Epistasis and immunity: the role of genetic interactions in autoimmune diseases

Ligation of Cytotoxic T Lymphocyte Antigen-4 to T Cell Receptor Inhibits T Cell Activation and Directs Differentiation into Foxp3+Regulatory T Cells

(2012) Jozsef Karman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)

(2012) Nathali Kaushansky et al.   Journal of Neuroinflammation

Skin Lesions in a Boy With X-linked Lymphoproliferative Disorder: Comparison of 5 SH2D1A Deletion Cases

(2012) E. Mejstrikova et al.   PEDIATRICS

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis

(2012) M. C. Castano Betancourt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Association Study Identified AFF1 as a Susceptibility Locus for Systemic Lupus Eyrthematosus in Japanese

(2012) Yukinori Okada et al.   PLoS Genetics

Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci

(2011) Nikolaos A. Patsopoulos et al.   ANNALS OF NEUROLOGY

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Presumptive role of 129 strain-derivedSle16locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background

(2011) Aya Sato-Hayashizaki et al.   ARTHRITIS AND RHEUMATISM

Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus

(2011) Travis Hughes et al.   ARTHRITIS AND RHEUMATISM

Between Candidate Genes and Whole Genomes: Time for Alternative Approaches in Blood Pressure Genetics

(2011) Jacob Basson et al.   CURRENT HYPERTENSION REPORTS

Epistasis: The key to understanding immunological disease?

(2011) N. Avrion Mitchison et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Susceptibility loci for the defective foreign protein-induced tolerance in New Zealand Black mice: Implication of epistatic effects of Fcgr2b and Slam family genes

(2011) Takuma Fujii et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A knowledge-driven interaction analysis reveals potential neurodegenerative mechanism of multiple sclerosis susceptibility

(2011) W S Bush et al.   GENES AND IMMUNITY

Genome-wide association study of severity in multiple sclerosis

(2011)   GENES AND IMMUNITY

The MHC, disease and selection

(2011) John Trowsdale   IMMUNOLOGY LETTERS

Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: Studies using HLA transgenic mice

(2011) David Luckey et al.   JOURNAL OF AUTOIMMUNITY

Initial impact of the sequencing of the human genome

(2011) Eric S. Lander   NATURE

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

Molecular mechanisms of epistasis within and between genes

(2011) Ben Lehner   TRENDS IN GENETICS

Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data

(2011) Joanne H Wang et al.   Genome Medicine

Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene

(2010) Eveliina Jakkula et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Using Biological Knowledge to Uncover the Mystery in the Search for Epistasis in Genome-Wide Association Studies

(2010) Marylyn D. Ritchie   ANNALS OF HUMAN GENETICS

Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis

(2010) Sergio E. Baranzini et al.   BRAIN

Genetic Heterogeneity in Human Disease

(2010) Jon McClellan et al.   CELL

The role of SLAM/CD2 polymorphisms in systemic autoimmunity

(2010) Andrew Wang et al.   CURRENT OPINION IN IMMUNOLOGY

Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis

(2010) Rajpreet K. Arora-Singh et al.   JOURNAL OF AUTOIMMUNITY

Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis

(2010) Sandra Nischwitz et al.   JOURNAL OF NEUROIMMUNOLOGY

Epistasis between HLA-DRB1 parental alleles in a Spanish cohort with multiple sclerosis

(2010) Lucía Romero-Pinel et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

(2010) Serena Sanna et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Missing heritability and strategies for finding the underlying causes of complex disease

(2010) Evan E. Eichler et al.   NATURE REVIEWS GENETICS

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis

(2010) Michael P. Pender   NEUROSCIENTIST

On epistasis: why it is unimportant in polygenic directional selection

(2010) J. F. Crow   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genotype to Phenotype: A Complex Problem

(2010) R. D. Dowell et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

(2010) Wanling Yang et al.   PLoS Genetics

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Copy number variation of Fc gamma receptor genes and disease predisposition

(2009) M. Fanciulli et al.   CYTOGENETIC AND GENOME RESEARCH

Epigenetic Inheritance and the Missing Heritability Problem

(2009) M. Slatkin   GENETICS

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

The extensive polymorphism of KIR genes

(2009) Derek Middleton et al.   IMMUNOLOGY

Influence of HLA-DRB1 alleles on the susceptibility and resistance to multiple sclerosis in Japanese patients with respect to anti-aquaporin 4 antibody status

(2009) N. Isobe et al.   Multiple Sclerosis Journal

Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia

(2009) Jing-Shan Wu et al.   Multiple Sclerosis Journal

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20

(2009) Melanie Bahlo et al.   NATURE GENETICS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Genomewide Association Studies — Illuminating Biologic Pathways

(2009) Joel N. Hirschhorn   NEW ENGLAND JOURNAL OF MEDICINE

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility

(2009) M. R. Lincoln et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Interactions Between Transcription Factors Cause Natural Variation in Yeast

(2009) J. Gerke et al.   SCIENCE

Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis

(2008) Sergio E. Baranzini et al.   HUMAN MOLECULAR GENETICS

Human MHC architecture and evolution: implications for disease association studies

(2008) J. A. Traherne   International Journal of Immunogenetics

A HapMap harvest of insights into the genetics of common disease

(2008) Teri A. Manolio et al.   JOURNAL OF CLINICAL INVESTIGATION

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms

(2008) Manuel Comabella et al.   PLoS One

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility

(2008) M. J. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits

(2008) William G. Hill et al.   PLoS Genetics