Protection of host cells by complement regulators

Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

(2016) M Martin et al.   CELL DEATH AND DIFFERENTIATION

Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode

(2016) Federico Forneris et al.   EMBO JOURNAL

Selectivity of C3-opsonin targeted complement inhibitors: A distinct advantage in the protection of erythrocytes from paroxysmal nocturnal hemoglobinuria patients

(2016) Christoph Q. Schmidt et al.   IMMUNOBIOLOGY

Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy

(2016) Thomas D. Barbour et al.   KIDNEY INTERNATIONAL

Complement in disease: a defence system turning offensive

(2016) Daniel Ricklin et al.   Nature Reviews Nephrology

Structural basis for therapeutic inhibition of complement C5

(2016) Matthijs M Jore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Complement inhibition in C3 glomerulopathy

(2016) Carla M. Nester et al.   SEMINARS IN IMMUNOLOGY

New milestones ahead in complement-targeted therapy

(2016) Daniel Ricklin et al.   SEMINARS IN IMMUNOLOGY

Structural basis for therapeutic inhibition of complement C5

(2016) Matthijs M Jore et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Glomerular Diseases Dependent on Complement Activation, Including Atypical Hemolytic Uremic Syndrome, Membranoproliferative Glomerulonephritis, and C3 Glomerulopathy: Core Curriculum 2015

(2015) Marina Noris et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

(2015) Z. Lin et al.   BLOOD

Molecular insights into the surface-specific arrangement of complement C5 convertase enzymes

(2015) Evelien T. M. Berends et al.   BMC BIOLOGY

Age-related macular degeneration: genome-wide association studies to translation

(2015) James R. M. Black et al.   GENETICS IN MEDICINE

Characterization of Inhibitors and Monoclonal Antibodies That Modulate the Interaction betweenPlasmodium falciparumAdhesin PfRh4 with Its Erythrocyte Receptor Complement Receptor 1

(2015) Nicholas T. Y. Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Evasion Mediated by Enhancement of Captured Factor H: Implications for Protection of Self-Surfaces from Complement

(2015) Andrew P. Herbert et al.   JOURNAL OF IMMUNOLOGY

Recruitment of Factor H as a Novel Complement Evasion Strategy for Blood-StagePlasmodium falciparumInfection

(2015) Alexander T. Kennedy et al.   JOURNAL OF IMMUNOLOGY

Comparative Analysis of Novel Complement-Targeted Inhibitors, MiniFH, and the Natural Regulators Factor H and Factor H–like Protein 1 Reveal Functional Determinants of Complement Regulation

(2015) Markus J. Harder et al.   JOURNAL OF IMMUNOLOGY

CD11b is protective in complement-mediated immune complex glomerulonephritis

(2015) Jessy J. Alexander et al.   KIDNEY INTERNATIONAL

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy

(2015) Eva-Maria Nichols et al.   KIDNEY INTERNATIONAL

More than just immune evasion: Hijacking complement by Plasmodium falciparum

(2015) Christoph Q. Schmidt et al.   MOLECULAR IMMUNOLOGY

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

(2015) Karolien Bettens et al.   Molecular Neurodegeneration

Age-Related Macular Degeneration: A Complementopathy?

(2015) Aize Kijlstra et al.   OPHTHALMIC RESEARCH

Factor H-related proteins determine complement-activating surfaces

(2015) Mihály Józsi et al.   TRENDS IN IMMUNOLOGY

Age-Related Macular Degeneration: Genetics and Biology Coming Together

(2014) Lars G. Fritsche et al.   Annual Review of Genomics and Human Genetics

Paroxysmal nocturnal hemoglobinuria

(2014) R. A. Brodsky   BLOOD

A New Map of Glycosaminoglycan and C3b Binding Sites on Factor H

(2014) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Human Factor H Interacts Selectively with Neisseria gonorrhoeae and Results in Species-Specific Complement Evasion

(2014) J. Ngampasutadol et al.   JOURNAL OF IMMUNOLOGY

Polyanion-Induced Self-Association of Complement Factor H

(2014) M. K. Pangburn et al.   JOURNAL OF IMMUNOLOGY

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

(2014) Simon J. Clark et al.   JOURNAL OF IMMUNOLOGY

Structural basis for sialic acid–mediated self-recognition by complement factor H

(2014) Bärbel S Blaum et al.   Nature Chemical Biology

Targeted Therapy with Eculizumab for Inherited CD59 Deficiency

(2014) Britta Höchsmann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clusterin: a key player in cancer chemoresistance and its inhibition

(2014) Tomas Koltai   OncoTargets and Therapy

Thrombosis in paroxysmal nocturnal hemoglobinuria

(2013) A. Hill et al.   BLOOD

Malaria Parasites Co-opt Human Factor H to Prevent Complement-Mediated Lysis in the Mosquito Midgut

(2013) Nina Simon et al.   Cell Host & Microbe

Polymorphism of the complement receptor 1 gene correlates with the hematologic response to eculizumab in patients with paroxysmal nocturnal hemoglobinuria

(2013) T. Rondelli et al.   HAEMATOLOGICA

CD46: The ‘multitasker’ of complement proteins

(2013) Hidekazu Yamamoto et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Using Mutagenesis and Structural Biology to Map the Binding Site for thePlasmodium falciparumMerozoite Protein PfRh4 on the Human Immune Adherence Receptor

(2013) Hyon Ju Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of Malondialdehyde-modified Proteins by the C Terminus of Complement Factor H Is Mediated via the Polyanion Binding Site and Impaired by Mutations Found in Atypical Hemolytic Uremic Syndrome

(2013) Satu Hyvärinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

(2013) Agustín Tortajada et al.   JOURNAL OF CLINICAL INVESTIGATION

Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay

(2013) Reecha Sofat et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H

(2013) M. Hebecker et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Interaction of Complement Factor H and Fibulin3 in Age-Related Macular Degeneration

(2013) M. Keith Wyatt et al.   PLoS One

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

(2013) G. Bajic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD59 deficiency is associated with chronic hemolysis and childhood relapsing immune-mediated polyneuropathy

(2012) Y. Nevo et al.   BLOOD

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

C5a Receptor-Dependent Cell Activation by Physiological Concentrations of Desarginated C5a: Insights from a Novel Label-Free Cellular Assay

(2012) E. S. Reis et al.   JOURNAL OF IMMUNOLOGY

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

(2012) Elisavet Makou et al.   JOURNAL OF MOLECULAR BIOLOGY

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

(2012) Thomas Hofmeyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Lack of Evidence from Studies of Soluble Protein Fragments that Knops Blood Group Polymorphisms in Complement Receptor-Type 1 Are Driven by Malaria

(2012) Patience B. Tetteh-Quarcoo et al.   PLoS One

Purification and biochemical characterization of functional complement factor H from human plasma fractions

(2012) H. Brandstätter et al.   VOX SANGUINIS

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes

(2011) W.-H. Tham et al.   BLOOD

Complement Factor H–ligand interactions: Self-association, multivalency and dissociation constants

(2011) Stephen J. Perkins et al.   IMMUNOBIOLOGY

Complement Regulation at Necrotic Cell Lesions Is Impaired by the Age-Related Macular Degeneration-Associated Factor-H His 402 Risk Variant

(2011) Nadine Lauer et al.   JOURNAL OF IMMUNOLOGY

Complement deficiency states and associated infections

(2011) Lillemor Skattum et al.   MOLECULAR IMMUNOLOGY

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

(2011) David Weismann et al.   NATURE

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration

(2011) Soumya Raychaudhuri et al.   NATURE GENETICS

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk

(2011) M. Heurich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

(2011) P. Roversi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

(2010) A. Hill et al.   HAEMATOLOGICA

Impaired Binding of the Age-related Macular Degeneration-associated Complement Factor H 402H Allotype to Bruch's Membrane in Human Retina

(2010) Simon J. Clark et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation

(2010) Mikkel-Ole Skjoedt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization of the Recombinant Human C1 Inhibitor Serpin Domain: Insights into Heparin Binding

(2010) V. Rossi et al.   JOURNAL OF IMMUNOLOGY

Treatment with human complement factor H rapidly reverses renal complement deposition in factor H-deficient mice

(2010) Fadi Fakhouri et al.   KIDNEY INTERNATIONAL

Recombinant human C1-inhibitor prevents acute antibody-mediated rejection in alloimmunized baboons

(2010) Xavier Tillou et al.   KIDNEY INTERNATIONAL

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Production of biologically active recombinant human factor H in Physcomitrella

(2010) Annette Büttner-Mainik et al.   PLANT BIOTECHNOLOGY JOURNAL

Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand

(2010) W.-H. Tham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of biologically active complement factor H in therapeutically useful quantities

(2010) Christoph Q. Schmidt et al.   PROTEIN EXPRESSION AND PURIFICATION

Complement Receptor 1 Is a Sialic Acid-Independent Erythrocyte Receptor of Plasmodium falciparum

(2010) Carmenza Spadafora et al.   PLoS Pathogens

Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab

(2009) A. M. Risitano et al.   BLOOD

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin-II, DNA, and Histones Serve as Factor H Ligands on the Surface of Apoptotic Cells

(2009) Jonatan Leffler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

The Central Portion of Factor H (Modules 10–15) Is Compact and Contains a Structurally Deviant CCP Module

(2009) Christoph Q. Schmidt et al.   JOURNAL OF MOLECULAR BIOLOGY

Early complement proteases: C1r, C1s and MASPs. A structural insight into activation and functions

(2009) Péter Gál et al.   MOLECULAR IMMUNOLOGY

Complement evasion strategies of pathogens—Acquisition of inhibitors and beyond

(2009) Anna M. Blom et al.   MOLECULAR IMMUNOLOGY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates

(2009) Muriel C. Schneider et al.   NATURE

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

Crystal Structure of the CUB1-EGF-CUB2Domain of Human MASP-1/3 and Identification of Its Interaction Sites with Mannan-binding Lectin and Ficolins

(2008) Florence Teillet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Factor H Binds to Denatured Rather than to Native Pentameric C-reactive Protein

(2008) Svetlana Hakobyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY