Complement System Part I – Molecular Mechanisms of Activation and Regulation

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

(2015) E. C. Schramm et al.   BLOOD

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

Structural Basis for the Function of Complement Component C4 within the Classical and Lectin Pathways of Complement

(2015) Sofia Mortensen et al.   JOURNAL OF IMMUNOLOGY

C4a: An Anaphylatoxin in Name Only

(2015) Scott R. Barnum   Journal of Innate Immunity

Interplay between fibrinolysis and complement: plasmin cleavage of iC3b modulates immune responses

(2015) J. H. Foley et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complementing the Sugar Code: Role of GAGs and Sialic Acid in Complement Regulation

(2015) Alex Langford-Smith et al.   Frontiers in Immunology

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

The Making of a Macromolecular Machine: Assembly of the Membrane Attack Complex

(2014) Doryen Bubeck   BIOCHEMISTRY

von Willebrand factor is a cofactor in complement regulation

(2014) S. Feng et al.   BLOOD

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

(2014) Antonio M. Risitano et al.   BLOOD

C5L2 is required for C5a-triggered receptor internalization and ERK signaling

(2014) Wei-Chan Hsu et al.   CELLULAR SIGNALLING

A Revised Mechanism for the Activation of Complement C3 to C3b

(2014) Elizabeth Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An internal ligand-bound, metastable state of a leukocyte integrin, αXβ2

(2014) Mehmet Sen et al.   JOURNAL OF CELL BIOLOGY

Mannose-Binding Lectin (MBL)-Associated Serine Protease (MASP)-1 Contributes to Activation of the Lectin Complement Pathway

(2014) Minoru Takahashi et al.   JOURNAL OF IMMUNOLOGY

Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages

(2014) N. N. Gorgani et al.   JOURNAL OF IMMUNOLOGY

A Novel Targeted Inhibitor of the Alternative Pathway of Complement and Its Therapeutic Application in Ischemia/Reperfusion Injury

(2014) Y. Huang et al.   JOURNAL OF IMMUNOLOGY

C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

(2014) H. Paidassi et al.   JOURNAL OF IMMUNOLOGY

Properdin Plays a Protective Role in Polymicrobial Septic Peritonitis

(2014) C. M. Stover et al.   JOURNAL OF IMMUNOLOGY

Relative Contribution of C1q and Apoptotic Cell-Surface Calreticulin to Macrophage Phagocytosis

(2014) Mélanie Verneret et al.   Journal of Innate Immunity

Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation

(2014) Elizabeth V. Clarke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement Factor B Mutations in Atypical Hemolytic Uremic Syndrome--Disease-Relevant or Benign?

(2014) M. C. Marinozzi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement anaphylatoxin C4a inhibits C5a-induced neointima formation following arterial injury

(2014) YAN ZHAO et al.   Molecular Medicine Reports

Structural basis for sialic acid–mediated self-recognition by complement factor H

(2014) Bärbel S Blaum et al.   Nature Chemical Biology

In Silico and In Vitro Studies on the Protein-Protein Interactions between Brugia malayi Immunomodulatory Protein Calreticulin and Human C1q

(2014) Sunita Yadav et al.   PLoS One

Complement activation by ligand-driven juxtaposition of discrete pattern recognition complexes

(2014) Søren E. Degn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens

(2014) L. Baudino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

(2014) C. A. Diebolder et al.   SCIENCE

IgGs are made for walking on bacterial and viral surfaces

(2014) Johannes Preiner et al.   Nature Communications

Structural and functional characterization of human and murine C5a anaphylatoxins

(2014) Janus Asbjørn Schatz-Jakobsen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

(2014) Christine Gaboriaud et al.   Frontiers in Immunology

Molecular Interactions between Complement Factor H and Its Heparin and Heparan Sulfate Ligands

(2014) Stephen J. Perkins et al.   Frontiers in Immunology

Structural and Functional Overview of the Lectin Complement Pathway: Its Molecular Basis and Physiological Implication

(2013) Misao Matsushita et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

(2013) J. Rayes et al.   BLOOD

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome

(2013) M. Frimat et al.   BLOOD

Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

(2013) J. D. Belcher et al.   BLOOD

C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independentin vivo

(2013) M. M. Ruseva et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Physiological and therapeutic complement regulators in kidney transplantation

(2013) Lubka T. Roumenina et al.   Current Opinion in Organ Transplantation

Quantitative Characterization of the Activation Steps of Mannan-binding Lectin (MBL)-associated Serine Proteases (MASPs) Points to the Central Role of MASP-1 in the Initiation of the Complement Lectin Pathway

(2013) Márton Megyeri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C3 glomerulopathy–associated CFHR1 mutation alters FHR oligomerization and complement regulation

(2013) Agustín Tortajada et al.   JOURNAL OF CLINICAL INVESTIGATION

Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions

(2013) S. J. Clark et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Mode of Complement Activation on Stimulated Platelets Mediated by Properdin and C3(H2O)

(2013) G. Saggu et al.   JOURNAL OF IMMUNOLOGY

Disruption of the Complement Anaphylatoxin Receptor C5L2 Exacerbates Inflammation in Allergic Contact Dermatitis

(2013) R. Wang et al.   JOURNAL OF IMMUNOLOGY

Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties

(2013) C. Q. Schmidt et al.   JOURNAL OF IMMUNOLOGY

An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H

(2013) M. Hebecker et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase Directs Properdin-Mediated Complement Activation

(2013) Joseph O'Flynn et al.   Journal of Innate Immunity

Toward a structure-based comprehension of the lectin pathway of complement

(2013) Troels R. Kjaer et al.   MOLECULAR IMMUNOLOGY

Complement factor H related proteins (CFHRs)

(2013) Christine Skerka et al.   MOLECULAR IMMUNOLOGY

The control of the complement lectin pathway activation revisited: Both C1-inhibitor and antithrombin are likely physiological inhibitors, while α2-macroglobulin is not

(2013) Katalin Paréj et al.   MOLECULAR IMMUNOLOGY

Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013)   NEW ENGLAND JOURNAL OF MEDICINE

The Serine Protease Domain of MASP-3: Enzymatic Properties and Crystal Structure in Complex with Ecotin

(2013) Christine Gaboriaud et al.   PLoS One

Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites

(2013) I. Bally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimerization of complement factor H-related proteins modulates complement activation in vivo

(2013) E. Goicoechea de Jorge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight on the recognition of surface-bound opsonins by the integrin I domain of complement receptor 3

(2013) G. Bajic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin

(2013) M. Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation

(2013) Umakhanth Venkatraman Girija et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meningococcal disease and the complement system

(2013) Lisa A Lewis et al.   Virulence

The Proteoglycan Glycomatrix: A Sugar Microenvironment Essential for Complement Regulation

(2013) Simon J. Clark et al.   Frontiers in Immunology

Local release of properdin in the cellular microenvironment: role in pattern recognition and amplification of the alternative pathway of complement

(2013) Claudio Cortes et al.   Frontiers in Immunology

Properdin and Factor H: Opposing Players on the Alternative Complement Pathway “See-Saw”

(2013) Lubna Kouser et al.   Frontiers in Immunology

The innate immune response to products of phospholipid peroxidation

(2012) David Weismann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Thrombin generates previously unidentified C5 products that support the terminal complement activation pathway

(2012) M. J. Krisinger et al.   BLOOD

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function

(2012) L. T. Roumenina et al.   BLOOD

The complement receptor 2/factor H fusion protein TT30 protects paroxysmal nocturnal hemoglobinuria erythrocytes from complement-mediated hemolysis and C3 fragment

(2012) A. M. Risitano et al.   BLOOD

C5L2 and C5aR interaction in adipocytes and macrophages: Insights into adipoimmunology

(2012) Pegah Poursharifi et al.   CELLULAR SIGNALLING

Regulation of Humoral Immunity by Complement

(2012) Michael C. Carroll et al.   IMMUNITY

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

Factor H and Properdin Recognize Different Epitopes on Renal Tubular Epithelial Heparan Sulfate

(2012) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human and Pneumococcal Cell Surface Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Proteins Are Both Ligands of Human C1q Protein

(2012) Rémi Terrasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasminogen Is a Complement Inhibitor

(2012) Diana Barthel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

(2012) Myriam Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function

(2012) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

C1q and phagocytosis: the perfect complement to a good meal

(2012) M. D. Galvan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Solution Structure of CCP Modules 10–12 Illuminates Functional Architecture of the Complement Regulator, Factor H

(2012) Elisavet Makou et al.   JOURNAL OF MOLECULAR BIOLOGY

Solution Structure of TT30, a Novel Complement Therapeutic Agent, Provides Insight into Its Joint Binding to Complement C3b and C3d

(2012) Keying Li et al.   JOURNAL OF MOLECULAR BIOLOGY

Arranged Sevenfold: Structural Insights into the C-Terminal Oligomerization Domain of Human C4b-Binding Protein

(2012) Thomas Hofmeyer et al.   JOURNAL OF MOLECULAR BIOLOGY

Hereditary angio-oedema

(2012) Hilary Longhurst et al.   LANCET

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

(2012) Julien Zuber et al.   Nature Reviews Nephrology

Structural Analysis of the C-Terminal Region (Modules 18–20) of Complement Regulator Factor H (FH)

(2012) Hugh P. Morgan et al.   PLoS One

Genetics of hemolytic uremic syndromes

(2012) Michal Malina et al.   PRESSE MEDICALE

Molecular basis for complement recognition by integrin  X 2

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revised mechanism of complement lectin-pathway activation revealing the role of serine protease MASP-1 as the exclusive activator of MASP-2

(2012) D. Heja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for activation of the complement system by component C4 cleavage

(2012) R. T. Kidmose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids

(2012) P. X. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg

(2012) Goran Bajic et al.   PROTEIN SCIENCE

Assembly and Regulation of the Membrane Attack Complex Based on Structures of C5b6 and sC5b9

(2012) Michael A. Hadders et al.   Cell Reports

The Human C1q Globular Domain: Structure and Recognition of Non-Immune Self Ligands

(2012) Christine Gaboriaud et al.   Frontiers in Immunology

Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: Two genes, five proteins and many functions?

(2011) Tang Yongqing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases

(2011) M. Fridkis-Hareli et al.   BLOOD

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex

(2011) Nick S Laursen et al.   EMBO JOURNAL

Complement Factor H–ligand interactions: Self-association, multivalency and dissociation constants

(2011) Stephen J. Perkins et al.   IMMUNOBIOLOGY

Heme Interacts with C1q and Inhibits the Classical Complement Pathway

(2011) Lubka T. Roumenina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement

(2011) Leslie L. Lovelace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the Intermedilysin-Human CD59 Receptor Interface Reveals a Deep Correspondence with the Binding Site on CD59 for Complement Binding Proteins C8α and C9

(2011) Stephanie E. Wickham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative complement pathway assessment in patients with atypical HUS

(2011) Lubka T. Roumenina et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Role of Mannose-Binding Lectin-Associated Serine Protease-3 in Activation of the Alternative Complement Pathway

(2011) D. Iwaki et al.   JOURNAL OF IMMUNOLOGY

Alternative Pathway Activation of Complement by Shiga Toxin Promotes Exuberant C3a Formation That Triggers Microvascular Thrombosis

(2011) M. Morigi et al.   JOURNAL OF IMMUNOLOGY

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

(2011) Helena Païdassi et al.   JOURNAL OF MOLECULAR BIOLOGY

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

(2011) David Weismann et al.   NATURE

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

(2011) Martin Alcorlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for complement factor I control and its disease-associated sequence polymorphisms

(2011) P. Roversi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bradykinin and the Pathogenesis of Hereditary Angioedema

(2011) Allen P. Kaplan   World Allergy Organization Journal

Structure of human desArg-C5a

(2010) William J. Cook et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Self-association and domain rearrangements between complement C3 and C3u provide insight into the activation mechanism of C3

(2010) Keying Li et al.   BIOCHEMICAL JOURNAL

Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis

(2010) R. Silasi-Mansat et al.   BLOOD

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

Evidence that the extracellular N-terminal domain of C5aR contains amino-acid residues crucial for C5a binding

(2010) Laurence Mery et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

(2010) Lars G. Fritsche et al.   HUMAN MOLECULAR GENETICS

Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement

(2010) Viviana P. Ferreira et al.   IMMUNOBIOLOGY

Mapping Surface Accessibility of the C1r/C1s Tetramer by Chemical Modification and Mass Spectrometry Provides New Insights into Assembly of the Human C1 Complex

(2010) Sébastien Brier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Tubular Heparan Sulfate as a Docking Platform for the Alternative Complement Component Properdin in Proteinuric Renal Disease

(2010) Azadeh Zaferani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

Complement Component C3 Binds to Activated Normal Platelets without Preceding Proteolytic Activation and Promotes Binding to Complement Receptor 1

(2010) Osama A. Hamad et al.   JOURNAL OF IMMUNOLOGY

Mutational Analyses Reveal that the Staphylococcal Immune Evasion Molecule Sbi and Complement Receptor 2 (CR2) Share Overlapping Contact Residues on C3d: Implications for the Controversy Regarding the CR2/C3d Cocrystal Structure

(2010) David E. Isenman et al.   JOURNAL OF IMMUNOLOGY

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d

(2010) Arnab Bhattacharjee et al.   MOLECULAR IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

The internal thioester and the covalent binding properties of the complement proteins C3 and C4

(2010) S. K. Alex Law et al.   PROTEIN SCIENCE

Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation

(2010) F. Forneris et al.   SCIENCE

C1 inhibitor, a multi-functional serine protease inhibitor

(2010) Fengxin Lu et al.   THROMBOSIS AND HAEMOSTASIS

Structure of the Extracellular Portion of CD46 Provides Insights into Its Interactions with Complement Proteins and Pathogens

(2010) B. David Persson et al.   PLoS Pathogens

The structure of C2b, a fragment of complement component C2 produced during C3 convertase formation

(2009) Vengadesan Krishnan et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

(2009) L. T. Roumenina et al.   BLOOD

Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation

(2009) S. Heinen et al.   BLOOD

Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex

(2009) Bert J C Janssen et al.   EMBO JOURNAL

Mutations of Factor H Impair Regulation of Surface-bound C3b by Three Mechanisms in Atypical Hemolytic Uremic Syndrome

(2009) Markus J. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the C1q-binding Sites of Human C1r and C1s

(2009) Isabelle Bally et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations

(2009) Azubuike I. Okemefuna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential role of Mannose-binding lectin-associated serine protease-1 in activation of the complement factor D

(2009) Minoru Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MAp44, a Human Protein Associated with Pattern Recognition Molecules of the Complement System and Regulating the Lectin Pathway of Complement Activation

(2009) S. E. Degn et al.   JOURNAL OF IMMUNOLOGY

Coexistence of Closed and Open Conformations of Complement Factor B in the Alternative Pathway C3bB(Mg2+) Proconvertase

(2009) E. Torreira et al.   JOURNAL OF IMMUNOLOGY

The Binding of Factor H to a Complex of Physiological Polyanions and C3b on Cells Is Impaired in Atypical Hemolytic Uremic Syndrome

(2009) V. P. Ferreira et al.   JOURNAL OF IMMUNOLOGY

Targeted Disruption of the Gene Encoding the Murine Small Subunit of Carboxypeptidase N (CPN1) Causes Susceptibility to C5a Anaphylatoxin-Mediated Shock

(2009) Stacey L. Mueller-Ortiz et al.   JOURNAL OF IMMUNOLOGY

Multimeric Interactions between Complement Factor H and Its C3d Ligand Provide New Insight on Complement Regulation

(2009) Azubuike I. Okemefuna et al.   JOURNAL OF MOLECULAR BIOLOGY

The Central Portion of Factor H (Modules 10–15) Is Compact and Contains a Structurally Deviant CCP Module

(2009) Christoph Q. Schmidt et al.   JOURNAL OF MOLECULAR BIOLOGY

Stringent regulation of complement lectin pathway C3/C5 convertase by C4b-binding protein (C4BP)

(2009) Nenoo Rawal et al.   MOLECULAR IMMUNOLOGY

The role of the anaphylatoxins in health and disease

(2009) Andreas Klos et al.   MOLECULAR IMMUNOLOGY

Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor

(2009) Suzan H M Rooijakkers et al.   NATURE IMMUNOLOGY

Structure of complement fragment C3b–factor H and implications for host protection by complement regulators

(2009) Jin Wu et al.   NATURE IMMUNOLOGY

Weibel–Palade bodies—sentinels of acute stress

(2009) Michael S. Goligorsky et al.   Nature Reviews Nephrology

Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome

(2009) Mieke Delvaeye et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atypical Hemolytic–Uremic Syndrome

(2009) Marina Noris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction of Human C1q with IgG and IgM: Revisited†

(2008) Mihaela G. Gadjeva et al.   BIOCHEMISTRY

Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide

(2008) Lubka T. Roumenina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome

(2008) V. Fremeaux-Bacchi et al.   BLOOD

The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition

(2008) Helena Païdassi et al.   FEBS LETTERS

The alternative complement pathway revisited

(2008) Morten Harboe et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A role of macrophage complement receptor CRIg in immune clearance and inflammation

(2008) Jeannie Q. He et al.   MOLECULAR IMMUNOLOGY

Modulation of the antitumor immune response by complement

(2008) Maciej M Markiewski et al.   NATURE IMMUNOLOGY

C1, MBL–MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation

(2008) László Beinrohr et al.   TRENDS IN MOLECULAR MEDICINE

The tick-over theory revisited: Formation and regulation of the soluble alternative complement C3 convertase (C3(H2O)Bb)

(2007) Fredrik Bexborn et al.   MOLECULAR IMMUNOLOGY