Complement in removal of the dead - balancing inflammation

Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

(2016) M Martin et al.   CELL DEATH AND DIFFERENTIATION

Uncoupling complement C1s activation from C1q binding in apoptotic cell phagocytosis and immunosuppressive capacity

(2016) Lucrezia Colonna et al.   CLINICAL IMMUNOLOGY

Age-related macular degeneration: Complement in action

(2016) Menno van Lookeren Campagne et al.   IMMUNOBIOLOGY

Complement-mediated ‘bystander’ damage initiates host NLRP3 inflammasome activation

(2016) Rahul Suresh et al.   JOURNAL OF CELL SCIENCE

The Complement Inhibitor Factor H Generates an Anti-Inflammatory and Tolerogenic State in Monocyte-Derived Dendritic Cells

(2016) Rut Olivar et al.   JOURNAL OF IMMUNOLOGY

Expression of Human Complement Factor H Prevents Age-Related Macular Degeneration–Like Retina Damage and Kidney Abnormalities in Aged Cfh Knockout Mice

(2015) Jin-Dong Ding et al.   AMERICAN JOURNAL OF PATHOLOGY

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

(2015) Eduardo Bonavita et al.   CELL

PTX3, Anti-PTX3, and Anti-C1q Autoantibodies in Lupus Glomerulonephritis

(2015) Nicola Bassi et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Secreted aspartic protease 2 of Candida albicans inactivates factor H and the macrophage factor H-receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18)

(2015) Eliška Svoboda et al.   IMMUNOLOGY LETTERS

Complement Component C5a Primes Retinal Pigment Epithelial Cells for Inflammasome Activation by Lipofuscin-mediated Photooxidative Damage

(2015) Carolina Brandstetter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical presentation of human C1q deficiency: How much of a lupus?

(2015) Mihaela Stegert et al.   MOLECULAR IMMUNOLOGY

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo

(2015) Johannes Westman et al.   PLoS Pathogens

Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity

(2014) R. Stienstra et al.   DIABETES

Anti-C1q autoantibodies from active lupus nephritis patients could inhibit the clearance of apoptotic cells and complement classical pathway activation mediated by C1q in vitro

(2014) Yun Pang et al.   IMMUNOBIOLOGY

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

(2014) L. Deban et al.   JOURNAL OF IMMUNOLOGY

C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

(2014) H. Paidassi et al.   JOURNAL OF IMMUNOLOGY

Residue Lys57 in the Collagen-Like Region of Human L-Ficolin and Its Counterpart Lys47 in H-Ficolin Play a Key Role in the Interaction with the Mannan-Binding Lectin-Associated Serine Proteases and the Collectin Receptor Calreticulin

(2014) M. Lacroix et al.   JOURNAL OF IMMUNOLOGY

Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement Activation

(2014) W. Xu et al.   JOURNAL OF IMMUNOLOGY

Identification of Factor H–like Protein 1 as the Predominant Complement Regulator in Bruch’s Membrane: Implications for Age-Related Macular Degeneration

(2014) Simon J. Clark et al.   JOURNAL OF IMMUNOLOGY

Relative Contribution of C1q and Apoptotic Cell-Surface Calreticulin to Macrophage Phagocytosis

(2014) Mélanie Verneret et al.   Journal of Innate Immunity

Complement protein C1q bound to apoptotic cells suppresses human macrophage and dendritic cell-mediated Th17 and Th1 T cell subset proliferation

(2014) Elizabeth V. Clarke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation

(2013) K. Triantafilou et al.   JOURNAL OF CELL SCIENCE

The  7 0 Isoform of the Complement Regulator C4b-Binding Protein Induces a Semimature, Anti-Inflammatory State in Dendritic Cells

(2013) R. Olivar et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The NLRP3 Inflammasome Links Complement-Mediated Inflammation and IL-1  Release

(2013) F. Laudisi et al.   JOURNAL OF IMMUNOLOGY

Ficolin-1-PTX3 Complex Formation Promotes Clearance of Altered Self-Cells and Modulates IL-8 Production

(2013) Y. J. Ma et al.   JOURNAL OF IMMUNOLOGY

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration

(2013) Johanna M Seddon et al.   NATURE GENETICS

A functional variant in the CFI gene confers a high risk of age-related macular degeneration

(2013) Johannes P H van de Ven et al.   NATURE GENETICS

Cooperation of Factor VII-Activating Protease and Serum DNase I in the Release of Nucleosomes From Necrotic Cells

(2013) Femke Stephan et al.   Arthritis & Rheumatology

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells—Implications for age-related macular degeneration (AMD)

(2012) Anu Kauppinen et al.   IMMUNOLOGY LETTERS

Annexin A2 and A5 Serve as New Ligands for C1q on Apoptotic Cells

(2012) Myriam Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

(2012) J. Leffler et al.   JOURNAL OF IMMUNOLOGY

Complement Protein C1q Directs Macrophage Polarization and Limits Inflammasome Activity during the Uptake of Apoptotic Cells

(2012) M. E. Benoit et al.   JOURNAL OF IMMUNOLOGY

Dying Cells and Extracellular Histones in AKI: Beyond a NET Effect?

(2012) D. L. Rosin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Factor H autoantibodies and deletion of Complement Factor H-Related protein-1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome

(2012) Anna Foltyn Zadura et al.   ARTHRITIS RESEARCH & THERAPY

The C1q Family of Proteins: Insights into the Emerging Non-Traditional Functions

(2012) Berhane Ghebrehiwet et al.   Frontiers in Immunology

Mannan-binding lectin deficiency — Good news, bad news, doesn't matter?

(2011) Sabine Heitzeneder et al.   CLINICAL IMMUNOLOGY

Nucleosome-induced neutrophil activation occurs independently of TLR9 and endosomal acidification: Implications for systemic lupus erythematosus

(2011) Dennis Lindau et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Monomeric C-reactive protein modulates classic complement activation on necrotic cells

(2011) Michael Mihlan et al.   FASEB JOURNAL

Molecular basis of hereditary C1q deficiency—revisited: identification of several novel disease-causing mutations

(2011) L Schejbel et al.   GENES AND IMMUNITY

Human complement Factor H modulates C1q-mediated phagocytosis of apoptotic cells

(2011) Yu-Hoi Kang et al.   IMMUNOBIOLOGY

Investigations on the C1q–Calreticulin–Phosphatidylserine Interactions Yield New Insights into Apoptotic Cell Recognition

(2011) Helena Païdassi et al.   JOURNAL OF MOLECULAR BIOLOGY

Human Pentraxin 3 Binds to the Complement Regulator C4b-Binding Protein

(2011) Anne Braunschweig et al.   PLoS One

Annexin A5 and anti-annexin antibodies in patients with systemic lupus erythematosus

(2011) Antoni Hrycek et al.   RHEUMATOLOGY INTERNATIONAL

Native polymeric forms of properdin selectively bind to targets and promote activation of the alternative pathway of complement

(2010) Viviana P. Ferreira et al.   IMMUNOBIOLOGY

Dependence on Vitamin K-dependent Protein S for Eukaryotic Cell Secretion of the β-Chain of C4b-binding Protein

(2010) Sofia Carlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages

(2010) Matvey Gorovoy et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis

(2010) Wen Ao et al.   RHEUMATOLOGY INTERNATIONAL

Properdin: Emerging Roles of a Pattern-Recognition Molecule

(2009) Claudia Kemper et al.   Annual Review of Immunology

Serum Cystatin C Level, Kidney Disease Markers, and Incidence of Age-Related Macular Degeneration

(2009) Ronald Klein   ARCHIVES OF OPHTHALMOLOGY

C1q inhibits immune complex-induced interferon-α production in plasmacytoid dendritic cells: A novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

(2009) Christian Lood et al.   ARTHRITIS AND RHEUMATISM

The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases

(2009) Rasmus Pagh et al.   FEBS Journal

Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity

(2009) Kinga K. Hosszu et al.   Innate Immunity

Annexin-II, DNA, and Histones Serve as Factor H Ligands on the Surface of Apoptotic Cells

(2009) Jonatan Leffler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells

(2009) C. Bigler et al.   JOURNAL OF IMMUNOLOGY

C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells

(2009) D. A. Fraser et al.   JOURNAL OF IMMUNOLOGY

Characteristics and Biological Variations of M-Ficolin, a Pattern Recognition Molecule, in Plasma

(2009) Thomas Wittenborn et al.   Journal of Innate Immunity

The Genetics of Ficolins

(2009) Peter Garred et al.   Journal of Innate Immunity

C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production

(2009) Deborah A. Fraser et al.   JOURNAL OF NEUROCHEMISTRY

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited

(2009) Don H. Anderson et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Pentraxins, humoral innate immunity and tissue injury

(2008) Angelo A Manfredi et al.   CURRENT OPINION IN IMMUNOLOGY

Pattern recognition receptors in the immune response against dying cells

(2008) Pascale Jeannin et al.   CURRENT OPINION IN IMMUNOLOGY

Nucleosome-releasing factor: a new role for factor VII-activating protease (FSAP)

(2008) Sacha Zeerleder et al.   FASEB JOURNAL

The lectin-like activity of human C1q and its implication in DNA and apoptotic cell recognition

(2008) Helena Païdassi et al.   FEBS LETTERS

Native, amyloid fibrils and β-oligomers of the C-terminal domain of human prion protein display differential activation of complement and bind C1q, factor H and C4b-binding protein directly

(2008) Andreas P. Sjöberg et al.   MOLECULAR IMMUNOLOGY

A role of macrophage complement receptor CRIg in immune clearance and inflammation

(2008) Jeannie Q. He et al.   MOLECULAR IMMUNOLOGY

Complement Receptor 1: Disease associations and therapeutic implications

(2008) Rohan Khera et al.   MOLECULAR IMMUNOLOGY

Human complement factor H-related protein 4 binds and recruits native pentameric C-reactive protein to necrotic cells

(2008) Michael Mihlan et al.   MOLECULAR IMMUNOLOGY

Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation

(2008) Andreas P. Sjöberg et al.   MOLECULAR IMMUNOLOGY

The complement protein properdin binds apoptotic T cells and promotes complement activation and phagocytosis

(2008) Claudia Kemper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors

(2007) Marcin Okroj et al.   MOLECULAR IMMUNOLOGY