T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
T Cell-Mediated Beta Cell Destruction: Autoimmunity and Alloimmunity in the Context of Type 1 Diabetes
Authors
Keywords
-
Journal
Frontiers in Endocrinology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-12-05
DOI
10.3389/fendo.2017.00343
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- An insulin-IAPP hybrid peptide is an endogenous antigen for CD4 T cells in the non-obese diabetic mouse
- (2017) Timothy A. Wiles et al. JOURNAL OF AUTOIMMUNITY
- Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes
- (2017) Maria J L Kracht et al. NATURE MEDICINE
- Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes
- (2017) Yoko Mullen PANCREAS
- Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy
- (2017) Howard R. Seay et al. Molecular Therapy-Methods & Clinical Development
- Detection of vasostatin-1-specific CD8+T cells in non-obese diabetic mice that contribute to diabetes pathogenesis
- (2016) E. Nikoopour et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Direct and indirect allograft recognition
- (2016) Christine M. Lin et al. Current Opinion in Organ Transplantation
- Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes
- (2016) Christine Bender et al. DIABETES
- Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes
- (2016) Kerry A. McLaughlin et al. DIABETES
- Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes
- (2016) Aaron W. Michels et al. DIABETES
- Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves
- (2016) Thomas O. Mundinger et al. DIABETES
- National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
- (2016) Camillo Ricordi et al. DIABETES
- Pancreatic Endoderm-Derived From Diabetic Patient-Specific Induced Pluripotent Stem Cell Generates Glucose-Responsive Insulin-Secreting Cells
- (2016) Bahareh Rajaei et al. JOURNAL OF CELLULAR PHYSIOLOGY
- A multiplex assay combining insulin, GAD, IA-2 and transglutaminase autoantibodies to facilitate screening for pre-type 1 diabetes and celiac disease
- (2016) Zhiyuan Zhao et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Memory CD4 T Cells Induce Antibody-Mediated Rejection of Renal Allografts
- (2016) V. Gorbacheva et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Genetic risk factors for type 1 diabetes
- (2016) Flemming Pociot et al. LANCET
- Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
- (2016) Jenny Aurielle B Babon et al. NATURE MEDICINE
- Clinical pancreatic islet transplantation
- (2016) A. M. James Shapiro et al. Nature Reviews Endocrinology
- Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion
- (2016) T. Delong et al. SCIENCE
- Characterization of immune response to novel HLA-A2-restricted epitopes from zinc transporter 8 in type 1 diabetes
- (2016) Xinyu Xu et al. VACCINE
- The Limits of Linked Suppression for Regulatory T Cells
- (2016) Toshiro Ito et al. Frontiers in Immunology
- Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes
- (2016) John A. Olsen et al. PLoS One
- Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection
- (2015) Shusen Wang et al. CELL TRANSPLANTATION
- Characterization of the autoimmune response against the nerve tissue S100β in patients with type 1 diabetes
- (2015) I. Gómez-Touriño et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Preventative role of interleukin-17 producing regulatory T helper type 17 (Treg17) cells in type 1 diabetes in non-obese diabetic mice
- (2015) S. M. Bellemore et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- Lessons From Pancreas Transplantation in Type 1 Diabetes: Recurrence of Islet Autoimmunity
- (2015) George W. Burke et al. Current Diabetes Reports
- Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes
- (2015) Lindsey E. Padgett et al. DIABETES
- Preexisting Insulin Autoantibodies Predict Efficacy of Otelixizumab in Preserving Residual β-Cell Function in Recent-Onset Type 1 Diabetes
- (2015) Simke Demeester et al. DIABETES CARE
- Mouse pancreatic beta cells express MHC class II and stimulate CD4+T cells to proliferate
- (2015) Yuxing Zhao et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection
- (2015) M M El Khatib et al. GENE THERAPY
- Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice
- (2015) Gayatri Mukherjee et al. IMMUNOLOGY
- Perforin facilitates beta cell killing and regulates autoreactive CD8+ T-cell responses to antigen in mouse models of type 1 diabetes
- (2015) Prerak Trivedi et al. IMMUNOLOGY AND CELL BIOLOGY
- Heterogeneity and Lobularity of Pancreatic Pathology in Type 1 Diabetes during the Prediabetic Phase
- (2015) Teresa Rodriguez-Calvo et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Therapeutic Regulatory T Cells Subvert Effector T Cell Function in Inflamed Islets To Halt Autoimmune Diabetes
- (2015) Ashley E. Mahne et al. JOURNAL OF IMMUNOLOGY
- The T Cell Repertoire–Diversifying Enzyme TSSP Contributes to Thymic Selection of Diabetogenic CD4 T Cell Specificities Reactive to ChgA and IAPP Autoantigens
- (2015) Christophe Viret et al. JOURNAL OF IMMUNOLOGY
- Thinking bedside at the bench: the NOD mouse model of T1DM
- (2015) James C. Reed et al. Nature Reviews Endocrinology
- N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes
- (2015) Niyun Jin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Type 1 diabetes immunotherapy using polyclonal regulatory T cells
- (2015) Jeffrey A. Bluestone et al. Science Translational Medicine
- Circulating Donor-Specific Anti–Human Leukocyte Antigen Antibodies and Complement C4d Deposition Are Associated With the Development of Cardiac Allograft Vasculopathy
- (2014) Renee Frank et al. AMERICAN JOURNAL OF CLINICAL PATHOLOGY
- Endogenous Memory CD8 T Cells Directly Mediate Cardiac Allograft Rejection
- (2014) C. A. Su et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Generation of Functional Human Pancreatic β Cells In Vitro
- (2014) Felicia W. Pagliuca et al. CELL
- Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up
- (2014) Natalia Marek-Trzonkowska et al. CLINICAL IMMUNOLOGY
- Stem Cell Therapies in the Management of Diabetic Retinopathy
- (2014) Roly Megaw et al. Current Diabetes Reports
- ZnT8-Reactive T Cells Are Weakly Pathogenic in NOD Mice but Can Participate in Diabetes Under Inflammatory Conditions
- (2014) D. K. Nayak et al. DIABETES
- Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes
- (2014) Teresa Rodriguez-Calvo et al. DIABETES
- Loss of NADPH Oxidase–Derived Superoxide Skews Macrophage Phenotypes to Delay Type 1 Diabetes
- (2014) Lindsey E. Padgett et al. DIABETES
- Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes
- (2014) Vimukthi Pathiraja et al. DIABETES
- A Minor Subset of Batf3-Dependent Antigen-Presenting Cells in Islets of Langerhans Is Essential for the Development of Autoimmune Diabetes
- (2014) Stephen T. Ferris et al. IMMUNITY
- Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse
- (2014) Hyun-Ja Ko et al. IMMUNOLOGY AND CELL BIOLOGY
- CD8 T-cell reactivity to islet antigens is unique to type 1 while CD4 T-cell reactivity exists in both type 1 and type 2 diabetes
- (2014) Ghanashyam Sarikonda et al. JOURNAL OF AUTOIMMUNITY
- IFN- -Dependent Regulatory Circuits in Immune Inflammation Highlighted in Diabetes
- (2014) B. Calderon et al. JOURNAL OF IMMUNOLOGY
- Diabetic kidney disease: from physiology to therapeutics
- (2014) Carmen Mora-Fernández et al. JOURNAL OF PHYSIOLOGY-LONDON
- Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
- (2014) Alireza Rezania et al. NATURE BIOTECHNOLOGY
- Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes
- (2014) J. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Biologic Agents in Islet Transplantation
- (2013) Boris Gala-Lopez et al. Current Diabetes Reports
- -Cell-Specific IL-2 Therapy Increases Islet Foxp3+Treg and Suppresses Type 1 Diabetes in NOD Mice
- (2013) M. C. Johnson et al. DIABETES
- Chromogranin A is a T cell antigen in human type 1 diabetes
- (2013) Peter A. Gottlieb et al. JOURNAL OF AUTOIMMUNITY
- Cutting Edge: Type 1 Diabetes Occurs despite Robust Anergy among Endogenous Insulin-Specific CD4 T Cells in NOD Mice
- (2013) K. E. Pauken et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: CD4 T Cells Reactive to an Islet Amyloid Polypeptide Peptide Accumulate in the Pancreas and Contribute to Disease Pathogenesis in Nonobese Diabetic Mice
- (2013) R. L. Baker et al. JOURNAL OF IMMUNOLOGY
- Type 1 diabetes
- (2013) Mark A Atkinson et al. LANCET
- Plasmid-Encoded Proinsulin Preserves C-Peptide While Specifically Reducing Proinsulin-Specific CD8+ T Cells in Type 1 Diabetes
- (2013) B. O. Roep et al. Science Translational Medicine
- Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?
- (2013) P. Marrack et al. Cold Spring Harbor Perspectives in Medicine
- The Pathogenesis and Natural History of Type 1 Diabetes
- (2013) M. A. Atkinson Cold Spring Harbor Perspectives in Medicine
- Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes
- (2013) M. Pietropaolo et al. Cold Spring Harbor Perspectives in Medicine
- Antigen Targets of Type 1 Diabetes Autoimmunity
- (2013) B. O. Roep et al. Cold Spring Harbor Perspectives in Medicine
- Trends in immunosuppression after pancreas transplantation
- (2012) Michael Kimelman et al. Current Opinion in Organ Transplantation
- ZnT8 Is a Major CD8+ T Cell-Recognized Autoantigen in Pediatric Type 1 Diabetes
- (2012) E. Enee et al. DIABETES
- Administration of CD4+CD25highCD127- Regulatory T Cells Preserves -Cell Function in Type 1 Diabetes in Children
- (2012) N. Marek-Trzonkowska et al. DIABETES CARE
- Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading
- (2012) Suchitra Prasad et al. JOURNAL OF AUTOIMMUNITY
- Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients
- (2012) Ken T. Coppieters et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Recurrence of Type 1 Diabetes After Simultaneous Pancreas-Kidney Transplantation in the Absence of GAD and IA-2 Autoantibodies
- (2011) M. Assalino et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Recurrence of Autoimmunity Following Pancreas Transplantation
- (2011) George W. Burke et al. Current Diabetes Reports
- Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
- (2011) T. C. Thayer et al. DIABETES
- Peripheral and Islet Interleukin-17 Pathway Activation Characterizes Human Autoimmune Diabetes and Promotes Cytokine-Mediated -Cell Death
- (2011) S. Arif et al. DIABETES
- Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4+ T Cells
- (2011) T. Delong et al. DIABETES
- Expression and Regulation of Chemokines in Murine and Human Type 1 Diabetes
- (2011) S. A. Sarkar et al. DIABETES
- Protection From Retinopathy and Other Complications in Patients With Type 1 Diabetes of Extreme Duration: The Joslin 50-Year Medalist Study
- (2011) J. K. Sun et al. DIABETES CARE
- Mapping of conformational autoantibody epitopes in ZNT8
- (2011) Janet M. Wenzlau et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Multiple antigens versus single major antigen in type 1 diabetes: arguing for multiple antigens
- (2011) Teresa P. DiLorenzo DIABETES-METABOLISM RESEARCH AND REVIEWS
- Human Type 1 Diabetes Is Associated with T Cell Autoimmunity to Zinc Transporter 8
- (2011) M. Dang et al. JOURNAL OF IMMUNOLOGY
- Pancreatic Islets Engineered with SA-FasL Protein Establish Robust Localized Tolerance by Inducing Regulatory T Cells in Mice
- (2011) E. S. Yolcu et al. JOURNAL OF IMMUNOLOGY
- Arthritogenic Self-Reactive CD4+ T Cells Acquire an FR4hiCD73hi Anergic State in the Presence of Foxp3+ Regulatory T Cells
- (2011) R. J. Martinez et al. JOURNAL OF IMMUNOLOGY
- Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade
- (2011) I. R. Ferrer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of cell death in diabetes using differentially methylated circulating DNA
- (2011) E. M. Akirav et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
- (2011) Jing Chen et al. Jove-Journal of Visualized Experiments
- Residual Insulin Production and Pancreatic -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
- (2010) H. A. Keenan et al. DIABETES
- Kinetics of the Post-Onset Decline in Zinc Transporter 8 Autoantibodies in Type 1 Diabetic Human Subjects
- (2010) J. M. Wenzlau et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients
- (2010) Jason L. Gaglia et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
- (2010) Yenkel Grinberg-Bleyer et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chromogranin A is an autoantigen in type 1 diabetes
- (2010) Brian D Stadinski et al. NATURE IMMUNOLOGY
- Diabetic cardiomyopathy, causes and effects
- (2010) Sihem Boudina et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Preferential Priming of Alloreactive T Cells with Indirect Reactivity
- (2009) T. V. Brennan et al. AMERICAN JOURNAL OF TRANSPLANTATION
- Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity
- (2009) Béatrice Regnault et al. BMC Medical Genomics
- Noninvasive assessment of pancreatic β-cell function in vivo with manganese-enhanced magnetic resonance imaging
- (2008) Patrick F. Antkowiak et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Insulin as an autoantigen in NOD/human diabetes
- (2008) Li Zhang et al. CURRENT OPINION IN IMMUNOLOGY
- T-Cell Promiscuity in Autoimmune Diabetes
- (2008) L. Li et al. DIABETES
- Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
- (2008) A. L. Putnam et al. DIABETES
- Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction
- (2008) Qizhi Tang et al. IMMUNITY
- CD4+ T cells from type 1 diabetic and healthy subjects exhibit different thresholds of activation to a naturally processed proinsulin epitope
- (2008) Junbao Yang et al. JOURNAL OF AUTOIMMUNITY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started