Complement regulators in human disease: lessons from modern genetics

Dynamics of complement activation in aHUS and how to monitor eculizumab therapy

(2014) M. Noris et al.   BLOOD

How I treat: the clinical differentiation and initial treatment of adult patients with atypical hemolytic uremic syndrome

(2014) S. R. Cataland et al.   BLOOD

Diagnosis and management of complement mediated thrombotic microangiopathies

(2014) Spero R. Cataland et al.   BLOOD REVIEWS

Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration

(2014) Yi Yu et al.   HUMAN MOLECULAR GENETICS

Factor C Acts as a Lipopolysaccharide-Responsive C3 Convertase in Horseshoe Crab Complement Activation

(2014) S. Ariki et al.   JOURNAL OF IMMUNOLOGY

Tailored eculizumab regimen for patients with atypical hemolytic uremic syndrome: requirement for comprehensive complement analysis

(2014) C. Wehling et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complement functional tests for monitoring eculizumab treatment in patients with atypical hemolytic uremic syndrome

(2014) M. Cugno et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anti-factor H autoantibody-associated hemolytic uremic syndrome: the earlier diagnosed and treated, the better

(2014) Chantal Loirat et al.   KIDNEY INTERNATIONAL

Genetic variants in the complement system predisposing to age-related macular degeneration: A review

(2014) Elizabeth C. Schramm et al.   MOLECULAR IMMUNOLOGY

Are complement deficiencies really rare? Overview on prevalence, clinical importance and modern diagnostic approach

(2014) Anete Sevciovic Grumach et al.   MOLECULAR IMMUNOLOGY

Genetics of Atypical Hemolytic Uremic Syndrome (aHUS)

(2014) Marta Hidalgo et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Spectrum of Complement-Mediated Thrombotic Microangiopathies: Pathogenetic Insights Identifying Novel Treatment Approaches

(2014) Magdalena Riedl et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Functional Anatomy of Complement Factor H

(2013) Elisavet Makou et al.   BIOCHEMISTRY

Eculizumab: A Review of Its Use in Atypical Haemolytic Uraemic Syndrome

(2013) Gillian M. Keating   DRUGS

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

(2013) Johanna M Seddon et al.   NATURE GENETICS

A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration

(2013) Hannes Helgason et al.   NATURE GENETICS

Identification of a rare coding variant in complement 3 associated with age-related macular degeneration

(2013) Xiaowei Zhan et al.   NATURE GENETICS

Seven new loci associated with age-related macular degeneration

(2013) Lars G Fritsche et al.   NATURE GENETICS

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Atypical Hemolytic Uremic Syndrome

(2013) David Kavanagh et al.   SEMINARS IN NEPHROLOGY

Defective Complement Inhibitory Function Predisposes to Renal Disease

(2012) Anuja Java et al.   Annual Review of Medicine

Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype

(2012) Reecha Sofat et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

CD46 in innate and adaptive immunity: an update

(2011) J. Cardone et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Age-related macular degeneration and the complement system

(2011) S. Khandhadia et al.   IMMUNOBIOLOGY

Acquisition of Complement Factor H Is Important for Pathogenesis of Streptococcus pyogenes Infections: Evidence from Bacterial In Vitro Survival and Human Genetic Association

(2011) K. Haapasalo et al.   JOURNAL OF IMMUNOLOGY

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration

(2011) Soumya Raychaudhuri et al.   NATURE GENETICS

Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort

(2011) Jane E. Salmon et al.   PLOS MEDICINE

Relative Role of Genetic Complement Abnormalities in Sporadic and Familial aHUS and Their Impact on Clinical Phenotype

(2010) M. Noris et al.   Clinical Journal of the American Society of Nephrology

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

The Plague and Macular Degeneration

(2010) Robert L. Avery   OPHTHALMOLOGY

Anti-Factor H Autoantibody–Associated Hemolytic Uremic Syndrome: Review of Literature of the Autoimmune Form of HUS

(2010) Marie-Agnès Dragon-Durey et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Clinical Significance of Complement Deficiencies

(2009) H. David Pettigrew et al.   Annals of the New York Academy of Sciences

Therapeutic potential of complement modulation

(2009) Eric Wagner et al.   NATURE REVIEWS DRUG DISCOVERY

Factor H, membrane cofactor protein, and factor I mutations in patients with hemolysis, elevated liver enzymes, and low platelet count syndrome

(2008) F. Fakhouri et al.   BLOOD

Advances in understanding of pathogenesis of aHUS and HELLP

(2008) Celia J. Fang et al.   BRITISH JOURNAL OF HAEMATOLOGY

The spectrum of complement alternative pathway-mediated diseases

(2008) V. Michael Holers   IMMUNOLOGICAL REVIEWS

Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis ofStreptococcus pyogenes

(2008) Karita Haapasalo et al.   MOLECULAR MICROBIOLOGY

Complement evasion by human pathogens

(2008) John D. Lambris et al.   NATURE REVIEWS MICROBIOLOGY

Complement Regulatory Genes and Hemolytic Uremic Syndromes

(2007) David Kavanagh et al.   Annual Review of Medicine

Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome

(2007) C. J. Fang et al.   BLOOD