B cells in the pathophysiology of myasthenia gravis

Myasthenia gravis: An emerging toxicity of immune checkpoint inhibitors

(2017) D. Makarious et al.   EUROPEAN JOURNAL OF CANCER

Multiple antibody detection in ‘seronegative’ myasthenia gravis patients

(2017) Y. Hong et al.   EUROPEAN JOURNAL OF NEUROLOGY

IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients

(2017) Inga Koneczny et al.   JOURNAL OF AUTOIMMUNITY

Dysregulation of B Cell Repertoire Formation in Myasthenia Gravis Patients Revealed through Deep Sequencing

(2017) Jason A. Vander Heiden et al.   JOURNAL OF IMMUNOLOGY

Myasthenia triggered by immune checkpoint inhibitors: New case and literature review

(2017) Natalia L. Gonzalez et al.   NEUROMUSCULAR DISORDERS

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Durability of the Rituximab Response in Acetylcholine Receptor Autoantibody–Positive Myasthenia Gravis

(2017) Kimberly R. Robeson et al.   JAMA Neurology

B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity

(2017) John S. Yi et al.   Frontiers in Neurology

Roles of collagen Q in MuSK antibody-positive myasthenia gravis

(2016) Kinji Ohno et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neurologic complications of immune checkpoint inhibitors

(2016) Andreas F. Hottinger   CURRENT OPINION IN NEUROLOGY

T follicular regulatory cells

(2016) Peter T. Sage et al.   IMMUNOLOGICAL REVIEWS

Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood

(2016) Tâm D. Quách et al.   JOURNAL OF IMMUNOLOGY

Autoreactive T Cells from Patients with Myasthenia Gravis Are Characterized by Elevated IL-17, IFN-γ, and GM-CSF and Diminished IL-10 Production

(2016) Yonghao Cao et al.   JOURNAL OF IMMUNOLOGY

Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients

(2016) Nele Claes et al.   JOURNAL OF IMMUNOLOGY

Augmentation of Circulating Follicular Helper T Cells and Their Impact on Autoreactive B Cells in Myasthenia Gravis

(2016) Cun-Jin Zhang et al.   JOURNAL OF IMMUNOLOGY

Titin antibodies in “seronegative” myasthenia gravis — A new role for an old antigen

(2016) C. Stergiou et al.   JOURNAL OF NEUROIMMUNOLOGY

Impaired regulatory B cells in myasthenia gravis

(2016) Jian Rong Sheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study

(2016) Scott Antonia et al.   LANCET ONCOLOGY

Exacerbation of myasthenia gravis in a patient with melanoma treated with pembrolizumab

(2016) K. H. Vincent Lau et al.   MUSCLE & NERVE

Epidemiology of myasthenia gravis in Northern Portugal: Frequency estimates and clinical epidemiological distribution of cases

(2016) Ernestina Santos et al.   MUSCLE & NERVE

Myasthenia gravis — autoantibody characteristics and their implications for therapy

(2016) Nils Erik Gilhus et al.   Nature Reviews Neurology

A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland

(2016) Stela Lefter et al.   NEUROLOGY

Imbalance of circulating CD4 + CXCR5 + FOXP3 + Tfr-like cells and CD4 + CXCR5 + FOXP3 − Tfh-like cells in myasthenia gravis

(2016) Yanbin Wen et al.   NEUROSCIENCE LETTERS

Myasthenia Gravis

(2016) Nils E. Gilhus   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Trial of Thymectomy in Myasthenia Gravis

(2016) Gil I. Wolfe et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Seronegative Myasthenia Gravis—A Vanishing Disorder?

(2016) Henry J. Kaminski   JAMA Neurology

Clinical Characteristics of Patients With Double-Seronegative Myasthenia Gravis and Antibodies to Cortactin

(2016) Elena Cortés-Vicente et al.   JAMA Neurology

Increased frequency of thymic T follicular helper cells in myasthenia gravis patients with thymoma

(2016) Yang Song et al.   Journal of Thoracic Disease

Ectopic Lymphoid Structures: Powerhouse of Autoimmunity

(2016) Elisa Corsiero et al.   Frontiers in Immunology

Compromised fidelity of B-cell tolerance checkpoints in AChR and MuSK myasthenia gravis

(2016) Jae-Yun Lee et al.   Annals of Clinical and Translational Neurology

Complicating autoimmune diseases in myasthenia gravis: a review

(2015) Aliona Nacu et al.   AUTOIMMUNITY

IL-17-producing CD4+T cells contribute to the loss of B-cell tolerance in experimental autoimmune myasthenia gravis

(2015) Hanne Schaffert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory B Cells: Origin, Phenotype, and Function

(2015) Elizabeth C. Rosser et al.   IMMUNITY

T follicular helper cells, T follicular regulatory cells and autoimmunity

(2015) Yangyang Zhu et al.   INTERNATIONAL IMMUNOLOGY

Regulatory B10 cell development and function: Fig. 1.

(2015) Jacquelyn M. Lykken et al.   INTERNATIONAL IMMUNOLOGY

Rituximab does not reset defective early B cell tolerance checkpoints

(2015) Nicolas Chamberlain et al.   JOURNAL OF CLINICAL INVESTIGATION

Myasthenia Gravis Induced by Ipilimumab in Patients With Metastatic Melanoma

(2015) Douglas B. Johnson et al.   JOURNAL OF CLINICAL ONCOLOGY

B10 Cells: A Functionally Defined Regulatory B Cell Subset

(2015) Thomas F. Tedder   JOURNAL OF IMMUNOLOGY

IL-10 derived from CD1dhiCD5+ B cells regulates experimental autoimmune myasthenia gravis

(2015) Jian Rong Sheng et al.   JOURNAL OF NEUROIMMUNOLOGY

Myasthenia gravis: a clinical-immunological update

(2015) Sophie Binks et al.   JOURNAL OF NEUROLOGY

Collagen Q – A potential target for autoantibodies in myasthenia gravis

(2015) Marta Zoltowska Katarzyna et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Myasthenia gravis: subgroup classification and therapeutic strategies

(2015) Nils Erik Gilhus et al.   LANCET NEUROLOGY

Myasthenia gravis associated with ipilimumab and nivolumab in the treatment of small cell lung cancer

(2015) Aaron I. Loochtan et al.   MUSCLE & NERVE

Differential Cytokine Changes in Patients with Myasthenia Gravis with Antibodies against AChR and MuSK

(2015) Vuslat Yilmaz et al.   PLoS One

A Genome-Wide Association Study of Myasthenia Gravis

(2015) Alan E. Renton et al.   JAMA Neurology

Cortactin autoantibodies in myasthenia gravis

(2014) Eduard Gallardo et al.   AUTOIMMUNITY REVIEWS

Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor

(2014) Kathleen Vrolix et al.   JOURNAL OF AUTOIMMUNITY

Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis

(2014) J.S. Yi et al.   JOURNAL OF AUTOIMMUNITY

Both Treg cells and Tconv cells are defective in the Myasthenia gravis thymus: Roles of IL-17 and TNF-α

(2014) Angeline Gradolatto et al.   JOURNAL OF AUTOIMMUNITY

Diagnostic and clinical classification of autoimmune myasthenia gravis

(2014) Sonia Berrih-Aknin et al.   JOURNAL OF AUTOIMMUNITY

Myasthenia gravis: A comprehensive review of immune dysregulation and etiological mechanisms

(2014) Sonia Berrih-Aknin et al.   JOURNAL OF AUTOIMMUNITY

Intrathymic Tfh/B Cells Interaction Leads to Ectopic GCs Formation and Anti-AChR Antibody Production: Central Role in Triggering MG Occurrence

(2014) Xiaoyan Zhang et al.   MOLECULAR NEUROBIOLOGY

Anti-agrin autoantibodies in myasthenia gravis

(2014) C. Gasperi et al.   NEUROLOGY

Autoantibodies to Agrin in Myasthenia Gravis Patients

(2014) Bin Zhang et al.   PLoS One

Phenotype and functions of memory Tfh cells in human blood

(2014) Nathalie Schmitt et al.   TRENDS IN IMMUNOLOGY

The different roles of the thymus in the pathogenesis of the various myasthenia gravis subtypes

(2013) Alexander Marx et al.   AUTOIMMUNITY REVIEWS

Antibodies to clustered acetylcholine receptor: expanding the phenotype

(2013) P. Devic et al.   EUROPEAN JOURNAL OF NEUROLOGY

Human T follicular helper (Tfh) cells and disease

(2013) Cindy S Ma et al.   IMMUNOLOGY AND CELL BIOLOGY

IgG4 production is confined to human IL-10–producing regulatory B cells that suppress antigen-specific immune responses

(2013) Willem van de Veen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of muscle-specific tyrosine kinase (MuSK) and mystery of MuSK myasthenia gravis

(2013) Inga Koneczny et al.   JOURNAL OF ANATOMY

Genetic basis of myasthenia gravis – A comprehensive review

(2013) Nili Avidan et al.   JOURNAL OF AUTOIMMUNITY

Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis

(2013) Chengyong Shen et al.   JOURNAL OF CLINICAL INVESTIGATION

Disturbed B cell subpopulations and increased plasma cells in myasthenia gravis patients

(2013) Siegfried Kohler et al.   JOURNAL OF NEUROIMMUNOLOGY

Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis

(2013) Chuanming Luo et al.   JOURNAL OF NEUROIMMUNOLOGY

RNA interference targeting Bcl-6 ameliorates experimental autoimmune myasthenia gravis in mice

(2013) Ning Xin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Interleukin-10 producing-B cells and their association with responsiveness to rituximab in myasthenia gravis

(2013) Feng Sun et al.   MUSCLE & NERVE

MuSK Myasthenia Gravis IgG4 Disrupts the Interaction of LRP4 with MuSK but Both IgG4 and IgG1-3 Can Disperse Preformed Agrin-Independent AChR Clusters

(2013) Inga Koneczny et al.   PLoS One

Plasmablasts as Migratory IgG-Producing Cells in the Pathogenesis of Neuromyelitis Optica

(2013) Norio Chihara et al.   PLoS One

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

Risk for myasthenia gravis maps to a151Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08

(2012) Peter K. Gregersen et al.   ANNALS OF NEUROLOGY

Presence and Pathogenic Relevance of Antibodies to Clustered Acetylcholine Receptor in Ocular and Generalized Myasthenia Gravis

(2012) Saiju Jacob et al.   ARCHIVES OF NEUROLOGY

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

(2012) Rinse Klooster et al.   BRAIN

Specific binding of collagen Q to the neuromuscular junction is exploited to cure congenital myasthenia and to explore bases of myasthenia gravis

(2012) Kinji Ohno et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Impaired regulatory function in circulating CD4+CD25highCD127low/− T cells in patients with myasthenia gravis

(2012) Muthusamy Thiruppathi et al.   CLINICAL IMMUNOLOGY

Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

(2012) Stuart Viegas et al.   EXPERIMENTAL NEUROLOGY

Changes of Treg-Associated Molecules on CD4+CD25+Treg Cells in Myasthenia Gravis and Effects of Immunosuppressants

(2012) Wen-Hua Xu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

IL-10-Producing Regulatory B Cells in the Pathogenesis of Chronic Hepatitis B Virus Infection

(2012) A. Das et al.   JOURNAL OF IMMUNOLOGY

Long-lasting treatment effect of rituximab in MuSK myasthenia

(2012) J. Diaz-Manera et al.   NEUROLOGY

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemiology of myasthenia gravis in Austria: rising prevalence in an ageing society

(2012) Hakan Cetin et al.   WIENER KLINISCHE WOCHENSCHRIFT

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

(2011) John S. Tzartos   ARCHIVES OF NEUROLOGY

Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice

(2011) Anna Rostedt Punga et al.   EXPERIMENTAL NEUROLOGY

The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function through Interleukin-10 Production

(2011) Masanori Matsumoto et al.   IMMUNITY

Twin studies in autoimmune disease: Genetics, gender and environment

(2011) Dimitrios P. Bogdanos et al.   JOURNAL OF AUTOIMMUNITY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis

(2011) Fredrik Romi et al.   JOURNAL OF NEUROLOGY

Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis

(2011) Alexandra Pevzner et al.   JOURNAL OF NEUROLOGY

Autosome-wide Copy Number Variation Association Analysis for Rheumatoid Arthritis Using the WTCCC High-density SNP Genotype Data

(2011) MOHAMMED UDDIN et al.   JOURNAL OF RHEUMATOLOGY

Anti-musk antibody myasthenia gravis: Clinical findings and response to treatment in two large cohorts

(2011) Jeffrey T. Guptill et al.   MUSCLE & NERVE

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab

(2011) H. L. Pellkofer et al.   NEUROLOGY

Interleukin 6 signaling promotes anti-aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica

(2011) Norio Chihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Utilizing Twins Concordance Rates to Infer the Predisposition to Myasthenia Gravis

(2011) Ryan Ramanujam et al.   Twin Research and Human Genetics

Response of patients with refractory myasthenia gravis to rituximab: a retrospective study

(2011) Richard J. Nowak et al.   Therapeutic Advances in Neurological Disorders

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis

(2010) Osamu Higuchi et al.   ANNALS OF NEUROLOGY

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

Ectopic GC in the thymus of myasthenia gravis patients show characteristics of normal GC

(2010) Neta S. Zuckerman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Clinical implication of peripheral CD4+CD25+ regulatory T cells and Th17 cells in myasthenia gravis patients

(2010) Masayuki Masuda et al.   JOURNAL OF NEUROIMMUNOLOGY

Undiminished regulatory T cells in the thymus of patients with myasthenia gravis

(2010) N. Matsui et al.   NEUROLOGY

Current status on B-cell depletion therapy in autoimmune diseases other than rheumatoid arthritis

(2009) Thomas Dörner et al.   AUTOIMMUNITY REVIEWS

T-bet deficiency decreases susceptibility to experimental myasthenia gravis

(2009) Ruolan Liu et al.   EXPERIMENTAL NEUROLOGY

Rituximab in the management of refractory myasthenia gravis

(2009) Nazlee Zebardast et al.   MUSCLE & NERVE

Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire

(2009) J. Glanville et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic Lymphoid Structures Support Ongoing Production of Class-Switched Autoantibodies in Rheumatoid Synovium

(2009) Frances Humby et al.   PLOS MEDICINE

IgG1 antibodies to acetylcholine receptors in ‘seronegative’ myasthenia gravis†

(2008) Maria Isabel Leite et al.   BRAIN

B-cell tolerance checkpoints in health and autoimmunity

(2008) Eric Meffre et al.   CURRENT OPINION IN IMMUNOLOGY

Successful treatment of refractory generalized myasthenia gravis with rituximab

(2008) C. Lebrun et al.   EUROPEAN JOURNAL OF NEUROLOGY

Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1

(2008) E.H. Niks et al.   JOURNAL OF NEUROIMMUNOLOGY

Sustained response to Rituximab in anti-AChR and anti-MuSK positive Myasthenia Gravis patients

(2008) Isabel Illa et al.   JOURNAL OF NEUROIMMUNOLOGY

The myasthenia gravis thymus: A rare source of human autoantibody-secreting plasma cells for testing potential therapeutics

(2008) Marguerite E. Hill et al.   JOURNAL OF NEUROIMMUNOLOGY

Decrease of CD4+CD25highFoxp3+ regulatory T cells and elevation of CD19+BAFF-R+ B cells and soluble ICAM-1 in myasthenia gravis

(2007) Xiang Li et al.   CLINICAL IMMUNOLOGY