jyotiska Chaudhuri et al.   Cell Metabolism

Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice

(2018) Yusuke Watanabe et al.   Stem Cells Translational Medicine

Effect of rosmarinic acid and carnosic acid on AGEs formation in vitro

(2017) Juanying Ou et al.   FOOD CHEMISTRY

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue

(2017) Alfonso Gautieri et al.   MATRIX BIOLOGY

Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation

(2017) Irena L. Ivanovska et al.   MOLECULAR BIOLOGY OF THE CELL

Tension stimulation drives tissue formation in scaffold-free systems

(2017) Jennifer K. Lee et al.   NATURE MATERIALS

A Phase II, Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab in Combination with FOLFIRI for the Second‐Line Treatment of MetastaticKRASMutant Colorectal Adenocarcinoma

(2017) J. Randolph Hecht et al.   ONCOLOGIST

A Phase II Randomized, Double‐Blind, Placebo‐Controlled Study of Simtuzumab or Placebo in Combination with Gemcitabine for the First‐Line Treatment of Pancreatic Adenocarcinoma

(2017) Al B. Benson et al.   ONCOLOGIST

Mesenchymal Stromal Cell Therapy for Chronic Lung Allograft Dysfunction: Results of a First-in-Man Study

(2017) Daniel C. Chambers et al.   Stem Cells Translational Medicine

Efficacy of simtuzumab versus placebo in patients with idiopathic pulmonary fibrosis: a randomised, double-blind, controlled, phase 2 trial

(2017) Ganesh Raghu et al.   Lancet Respiratory Medicine

Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target

(2016) Navneet Agnihotri et al.   AMINO ACIDS

Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease

(2016) Manveen K. Sethi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Clinical Trials with Mesenchymal Stem Cells: An Update

(2016) Tiziana Squillaro et al.   CELL TRANSPLANTATION

Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases

(2016) Nancy Chan et al.   CLINICAL CANCER RESEARCH

Lysyl oxidase activity contributes to collagen stabilization during liver fibrosis progression and limits spontaneous fibrosis reversal in mice

(2016) Susan B. Liu et al.   FASEB JOURNAL

Extracellular matrix protein expression is brain region dependent

(2016) Stephanie Dauth et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Status of and candidates for cell therapy in liver cirrhosis: overcoming the “point of no return” in advanced liver cirrhosis

(2016) Shuji Terai et al.   JOURNAL OF GASTROENTEROLOGY

Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells

(2016) Darwin J. Prockop   MATRIX BIOLOGY

Measurement of Elastic Modulus of Collagen Type I Single Fiber

(2016) Pavel Dutov et al.   PLoS One

Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs

(2016) Matthew S. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix stiffening promotes a tumor vasculature phenotype

(2016) Francois Bordeleau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating materials formation with liquid-phase and cryogenic TEM

(2016) J. J. De Yoreo et al.   Nature Reviews Materials

Interplay between transglutaminases and heparan sulphate in progressive renal scarring

(2016) Izhar Burhan et al.   Scientific Reports

Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments

(2015) Brendon M. Baker et al.   NATURE MATERIALS

Imaging collagen type I fibrillogenesis with high spatiotemporal resolution

(2015) Dimitar R Stamov et al.   ULTRAMICROSCOPY

Cellular contractility and extracellular matrix stiffness regulate matrix metalloproteinase activity in pancreatic cancer cells

(2014) Amanda Haage et al.   FASEB JOURNAL

Preparing the ground for tissue regeneration: from mechanism to therapy

(2014) Stuart J Forbes et al.   NATURE MEDICINE

Is there new hope for therapeutic matrix metalloproteinase inhibition?

(2014) Roosmarijn E. Vandenbroucke et al.   NATURE REVIEWS DRUG DISCOVERY

Advanced Glycation End-Products Reduce Collagen Molecular Sliding to Affect Collagen Fibril Damage Mechanisms but Not Stiffness

(2014) Gion Fessel et al.   PLoS One

Lysyl oxidase-mediated collagen crosslinks may be assessed as markers of functional properties of tendon tissue formation

(2013) Joseph E. Marturano et al.   Acta Biomaterialia

Inhibition of Transglutaminase 2, a Novel Target for Pulmonary Fibrosis, by Two Small Electrophilic Molecules

(2013) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Estimating the 3D Pore Size Distribution of Biopolymer Networks from Directionally Biased Data

(2013) Nadine R. Lang et al.   BIOPHYSICAL JOURNAL

Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products

(2013) Alfonso Gautieri et al.   MATRIX BIOLOGY

Microrheological Characterization of Collagen Systems: From Molecular Solutions to Fibrillar Gels

(2013) Marjan Shayegan et al.   PLoS One

Autologous Bone Marrow-Derived Mesenchymal Stromal Cells for the Treatment of Allograft Rejection After Renal Transplantation: Results of a Phase I Study

(2013) Marlies E.J. Reinders et al.   Stem Cells Translational Medicine

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Induction Therapy With Autologous Mesenchymal Stem Cells in Living-Related Kidney Transplants

(2012) Jianming Tan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Imaging and 3D morphological analysis of collagen fibrils

(2012) H. ALTENDORF et al.   JOURNAL OF MICROSCOPY

Inhibition of Mammary Tumor Growth Using Lysyl Oxidase-Targeting Nanoparticles to Modify Extracellular Matrix

(2012) Mathumai Kanapathipillai et al.   NANO LETTERS

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

(2012) Manoj M. Lalu et al.   PLoS One

Cardiovascular Protection by ApoE and ApoE-HDL Linked to Suppression of ECM Gene Expression and Arterial Stiffening

(2012) Devashish Kothapalli et al.   Cell Reports

Transglutaminase 2 and Its Role in Pulmonary Fibrosis

(2011) Keith C. Olsen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing

(2011) Y. Okuno et al.   BLOOD

Tissue Transglutaminase Does Not Affect Fibrotic Matrix Stability or Regression of Liver Fibrosis in Mice

(2011) Yury Popov et al.   GASTROENTEROLOGY

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

Characterization of the complete fiber network topology of planar fibrous tissues and scaffolds

(2010) Antonio D’Amore et al.   BIOMATERIALS

Targeted delivery of a novel group of site-directed transglutaminase inhibitors to the liver using liposomes: a new approach for the potential treatment of liver fibrosis

(2010) Nooshin Daneshpour et al.   JOURNAL OF DRUG TARGETING

The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors

(2010) Fabio Nudelman et al.   NATURE MATERIALS

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Cryo-electron tomography: 3-dimensional imaging of soft matter

(2010) Fabio Nudelman et al.   Soft Matter

Elastic Moduli of Collagen Gels Can Be Predicted from Two-Dimensional Confocal Microscopy

(2009) Ya-li Yang et al.   BIOPHYSICAL JOURNAL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver

(2009) L. Elli et al.   DIGESTIVE AND LIVER DISEASE

Structural and micromechanical characterization of type I collagen gels

(2009) Olga Latinovic et al.   JOURNAL OF BIOMECHANICS

Processing of type I collagen gels using nonenzymatic glycation

(2009) Rani Roy et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus

(2009) M. Saito et al.   OSTEOPOROSIS INTERNATIONAL

Tissue transglutaminase-induced down-regulation of matrix metalloproteinase-9

(2008) Jun-Seok Ahn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Advanced Glycation End Products (AGEs) and their Involvement in Liver Disease

(2008) Hideyuki Hyogo et al.   CURRENT PHARMACEUTICAL DESIGN

Fibrillogenesis in Dense Collagen Solutions: A Physicochemical Study

(2008) F. Gobeaux et al.   JOURNAL OF MOLECULAR BIOLOGY

Extracellular Transglutaminase 2 Is Catalytically Inactive, but Is Transiently Activated upon Tissue Injury

(2008) Matthew Siegel et al.   PLoS One

Collagen fibril architecture, domain organization, and triple-helical conformation govern its proteolysis

(2008) S. Perumal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Properties of Native and Cross-linked Type I Collagen Fibrils

(2007) Lanti Yang et al.   BIOPHYSICAL JOURNAL