Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention

The paradoxical roles of C1q and C3 in autoimmunity

(2016) Diane Scott et al.   IMMUNOBIOLOGY

Therapeutic control of complement activation at the level of the central component C3

(2016) Daniel Ricklin et al.   IMMUNOBIOLOGY

Complement C3dg-mediated erythrophagocytosis: implications for paroxysmal nocturnal hemoglobinuria

(2015) Z. Lin et al.   BLOOD

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

(2015) Dimitrios C. Mastellos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Current and Future Pharmacologic Complement Inhibitors

(2015) Antonio M. Risitano   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Compstatin analog Cp40 inhibits complement dysregulation in vitro in C3 glomerulopathy

(2015) Yuzhou Zhang et al.   IMMUNOBIOLOGY

Therapeutic C3 inhibitor Cp40 abrogates complement activation induced by modern hemodialysis filters

(2015) Edimara S. Reis et al.   IMMUNOBIOLOGY

Polymicrobial synergy and dysbiosis in inflammatory disease

(2015) Richard J. Lamont et al.   TRENDS IN MOLECULAR MEDICINE

Mediation of a non-proteolytic activation of complement component C3 by phospholipid vesicles

(2014) Yvonne Klapper et al.   BIOMATERIALS

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

(2014) Antonio M. Risitano et al.   BLOOD

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

Conjugation to Albumin-Binding Molecule Tags as a Strategy to Improve Both Efficacy and Pharmacokinetic Properties of the Complement Inhibitor Compstatin

(2014) Yijun Huang et al.   ChemMedChem

Community-wide transcriptome of the oral microbiome in subjects with and without periodontitis

(2014) Ana E Duran-Pinedo et al.   ISME Journal

Newly Identified Pathogens Associated with Periodontitis

(2014) P.J. Pérez-Chaparro et al.   JOURNAL OF DENTAL RESEARCH

Regulation of Osteoclast Homeostasis and Inflammatory Bone Loss by MFG-E8

(2014) T. Abe et al.   JOURNAL OF IMMUNOLOGY

Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis

(2014) T. Maekawa et al.   JOURNAL OF IMMUNOLOGY

Antibiotic Susceptibility of Periodontal Streptococcus constellatus and Streptococcus intermedius Clinical Isolates

(2014) Thomas E. Rams et al.   JOURNAL OF PERIODONTOLOGY

Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools

(2014) Yuanbo Zhan et al.   JOURNAL OF PERIODONTOLOGY

Genetic variants in the complement system predisposing to age-related macular degeneration: A review

(2014) Elizabeth C. Schramm et al.   MOLECULAR IMMUNOLOGY

The inflammophilic character of the periodontitis-associated microbiota

(2014) G. Hajishengallis   Molecular Oral Microbiology

Genetic Variants in C5 and Poor Response to Eculizumab

(2014) Jun-ichi Nishimura et al.   NEW ENGLAND JOURNAL OF MEDICINE

Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss

(2014) N. M. Moutsopoulos et al.   Science Translational Medicine

Metatranscriptomics of the Human Oral Microbiome during Health and Disease

(2014) P. Jorth et al.   mBio

Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape

(2014) Dimitrios C Mastellos et al.   Expert Review of Hematology

Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity

(2013) Yizu Jiao et al.   Cell Host & Microbe

Post challenge inhibition of C3 and CD14 attenuates Escherichia coli-induced inflammation in human whole blood

(2013) Kjetil H Egge et al.   Innate Immunity

The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation

(2013) Loreto Abusleme et al.   ISME Journal

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

(2013) George Hajishengallis   TRENDS IN IMMUNOLOGY

Autoregulation of thromboinflammation on biomaterial surfaces by a multicomponent therapeutic coating

(2012) Per H. Nilsson et al.   BIOMATERIALS

Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

(2012) Antonio M. Risitano   IMMUNOBIOLOGY

Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis

(2012) Robert A. DeAngelis et al.   IMMUNOBIOLOGY

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

Fusobacterium nucleatum and Tannerella forsythia Induce Synergistic Alveolar Bone Loss in a Mouse Periodontitis Model

(2012) Rajendra P. Settem et al.   INFECTION AND IMMUNITY

Structure of Factor H-binding Protein B (FhbB) of the Periopathogen,Treponema denticola

(2012) Daniel P. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

(2012) P.I. Eke et al.   JOURNAL OF DENTAL RESEARCH

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

(2012) T. Abe et al.   JOURNAL OF IMMUNOLOGY

A Metalloproteinase Karilysin Present in the Majority of Tannerella forsythia Isolates Inhibits All Pathways of the Complement System

(2012) M. Jusko et al.   JOURNAL OF IMMUNOLOGY

Impact of Periodontal Therapy on the Subgingival Microbiota of Severe Periodontitis: Comparison Between Good Responders and Individuals With Refractory Periodontitis Using the Human Oral Microbe Identification Microarray

(2012) Ana Paula V. Colombo et al.   JOURNAL OF PERIODONTOLOGY

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

(2012) G. Hajishengallis et al.   Molecular Oral Microbiology

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

The complotype: dictating risk for inflammation and infection

(2012) Claire L. Harris et al.   TRENDS IN IMMUNOLOGY

The inflammatory response in sepsis

(2012) Markus Bosmann et al.   TRENDS IN IMMUNOLOGY

Monoclonal antibodies: magic bullets with a hefty price tag

(2012) A. F. Shaughnessy   BMJ-British Medical Journal

Innate immunity activation on biomaterial surfaces: A mechanistic model and coping strategies

(2011) Kristina N. Ekdahl et al.   ADVANCED DRUG DELIVERY REVIEWS

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing

(2011) Ann L Griffen et al.   ISME Journal

The RANKL-OPG system in clinical periodontology

(2011) Georgios N. Belibasakis et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Protection of Nonself Surfaces from Complement Attack by Factor H-Binding Peptides: Implications for Therapeutic Medicine

(2011) You-Qiang Wu et al.   JOURNAL OF IMMUNOLOGY

Diabetes mellitus and periodontitis: a tale of two common interrelated diseases

(2011) Evanthia Lalla et al.   Nature Reviews Endocrinology

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

(2010) R. Silasi-Mansat et al.   BLOOD

Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis

(2010) I. Kourtzelis et al.   BLOOD

Paroxysmal nocturnal hemoglobinuria and eculizumab

(2010) L. Luzzatto et al.   HAEMATOLOGICA

The Human Oral Microbiome

(2010) F. E. Dewhirst et al.   JOURNAL OF BACTERIOLOGY

“Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

(2010) M. Kebschull et al.   JOURNAL OF DENTAL RESEARCH

The C5a Receptor Impairs IL-12-Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss

(2010) S. Liang et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Oral biofilm-associated diseases: trends and implications for quality of life, systemic health and expenditures

(2010) Thomas Beikler et al.   PERIODONTOLOGY 2000

Microbial Hijacking of Complement-Toll-Like Receptor Crosstalk

(2010) M. Wang et al.   Science Signaling

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Targeted Inhibition of the Complement Alternative Pathway with Complement Receptor 2 and Factor H Attenuates Collagen Antibody-Induced Arthritis in Mice

(2009) N. K. Banda et al.   JOURNAL OF IMMUNOLOGY

Recent developments in low molecular weight complement inhibitors

(2009) Hongchang Qu et al.   MOLECULAR IMMUNOLOGY

Can cells and biomaterials in therapeutic medicine be shielded from innate immune recognition?

(2009) Bo Nilsson et al.   TRENDS IN IMMUNOLOGY

Interpain A, a Cysteine Proteinase from Prevotella intermedia, Inhibits Complement by Degrading Complement Factor C3

(2009) Michal Potempa et al.   PLoS Pathogens