Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation

Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices

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Systems Mechano-Biology: Tension-Inhibited Protein Turnover is Sufficient to Physically Control Gene Circuits

(2015) P.C. Dave P. Dingal et al.   BIOPHYSICAL JOURNAL

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

(2015) P. C. Dave P. Dingal et al.   NATURE MATERIALS

Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma

(2015) Dany Nassar et al.   NATURE MEDICINE

In Situ Mechanical Characterization of the Cell Nucleus by Atomic Force Microscopy

(2014) Haijiao Liu et al.   ACS Nano

Matrix elasticity, replicative senescence and DNA methylation patterns of mesenchymal stem cells

(2014) Anne Schellenberg et al.   BIOMATERIALS

The regulation of gene expression during onset of differentiation by nuclear mechanical heterogeneity

(2014) Shefali Talwar et al.   BIOMATERIALS

Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit

(2014) Hind Medyouf et al.   Cell Stem Cell

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Substratum-induced differentiation of human pluripotent stem cells reveals the coactivator YAP is a potent regulator of neuronal specification

(2014) S. Musah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlling low rates of cell differentiation through noise and ultrahigh feedback

(2014) R. Ahrends et al.   SCIENCE

Correlated Spatio-Temporal Fluctuations in Chromatin Compaction States Characterize Stem Cells

(2013) Shefali Talwar et al.   BIOPHYSICAL JOURNAL

LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis

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Modulation of Nuclear Shape by Substrate Rigidity

(2013) David B. Lovett et al.   Cellular and Molecular Bioengineering

Heart-Specific Stiffening in Early Embryos Parallels Matrix and Myosin Expression to Optimize Beating

(2013) Stephanie Majkut et al.   CURRENT BIOLOGY

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Role of the extracellular matrix in regulating stem cell fate

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Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility

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Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

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Retinoids induce stem cell differentiation via epigenetic changes

(2013) Lorraine J. Gudas   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells

(2013) Joe Swift et al.   Nucleus

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells

(2012) Florian Rehfeldt et al.   Integrative Biology

Naturally Occurring Eccentric Cleavage Products of Provitamin A β-Carotene Function as Antagonists of Retinoic Acid Receptors

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Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain

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The nanometre-scale physiology of bone: steric modelling and scanning transmission electron microscopy of collagen-mineral structure

(2012) B. Alexander et al.   Journal of the Royal Society Interface

Erratum: Corrigendum: Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor–γ agonists

(2012) Kengo Shimono et al.   NATURE MEDICINE

A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned

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Post-natal myogenic and adipogenic developmental

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Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

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Integration of statistical modeling and high-content microscopy to systematically investigate cell–substrate interactions

(2010) Wen Li Kelly Chen et al.   BIOMATERIALS

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Interaction between Periostin and BMP-1 Promotes Proteolytic Activation of Lysyl Oxidase

(2010) Takumi Maruhashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gene expression patterns in bone following mechanical loading

(2010) Sara M Mantila Roosa et al.   JOURNAL OF BONE AND MINERAL RESEARCH

How deeply cells feel: methods for thin gels

(2010) Amnon Buxboim et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Disruption of Pdia3 gene results in bone abnormality and affects 1α,25-dihydroxy-vitamin D3-induced rapid activation of PKC

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Optimal matrix rigidity for stress-fibre polarization in stem cells

(2010) A. Zemel et al.   Nature Physics

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

(2009) Evelyn K.F. Yim et al.   BIOMATERIALS

Retinoic acid receptors are required for skeletal growth, matrix homeostasis and growth plate function in postnatal mouse

(2009) Julie A. Williams et al.   DEVELOPMENTAL BIOLOGY

Osteoblastic bone formation is induced by using nanogel-crosslinking hydrogel as novel scaffold for bone growth factor

(2009) Chikako Hayashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Early detection of aging cartilage and osteoarthritis in mice and patient samples using atomic force microscopy

(2009) Martin Stolz et al.   Nature Nanotechnology

Multiway modeling and analysis in stem cell systems biology

(2008) Bulent Yener et al.   BMC Systems Biology

Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells

(2008) Danielle S. W. Benoit et al.   NATURE MATERIALS

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Viscoelastic properties of human mesenchymally-derived stem cells and primary osteoblasts, chondrocytes, and adipocytes

(2007) Eric M. Darling et al.   JOURNAL OF BIOMECHANICS