Inhibition of pre-existing natural periodontitis in non-human primates by a locally administered peptide inhibitor of complement C3

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

(2015) Dimitrios C. Mastellos et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012

(2015) Paul I. Eke et al.   JOURNAL OF PERIODONTOLOGY

Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa

(2015) J.L. Ebersole et al.   Molecular Oral Microbiology

Complement therapeutics in inflammatory diseases: promising drug candidates for C3-targeted intervention

(2015) D.C. Mastellos et al.   Molecular Oral Microbiology

Basic biology and role of interleukin-17 in immunity and inflammation

(2015) Camille Zenobia et al.   PERIODONTOLOGY 2000

DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates

(2015) Jieun Shin et al.   Science Translational Medicine

Polymicrobial synergy and dysbiosis in inflammatory disease

(2015) Richard J. Lamont et al.   TRENDS IN MOLECULAR MEDICINE

Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

(2014) Antonio M. Risitano et al.   BLOOD

ATF3 is a novel regulator of mouse neutrophil migration

(2014) Nicholas D. Boespflug et al.   BLOOD

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

(2014) Tomoki Maekawa et al.   Cell Host & Microbe

Cytokine gene expression profiles during initiation, progression and resolution of periodontitis

(2014) Jeffrey L. Ebersole et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Regulation of Osteoclast Homeostasis and Inflammatory Bone Loss by MFG-E8

(2014) T. Abe et al.   JOURNAL OF IMMUNOLOGY

Genetic and Intervention Studies Implicating Complement C3 as a Major Target for the Treatment of Periodontitis

(2014) T. Maekawa et al.   JOURNAL OF IMMUNOLOGY

Prioritization of Candidate Genes for Periodontitis Using Multiple Computational Tools

(2014) Yuanbo Zhan et al.   JOURNAL OF PERIODONTOLOGY

The inflammophilic character of the periodontitis-associated microbiota

(2014) G. Hajishengallis   Molecular Oral Microbiology

Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17-Driven Inflammatory Bone Loss

(2014) N. M. Moutsopoulos et al.   Science Translational Medicine

Time to take periodontitis seriously

(2014) I. L. C. Chapple   BMJ-British Medical Journal

The Link Between Periodontal Disease and Rheumatoid Arthritis: An Updated Review

(2014) Joanna Koziel et al.   Current Rheumatology Reports

Common Risk Factors in the Management of Periodontal and Associated Systemic Diseases: The Dental Setting and Interprofessional Collaboration

(2014) Robert J. Genco et al.   Journal of Evidence-Based Dental Practice

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation

(2013) Loreto Abusleme et al.   ISME Journal

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

Complement Factor B Is the Downstream Effector of TLRs and Plays an Important Role in a Mouse Model of Severe Sepsis

(2013) L. Zou et al.   JOURNAL OF IMMUNOLOGY

Complement in Immune and Inflammatory Disorders: Therapeutic Interventions

(2013) D. Ricklin et al.   JOURNAL OF IMMUNOLOGY

Antibiotic Resistance in Human Chronic Periodontitis Microbiota

(2013) Thomas E. Rams et al.   JOURNAL OF PERIODONTOLOGY

Adult Dental Health Survey 2009: common oral health conditions and their impact on the population

(2012) D. A. White et al.   BRITISH DENTAL JOURNAL

New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties

(2012) Hongchang Qu et al.   IMMUNOBIOLOGY

Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis

(2012) Niki M. Moutsopoulos et al.   JOURNAL OF AUTOIMMUNITY

Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

(2012) P.I. Eke et al.   JOURNAL OF DENTAL RESEARCH

Local Complement-Targeted Intervention in Periodontitis: Proof-of-Concept Using a C5a Receptor (CD88) Antagonist

(2012) T. Abe et al.   JOURNAL OF IMMUNOLOGY

Impact of Periodontal Therapy on the Subgingival Microbiota of Severe Periodontitis: Comparison Between Good Responders and Individuals With Refractory Periodontitis Using the Human Oral Microbe Identification Microarray

(2012) Ana Paula V. Colombo et al.   JOURNAL OF PERIODONTOLOGY

The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

(2012) Mehmet A Eskan et al.   NATURE IMMUNOLOGY

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus

(2012) Sapna Devi et al.   NATURE MEDICINE

Targeting IL-17 and TH17 cells in chronic inflammation

(2012) Pierre Miossec et al.   NATURE REVIEWS DRUG DISCOVERY

Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

(2011) George Hajishengallis et al.   Cell Host & Microbe

The RANKL-OPG system in clinical periodontology

(2011) Georgios N. Belibasakis et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Oral treatment with complement factor C5a receptor (CD88) antagonists inhibits experimental periodontitis in rats

(2011) T. Breivik et al.   JOURNAL OF PERIODONTAL RESEARCH

Diabetes mellitus and periodontitis: a tale of two common interrelated diseases

(2011) Evanthia Lalla et al.   Nature Reviews Endocrinology

Yersinia enterocolitica Serum Resistance Proteins YadA and Ail Bind the Complement Regulator C4b-Binding Protein

(2011) Vesa Kirjavainen et al.   PLoS Pathogens

Complement and periodontitis

(2010) George Hajishengallis   BIOCHEMICAL PHARMACOLOGY

Extracellular matrix molecules: endogenous danger signals as new drug targets in kidney diseases

(2010) Liliana Schaefer   CURRENT OPINION IN PHARMACOLOGY

“Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

(2010) M. Kebschull et al.   JOURNAL OF DENTAL RESEARCH

The C5a Receptor Impairs IL-12-Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss

(2010) S. Liang et al.   JOURNAL OF IMMUNOLOGY

Complement: a key system for immune surveillance and homeostasis

(2010) Daniel Ricklin et al.   NATURE IMMUNOLOGY

Effects of 0.12% chlorhexidine gluconate on experimental gingivitis in non-human primates: clinical and microbiological alterations

(2010) D. Cappelli et al.   ORAL DISEASES

Oral biofilm-associated diseases: trends and implications for quality of life, systemic health and expenditures

(2010) Thomas Beikler et al.   PERIODONTOLOGY 2000

Epidemiologic patterns of chronic and aggressive periodontitis

(2010) Ryan T. Demmer et al.   PERIODONTOLOGY 2000

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

(2009) N. Bostanci et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokines That Promote Periodontal Tissue Destruction

(2008) Dana Graves   JOURNAL OF PERIODONTOLOGY