Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway

Regulation of Cell Behavior by Hydrostatic Pressure

(2019) Shaobao Liu et al.   Applied Mechanics Reviews

Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

(2018) Jamie E. Moscovitz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function

(2018) Xiaolin Wang et al.   LAB ON A CHIP

Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research

(2017) Trenton L. Place et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG

(2017) Martin Krøyer Rasmussen et al.   TOXICOLOGY LETTERS

A Predictive 3D Multi-Scale Model of Biliary Fluid Dynamics in the Liver Lobule

(2017) Kirstin Meyer et al.   Cell Systems

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

(2016) James A. Heslop et al.   ARCHIVES OF TOXICOLOGY

Multiscale computational model of fluid flow and matrix deformation in decellularized liver

(2016) Kenichiro Nishii et al.   Journal of the Mechanical Behavior of Biomedical Materials

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

Hydrostatic Pressure Does Not Cause Detectable Changes in Survival of Human Retinal Ganglion Cells

(2015) Andrew Osborne et al.   PLoS One

Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

(2014) Manjunath Hegde et al.   LAB ON A CHIP

Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro

(2013) A. Dash et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Three-Dimensional Imaging of Hepatic Sinusoids in Mice Using Synchrotron Radiation Micro-Computed Tomography

(2013) Yae Jin Yoon et al.   PLoS One

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

(2013) Sabine U. Vorrink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion

(2012) Charlotte Debbaut et al.   COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING

Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes

(2011) Bruna Vinci et al.   Biotechnology Journal

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

(2011) David Hallifax et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Coordinate Regulation of Cytochrome P450 1A1 Expression in Mouse Liver by the Aryl Hydrocarbon Receptor and the β-Catenin Pathway

(2011) Albert Braeuning et al.   TOXICOLOGICAL SCIENCES

The Interplay of the Aryl Hydrocarbon Receptor and β-Catenin Alters Both AhR-Dependent Transcription and Wnt/β-Catenin Signaling in Liver Progenitors

(2011) Jiřina Procházková et al.   TOXICOLOGICAL SCIENCES

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor

(2010) Bin Zhao et al.   TOXICOLOGICAL SCIENCES

Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

(2009) Masato Chiba et al.   AAPS Journal

Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress

(2009) Daniel E. Conway et al.   CARDIOVASCULAR RESEARCH

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

(2009) S. Kidambi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Sustained Hydrostatic Pressure on Rat Bladder Smooth Muscle Cell Function

(2009) Margaret Rebecca Drumm et al.   UROLOGY