Mechanosensitive Regulation of Fibrosis

3D mesenchymal cell migration is driven by anterior cellular contraction that generates an extracellular matrix prestrain

(2021) Andrew D. Doyle et al.   DEVELOPMENTAL CELL

Mechanical Regulation of Transcription: Recent Advances

(2021) Kaustubh Wagh et al.   TRENDS IN CELL BIOLOGY

Cytoskeletal tension actively sustains the migratory T‐cell synaptic contact

(2020) Sudha Kumari et al.   EMBO JOURNAL

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair

(2020) Filipa C. Simões et al.   Nature Communications

Activation of pH-Sensing Receptor OGR1 (GPR68) Induces ER Stress Via the IRE1α/JNK Pathway in an Intestinal Epithelial Cell Model

(2020) Chiaki Maeyashiki et al.   Scientific Reports

The stiffness of living tissues and its implications for tissue engineering

(2020) Carlos F. Guimarães et al.   Nature Reviews Materials

Molecular mapping of transmembrane mechanotransduction through the β1 integrin-CD98hc-TRPV4 axis

(2020) Ratnakar Potla et al.   JOURNAL OF CELL SCIENCE

TRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions

(2020) Wei Yang et al.   Scientific Reports

Durotaxis by Human Cancer Cells

(2019) Brian J. DuChez et al.   BIOPHYSICAL JOURNAL

Epidermal growth factor receptor (EGFR) paracrine upregulation in idiopathic pulmonary fibrosis (IPF) fibroblasts is blocked by nintedanib

(2019) Gali Epstein Shochet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Extracellular Matrix Modulates the Metastatic Journey

(2019) FuiBoon Kai et al.   DEVELOPMENTAL CELL

The plasma membrane as a mechanochemical transducer

(2019) Anabel-Lise Le Roux et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Fiber alignment drives changes in architectural and mechanical features in collagen matrices

(2019) Paul V. Taufalele et al.   PLoS One

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment

(2019) Brown et al.   Cancers

Analysis of fibroblast migration dynamics in idiopathic pulmonary fibrosis using image-based scaffolds of the lung extracellular matrix

(2019) Marisa Tisler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions

(2019) Julieann I. Puleo et al.   JOURNAL OF CELL BIOLOGY

Helix 8 is the essential structural motif of mechanosensitive GPCRs

(2019) Serap Erdogmus et al.   Nature Communications

GPR68 Senses Flow and Is Essential for Vascular Physiology

(2018) Jie Xu et al.   CELL

Mechanisms linking mechanotransduction and cell metabolism

(2018) Alicia M Salvi et al.   CURRENT OPINION IN CELL BIOLOGY

GPR68, a proton-sensing GPCR, mediates interaction of cancer-associated fibroblasts and cancer cells

(2018) Shu Z. Wiley et al.   FASEB JOURNAL

FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis

(2018) Dariusz Lachowski et al.   FASEB JOURNAL

An investigation of the distribution and location of mast cells affected by the stiffness of substrates as a mechanical niche

(2018) Hong-Wei Yang et al.   International Journal of Biological Sciences

Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction

(2018) David M. Graham et al.   JOURNAL OF CELL BIOLOGY

Extracellular matrix as a driver of progressive fibrosis

(2018) Jeremy Herrera et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanosensing and fibrosis

(2018) Daniel J. Tschumperlin et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Contextual determinants of TGFβ action in development, immunity and cancer

(2018) Charles J. David et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia

(2018) Jindong Sheng et al.   Cell Death & Disease

Mechanical properties of the in vivo adolescent human brain

(2018) Grace McIlvain et al.   Developmental Cognitive Neuroscience

The MEK Inhibitor Trametinib Ameliorates Kidney Fibrosis by Suppressing ERK1/2 and mTORC1 Signaling

(2018) Petros Andrikopoulos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Transient receptor potential vanilloid 2 activation by focal mechanical stimulation requires interaction with the actin cytoskeleton and enhances growth cone motility

(2017) Shouta Sugio et al.   FASEB JOURNAL

The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review

(2017) Linyi Cai et al.   Tissue Engineering and Regenerative Medicine

Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

(2017) Michael Saitakis et al.   eLife

The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review

(2017) Linyi Cai et al.   Tissue Engineering and Regenerative Medicine

Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

(2017) Dariusz Lachowski et al.   Scientific Reports

Active Traction Force Response to Long-Term Cyclic Stretch Is Dependent on Cell Pre-stress

(2016) Heather Cirka et al.   BIOPHYSICAL JOURNAL

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Vascular smooth muscle cell durotaxis depends on extracellular matrix composition

(2016) Christopher D. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

IL-13 mediates collagen deposition via STAT6 and microRNA-135b: a role for epigenetics

(2016) Steven O’Reilly et al.   Scientific Reports

Matrix Metalloproteinases as Therapeutic Targets for Idiopathic Pulmonary Fibrosis

(2015) Vanessa J. Craig et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Rac1-Dependent Phosphorylation and Focal Adhesion Recruitment of Myosin IIA Regulates Migration and Mechanosensing

(2015) Ana M. Pasapera et al.   CURRENT BIOLOGY

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

(2015) Johanna A. Knipper et al.   IMMUNITY

Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications

(2015) Preety Panwar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diverse functions of matrix metalloproteinases during fibrosis

(2014) M. Giannandrea et al.   Disease Models & Mechanisms

Lysine post-translational modifications of collagen

(2014) Mitsuo Yamauchi et al.   Essays in Biochemistry

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling

(2014) Xiwu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis

(2014) Duncan B. Wormer et al.   PLoS One

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases

(2014) Guillermo Arango Duque et al.   Frontiers in Immunology

Antifibrotic Effects of Focal Adhesion Kinase Inhibitor in Bleomycin-Induced Pulmonary Fibrosis in Mice

(2013) Katsuhiro Kinoshita et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength

(2013) Ludovic G. Vincent et al.   Biotechnology Journal

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

From Mechanical Force to RhoA Activation

(2012) Elizabeth C. Lessey et al.   BIOCHEMISTRY

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Matrix Metalloproteinase-1-mediated Up-regulation of Vascular Endothelial Growth Factor-2 in Endothelial Cells

(2012) Rafi Mazor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tension is required but not sufficient for focal adhesion maturation without a stress fiber template

(2012) Patrick W. Oakes et al.   JOURNAL OF CELL BIOLOGY

Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

(2012) Matthew Raab et al.   JOURNAL OF CELL BIOLOGY

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

Classical Macrophage Activation Up-Regulates Several Matrix Metalloproteinases through Mitogen Activated Protein Kinases and Nuclear Factor-κB

(2012) Wei-Chun Huang et al.   PLoS One

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells

(2011) V Morello et al.   ONCOGENE

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Importance of Non-Selective Cation Channel TRPV4 Interaction with Cytoskeleton and Their Reciprocal Regulations in Cultured Cells

(2010) Chandan Goswami et al.   PLoS One

Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells

(2009) Yan-Liang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cooperation between integrin ανβ3 and VEGFR2 in angiogenesis

(2009) Payaningal R. Somanath et al.   ANGIOGENESIS

TNF-α induces TGF-β1expression in lung fibroblasts at the transcriptional levelviaAP-1 activation

(2009) Deborah E. Sullivan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Neurite growth in 3D collagen gels with gradients of mechanical properties

(2008) Harini G. Sundararaghavan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction

(2008) Michael Mederos y Schnitzler et al.   EMBO JOURNAL

Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway

(2008) Lynda Aoudjehane et al.   LABORATORY INVESTIGATION

Collagen Fibril Flow and Tissue Translocation Coupled to Fibroblast Migration in 3D Collagen Matrices

(2008) Miguel Miron-Mendoza et al.   MOLECULAR BIOLOGY OF THE CELL

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE