Chimeric antigen receptor T-cell therapy beyond cancer: current practice and future prospects

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

(2019) Kim Anthony-Gonda et al.   Science Translational Medicine

Universal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses

(2018) Jang Hwan Cho et al.   CELL

Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti–human immunodeficiency virus potency and breadth with minimal immunogenicity

(2018) Mustafa H. Ghanem et al.   CYTOTHERAPY

HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice

(2018) Robert L. Kruse et al.   CYTOTHERAPY

Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

(2018) Julia Proff et al.   Journal of Translational Medicine

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

(2018) Concetta Quintarelli et al.   OncoImmunology

Chimeric antigen receptor T cell therapy for non-Hodgkin lymphoma

(2018) Armin Ghobadi   Current Research in Translational Medicine

CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells

(2018) Marion Alcantara et al.   LEUKEMIA

Engineering CAR-T Cells for Improved Function Against Solid Tumors

(2018) Michael A. Morgan et al.   Frontiers in Immunology

CART Immunotherapy: Development, Success, and Translation to Malignant Gliomas and Other Solid Tumors

(2018) Anna C. Filley et al.   Frontiers in Oncology

CD19, from bench to bedside

(2017) Xinchen Li et al.   IMMUNOLOGY LETTERS

FDA Approval of Tisagenlecleucel

(2017) Peter B. Bach et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

(2017) Robert T. Manguso et al.   NATURE

B-Cell Depletion — A Frontier in Monoclonal Antibodies for Multiple Sclerosis

(2017) Peter A. Calabresi   NEW ENGLAND JOURNAL OF MEDICINE

Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

(2017) Biliang Hu et al.   Cell Reports

Tonic 4-1BB Costimulation in Chimeric Antigen Receptors Impedes T Cell Survival and Is Vector-Dependent

(2017) Diogo Gomes-Silva et al.   Cell Reports

Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

(2017) Anjie Zhen et al.   PLoS Pathogens

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

(2017) Rachel S. Leibman et al.   PLoS Pathogens

Increasing the safety and efficacy of chimeric antigen receptor T cell therapy

(2017) Hua Li et al.   Protein & Cell

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma

(2017) Jelena Skuljec et al.   Frontiers in Immunology

T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

(2016) S. A. Ali et al.   BLOOD

Persistence of long-lived plasma cells and humoral immunity in individuals responding to CD19-directed CAR T-cell therapy

(2016) V. G. Bhoj et al.   BLOOD

Advances and hope for perinatal HIV remission and cure in children and adolescents

(2016) Kaitlin Rainwater-Lovett et al.   CURRENT OPINION IN PEDIATRICS

Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

(2016) Omkar U. Kawalekar et al.   IMMUNITY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Chimeric Antigen Receptor T Cells Guided by the Single-Chain Fv of a Broadly Neutralizing Antibody Specifically and Effectively Eradicate Virus Reactivated from Latency in CD4 + T Lymphocytes Isolated from HIV-1-Infected Individuals Receiving Suppressive Combined Antiretroviral Therapy

(2016) Bingfeng Liu et al.   JOURNAL OF VIROLOGY

Anti-BCMA CAR T cells show promise in MM

(2016) Peter Sidaway   Nature Reviews Clinical Oncology

Global epidemiology and burden of HCV infection and HCV-related disease

(2016) Aaron P. Thrift et al.   Nature Reviews Gastroenterology & Hepatology

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

(2016) Lenka V. Hurton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Treatment of solid tumors with chimeric antigen receptor-engineered T cells: current status and future prospects

(2016) Shengmeng Di et al.   Science China-Life Sciences

Current status and prospects of HIV treatment

(2016) Tomas Cihlar et al.   Current Opinion in Virology

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

(2016) George J. Leslie et al.   PLoS Pathogens

MEDI-551 Treatment Effectively Depletes B Cells and Reduces Serum Titers of Autoantibodies in Mice Transgenic forSle1and Human CD19

(2016) Sandra Gallagher et al.   Arthritis & Rheumatology

Ectopic expression of anti-HIV-1 shRNAs protects CD8 + T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation

(2015) Masakazu Kamata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tumor indoleamine 2,3-dioxygenase (IDO) inhibits CD19-CAR T cells and is downregulated by lymphodepleting drugs

(2015) Soranobu Ninomiya et al.   BLOOD

CD19 chimeric antigen receptor T cell therapy for haematological malignancies

(2015) Sara Ghorashian et al.   BRITISH JOURNAL OF HAEMATOLOGY

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

(2015) Anke Theil et al.   CYTOTHERAPY

AASLD guidelines for treatment of chronic hepatitis B

(2015) Norah A. Terrault et al.   HEPATOLOGY

Persistence of Anti-Desmoglein 3 IgG + B-Cell Clones in Pemphigus Patients over Years

(2015) Christoph M. Hammers et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Novel CD4-Based Bispecific Chimeric Antigen Receptor Designed for Enhanced Anti-HIV Potency and Absence of HIV Entry Receptor Activity

(2015) Li Liu et al.   JOURNAL OF VIROLOGY

HIV-specific Immunity Derived From Chimeric Antigen Receptor-engineered Stem Cells

(2015) Anjie Zhen et al.   MOLECULAR THERAPY

Engineering T Cells to Functionally Cure HIV-1 Infection

(2015) Rachel S Leibman et al.   MOLECULAR THERAPY

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

The pharmacology of second-generation chimeric antigen receptors

(2015) Sjoukje J. C. van der Stegen et al.   NATURE REVIEWS DRUG DISCOVERY

Construction of Anti-CD20 Single-Chain Antibody-CD28-CD137-TCRζ Recombinant Genetic Modified T Cells and its Treatment Effect on B Cell Lymphoma

(2015) Fei Chen et al.   MEDICAL SCIENCE MONITOR

Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2015) Venkat Reddy et al.   Arthritis & Rheumatology

Effective response and delayed toxicities of refractory advanced diffuse large B-cell lymphoma treated by CD20-directed chimeric antigen receptor-modified T cells

(2014) Yao Wang et al.   CLINICAL IMMUNOLOGY

B Cell Depletion with Anti-CD79 mAbs Ameliorates Autoimmune Disease in MRL/lpr Mice

(2014) Y. Li et al.   JOURNAL OF IMMUNOLOGY

Target Antigen Density Governs the Efficacy of Anti–CD20-CD28-CD3 ζ Chimeric Antigen Receptor–Modified Effector CD8+T Cells

(2014) Keisuke Watanabe et al.   JOURNAL OF IMMUNOLOGY

A novel real-time CTL assay to measure designer T-cell function against HIV Env+cells

(2014) Andrew G. MacLean et al.   JOURNAL OF MEDICAL PRIMATOLOGY

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations

(2014) Faviel F. González-Galarza et al.   NUCLEIC ACIDS RESEARCH

Bioengineering T cells to target carbohydrate to treat opportunistic fungal infection

(2014) P. R. Kumaresan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CMV: Prevention, Diagnosis and Therapy

(2013) C. N. Kotton   AMERICAN JOURNAL OF TRANSPLANTATION

Incidence of Types of Cancer among HIV-Infected Persons Compared with the General Population in the United States, 1992–2003

(2013) Pragna Patel et al.   ANNALS OF INTERNAL MEDICINE

T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

(2013) Karin Krebs et al.   GASTROENTEROLOGY

Contributions of B cells to lupus pathogenesis

(2013) Allison Sang et al.   MOLECULAR IMMUNOLOGY

Stem-Cell-Based Gene Therapy for HIV Infection

(2013) Anjie Zhen et al.   Viruses-Basel

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

(2013) Asier Sáez-Cirión et al.   PLoS Pathogens

Treatment of fungal disease in the setting of neutropenia

(2013) T. J. Walsh et al.   Hematology-American Society of Hematology Education Program

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

HIV-associated opportunistic infections of the CNS

(2012) Ik Lin Tan et al.   LANCET NEUROLOGY

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

(2012) Elena Provasi et al.   NATURE MEDICINE

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

CAR–T cells and solid tumors: tuning T cells to challenge an inveterate foe

(2012) David E. Gilham et al.   TRENDS IN MOLECULAR MEDICINE

Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity

(2012) J.J. Ott et al.   VACCINE

In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells

(2012) Scott G. Kitchen et al.   PLoS Pathogens

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Prevention of HIV-1 Infection with Early Antiretroviral Therapy

(2011) Myron S. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-Term Renal Allograft Survival in the United States: A Critical Reappraisal

(2010) K. E. Lamb et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HIV Infection, Inflammation, Immunosenescence, and Aging

(2010) Steven G. Deeks   Annual Review of Medicine

The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: Results of a twelve-month, multicenter, exploratory, phase IIb, randomized, double-blind, placebo-controlled trial

(2010) J. T. Merrill et al.   ARTHRITIS AND RHEUMATISM

Targeting lymphocyte co-stimulation: From bench to bedside

(2010) Nathan J. Felix et al.   AUTOIMMUNITY

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Immune Evasion and Counteraction of Restriction Factors by HIV-1 and Other Primate Lentiviruses

(2010) Frank Kirchhoff   Cell Host & Microbe

T Cells Engineered with a Cytomegalovirus-Specific Chimeric Immunoreceptor

(2010) F. Full et al.   JOURNAL OF VIROLOGY

Antiretroviral therapy and management of HIV infection

(2010) Paul A Volberding et al.   LANCET

Rejection of the Kidney Allograft

(2010) Brian J. Nankivell et al.   NEW ENGLAND JOURNAL OF MEDICINE

International Consensus Guidelines on the Management of Cytomegalovirus in Solid Organ Transplantation

(2010) Camille N. Kotton et al.   TRANSPLANTATION

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Activating systemic autoimmunity: B's, T's, and tolls

(2009) Mark J Shlomchik   CURRENT OPINION IN IMMUNOLOGY

Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

(2009) Eran Elinav et al.   GASTROENTEROLOGY

Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells

(2009) Hélène Bour-Jordan et al.   IMMUNOLOGICAL REVIEWS

Cell-to-cell HIV-1 spread and its implications for immune evasion

(2009) Nicola Martin et al.   Current Opinion in HIV and AIDS

Long-term management of immunosuppression after pediatric liver transplantation: is minimization or withdrawal desirable or possible or both?

(2008) Sandy Feng   Current Opinion in Organ Transplantation

T Cells Redirected Against Hepatitis B Virus Surface Proteins Eliminate Infected Hepatocytes

(2008) Felix Bohne et al.   GASTROENTEROLOGY

CTLA4Ig treatment in patients with multiple sclerosis: An open-label, phase 1 clinical trial

(2008) V. Viglietta et al.   NEUROLOGY