CAR Treg: A new approach in the treatment of autoimmune diseases

Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

(2021) Ista A. Egbeto et al.   Frontiers in Immunology

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII

(2021) Jyoti Rana et al.   MOLECULAR THERAPY

Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation

(2021) Claudia Selck et al.   Frontiers in Immunology

Editorial: Immunology of Vitiligo

(2021) Julien Seneschal et al.   Frontiers in Immunology

The significance of exosomes in the development and treatment of hepatocellular carcinoma

(2020) Xin Li et al.   Molecular Cancer

Altered expression of nuclear factor of activated T cells, forkhead box P3, and immune‐suppressive genes in regulatory T cells of generalized vitiligo patients

(2020) Prashant S. Giri et al.   Pigment Cell & Melanoma Research

Toward an Optimized Process for Clinical Manufacturing of CAR-Treg Cell Therapy

(2020) Enrico Fritsche et al.   TRENDS IN BIOTECHNOLOGY

Immunotherapy Deriving from CAR-T Cell Treatment in Autoimmune Diseases

(2020) Yuehong Chen et al.   Journal of Immunology Research

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

(2020) Alessandra Colamatteo et al.   Frontiers in Immunology

Recent Progress and Future Directions: The Nano-Drug Delivery System for the Treatment of Vitiligo

(2020) Ming-Chen Sun et al.   International Journal of Nanomedicine

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

(2020) Michael Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric antigen receptor T-cell therapy beyond cancer: current practice and future prospects

(2020) Peng-Fei Zhang et al.   Immunotherapy

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

(2020) Yuchi Honaker et al.   Science Translational Medicine

Novel Treatments in Myasthenia Gravis

(2020) Deepak Menon et al.   Frontiers in Neurology

Treg Enhancing Therapies to Treat Autoimmune Diseases

(2020) Peter J. Eggenhuizen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations

(2020) Lauren V. Terry et al.   Frontiers in Immunology

Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2-based chimeric antigen receptor

(2020) Ilian A. Radichev et al.   CELLULAR IMMUNOLOGY

Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

(2020) Zhussipbek Mukhatayev et al.   Frontiers in Immunology

Vitiligo as a skin memory disease: The need for early intervention with immunomodulating agents and a maintenance therapy to target resident memory T cells

(2019) Katia Boniface et al.   EXPERIMENTAL DERMATOLOGY

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

Repurposing CAR T cells to treat SLE

(2019) Monica Wang   Nature Reviews Nephrology

mTOR Signaling pathway as a master regulator of memory CD8+ T-cells, Th17, and NK cells development and their functional properties

(2019) Davood Rostamzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?

(2019) Yoshihiro Ohue et al.   CANCER SCIENCE

B cell checkpoints in autoimmune rheumatic diseases

(2019) Samuel J. S. Rubin et al.   Nature Reviews Rheumatology

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

The Role of Memory CD8+ T Cells in Vitiligo

(2019) Rebecca L. Riding et al.   JOURNAL OF IMMUNOLOGY

Biologics in the Treatment of Lupus Erythematosus: A Critical Literature Review

(2019) Dominik Samotij et al.   Biomed Research International

Pemphigus: Current and Future Therapeutic Strategies

(2019) Dario Didona et al.   Frontiers in Immunology

T cells engrafted with a UniCAR 28/z outperform UniCAR BB/z-transduced T cells in the face of regulatory T cell-mediated immunosuppression

(2019) Alexandra Kegler et al.   OncoImmunology

Myasthenia Gravis: Pathogenic Effects of Autoantibodies on Neuromuscular Architecture

(2019) Koneczny et al.   Cells

Slamming the brakes on lupus with CAR T cells

(2019) Rachael A. Clark   Science Immunology

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

Metabolic Pathways Involved in Regulatory T Cell Functionality

(2019) Rosalie W. M. Kempkes et al.   Frontiers in Immunology

Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: A novel gut-immune system-based therapy for metaflammation and NASH

(2018) Yaron Ilan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

CAR T cell immunotherapy in hematology and beyond

(2018) Claudia Rossig   CLINICAL IMMUNOLOGY

The convergence theory for vitiligo: A reappraisal

(2018) Roopal V. Kundu et al.   EXPERIMENTAL DERMATOLOGY

Changes in Th17 cells function after nanocurcumin use to treat multiple sclerosis

(2018) Sanam Dolati et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Vitiligo Skin Is Imprinted with Resident Memory CD8 T Cells Expressing CXCR3

(2018) Katia Boniface et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

(2018) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

(2018) Jillian M. Richmond et al.   Science Translational Medicine

Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells

(2018) D. Calzada et al.   Journal of Immunology Research

The application of CAR-T cell therapy in hematological malignancies: Advantages and challenges

(2018) Zijun Zhao et al.   Acta Pharmaceutica Sinica B

Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes

(2018) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

Description of CD8+ Regulatory T Lymphocytes and Their Specific Intervention in Graft-versus-Host and Infectious Diseases, Autoimmunity, and Cancer

(2018) Martha R. Vieyra-Lobato et al.   Journal of Immunology Research

Cytokine Release Syndrome with Chimeric Antigen Receptor T Cell Therapy

(2018) Noelle Frey et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Polymorphism of Foxp3 gene affects the frequency of regulatory T cells and disease activity in patients with rheumatoid arthritis in Iranian population

(2018) Vida Hashemi et al.   IMMUNOLOGY LETTERS

Effects of tumor metabolic microenvironment on regulatory T cells

(2018) Yi-an Wang et al.   Molecular Cancer

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance

(2018) Qunfang Zhang et al.   Frontiers in Immunology

Tim3+ Foxp3 + Treg Cells Are Potent Inhibitors of Effector T Cells and Are Suppressed in Rheumatoid Arthritis

(2017) Huaqiang Sun et al.   INFLAMMATION

Mucosal administration of CD3-specific monoclonal antibody inhibits diabetes in NOD mice and in a preclinical mouse model transgenic for the CD3 epsilon chain

(2017) Chantal Kuhn et al.   JOURNAL OF AUTOIMMUNITY

Regulatory T cells in multiple sclerosis and myasthenia gravis

(2017) K. M. Danikowski et al.   Journal of Neuroinflammation

Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure

(2017) Lucy Y. Liu et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

B cells in the pathophysiology of myasthenia gravis

(2017) John S. Yi et al.   MUSCLE & NERVE

Concise Review: Emerging Principles from the Clinical Application of Chimeric Antigen Receptor T Cell Therapies for B Cell Malignancies

(2017) Michael D. Jain et al.   STEM CELLS

Antigen-specific regulatory T cells: are police CARs the answer?

(2017) Nicholas A.J. Dawson et al.   Translational Research

Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective

(2017) Vaishali R. Moulton et al.   TRENDS IN MOLECULAR MEDICINE

Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics

(2017) Ping Li et al.   Frontiers in Pharmacology

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma

(2017) Jelena Skuljec et al.   Frontiers in Immunology

T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes

(2017) Adam L. Burrack et al.   Frontiers in Endocrinology

Global Manufacturing of CAR T Cell Therapy

(2017) Bruce L. Levine et al.   Molecular Therapy-Methods & Clinical Development

Presence of diabetes autoantigens in extracellular vesicles derived from human islets

(2017) Craig P. Hasilo et al.   Scientific Reports

Mechanisms of Disease: Pemphigus and Bullous Pemphigoid

(2016) Christoph M. Hammers et al.   Annual Review of Pathology-Mechanisms of Disease

Recent advances of exosomes in immune modulation and autoimmune diseases

(2016) Lina Tan et al.   AUTOIMMUNITY

Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy?

(2016) Dominic Boardman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Understanding mechanisms of autoimmunity through translational research in vitiligo

(2016) James P Strassner et al.   CURRENT OPINION IN IMMUNOLOGY

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity

(2016) Chiara Cianciaruso et al.   DIABETES

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside

(2016) Chantal Kuhn et al.   Immunotherapy

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Like Angler Fish, CAARs Lure Their Prey

(2016) Anne Galy   MOLECULAR THERAPY

Precision medicine for autoimmune disease

(2016) Lucienne Chatenoud   NATURE BIOTECHNOLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

(2016) Daniel T. Harris et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Increased CD4+CD45RA-FoxP3low cells alter the balance between Treg and Th17 cells in colitis mice

(2016) Ya-Hui Ma et al.   WORLD JOURNAL OF GASTROENTEROLOGY

How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity

(2016) R. E. Hoeppli et al.   HLA

Biotherapies targeting T and B cells: from immune suppression to immune tolerance

(2015) Lucienne Chatenoud   CURRENT OPINION IN PHARMACOLOGY

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

(2015) Anke Theil et al.   CYTOTHERAPY

TRUCKs: the fourth generation of CARs

(2015) Markus Chmielewski et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Graves’ Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies

(2015) S. Morshed et al.   HORMONE AND METABOLIC RESEARCH

Human autoimmune diseases: a comprehensive update

(2015) Lifeng Wang et al.   JOURNAL OF INTERNAL MEDICINE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Regulatory T Cells: Serious Contenders in the Promise for Immunological Tolerance in Transplantation

(2015) Niloufar Safinia et al.   Frontiers in Immunology

Highlights in pathogenesis of vitiligo

(2015) Ghada F Mohammed   World Journal of Clinical Cases

Regulatory T cells and their roles in immune dysregulation and allergy

(2014) Laurence Pellerin et al.   IMMUNOLOGIC RESEARCH

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

(2014) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treg Cell Function in Rheumatoid Arthritis Is Compromised by CTLA-4 Promoter Methylation Resulting in a Failure to Activate the Indoleamine 2,3-Dioxygenase Pathway

(2014) Adam P. Cribbs et al.   Arthritis & Rheumatology

Biologic therapy for autoimmune diseases: an update

(2013) Ziv Rosman et al.   BMC Medicine

How do autoimmune diseases cluster in families? A systematic review and meta-analysis

(2013) Jorge Cárdenas-Roldán et al.   BMC Medicine

Clinical-scale selection and viral transduction of human naïve and central memory CD8+ T cells for adoptive cell therapy of cancer patients

(2013) Anna Casati et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anti-cytokine therapies in T1D: Concepts and strategies

(2013) Gerald T. Nepom et al.   CLINICAL IMMUNOLOGY

Anti-CD3 clinical trials in type 1 diabetes mellitus

(2013) Anastasia G. Daifotis et al.   CLINICAL IMMUNOLOGY

Use of gene-modified regulatory T-cells to control autoimmune and alloimmune pathology: Is now the right time?

(2013) Hannah Jethwa et al.   CLINICAL IMMUNOLOGY

Design and development of therapies using chimeric antigen receptor-expressing T cells

(2013) Gianpietro Dotti et al.   IMMUNOLOGICAL REVIEWS

Regulatory T-cell directed therapies in liver diseases

(2013) Ye Htun Oo et al.   JOURNAL OF HEPATOLOGY

A Quantitative Increase in Regulatory T Cells Controls Development of Vitiligo

(2013) Shilpak Chatterjee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Disturbed B cell subpopulations and increased plasma cells in myasthenia gravis patients

(2013) Siegfried Kohler et al.   JOURNAL OF NEUROIMMUNOLOGY

Regulatory T cell proliferative potential is impaired in human autoimmune disease

(2013) Fortunata Carbone et al.   NATURE MEDICINE

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuromyelitis optica

(2012) B. Wildemann et al.   AKTUELLE NEUROLOGIE

Impaired regulatory function in circulating CD4+CD25highCD127low/− T cells in patients with myasthenia gravis

(2012) Muthusamy Thiruppathi et al.   CLINICAL IMMUNOLOGY

The genetics of multiple sclerosis: an up-to-date review

(2012) Pierre-Antoine Gourraud et al.   IMMUNOLOGICAL REVIEWS

Epistasis and immunity: the role of genetic interactions in autoimmune diseases

(2012) Anna M. Rose et al.   IMMUNOLOGY

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

Accumulation of CCR4+ CTLA-4hi FOXP3+CD25hi Regulatory T Cells in Colon Adenocarcinomas Correlate to Reduced Activation of Conventional T Cells

(2012) Helena Svensson et al.   PLoS One

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

The Pharmacology of Immunosuppression

(2011) Martin M. Zdanowicz   AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION

Scale-up and manufacturing of clinical-grade self-inactivating γ-retroviral vectors by transient transfection

(2011) J C M van der Loo et al.   GENE THERAPY

CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers Game

(2011) S. A. Long et al.   JOURNAL OF IMMUNOLOGY

Desmoglein as a Target in Skin Disease and Beyond

(2011) Masayuki Amagai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

T regulatory cells lacking CD25 are increased in MS during relapse

(2010) Moa Fransson et al.   AUTOIMMUNITY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

(2010) A. K. Marwaha et al.   JOURNAL OF IMMUNOLOGY

Multiple sclerosis: risk factors, prodromes, and potential causal pathways

(2010) Sreeram V Ramagopalan et al.   LANCET NEUROLOGY

Environmental factors and their timing in adult-onset multiple sclerosis

(2010) Adam E. Handel et al.   Nature Reviews Neurology

Anti-aquaporin-4 antibodies in Devic’s neuromyelitis optica: therapeutic implications

(2010) Romain Marignier et al.   Therapeutic Advances in Neurological Disorders

Identification of regulatory T cells in systemic lupus erythematosus

(2009) Roberto Gerli et al.   AUTOIMMUNITY REVIEWS

Definition of human autoimmunity — autoantibodies versus autoimmune disease

(2009) Ana Lleo et al.   AUTOIMMUNITY REVIEWS

Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects

(2009) S. A. Long et al.   DIABETES

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

(2009) Eran Elinav et al.   GASTROENTEROLOGY

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

(2008) Eran Elinav et al.   GASTROENTEROLOGY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE

Specificity in cancer immunotherapy

(2008) Andrea Schietinger et al.   SEMINARS IN IMMUNOLOGY

Compromised CD4+ CD25highregulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level

(2007) Koen Venken et al.   IMMUNOLOGY