Pentraxins in the activation and regulation of innate immunity

Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome

(2016) S. Hyvarinen et al.   BLOOD

PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition

(2016) Cecilia Garlanda et al.   CURRENT OPINION IN IMMUNOLOGY

Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy

(2016) Bernt van den Blink et al.   EUROPEAN RESPIRATORY JOURNAL

Self-nonself discrimination by the complement system

(2016) Seppo Meri   FEBS LETTERS

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

(2016) Barbara Bottazzi et al.   JOURNAL OF HEPATOLOGY

Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo

(2016) Jai-Nien Tung et al.   JOURNAL OF NEURO-ONCOLOGY

Long-Pentraxin 3 Derivative as a Small-Molecule FGF Trap for Cancer Therapy

(2015) Roberto Ronca et al.   CANCER CELL

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

(2015) Eduardo Bonavita et al.   CELL

Pentraxin 3 Induces Vascular Endothelial Dysfunction Through a P-selectin/Matrix Metalloproteinase-1 Pathway

(2015) A. Carrizzo et al.   CIRCULATION

Elevations of inflammatory markers PTX3 and sST2 after resuscitation from cardiac arrest are associated with multiple organ dysfunction syndrome and early death

(2015) Giuseppe Ristagno et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

PTX3Polymorphisms and Invasive Mold Infections After Solid Organ Transplant: Figure 1.

(2015) Agnieszka Wójtowicz et al.   CLINICAL INFECTIOUS DISEASES

The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3

(2015) Anna Paeschke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential expression of pentraxin 3 in neutrophils

(2015) Olga Razvina et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Prognostic and diagnostic potential of local and circulating levels of pentraxin 3 in lung cancer patients

(2015) Maurizio Infante et al.   INTERNATIONAL JOURNAL OF CANCER

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

(2015) Andrea Doni et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association between levels of pentraxin 3 and incidence of chronic kidney disease in the elderly

(2015) B. Sjöberg et al.   JOURNAL OF INTERNAL MEDICINE

Genetic variation in PTX3 and plasma levels associated with hepatocellular carcinoma in patients with HCV

(2015) R. F. Carmo et al.   JOURNAL OF VIRAL HEPATITIS

Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?

(2015) Suan-Sin Foo et al.   TRENDS IN MICROBIOLOGY

PTX3 gene activation in EGF-induced head and neck cancer cell metastasis

(2015) Wei-Chiao Chang et al.   Oncotarget

Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: From Enhanced Viral Replication to Immunomodulation

(2015) Suan-Sin Foo et al.   PLoS Pathogens

Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant

(2015) Barbara Bottazzi et al.   PLoS One

Elevated Pentraxin 3 in bone metastatic breast cancer is correlated with osteolytic function

(2015) Bongkun Choi et al.   Oncotarget

Pentraxin 3: A Novel Biomarker for Predicting Progression from Prostatic Inflammation to Prostate Cancer

(2014) G. Stallone et al.   CANCER RESEARCH

The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection

(2014) Sébastien Jaillon et al.   IMMUNITY

Pentraxin 3 Inhibits Acute Renal Injury-Induced Interstitial Fibrosis Through Suppression of IL-6/Stat3 Pathway

(2014) Yuefei Xiao et al.   INFLAMMATION

Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

(2014) Natalia S. Baranova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses

(2014) P. C. Reading et al.   JOURNAL OF IMMUNOLOGY

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

(2014) L. Deban et al.   JOURNAL OF IMMUNOLOGY

PTX3 Binds MD-2 and Promotes TRIF-Dependent Immune Protection in Aspergillosis

(2014) Silvia Bozza et al.   JOURNAL OF IMMUNOLOGY

Associations of pentraxin 3 with cardiovascular disease: the Multi-Ethnic Study of Atherosclerosis

(2014) N. S. Jenny et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation

(2014) Cristina Cunha et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protective effect of the long pentraxin PTX3 against histone-mediated endothelial cell cytotoxicity in sepsis

(2014) K. Daigo et al.   Science Signaling

Incremental Prognostic Significance of the Elevated Levels of Pentraxin 3 in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction

(2014) Junichi Matsubara et al.   Journal of the American Heart Association

Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

(2014) Christine Gaboriaud et al.   Frontiers in Immunology

Clinical impact of pentraxin family expression on prognosis of pancreatic carcinoma

(2013) S Kondo et al.   BRITISH JOURNAL OF CANCER

Complement activation in diseases presenting with thrombotic microangiopathy

(2013) Seppo Meri   European Journal of Internal Medicine

The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury

(2013) Beatriz Rodriguez-Grande et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue-Specific Host Recognition by Complement Factor H Is Mediated by Differential Activities of Its Glycosaminoglycan-Binding Regions

(2013) S. J. Clark et al.   JOURNAL OF IMMUNOLOGY

A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice

(2013) E. R. Job et al.   JOURNAL OF IMMUNOLOGY

Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury

(2013) Maciej Lech et al.   KIDNEY INTERNATIONAL

Pentraxin 3 (PTX3) Is Associated with Severe Sepsis and Fatal Disease in Emergency Room Patients with Suspected Infection: A Prospective Cohort Study

(2013) Raija Uusitalo-Seppälä et al.   PLoS One

Pentraxin-3 Serum Levels Are Associated with Disease Severity and Mortality in Patients with Systemic Inflammatory Response Syndrome

(2013) Simone Bastrup-Birk et al.   PLoS One

Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis

(2013) M.R. Dillingh et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

PTX3 as a paradigm for the interaction of pentraxins with the Complement system

(2013) Antonio Inforzato et al.   SEMINARS IN IMMUNOLOGY

Microbes Bind Complement Inhibitor Factor H via a Common Site

(2013) T. Meri et al.   PLoS Pathogens

The “sweet” side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation

(2013) Antonio Inforzato et al.   Frontiers in Immunology

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

(2013) Cecilia Garlanda et al.   Frontiers in Immunology

Associations of pentraxin-3 with cardiovascular events, incident heart failure, and mortality among persons with coronary heart disease: Data from the Heart and Soul Study

(2012) Ruth Dubin et al.   AMERICAN HEART JOURNAL

Long Pentraxin 3/Tumor Necrosis Factor-Stimulated Gene-6 Interaction

(2012) Daria Leali et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pentraxin 3, a Sensitive Early Marker of Hemodialysis-Induced Inflammation

(2012) Bodil Sjöberg et al.   BLOOD PURIFICATION

Pentraxin-3 in chronic heart failure: the CORONA and GISSI-HF trials

(2012) Roberto Latini et al.   EUROPEAN JOURNAL OF HEART FAILURE

Interactions of the humoral pattern recognition molecule PTX3 with the complement system

(2012) Andrea Doni et al.   IMMUNOBIOLOGY

Pentraxins and Fc receptors

(2012) Jinghua Lu et al.   IMMUNOLOGICAL REVIEWS

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

Myeloperoxidase: a front-line defender against phagocytosed microorganisms

(2012) S. J. Klebanoff et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Pentraxin 3 accelerates lung injury in high tidal volume ventilation in mice

(2012) Juliana Monte Real et al.   MOLECULAR IMMUNOLOGY

Influence of Pentraxin 3 (PTX3) Genetic Variants on Myocardial Infarction Risk and PTX3 Plasma Levels

(2012) Elisa Barbati et al.   PLoS One

Inflammation and colorectal cancer: colitis-associated neoplasia

(2012) Sergei I. Grivennikov   Seminars in Immunopathology

Mannose Binding Lectin Is Required for Alphavirus-Induced Arthritis/Myositis

(2012) Bronwyn M. Gunn et al.   PLoS Pathogens

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Pentraxin-3 Is a Novel Biomarker of Lung Carcinoma

(2011) E. P. Diamandis et al.   CLINICAL CANCER RESEARCH

The Therapeutic Potential of the Humoral Pattern Recognition Molecule PTX3 in Chronic Lung Infection Caused by Pseudomonas aeruginosa

(2011) F. Moalli et al.   JOURNAL OF IMMUNOLOGY

M-Ficolin Interacts with the Long Pentraxin PTX3: A Novel Case of Cross-Talk between Soluble Pattern-Recognition Molecules

(2011) E. Gout et al.   JOURNAL OF IMMUNOLOGY

Pentraxin 3 Is a New Inflammatory Marker Correlated With Left Ventricular Diastolic Dysfunction and Heart Failure With Normal Ejection Fraction

(2011) Junichi Matsubara et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Implication of the oligomeric state of the N-terminal PTX3 domain in cumulus matrix assembly

(2011) Elena Ievoli et al.   MATRIX BIOLOGY

Complement deficiency states and associated infections

(2011) Lillemor Skattum et al.   MOLECULAR IMMUNOLOGY

Structural basis for engagement by complement factor H of C3b on a self surface

(2011) Hugh P Morgan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis

(2011) Alexander S. Savchenko et al.   PATHOLOGY INTERNATIONAL

High Plasma Level of Long Pentraxin 3 (PTX3) Is Associated with Fatal Disease in Bacteremic Patients: A Prospective Cohort Study

(2011) Reetta Huttunen et al.   PLoS One

Lack of the Long Pentraxin PTX3 Promotes Autoimmune Lung Disease but not Glomerulonephritis in Murine Systemic Lupus Erythematosus

(2011) Maciej Lech et al.   PLoS One

Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein

(2011) Anne Braunschweig et al.   PLoS One

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

(2011) T. Kajander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aberrant methylation of the 3q25 tumor suppressor genePTX3in human esophageal squamous cell carcinoma

(2011) Jun-Xiong Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Role of complement and Fc  receptors in the protective activity of the long pentraxin PTX3 against Aspergillus fumigatus

(2010) F. Moalli et al.   BLOOD

Antitumor and Anti-inflammatory Effects of Trabectedin on Human Myxoid Liposarcoma Cells

(2010) G. Germano et al.   CANCER RESEARCH

PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients

(2010) M Chiarini et al.   GENES AND IMMUNITY

Persisting high levels of plasma pentraxin 3 over the first days after severe sepsis and septic shock onset are associated with mortality

(2010) Tommaso Mauri et al.   INTENSIVE CARE MEDICINE

The Angiogenic Inhibitor Long Pentraxin PTX3 Forms an Asymmetric Octamer with Two Binding Sites for FGF2

(2010) Antonio Inforzato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

(2010) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies

(2010) E. R. Job et al.   JOURNAL OF IMMUNOLOGY

Regulation of leukocyte recruitment by the long pentraxin PTX3

(2010) Livija Deban et al.   NATURE IMMUNOLOGY

Genetics and complement in atypical HUS

(2010) David Kavanagh et al.   PEDIATRIC NEPHROLOGY

The Long Pentraxin PTX3: A Modulator of the Immunoinflammatory Response in Atherosclerosis and Cardiovascular Diseases

(2010) Giuseppe Danilo Norata et al.   TRENDS IN CARDIOVASCULAR MEDICINE

The Long Pentraxin PTX3 Is Crucial for Tissue Inflammation after Intestinal Ischemia and Reperfusion in Mice

(2009) Danielle G. Souza et al.   AMERICAN JOURNAL OF PATHOLOGY

An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

(2009) Barbara Bottazzi et al.   Annual Review of Immunology

Associations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death

(2009) Nancy Swords Jenny et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Deficiency of the Long Pentraxin PTX3 Promotes Vascular Inflammation and Atherosclerosis

(2009) Giuseppe Danilo Norata et al.   CIRCULATION

Heparin‐Binding Protein: An Early Marker of Circulatory Failure in Sepsis

(2009) Adam Linder et al.   CLINICAL INFECTIOUS DISEASES

iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-κB-dependent blockade

(2009) Gil Amarilyo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition

(2009) Ying Jie Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement Factor H Binds at Two Independent Sites to C-reactive Protein in Acute Phase Concentrations

(2009) Azubuike I. Okemefuna et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long pentraxin PTX3 is associated with mortality and disease severity in severe Leptospirosis

(2009) Jiri F.P. Wagenaar et al.   JOURNAL OF INFECTION

PTX3 as a Potential Novel Tool for the Diagnosis and Monitoring of Pulmonary Fungal Infections in Immuno-compromised Pediatric Patients

(2009) Ettore Biagi et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarction

(2008) Monica Salio et al.   CIRCULATION

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome

(2008) R. W. Tothill et al.   CLINICAL CANCER RESEARCH

Novel Links between the Long Pentraxin 3, Endothelial Dysfunction, and Albuminuria in Early and Advanced Chronic Kidney Disease

(2008) M. E. Suliman et al.   Clinical Journal of the American Society of Nephrology

Structural Characterization of PTX3 Disulfide Bond Network and Its Multimeric Status in Cumulus Matrix Organization

(2008) Antonio Inforzato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-reactive protein and coronary heart disease: a critical review

(2008) J. P. Casas et al.   JOURNAL OF INTERNAL MEDICINE

Neutrophil-derived azurocidin alarms the immune system

(2008) Oliver Soehnlein et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural recognition and functional activation of FcγR by innate pentraxins

(2008) Jinghua Lu et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

The long pentraxin PTX-3 in prevalent hemodialysis patients: associations with comorbidities and mortality

(2008) M.E. Suliman et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

PENTRAXIN 3 AND C-REACTIVE PROTEIN IN SEVERE MENINGOCOCCAL DISEASE

(2008) Tom Sprong et al.   SHOCK

Pentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure

(2007) Satoshi Suzuki et al.   AMERICAN HEART JOURNAL