Neisseria meningitidisfactor H-binding protein fHbp: a key virulence factor and vaccine antigen
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Title
Neisseria meningitidisfactor H-binding protein fHbp: a key virulence factor and vaccine antigen
Authors
Keywords
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Journal
Expert Review of Vaccines
Volume 14, Issue 6, Pages 841-859
Publisher
Informa UK Limited
Online
2015-02-23
DOI
10.1586/14760584.2015.1016915
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Note: Only part of the references are listed.- Effect of a quadrivalent meningococcal ACWY glycoconjugate or a serogroup B meningococcal vaccine on meningococcal carriage: an observer-blind, phase 3 randomised clinical trial
- (2014) Robert C Read et al. LANCET
- Persistence of Bactericidal Antibodies to 5 Years of Age After Immunization With Serogroup B Meningococcal Vaccines at 6, 8, 12 and 40 Months of Age
- (2014) Fiona McQuaid et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Progressive Decrease in the Potential Usefulness of Meningococcal Serogroup B Vaccine (4CMenB, Bexsero®) in Gipuzkoa, Northern Spain
- (2014) Emilio Pérez-Trallero et al. PLoS One
- A randomized, phase 1/2 trial of the safety, tolerability, and immunogenicity of bivalent rLP2086 meningococcal B vaccine in healthy infants
- (2014) Federico Martinon-Torres et al. VACCINE
- Variability of genes encoding surface proteins used as vaccine antigens in meningococcal endemic and epidemic strain panels from Norway
- (2014) Johan Holst et al. VACCINE
- Human Factor H (FH) Impairs Protective Meningococcal Anti-FHbp Antibody Responses and the Antibodies Enhance FH Binding
- (2014) I. Costa et al. mBio
- A phase II randomized controlled trial of a multicomponent meningococcal serogroup B vaccine, 4CMenB, in infants (II)
- (2014) Susanna Esposito et al. Human Vaccines & Immunotherapeutics
- A phase 2 randomized controlled trial of a multicomponent meningococcal serogroup B vaccine (I)
- (2014) Roman Prymula et al. Human Vaccines & Immunotherapeutics
- The Discovery and Development of a Novel Vaccine to Protect againstNeisseria meningitidisSerogroup B Disease
- (2014) Gary W Zlotnick et al. Human Vaccines & Immunotherapeutics
- Persistence of bactericidal antibodies following early infant vaccination with a serogroup B meningococcal vaccine and immunogenicity of a preschool booster dose
- (2013) M. D. Snape et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- Genetic Distribution of Noncapsular Meningococcal Group B Vaccine Antigens in Neisseria lactamica
- (2013) Jay Lucidarme et al. Clinical and Vaccine Immunology
- A Multi-Component Meningococcal Serogroup B Vaccine (4CMenB): The Clinical Development Program
- (2013) Miguel O’Ryan et al. DRUGS
- Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties
- (2013) Agnese Faleri et al. FASEB JOURNAL
- Nonfunctional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine Candidates
- (2013) Stijn van der Veen et al. INFECTION AND IMMUNITY
- Importance of Inhibition of Binding of Complement Factor H for Serum Bactericidal Antibody Responses to Meningococcal Factor H-binding Protein Vaccines
- (2013) Monica Konar et al. JOURNAL OF INFECTIOUS DISEASES
- Immunogenicity and safety of an investigational multicomponent, recombinant, meningococcal serogroup B vaccine (4CMenB) administered concomitantly with routine infant and child vaccinations: results of two randomised trials
- (2013) Timo Vesikari et al. LANCET
- Predicted strain coverage of a meningococcal multicomponent vaccine (4CMenB) in Europe: a qualitative and quantitative assessment
- (2013) Ulrich Vogel et al. LANCET INFECTIOUS DISEASES
- Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal Disease
- (2013) L. K. McNeil et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- A Multi-country Evaluation of Neisseria meningitidis Serogroup B Factor H–Binding Proteins and Implications for Vaccine Coverage in Different Age Groups
- (2013) Susan K. Hoiseth et al. PEDIATRIC INFECTIOUS DISEASE JOURNAL
- Mutant Native Outer Membrane Vesicles Combined with a Serogroup A Polysaccharide Conjugate Vaccine for Prevention of Meningococcal Epidemics in Africa
- (2013) Rolando Pajon et al. PLoS One
- An Analysis of the Sequence Variability of Meningococcal fHbp, NadA and NHBA over a 50-Year Period in the Netherlands
- (2013) Stefania Bambini et al. PLoS One
- Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen
- (2013) Enrico Malito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- fH-dependent complement evasion by disease-causing meningococcal strains with absent fHbp genes or frameshift mutations
- (2013) Serena Giuntini et al. VACCINE
- Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain coverage
- (2013) Giacomo Frosi et al. VACCINE
- A phase 2 open-label safety and immunogenicity study of a meningococcal B bivalent rLP2086 vaccine in healthy adults
- (2013) Helen S. Marshall et al. VACCINE
- Meningococcal factor H-binding protein vaccines with decreased binding to human complement factor H have enhanced immunogenicity in human factor H transgenic mice
- (2013) Raffaella Rossi et al. VACCINE
- Conservation of Meningococcal Antigens in the Genus Neisseria
- (2013) A. Muzzi et al. mBio
- Factor H-Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis
- (2013) L. A. Lewis et al. mBio
- Meningococcal disease and the complement system
- (2013) Lisa A Lewis et al. Virulence
- Vaccines, Reverse Vaccinology, and Bacterial Pathogenesis
- (2013) I. Delany et al. Cold Spring Harbor Perspectives in Medicine
- Persistence of antibodies in adolescents 18−24 months after immunization with one, two, or three doses of 4CMenB meningococcal serogroup B vaccine
- (2013) Maria Elena Santolaya et al. Human Vaccines & Immunotherapeutics
- Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): Lessons from past programs and implications for the future
- (2013) Johan Holst et al. Human Vaccines & Immunotherapeutics
- Potential impact of the bivalent rLP2086 vaccine onNeisseria meningitidiscarriage and invasive serogroup B disease
- (2013) Annaliesa S. Anderson et al. Human Vaccines & Immunotherapeutics
- Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding Protein
- (2013) Ilse Jongerius et al. PLoS Pathogens
- The Factor H Binding Protein of Neisseria meningitidis Interacts with Xenosiderophores in Vitro
- (2012) Daniele Veggi et al. BIOCHEMISTRY
- Interlaboratory Standardization of the Sandwich Enzyme-Linked Immunosorbent Assay Designed for MATS, a Rapid, Reproducible Method for Estimating the Strain Coverage of Investigational Vaccines
- (2012) Brian D. Plikaytis et al. Clinical and Vaccine Immunology
- Design of Meningococcal Factor H Binding Protein Mutant Vaccines That Do Not Bind Human Complement Factor H
- (2012) Rolando Pajon et al. INFECTION AND IMMUNITY
- Transcriptional Regulation of thenadAGene in Neisseria meningitidis Impacts the Prediction of Coverage of a Multicomponent Meningococcal Serogroup B Vaccine
- (2012) Luca Fagnocchi et al. INFECTION AND IMMUNITY
- Immunogenicity and Tolerability of Recombinant Serogroup B Meningococcal Vaccine Administered With or Without Routine Infant Vaccinations According to Different Immunization Schedules
- (2012) Nicoletta Gossger et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- The Relative Roles of Factor H Binding Protein, Neisserial Surface Protein A, and Lipooligosaccharide Sialylation in Regulation of the Alternative Pathway of Complement on Meningococci
- (2012) L. A. Lewis et al. JOURNAL OF IMMUNOLOGY
- Immunogenicity and tolerability of a multicomponent meningococcal serogroup B (4CMenB) vaccine in healthy adolescents in Chile: a phase 2b/3 randomised, observer-blind, placebo-controlled study
- (2012) María Elena Santolaya et al. LANCET
- Safety, immunogenicity, and tolerability of meningococcal serogroup B bivalent recombinant lipoprotein 2086 vaccine in healthy adolescents: a randomised, single-blind, placebo-controlled, phase 2 trial
- (2012) Peter C Richmond et al. LANCET INFECTIOUS DISEASES
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- (2012) H. Sanders et al. MICROBIOLOGY-SGM
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- (2012) Serena Giuntini et al. PLoS One
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- (2012) Asa K. Hedman et al. PLoS One
- Functional impacts of the diversity of the meningococcal factor H binding protein
- (2012) Eva Hong et al. VACCINE
- A bivalent Neisseria meningitidis recombinant lipidated factor H binding protein vaccine in young adults: Results of a randomised, controlled, dose-escalation phase 1 trial
- (2012) P.C. Richmond et al. VACCINE
- A phase 1, randomized, open-label, active-controlled trial to assess the safety of a meningococcal serogroup B bivalent rLP2086 vaccine in healthy adults
- (2012) Eric Sheldon et al. Human Vaccines & Immunotherapeutics
- The Effect of Human Factor H on Immunogenicity of Meningococcal Native Outer Membrane Vesicle Vaccines with Over-Expressed Factor H Binding Protein
- (2012) Peter T. Beernink et al. PLoS Pathogens
- Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules
- (2012) Steven Johnson et al. PLoS Pathogens
- Structure of the uncomplexedNeisseria meningitidisfactor H-binding protein fHbp (rLP2086)
- (2011) Laura Cendron et al. Acta Crystallographica Section F-Structural Biology and Crystallization Communications
- A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines
- (2011) Oliver Koeberling et al. Clinical and Vaccine Immunology
- Characterization of Neisseria meningitidis Isolates That Do Not Express the Virulence Factor and Vaccine Antigen Factor H Binding Protein
- (2011) Jay Lucidarme et al. Clinical and Vaccine Immunology
- The first use of an investigational multicomponent meningococcal serogroup B vaccine (4CMenB) in humans
- (2011) Daniela Toneatto et al. Human vaccines & immunotherapeutics
- Enhanced Bacteremia in Human Factor H Transgenic Rats Infected by Neisseria meningitidis
- (2011) David M. Vu et al. INFECTION AND IMMUNITY
- Combined Roles of Human IgG Subclass, Alternative Complement Pathway Activation, and Epitope Density in the Bactericidal Activity of Antibodies to Meningococcal Factor H Binding Protein
- (2011) Serena Giuntini et al. INFECTION AND IMMUNITY
- Complement-Mediated Bactericidal Activity of Anti-Factor H Binding Protein Monoclonal Antibodies against the Meningococcus Relies upon Blocking Factor H Binding
- (2011) Serena Giuntini et al. INFECTION AND IMMUNITY
- In the NadR Regulon, Adhesins and Diverse Meningococcal Functions Are Regulated in Response to Signals in Human Saliva
- (2011) L. Fagnocchi et al. JOURNAL OF BACTERIOLOGY
- A Meningococcal Factor H Binding Protein Mutant That Eliminates Factor H Binding Enhances Protective Antibody Responses to Vaccination
- (2011) P. T. Beernink et al. JOURNAL OF IMMUNOLOGY
- Rational Design of a Meningococcal Antigen Inducing Broad Protective Immunity
- (2011) M. Scarselli et al. Science Translational Medicine
- Immunogenicity of a meningococcal native outer membrane vesicle vaccine with attenuated endotoxin and over-expressed factor H binding protein in infant rhesus monkeys
- (2011) Oliver Koeberling et al. VACCINE
- Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates
- (2011) Jane W. Marsh et al. VACCINE
- Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States
- (2011) Xin Wang et al. VACCINE
- A phase 1 study of a meningococcal native outer membrane vesicle vaccine made from a group B strain with deleted lpxL1 and synX, over-expressed factor H binding protein, two PorAs and stabilized OpcA expression
- (2011) P.B. Keiser et al. VACCINE
- Transcriptome Analysis of Neisseria meningitidis in Human Whole Blood and Mutagenesis Studies Identify Virulence Factors Involved in Blood Survival
- (2011) Hebert Echenique-Rivera et al. PLoS Pathogens
- Immunogenicity and Safety of a Multicomponent Meningococcal Serogroup B Vaccine and a Quadrivalent Meningococcal CRM197Conjugate Vaccine against Serogroups A, C, W-135, and Y in Adults Who Are at Increased Risk for Occupational Exposure to Meningococcal Isolates
- (2010) Alan Kimura et al. Clinical and Vaccine Immunology
- Multicenter, Open‐Label, Randomized Phase II Controlled Trial of an Investigational Recombinant Meningococcal Serogroup B Vaccine With and Without Outer Membrane Vesicles, Administered in Infancy
- (2010) Jamie Findlow et al. CLINICAL INFECTIOUS DISEASES
- Menveo®: a novel quadrivalent meningococcal CRM197conjugate vaccine against serogroups A, C, W-135 and Y
- (2010) Brian Cooper et al. Expert Review of Vaccines
- Characterization of Diverse Subvariants of the Meningococcal Factor H (fH) Binding Protein for Their Ability To Bind fH, To Mediate Serum Resistance, and To Induce Bactericidal Antibodies
- (2010) Kate L. Seib et al. INFECTION AND IMMUNITY
- Complement control protein factor H: The good, the bad, and the inadequate
- (2010) Viviana P. Ferreira et al. MOLECULAR IMMUNOLOGY
- Neisseria meningitidis GNA2132, a heparin-binding protein that induces protective immunity in humans
- (2010) Davide Serruto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines
- (2010) J. Donnelly et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Influence of serogroup B meningococcal vaccine antigens on growth and survival of the meningococcus in vitro and in ex vivo and in vivo models of infection
- (2010) Kate L. Seib et al. VACCINE
- Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage
- (2010) Dlawer A.A. Ala’Aldeen et al. VACCINE
- Measuring antigen-specific bactericidal responses to a multicomponent vaccine against serogroup B meningococcus
- (2010) Marzia M. Giuliani et al. VACCINE
- Broad vaccine coverage predicted for a bivalent recombinant factor H binding protein based vaccine to prevent serogroup B meningococcal disease
- (2010) Han-Qing Jiang et al. VACCINE
- Influence of sequence variability on bactericidal activity sera induced by Factor H binding protein variant 1.1
- (2010) Brunella Brunelli et al. VACCINE
- The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to Complement
- (2010) Lisa A. Lewis et al. PLoS Pathogens
- NMR dynamics and antibody recognition of the meningococcal lipidated outer membrane protein LP2086 in micellar solution
- (2009) Alessandro Mascioni et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Functional Comparison of the Binding of Factor H Short Consensus Repeat 6 (SCR 6) to Factor H Binding Protein from Neisseria meningitidis and the Binding of Factor H SCR 18 to 20 to Neisseria gonorrhoeae Porin
- (2009) J. Shaughnessy et al. INFECTION AND IMMUNITY
- Expression of Factor H Binding Protein of Meningococcus Responds to Oxygen Limitation through a Dedicated FNR-Regulated Promoter
- (2009) F. Oriente et al. JOURNAL OF BACTERIOLOGY
- Solution Structure of the Factor H-binding Protein, a Survival Factor and Protective Antigen ofNeisseria meningitidis
- (2009) Francesca Cantini et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sequence Diversity of the Factor H Binding Protein Vaccine Candidate in Epidemiologically Relevant Strains of Serogroup BNeisseria meningitidis
- (2009) Ellen Murphy et al. JOURNAL OF INFECTIOUS DISEASES
- The modular architecture of meningococcal factor H-binding protein
- (2009) P. T. Beernink et al. MICROBIOLOGY-SGM
- Variation of the factor H-binding protein of Neisseria meningitidis
- (2009) C. Brehony et al. MICROBIOLOGY-SGM
- A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups
- (2009) Peter T. Beernink et al. MOLECULAR IMMUNOLOGY
- Neisseria meningitidis recruits factor H using protein mimicry of host carbohydrates
- (2009) Muriel C. Schneider et al. NATURE
- Distribution and genetic variability of three vaccine components in a panel of strains representative of the diversity of serogroup B meningococcus
- (2009) Stefania Bambini et al. VACCINE
- Seroprevalence of antibodies against fHbp and NadA, two potential vaccine antigens for Neisseria meningitidis
- (2009) Susanne Jacobsson et al. VACCINE
- Bactericidal antibody is the immunologic surrogate of protection against meningococcal disease
- (2009) Carl E. Frasch et al. VACCINE
- Frequency of factor H-binding protein modular groups and susceptibility to cross-reactive bactericidal activity in invasive meningococcal isolates
- (2009) Rolando Pajon et al. VACCINE
- A Novel Phase Variation Mechanism in the Meningococcus Driven by a Ligand-Responsive Repressor and Differential Spacing of Distal Promoter Elements
- (2009) Matteo M. E. Metruccio et al. PLoS Pathogens
- Fine Antigenic Specificity and Cooperative Bactericidal Activity of Monoclonal Antibodies Directed at the Meningococcal Vaccine Candidate Factor H-Binding Protein
- (2008) P. T. Beernink et al. INFECTION AND IMMUNITY
- Binding of Complement Factor H (fH) to Neisseria meningitidis Is Specific for Human fH and Inhibits Complement Activation by Rat and Rabbit Sera
- (2008) D. M. Granoff et al. INFECTION AND IMMUNITY
- Factor H-Binding Protein Is Important for Meningococcal Survival in Human Whole Blood and Serum and in the Presence of the Antimicrobial Peptide LL-37
- (2008) K. L. Seib et al. INFECTION AND IMMUNITY
- Structural Basis for the Immunogenic Properties of the Meningococcal Vaccine Candidate LP2086
- (2008) Alessandro Mascioni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Complement‐Dependent Synergistic Bactericidal Activity of Antibodies against Factor H–Binding Protein, a Sparsely Distributed Meningococcal Vaccine Antigen
- (2008) Jo Anne Welsch et al. JOURNAL OF INFECTIOUS DISEASES
- Epitope Mapping of a Bactericidal Monoclonal Antibody against the Factor H Binding Protein of Neisseria meningitidis
- (2008) Maria Scarselli et al. JOURNAL OF MOLECULAR BIOLOGY
- Factor H-binding protein, a unique meningococcal vaccine antigen
- (2008) Mariagrazia Pizza et al. VACCINE
- Microbial complement inhibitors as vaccines
- (2008) Seppo Meri et al. VACCINE
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