Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway

(2010) Santiago Rodríguez de Córdoba et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular analysis of C3 allotypes in patients with nephritic factor

(2010) J. E. FINN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Association study of TRAF1-C5 polymorphisms with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese

(2009) K Nishimoto et al.   ANNALS OF THE RHEUMATIC DISEASES

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

(2009) Bert J C Janssen et al.   EMBO JOURNAL

Genetic profile for five common variants associated with age-related macular degeneration in densely affected families: a novel analytic approach

(2009) Lucia Sobrin et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic control of the alternative pathway of complement in humans and age-related macular degeneration

(2009) Laura A. Hecker et al.   HUMAN MOLECULAR GENETICS

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity

(2009) A. Tortajada et al.   HUMAN MOLECULAR GENETICS

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase

(2009) Eva Torreira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor B

(2009) T. Montes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication of the tumor necrosis factor receptor−associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study

(2008) F. A. S. Kurreeman et al.   ARTHRITIS AND RHEUMATISM

Variation near complement factor I is associated with risk of advanced AMD

(2008) Jesen A Fagerness et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

C3 R102G polymorphism increases risk of age-related macular degeneration

(2008) K. L. Spencer et al.   HUMAN MOLECULAR GENETICS

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS

Systemic Complement Activation in Age-Related Macular Degeneration

(2008) Hendrik P. N. Scholl et al.   PLoS One