Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro

Are Liver Pericytes Just Precursors of Myofibroblasts in Hepatic Diseases? Insights from the Crosstalk between Perivascular and Inflammatory Cells in Liver Injury and Repair

(2020) Lindolfo da Silva Meirelles et al.   Cells

Collagen microarchitecture mechanically controls myofibroblast differentiation

(2020) Bo Ri Seo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells

(2019) Mi-Ok Lee et al.   Journal of Biological Engineering

In Vivo Generation of Post-infarct Human Cardiac Muscle by Laminin-Promoted Cardiovascular Progenitors

(2019) Lynn Yap et al.   Cell Reports

Matrix stiffness modulates the activity of MMP-9 and TIMP-1 in hepatic stellate cells to perpetuate fibrosis

(2019) Dariusz Lachowski et al.   Scientific Reports

Biowire Model of Interstitial and Focal Cardiac Fibrosis

(2019) Erika Yan Wang et al.   ACS Central Science

Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues

(2019) Gabriela Leão Santos et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The right ventricular fibroblast secretome drives cardiomyocyte dedifferentiation

(2019) Danielle R. Bruns et al.   PLoS One

Endothelium-mediated contributions to fibrosis

(2019) Xuetao Sun et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Continuous WNT Control Enables Advanced hPSC Cardiac Processing and Prognostic Surface Marker Identification in Chemically Defined Suspension Culture

(2019) Caroline Halloin et al.   Stem Cell Reports

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

(2019) Olya Mastikhina et al.   BIOMATERIALS

Inhibition of LYPD1 is critical for endothelial network formation in bioengineered tissue with human cardiac fibroblasts

(2018) Shinako Masuda et al.   BIOMATERIALS

A gene therapeutic approach to inhibit calcium and integrin binding protein 1 ameliorates maladaptive remodelling in pressure overload

(2018) Andrea Grund et al.   CARDIOVASCULAR RESEARCH

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

(2018) David Oliveira Dias et al.   CELL

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

(2018) Mar Coll et al.   Cell Stem Cell

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

(2018) Andrea Leonard et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Traction force microscopy of engineered cardiac tissues

(2018) Francesco Silvio Pasqualini et al.   PLoS One

Differentiation of Human Pluripotent Stem Cells into Functional Endothelial Cells in Scalable Suspension Culture

(2018) Ruth Olmer et al.   Stem Cell Reports

Vasa Vasorum Angiogenesis: Key Player in the Initiation and Progression of Atherosclerosis and Potential Target for the Treatment of Cardiovascular Disease

(2018) Daniel G. Sedding et al.   Frontiers in Immunology

Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice

(2018) Natali Froese et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

(2017) Ilya Y. Shadrin et al.   Nature Communications

Engineered 3D Cardiac Fibrotic Tissue to Study Fibrotic Remodeling

(2017) Amir Hossein Sadeghi et al.   Advanced Healthcare Materials

Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts

(2017) Akhilesh Kumar et al.   Cell Reports

Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium

(2017) Junjun Li et al.   Stem Cell Reports

Engraftment and morphological development of vascularized human iPS cell-derived 3D-cardiomyocyte tissue after xenotransplantation

(2017) Hirokazu Narita et al.   Scientific Reports

Cardiac Fibrosis

(2016) Joshua G. Travers et al.   CIRCULATION RESEARCH

The cardiac fibroblast: Origin, identity and role in homeostasis and disease

(2016) Milena B. Furtado et al.   DIFFERENTIATION

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

Modeling the Human Scarred Heart In Vitro: Toward New Tissue Engineered Models

(2016) Janine C. Deddens et al.   Advanced Healthcare Materials

Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors

(2016) Christina Kropp et al.   Stem Cells Translational Medicine

The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages

(2016) Hidetoshi Masumoto et al.   Scientific Reports

Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor

(2015) Amogh Sivarapatna et al.   BIOMATERIALS

Revisiting Cardiac Cellular CompositionNovelty and Significance

(2015) Alexander R. Pinto et al.   CIRCULATION RESEARCH

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells

(2015) Christoph Patsch et al.   NATURE CELL BIOLOGY

Pericytes are progenitors for coronary artery smooth muscle

(2015) Katharina S Volz et al.   eLife

Mechanisms of vasculogenesis in 3D fibrin matrices mediated by the interaction of adipose-derived stem cells and endothelial cells

(2014) Sabrina Rohringer et al.   ANGIOGENESIS

Myocardial Extracellular Matrix

(2014) Marieke Rienks et al.   CIRCULATION RESEARCH

Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells

(2014) Valeria V Orlova et al.   Nature Protocols

Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells

(2014) Kristin Schwanke et al.   Human Gene Therapy Methods

Efficient Designer Nuclease-Based Homologous Recombination Enables Direct PCR Screening for Footprintless Targeted Human Pluripotent Stem Cells

(2014) Sylvia Merkert et al.   Stem Cell Reports

Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture

(2014) Henning Kempf et al.   Stem Cell Reports

Role of Lung Pericytes and Resident Fibroblasts in the Pathogenesis of Pulmonary Fibrosis

(2013) Chi Hung et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Functionality of Endothelial Cells and Pericytes From Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts

(2013) Valeria V. Orlova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The use of agarose microwells for scalable embryoid body formation and cardiac differentiation of human and murine pluripotent stem cells

(2013) Julia Dahlmann et al.   BIOMATERIALS

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functional cardiomyocytes from human stem cells: a tool for determining the cardiotoxic potential of preclinical drugs

(2013) Naama Zeevi-Levin et al.   Future Medicinal Chemistry

Aligned human microvessels formed in 3D fibrin gel by constraint of gel contraction

(2013) Kristen T. Morin et al.   MICROVASCULAR RESEARCH

Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix

(2013) S. Kusuma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis

(2012) Michael Zeisberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering

(2012) Julia Dahlmann et al.   BIOMATERIALS

Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro

(2012) George Kensah et al.   EUROPEAN HEART JOURNAL

Collagen Cross-Linking But Not Collagen Amount Associates With Elevated Filling Pressures in Hypertensive Patients With Stage C Heart Failure

(2012) Begoña López et al.   HYPERTENSION

Adventitial Pericyte Progenitor/Mesenchymal Stem Cells Participate in the Restenotic Response to Arterial Injury

(2012) Ulrich Tigges et al.   JOURNAL OF VASCULAR RESEARCH

Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility

(2012) Christine Cheung et al.   NATURE BIOTECHNOLOGY

Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs

(2012) Konstantin Stark et al.   NATURE IMMUNOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Cozzarelli Prize Winner: Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

(2012) X. Lian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wall structures of myocardial precapillary arterioles and postcapillary venules reexamined and reconstructed in vitro for studies on barrier functions

(2011) Stephan Nees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Isolation, bulk cultivation, and characterization of coronary microvascular pericytes: the second most frequent myocardial cell type in vitro

(2011) Stephan Nees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

JAGGED1 Signaling Regulates Hemangioma Stem Cell–to–Pericyte/Vascular Smooth Muscle Cell Differentiation

(2011) Elisa Boscolo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Stage-Specific Optimization of Activin/Nodal and BMP Signaling Promotes Cardiac Differentiation of Mouse and Human Pluripotent Stem Cell Lines

(2011) Steven J. Kattman et al.   Cell Stem Cell

Multipotent Vasculogenic Pericytes From Human Pluripotent Stem Cells Promote Recovery of Murine Ischemic Limb

(2011) Ayelet Dar et al.   CIRCULATION

A Universal System for Highly Efficient Cardiac Differentiation of Human Induced Pluripotent Stem Cells That Eliminates Interline Variability

(2011) Paul W. Burridge et al.   PLoS One

Assessing the Permeability of Engineered Capillary Networks in a 3D Culture

(2011) Stephanie J. Grainger et al.   PLoS One

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium

(2010) Ruth Olmer et al.   Stem Cell Research

A Novel Miniaturized Multimodal Bioreactor for Continuous In Situ Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation

(2010) George Kensah et al.   TISSUE ENGINEERING PART C-METHODS

Generation of Induced Pluripotent Stem Cells from Human Cord Blood

(2009) Alexandra Haase et al.   Cell Stem Cell

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

(2009) K. R. Stevens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericytes and Perivascular Fibroblasts Are the Primary Source of Collagen-Producing Cells in Obstructive Fibrosis of the Kidney

(2008) Shuei-Liong Lin et al.   AMERICAN JOURNAL OF PATHOLOGY

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON