Complement component C3 - The “Swiss Army Knife” of innate immunity and host defense

Comprehensive Analysis of Complement Genes in Patients with Atypical Hemolytic Uremic Syndrome

(2016) Tao Zhang et al.   AMERICAN JOURNAL OF NEPHROLOGY

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

(2016) Zhutian Zeng et al.   Cell Host & Microbe

Using an in vitro xenoantibody-mediated complement-dependent cytotoxicity model to evaluate the complement inhibitory activity of the peptidic C3 inhibitor Cp40

(2016) Junxiang Wang et al.   CLINICAL IMMUNOLOGY

Compstatin Cp40 blocks hematin-mediated deposition of C3b fragments on erythrocytes: Implications for treatment of malarial anemia

(2016) Margaret A. Lindorfer et al.   CLINICAL IMMUNOLOGY

Control of the collective migration of enteric neural crest cells by the Complement anaphylatoxin C3a and N-cadherin

(2016) Florence Broders-Bondon et al.   DEVELOPMENTAL BIOLOGY

The Molecular Basis of Radial Intercalation during Tissue Spreading in Early Development

(2016) András Szabó et al.   DEVELOPMENTAL CELL

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

(2016) Federico Forneris et al.   EMBO JOURNAL

Characterization of the gene encoding component C3 of the complement system from the spider Loxosceles laeta venom glands: Phylogenetic implications

(2016) D.T. Myamoto et al.   IMMUNOBIOLOGY

Utilizing complement evasion strategies to design complement-based antibacterial immunotherapeutics: Lessons from the pathogenic Neisseriae

(2016) Sanjay Ram et al.   IMMUNOBIOLOGY

Skipping of exon 27 in C3 gene compromises TED domain and results in complete human C3 deficiency

(2016) Karina Ribeiro da Silva et al.   IMMUNOBIOLOGY

Therapeutic control of complement activation at the level of the central component C3

(2016) Daniel Ricklin et al.   IMMUNOBIOLOGY

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

(2016) Christoph Q. Schmidt et al.   IMMUNOBIOLOGY

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage

(2016) Dimitrios C. Mastellos et al.   IMMUNOBIOLOGY

The complement factor H-related proteins

(2016) Nicholas Medjeral-Thomas et al.   IMMUNOLOGICAL REVIEWS

Preformed mediators of defense-Gatekeepers enter the spotlight

(2016) Daniel Ricklin et al.   IMMUNOLOGICAL REVIEWS

Old dogs-new tricks: immunoregulatory properties of C3 and C5 cleavage fragments

(2016) Admar Verschoor et al.   IMMUNOLOGICAL REVIEWS

The versatile functions of complement C3-derived ligands

(2016) Anna Erdei et al.   IMMUNOLOGICAL REVIEWS

Complement in removal of the dead - balancing inflammation

(2016) Myriam Martin et al.   IMMUNOLOGICAL REVIEWS

Endothelial cells: source, barrier, and target of defensive mediators

(2016) Lubka T. Roumenina et al.   IMMUNOLOGICAL REVIEWS

Pentraxins in the activation and regulation of innate immunity

(2016) Kenji Daigo et al.   IMMUNOLOGICAL REVIEWS

Properdin: a tightly regulated critical inflammatory modulator

(2016) Adam Z. Blatt et al.   IMMUNOLOGICAL REVIEWS

Protection of host cells by complement regulators

(2016) Christoph Q. Schmidt et al.   IMMUNOLOGICAL REVIEWS

Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

(2016) Tomoki Maekawa et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Diagnosis of complement alternative pathway disorders

(2016) Andrea Angioi et al.   KIDNEY INTERNATIONAL

Infections Revealing Complement Deficiency in Adults

(2016) A. Audemard-Verger et al.   MEDICINE

Structure of Complement C3(H2O) Revealed By Quantitative Cross-Linking/Mass Spectrometry And Modeling

(2016) Zhuo A. Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Genetic analysis and functional characterization of novel mutations in a series of patients with atypical hemolytic uremic syndrome

(2016) Nóra Szarvas et al.   MOLECULAR IMMUNOLOGY

Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome

(2016) Paraskevas Iatropoulos et al.   MOLECULAR IMMUNOLOGY

Retraction Note to: Retraction: The structure of complement C3b provides insights into complement activation and regulation

(2016) A. Abdul Ajees et al.   NATURE

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Complement inhibition in pre-clinical models of periodontitis and prospects for clinical application

(2016) George Hajishengallis et al.   SEMINARS IN IMMUNOLOGY

New milestones ahead in complement-targeted therapy

(2016) Daniel Ricklin et al.   SEMINARS IN IMMUNOLOGY

Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood

(2016) Jan-Michael Abicht et al.   XENOTRANSPLANTATION

Rare Genetic Variants Associated With Development of Age-Related Macular Degeneration

(2016) Nicole T. M. Saksens et al.   JAMA Ophthalmology

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

(2015) E. C. Schramm et al.   BLOOD

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

(2015) Z. Lin et al.   BLOOD

Applying complement therapeutics to rare diseases

(2015) Edimara S. Reis et al.   CLINICAL IMMUNOLOGY

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

(2015) Dimitrios C. Mastellos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Dysregulation of adaptive immune responses in complement C3-deficient patients

(2015) Pirkka T. Pekkarinen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The role of complement in neurological and neuropsychiatric diseases

(2015) Bryan Paul Morgan   Expert Review of Clinical Immunology

Neisseria meningitidisfactor H-binding protein fHbp: a key virulence factor and vaccine antigen

(2015) Kate L Seib et al.   Expert Review of Vaccines

Genetically engineered fusion of MAP-1 and factor H domains 1–5 generates a potent dual upstream inhibitor of both the lectin and alternative complement pathways

(2015) Mie Anemone Nordmaj et al.   FASEB JOURNAL

Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy

(2015) Yuzhou Zhang et al.   IMMUNOBIOLOGY

Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

(2015) Edimara S. Reis et al.   IMMUNOBIOLOGY

Complement inhibition decreases early fibrogenic events in the lung of septic baboons

(2015) Robert Silasi-Mansat et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

(2015) Andrew P. Herbert et al.   JOURNAL OF IMMUNOLOGY

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

Complement regulators in human disease: lessons from modern genetics

(2015) M. K. Liszewski et al.   JOURNAL OF INTERNAL MEDICINE

High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies

(2015) F. Bu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy

(2015) Eva-Maria Nichols et al.   KIDNEY INTERNATIONAL

The role of complement factor C3 in lipid metabolism

(2015) Andreea Barbu et al.   MOLECULAR IMMUNOLOGY

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome

(2015) Rubén Martínez-Barricarte et al.   MOLECULAR IMMUNOLOGY

More than just immune evasion: Hijacking complement by Plasmodium falciparum

(2015) Christoph Q. Schmidt et al.   MOLECULAR IMMUNOLOGY

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention

(2015) D.C. Mastellos et al.   Molecular Oral Microbiology

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

(2015) Lars G Fritsche et al.   NATURE GENETICS

Complement, a target for therapy in inflammatory and degenerative diseases

(2015) B. Paul Morgan et al.   NATURE REVIEWS DRUG DISCOVERY

An anticomplement agent that homes to the damaged brain and promotes recovery after traumatic brain injury in mice

(2015) Marieta M. Ruseva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of the immune system in humans from infancy to old age

(2015) A. Katharina Simon et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Factor H-related proteins determine complement-activating surfaces

(2015) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

(2014) Antonio M. Risitano et al.   BLOOD

Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin

(2014) Yijun Huang et al.   ChemMedChem

Human C3 Deficiency Associated with Impairments in Dendritic Cell Differentiation, Memory B Cells, and Regulatory T Cells

(2014) A. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Members of the Staphylococcus aureus Extracellular Fibrinogen-Binding Protein Family Inhibit the Interaction of C3d with Complement Receptor 2

(2014) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

(2014) Simon J. Clark et al.   JOURNAL OF IMMUNOLOGY

Viral regulators of complement activation: Structure, function and evolution

(2014) Hina Ojha et al.   MOLECULAR IMMUNOLOGY

The Evolution and Appearance of C3 Duplications in Fish Originate an Exclusive Teleost c3 Gene Form with Anti-Inflammatory Activity

(2014) Gabriel Forn-Cuní et al.   PLoS One

Analysis of Rare Variants in the C3 Gene in Patients with Age-Related Macular Degeneration

(2014) Maheswara R. Duvvari et al.   PLoS One

CMAP: Complement Map Database

(2013) Kun Yang et al.   BIOINFORMATICS

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Malaria Parasites Co-opt Human Factor H to Prevent Complement-Mediated Lysis in the Mosquito Midgut

(2013) Nina Simon et al.   Cell Host & Microbe

Genetics and Outcome of Atypical Hemolytic Uremic Syndrome: A Nationwide French Series Comparing Children and Adults

(2013) V. Fremeaux-Bacchi et al.   Clinical Journal of the American Society of Nephrology

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

CD46: The ‘multitasker’ of complement proteins

(2013) Hidekazu Yamamoto et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Staphylococcal Ecb Protein and Host Complement Regulator Factor H Enhance Functions of Each Other in Bacterial Immune Evasion

(2013) H. Amdahl et al.   JOURNAL OF IMMUNOLOGY

Induction of Complement C3a Receptor Responses by Kallikrein-Related Peptidase 14

(2013) K. Oikonomopoulou et al.   JOURNAL OF IMMUNOLOGY

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H

(2013) M. Hebecker et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Novel roles for complement receptors in T cell regulation and beyond

(2013) Claudia Kemper et al.   MOLECULAR IMMUNOLOGY

Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation

(2013) Arije Ghannam et al.   MOLECULAR IMMUNOLOGY

Complement C3 and its polymorphism: biological and clinical consequences

(2013) Joris R. Delanghe et al.   PATHOLOGY

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

(2013) G. Bajic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anaphylatoxins coordinate innate and adaptive immune responses in allergic asthma

(2013) Inken Schmudde et al.   SEMINARS IN IMMUNOLOGY

Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration

(2013) Tracy Haynes et al.   Nature Communications

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

(2012) Alexander H. Stephan et al.   Annual Review of Neuroscience

Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating

(2012) Per H. Nilsson et al.   BIOMATERIALS

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy

(2012) Daniel Ricklin   IMMUNOBIOLOGY

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite

(2012) Kenneth J. Katschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

(2012) T. Abe et al.   JOURNAL OF IMMUNOLOGY

The Role of Properdin in Zymosan- and Escherichia coli-Induced Complement Activation

(2012) M. Harboe et al.   JOURNAL OF IMMUNOLOGY

STEC-HUS, atypical HUS and TTP are all diseases of complement activation

(2012) Marina Noris et al.   Nature Reviews Nephrology

Staphylococcus aureus Surface Protein SdrE Binds Complement Regulator Factor H as an Immune Evasion Tactic

(2012) Julia A. Sharp et al.   PLoS One

Molecular basis for complement recognition by integrin  X 2

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The complotype: dictating risk for inflammation and infection

(2012) Claire L. Harris et al.   TRENDS IN IMMUNOLOGY

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Complement Fragment C3a Controls Mutual Cell Attraction during Collective Cell Migration

(2011) Carlos Carmona-Fontaine et al.   DEVELOPMENTAL CELL

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides: Implications for Therapeutic Medicine

(2011) You-Qiang Wu et al.   JOURNAL OF IMMUNOLOGY

A novel mutation in the C3 gene and recurrent invasive pneumococcal infection: A clue for vaccine development

(2011) Michael Goldberg et al.   MOLECULAR IMMUNOLOGY

Complement factor I in health and disease

(2011) Sara C. Nilsson et al.   MOLECULAR IMMUNOLOGY

Novel compound heterozygous mutations in the C3 gene: hereditary C3 deficiency

(2011) Yuka Okura et al.   PEDIATRICS INTERNATIONAL

Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

(2011) M. Heurich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

(2011) Martin Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

(2011) P. Roversi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3

(2010) Keying Li et al.   BIOCHEMICAL JOURNAL

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

(2010) R. Silasi-Mansat et al.   BLOOD

Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

(2010) M. Noris et al.   Clinical Journal of the American Society of Nephrology

Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation

(2010) Rubén Martínez-Barricarte et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-  Production in a Receptor for Advanced Glycation End Product-Dependent Manner

(2010) B. H. Ruan et al.   JOURNAL OF IMMUNOLOGY

Novel analogues of the therapeutic complement inhibitor compstatin with significantly improved affinity and potency

(2010) Hongchang Qu et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Allosteric inhibition of complement function by a staphylococcal immune evasion protein

(2010) Hui Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

Cobra venom factor: Structure, function, and humanization for therapeutic complement depletion

(2010) Carl-Wilhelm Vogel et al.   TOXICON

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

(2009) Bert J C Janssen et al.   EMBO JOURNAL

Structural and Functional Analysis of a C3b-specific Antibody That Selectively Inhibits the Alternative Pathway of Complement

(2009) Kenneth J. Katschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staphylococcal Complement Inhibitor Modulates Phagocyte Responses by Dimerization of Convertases

(2009) Ilse Jongerius et al.   JOURNAL OF IMMUNOLOGY

A Molecular Insight into Complement Evasion by the Staphylococcal Complement Inhibitor Protein Family

(2009) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Coexistence of Closed and Open Conformations of Complement Factor B in the Alternative Pathway C3bB(Mg2+) Proconvertase

(2009) E. Torreira et al.   JOURNAL OF IMMUNOLOGY

Structure-kinetic relationship analysis of the therapeutic complement inhibitor compstatin

(2009) Paola Magotti et al.   JOURNAL OF MOLECULAR RECOGNITION

The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification

(2009) Morten Harboe et al.   MOLECULAR IMMUNOLOGY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

(2009) Muriel C. Schneider et al.   NATURE

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

(2009) Suzan H M Rooijakkers et al.   NATURE IMMUNOLOGY

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

A role of macrophage complement receptor CRIg in immune clearance and inflammation

(2008) Jeannie Q. He et al.   MOLECULAR IMMUNOLOGY

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

Electrostatic contributions drive the interaction betweenStaphylococcus aureusprotein Efb-C and its complement target C3d

(2008) Nurit Haspel et al.   PROTEIN SCIENCE

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY