A glass-based, continuously zonated and vascularized human liver acinus microphysiological system (vLAMPS) designed for experimental modeling of diseases and ADME/TOX

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Fitting tissue chips and microphysiological systems into the grand scheme of medicine, biology, pharmacology, and toxicology

(2017) David E Watson et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Pre-clinical and clinical investigations of metabolic zonation in liver diseases: The potential of microphysiology systems

(2017) Alejandro Soto-Gutierrez et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

(2017) Felipe T Lee-Montiel et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Biology of portal hypertension

(2017) Matthew McConnell et al.   Hepatology International

Organ-, body- and disease-on-a-chip systems

(2017) Michael L. Shuler   LAB ON A CHIP

Organ-on-a-chip devices advance to market

(2017) Boyang Zhang et al.   LAB ON A CHIP

SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

(2017) Karel Domansky et al.   Microfluidics and Nanofluidics

Single-cell spatial reconstruction reveals global division of labour in the mammalian liver

(2017) Keren Bahar Halpern et al.   NATURE

Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

(2017) Ruth C. R. Meex et al.   Nature Reviews Endocrinology

Immunofluorescence identifies distinct subsets of endothelial cells in the human liver

(2017) Otto Strauss et al.   Scientific Reports

Erratum: Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study

(2017) Young Kang et al.   Micromachines

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Long-term human primary hepatocyte cultures in a microfluidic liver biochip show maintenance of mRNA levels and higher drug metabolism compared with Petri cultures

(2016) Rachid Jellali et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Immunological functions of liver sinusoidal endothelial cells

(2016) Percy A Knolle et al.   Cellular & Molecular Immunology

Liver metastases: Microenvironments and ex-vivo models

(2016) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Judging the value of ‘liver-on-a-chip’ devices for prediction of toxicity

(2016) Viktoriia Starokozhko et al.   Expert Opinion on Drug Metabolism & Toxicology

Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue

(2016) Mandy B. Esch et al.   LAB ON A CHIP

One-step fabrication of an organ-on-a-chip with spatial heterogeneity using a 3D bioprinting technology

(2016) Hyungseok Lee et al.   LAB ON A CHIP

Real-time monitoring of metabolic function in liver-on-chip microdevices tracks the dynamics of mitochondrial dysfunction

(2016) Danny Bavli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

(2016) Manuele Gori et al.   PLoS One

Drug-Induced Liver Injury

(2015) Kurt Fisher et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

A microfluidically perfused three dimensional human liver model

(2015) Knut Rennert et al.   BIOMATERIALS

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

(2015) Skarphedinn Halldorsson et al.   BIOSENSORS & BIOELECTRONICS

Long-term maintenance of a microfluidic 3D human liver sinusoid

(2015) Ljupcho Prodanov et al.   BIOTECHNOLOGY AND BIOENGINEERING

Fluorescent protein biosensors applied to microphysiological systems

(2015) Nina Senutovitch et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

(2015) Lawrence A Vernetti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

3D liver models on a microplatform: well-defined culture, engineering of liver tissue and liver-on-a-chip

(2015) Da Yoon No et al.   LAB ON A CHIP

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

(2015) Mandy B. Esch et al.   LAB ON A CHIP

Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

(2015) Mohamed Asrih et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Epidemiology and Natural History of Nonalcoholic Fatty Liver Disease

(2015) Sanjaya Satapathy et al.   SEMINARS IN LIVER DISEASE

In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells

(2015) Sarada Devi Ramachandran et al.   PLoS One

A microphysiological system model of therapy for liver micrometastases

(2014) Amanda M Clark et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Oxygen control with microfluidics

(2014) Martin D. Brennan et al.   LAB ON A CHIP

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Physiologically relevant organs on chips

(2013) Kyungsuk Yum et al.   Biotechnology Journal

Scaling and systems biology for integrating multiple organs-on-a-chip

(2013) John P. Wikswo et al.   LAB ON A CHIP

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

(2013) Ilka Wagner et al.   LAB ON A CHIP

Simple replica micromolding of biocompatible styrenic elastomers

(2013) Mark D. Borysiak et al.   LAB ON A CHIP

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

(2013) Eva-Maria Materne et al.   LAB ON A CHIP

Oxygen levels in thermoplastic microfluidic devices during cell culture

(2013) Christopher J. Ochs et al.   LAB ON A CHIP

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity

(2013) Radina Kostadinova et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans

(2013) Abhinav Bhushan et al.   Stem Cell Research & Therapy

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Regulating Oxygen Levels in a Microfluidic Device

(2011) Peter C. Thomas et al.   ANALYTICAL CHEMISTRY

“Artificial micro organs”—a microfluidic device for dielectrophoretic assembly of liver sinusoids

(2011) Julia Schütte et al.   BIOMEDICAL MICRODEVICES

Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants

(2010) Vasiliy N. Goral et al.   LAB ON A CHIP

Immortalized liver endothelial cells: a cell culture model for studies of motility and angiogenesis

(2010) Robert C Huebert et al.   LABORATORY INVESTIGATION

Perfused multiwell plate for 3D liver tissue engineering

(2009) Karel Domansky et al.   LAB ON A CHIP

The Hepatic Microvascular System in Health and Its Response to Toxicants

(2008) Robert S. Mccuskey   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Generation of Oxygen Deficiency in Cell Culture Using a Two-Enzyme System to Evaluate Agents Targeting Hypoxic Tumor Cells

(2008) Raymond P. Baumann et al.   RADIATION RESEARCH