Hepatic microcirculation and mechanisms of portal hypertension

Establishment of practical recellularized liver graft for blood perfusion using primary rat hepatocytes and liver sinusoidal endothelial cells

(2018) H. Kojima et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications

(2018) Martí Ortega-Ribera et al.   BIOTECHNOLOGY AND BIOENGINEERING

Pharmacokinetics and tolerability of semaglutide in people with hepatic impairment

(2018) Lene Jensen et al.   DIABETES OBESITY & METABOLISM

Improved hemodynamic and liver function in portal hypertensive cirrhotic rats after administration of B. pseudocatenulatum CECT 7765

(2018) Isabel Gómez-Hurtado et al.   EUROPEAN JOURNAL OF NUTRITION

Stem cells as a new therapeutic strategy for portal hypertension and cirrhosis

(2018) A. Fernández-Iglesias et al.   JOURNAL OF HEPATOLOGY

Effects of aging on liver microcirculatory function and sinusoidal phenotype

(2018) Raquel Maeso-Díaz et al.   AGING CELL

Emricasan (IDN-6556) Lowers Portal Pressure in Patients with Compensated Cirrhosis and Severe Portal Hypertension

(2018) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

Simvastatin Prevents Progression of Acute on Chronic Liver Failure in Rats With Cirrhosis and Portal Hypertension

(2018) Dinesh Mani Tripathi et al.   GASTROENTEROLOGY

4 in 1: Antibody-free protocol for isolating the main hepatic cells from healthy and cirrhotic single rat livers

(2018) Anabel Fernández-Iglesias et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effects of All-Oral Anti-Viral Therapy on HVPG and Systemic Hemodynamics in Patients With Hepatitis C Virus-Associated Cirrhosis

(2017) Sabela Lens et al.   GASTROENTEROLOGY

Posters (Abstracts 264-2239)

(2017)   HEPATOLOGY

The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial

(2017) Rohit Loomba et al.   HEPATOLOGY

Effects of an intensive lifestyle intervention program on portal hypertension in patients with cirrhosis and obesity: The SportDiet study

(2017) Annalisa Berzigotti et al.   HEPATOLOGY

The anticoagulant rivaroxaban lowers portal hypertension in cirrhotic rats mainly by deactivating hepatic stellate cells

(2017) Marina Vilaseca et al.   HEPATOLOGY

The portal hypertension syndrome: etiology, classification, relevance, and animal models

(2017) Jaime Bosch et al.   Hepatology International

Cross-talk between autophagy and KLF2 determines endothelial cell phenotype and microvascular function in acute liver injury

(2017) Sergi Guixé-Muntet et al.   JOURNAL OF HEPATOLOGY

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction

(2017) Philipp Schwabl et al.   JOURNAL OF HEPATOLOGY

Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet

(2017) Gregory G. Martin et al.   JOURNAL OF LIPID RESEARCH

Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip

(2017) Yu Du et al.   LAB ON A CHIP

Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats

(2017) Marina Vilaseca et al.   LIVER INTERNATIONAL

Enoxaparin does not ameliorate liver fibrosis or portal hypertension in rats with advanced cirrhosis

(2017) José I. Fortea et al.   LIVER INTERNATIONAL

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies

(2017) Fernanda Cristina de Mesquita et al.   Scientific Reports

Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization

(2017) Giuseppe Mazza et al.   Scientific Reports

Changing Concepts of Cirrhotic Coagulopathy

(2016) Armando Tripodi et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Novel human hepatic organoid model enables testing of drug-induced liver fibrosis in vitro

(2016) Sofia B. Leite et al.   BIOMATERIALS

Isolation and Culture of Single Cell Types from Rat Liver

(2016) Qidi Zhang et al.   CELLS TISSUES ORGANS

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Liver Fibrosis Reversion After Suppression of Hepatitis B Virus

(2016) Don C. Rockey   Clinics in Liver Disease

An optimized method for mouse liver sinusoidal endothelial cell isolation

(2016) Jeremy Meyer et al.   EXPERIMENTAL CELL RESEARCH

Cannabinoids, inflammation, and fibrosis

(2016) Robert B. Zurier et al.   FASEB JOURNAL

Statins Are Associated With a Decreased Risk of Decompensation and Death in Veterans With Hepatitis C–Related Compensated Cirrhosis

(2016) Arpan Mohanty et al.   GASTROENTEROLOGY

Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients With Cirrhosis

(2016) Juan G. Abraldes et al.   GASTROENTEROLOGY

Poster Session IV (Abstracts 1638 - 2112)

(2016)   HEPATOLOGY

Atorvastatin and fluvastatin are associated with dose-dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES

(2016) Tracey G. Simon et al.   HEPATOLOGY

The Non-Steroidal Fxr Agonist Gs-9674 Reduces Liver Fibrosis and Ameliorates Portal Hypertension in a Rat Nash Model

(2016) P. Schwabl et al.   JOURNAL OF HEPATOLOGY

Sinusoidal communication in liver fibrosis and regeneration

(2016) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Enoxaparin reduces hepatic vascular resistance and portal pressure in cirrhotic rats

(2016) Federica Cerini et al.   JOURNAL OF HEPATOLOGY

Mechanisms of CCl4-induced liver fibrosis with combined transcriptomic and proteomic analysis

(2016) Shu Dong et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study

(2016) Matthew James Armstrong et al.   LANCET

Antithrombotic treatment with direct-acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis

(2016) Andrea De Gottardi et al.   LIVER INTERNATIONAL

FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

(2016) Len Verbeke et al.   Scientific Reports

Molecular pathophysiology of portal hypertension

(2015) Mercedes Fernandez   HEPATOLOGY

Malnutrition in cirrhosis increases morbidity and mortality

(2015) Sudhir Maharshi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Hepatic dimethylarginine-dimethylaminohydrolase1 is reduced in cirrhosis and is a target for therapy in portal hypertension

(2015) Rajeshwar P. Mookerjee et al.   JOURNAL OF HEPATOLOGY

Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments

(2015) Jaume Bosch et al.   JOURNAL OF HEPATOLOGY

Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow–Derived Monocytes/Macrophages in a CB1-Dependent Manner

(2015) Ping Mai et al.   JOURNAL OF IMMUNOLOGY

Farnesoid X receptor agonist CDCA reduces blood pressure and regulates vascular tone in spontaneously hypertensive rats

(2015) Chenyu Li et al.   Journal of the American Society of Hypertension

The carbon tetrachloride model in mice

(2015) D Scholten et al.   LABORATORY ANIMALS

Arachidonic acid metabolites and endothelial dysfunction of portal hypertension

(2015) David Sacerdoti et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Pharmacologic Management of Portal Hypertension

(2014) Annalisa Berzigotti et al.   Clinics in Liver Disease

Soluble factors derived from human amniotic epithelial cells suppress collagen production in human hepatic stellate cells

(2014) Alexander Hodge et al.   CYTOTHERAPY

A farnesoid X receptor polymorphism predisposes to spontaneous bacterial peritonitis

(2014) Philipp Lutz et al.   DIGESTIVE AND LIVER DISEASE

Coagulopathy in Liver Diseases: Complication or Therapy?

(2014) Marcello Bianchini et al.   DIGESTIVE DISEASES

Statin Use in Patients with Cirrhosis: A Retrospective Cohort Study

(2014) Sonal Kumar et al.   DIGESTIVE DISEASES AND SCIENCES

Featured Article: Isolation, characterization, and cultivation of human hepatocytes and non-parenchymal liver cells

(2014) Elisa Pfeiffer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Envejecimiento y enfermedades del hígado

(2014) Miguel Bruguera   Gastroenterologia y Hepatologia

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

(2014) Marc Mejias et al.   GUT

KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

(2014) Giusi Marrone et al.   GUT

Disruption of negative feedback loop between vasohibin-1 and vascular endothelial growth factor decreases portal pressure, angiogenesis, and fibrosis in cirrhotic rats

(2014) Laura Coch et al.   HEPATOLOGY

Sodium ferulate lowers portal pressure in rats with secondary biliary cirrhosis through the RhoA/Rho-kinase signaling pathway: A preliminary study

(2014) LAI WEI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

O15 EFFECTS OF THE FXR AGONIST OBETICHOLIC ACID ON HEPATIC VENOUS PRESSURE GRADIENT (HVPG) IN ALCOHOLIC CIRRHOSIS: A PROOF OF CONCEPT PHASE 2A STUDY

(2014) R. Mookerjee et al.   JOURNAL OF HEPATOLOGY

Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats

(2014) Philipp Schwabl et al.   JOURNAL OF HEPATOLOGY

A Novel Modular Bioreactor to In Vitro Study the Hepatic Sinusoid

(2014) Xavi Illa et al.   PLoS One

Liver diseases and aging: friends or foes?

(2013) Fareeba Sheedfar et al.   AGING CELL

Leptin receptor blockade reduces intrahepatic vascular resistance and portal pressure in an experimental model of rat liver cirrhosis

(2013) María Gabriela Delgado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Double-Blind, Placebo-Controlled Clinical Trial With a Rho-Kinase Inhibitor in Pulmonary Arterial Hypertension

(2013) Yoshihiro Fukumoto et al.   CIRCULATION JOURNAL

Upregulation of thrombomodulin expression by activation of farnesoid X receptor in vascular endothelial cells

(2013) Xie He et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats

(2013) Eugenio Rosado et al.   HEPATOLOGY

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis

(2013) Takeshi Fukuda et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Beneficial effects of dual vascular endothelial growth factor receptor/fibroblast growth factor receptor inhibitor brivanib alaninate in cirrhotic portal hypertensive rats

(2013) Han-Chieh Lin et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Cannabinoid signaling and liver therapeutics

(2013) Ariane Mallat et al.   JOURNAL OF HEPATOLOGY

Immune surveillance by the liver

(2013) Craig N Jenne et al.   NATURE IMMUNOLOGY

Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial

(2012) Andrea De Gottardi et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The direct profibrotic and indirect immune antifibrotic balance of blocking the cannabinoid 2 receptor

(2012) Yosefa Avraham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats

(2012) M. D'Amico et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enoxaparin Prevents Portal Vein Thrombosis and Liver Decompensation in Patients With Advanced Cirrhosis

(2012) Erica Villa et al.   GASTROENTEROLOGY

Adenoviral dominant-negative soluble PDGFRβ improves hepatic collagen, systemic hemodynamics, and portal pressure in fibrotic rats

(2012) V. Reichenbach et al.   JOURNAL OF HEPATOLOGY

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

(2012) Sabine Klein et al.   JOURNAL OF HEPATOLOGY

Functional aspects on the pathophysiology of portal hypertension in cirrhosis

(2012) Juan-Carlos García-Pagán et al.   JOURNAL OF HEPATOLOGY

PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats

(2012) Aina Rodríguez-Vilarrupla et al.   JOURNAL OF HEPATOLOGY

Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats

(2012) Maeva Guillaume et al.   JOURNAL OF HEPATOLOGY

Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats

(2012) Marco Di Pascoli et al.   JOURNAL OF HEPATOLOGY

The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial–stellate cell deactivation induced by statins

(2012) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Severe muscle depletion in patients on the liver transplant wait list: Its prevalence and independent prognostic value

(2012) Puneeta Tandon et al.   LIVER TRANSPLANTATION

Human Amniotic Epithelial Cell Transplantation Induces Markers of Alternative Macrophage Activation and Reduces Established Hepatic Fibrosis

(2012) Ursula Manuelpillai et al.   PLoS One

Hepatocyte-like cells differentiated from human induced pluripotent stem cells: Relevance to cellular therapies

(2012) Yue Yu et al.   Stem Cell Research

The effects of sorafenib on the portal hypertensive syndrome in patients with liver cirrhosis and hepatocellular carcinoma - a pilot study

(2011) M. Pinter et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Liver cirrhosis

(2011) Massimo Pinzani et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Bile Acids Regulate Cardiovascular Function

(2011) Sandeep Khurana et al.   CTS-Clinical and Translational Science

Obesity is an independent risk factor for clinical decompensation in patients with cirrhosis

(2011) Annalisa Berzigotti et al.   HEPATOLOGY

Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

(2011) Alexandre Louvet et al.   HEPATOLOGY

Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats

(2011) Ying-Ying Yang et al.   LIVER INTERNATIONAL

Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver

(2010) J. Gracia-Sancho et al.   GUT

Treatment with the leukotriene inhibitor montelukast for 10 days attenuates portal hypertension in rat liver cirrhosis

(2010) Christian J. Steib et al.   HEPATOLOGY

Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B

(2010) Ting-Tsung Chang et al.   HEPATOLOGY

Endocannabinoids in liver disease

(2010) Joseph Tam et al.   HEPATOLOGY

The use of whole organ decellularization for the generation of a vascularized liver organoid

(2010) Pedro M. Baptista et al.   HEPATOLOGY

Cirrhotic cardiomyopathy

(2010) Søren Møller et al.   JOURNAL OF HEPATOLOGY

Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells

(2010) Jonel Trebicka et al.   JOURNAL OF HEPATOLOGY

Tempol administration, a superoxide dismutase mimetic, reduces hepatic vascular resistance and portal pressure in cirrhotic rats

(2010) Héctor García-Calderó et al.   JOURNAL OF HEPATOLOGY

Network Analysis of Primary Hepatocyte Dedifferentiation Using a Shotgun Proteomics Approach

(2010) Cliff Rowe et al.   JOURNAL OF PROTEOME RESEARCH

Angiogenesis in chronic liver disease and its complications

(2010) Stephanie Coulon et al.   LIVER INTERNATIONAL

Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix

(2010) Basak E Uygun et al.   NATURE MEDICINE

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Natural taurine promotes apoptosis of human hepatic stellate cells in proteomics analysis

(2010) Xin Deng   WORLD JOURNAL OF GASTROENTEROLOGY

Sorafenib targets dysregulated Rho kinase expression and portal hypertension in rats with secondary biliary cirrhosis

(2009) M Hennenberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a pilot randomized controlled study

(2009) Andre Castro Lyra et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

An Imbalance of Pro- vs Anti-Coagulation Factors in Plasma From Patients With Cirrhosis

(2009) Armando Tripodi et al.   GASTROENTEROLOGY

Simvastatin Lowers Portal Pressure in Patients With Cirrhosis and Portal Hypertension: A Randomized Controlled Trial

(2009) Juan G. Abraldes et al.   GASTROENTEROLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

Microenvironmental regulation of the sinusoidal endothelial cell phenotype in vitro

(2009) Sandra March et al.   HEPATOLOGY

Old age is associated with ultrastructural changes in isolated rat liver sinusoidal endothelial cells

(2009) J. N. O'Reilly et al.   Microscopy

Simvastatin effects on portal-systemic collaterals of portal hypertensive rats

(2009) Hui-Chun Huang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

(2009) Joy X. Jiang et al.   JOURNAL OF HEPATOLOGY

Angiogenesis in liver disease

(2009) Mercedes Fernández et al.   JOURNAL OF HEPATOLOGY

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis

(2009) Paolo Caraceni et al.   LIVER INTERNATIONAL

Vascularization Strategies for Tissue Engineering

(2009) Michael Lovett et al.   TISSUE ENGINEERING PART B-REVIEWS

Attenuation of portal hypertension by natural taurine in rats with liver cirrhosis

(2009) Jian Liang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Extracellular matrix as a biological scaffold material: Structure and function

(2008) S BADYLAK et al.   Acta Biomaterialia

Placenta-derived stem cells: new hope for cell therapy?

(2008) Marco Evangelista et al.   CYTOTECHNOLOGY

Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells

(2008) Frank A. Schildberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

(2008) Marc Mejias et al.   HEPATOLOGY

Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation

(2008) Anja M. Geerts et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Effects of N-acetylcysteine administration in hepatic microcirculation of rats with biliary cirrhosis

(2008) Ying-Ying Yang et al.   JOURNAL OF HEPATOLOGY

Endocannabinoids and Liver Disease. I. Endocannabinoids and their receptors in the liver

(2007) A. Mallat et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CB2 receptors as new therapeutic targets for liver diseases

(2007) S Lotersztajn et al.   BRITISH JOURNAL OF PHARMACOLOGY

Concise Review: Isolation and Characterization of Cells from Human Term Placenta: Outcome of the First International Workshop on Placenta Derived Stem Cells

(2007) Ornella Parolini et al.   STEM CELLS