Metabolic Pathways Involved in Regulatory T Cell Functionality

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

(2019) Frédéric Van Gool et al.   IMMUNITY

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Deptor modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation

(2018) Johannes Wedel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Celastrol mediates Th17 and Treg cell generation via metabolic signaling

(2018) Jiabi Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CD4+ Foxp3+ regulatory T cell-mediated immunomodulation by anti-depressants inhibiting acid sphingomyelinase

(2018) Jürgen Schneider-Schaulies et al.   BIOLOGICAL CHEMISTRY

Regulatory T cells for tolerance

(2018) Kento Kawai et al.   HUMAN IMMUNOLOGY

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

(2018) Saige L. Pompura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Abstracts

(2018)   MOLECULAR GENETICS AND METABOLISM

mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis

(2018) Nicole M. Chapman et al.   Nature Communications

An Autocrine TNFα–Tumor Necrosis Factor Receptor 2 Loop Promotes Epigenetic Effects Inducing Human Treg Stability In Vitro

(2018) Paulo C. M. Urbano et al.   Frontiers in Immunology

Regulatory T Cell Metabolism in the Hepatic Microenvironment

(2018) Rebecca Ellen Wawman et al.   Frontiers in Immunology

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

(2018) Bhavana Priyadharshini et al.   JOURNAL OF IMMUNOLOGY

Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance

(2018) Mounia S. Braza et al.   IMMUNITY

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

Stabilizing human regulatory T cells for tolerance inducing immunotherapy

(2017) Xuehui He et al.   Immunotherapy

Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis

(2017) Laura Negrotto et al.   JOURNAL OF IMMUNOLOGY

The Insulin Receptor Plays a Critical Role in T Cell Function and Adaptive Immunity

(2017) Henrike J. Fischer et al.   JOURNAL OF IMMUNOLOGY

ACTRIMS Forum 2017

(2017)   Multiple Sclerosis Journal

D-mannose induces regulatory T cells and suppresses immunopathology

(2017) Dunfang Zhang et al.   NATURE MEDICINE

Treg therapy in transplantation: a general overview

(2017) Marco Romano et al.   TRANSPLANT INTERNATIONAL

Ndfip1 restricts mTORC1 signalling and glycolysis in regulatory T cells to prevent autoinflammatory disease

(2017) Awo Akosua Kesewa Layman et al.   Nature Communications

ACTRIMS Forum 2017

(2017)   Multiple Sclerosis Journal

The AMP analog AICAR modulates the Treg/Th17 axis through enhancement of fatty acid oxidation

(2016) Guido A. Gualdoni et al.   FASEB JOURNAL

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Immunometabolism and autoimmunity

(2016) Jenny Freitag et al.   IMMUNOLOGY AND CELL BIOLOGY

The Lupus Susceptibility GenePbx1Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation

(2016) Seung-Chul Choi et al.   JOURNAL OF IMMUNOLOGY

A Novel mTORC1-Dependent, Akt-Independent Pathway Differentiates the Gut Tropism of Regulatory and Conventional CD4 T Cells

(2016) Leo C. Chen et al.   JOURNAL OF IMMUNOLOGY

Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism

(2016) Naoyuki Makita et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

(2015) Michel DuPage et al.   IMMUNITY

The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways

(2015) Deepali V. Sawant et al.   IMMUNOLOGY

Controlling the fire - tissue-specific mechanisms of effector regulatory T-cell homing

(2015) Zachary Chow et al.   IMMUNOLOGY AND CELL BIOLOGY

T cell metabolism drives immunity

(2015) Michael D. Buck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

(2015) Veronica De Rosa et al.   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Regulatory T cells: first steps of clinical application in solid organ transplantation

(2015) Jeroen B. van der Net et al.   TRANSPLANT INTERNATIONAL

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions

(2015) Robert Haas et al.   PLOS BIOLOGY

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

(2015) Dorota Klysz et al.   Science Signaling

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

(2015) Seon-Yeong Lee et al.   PLoS One

Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity

(2014) Xudong Li et al.   CELL

The alteration of Th1/Th2/Th17/Treg paradigm in patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy

(2014) Cuiping Zhang et al.   HUMAN IMMUNOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Activation of Gpr109a, Receptor for Niacin and the Commensal Metabolite Butyrate, Suppresses Colonic Inflammation and Carcinogenesis

(2014) Nagendra Singh et al.   IMMUNITY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

(2014) Saul J. Priceman et al.   Cell Reports

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk

(2013) Nana-Maria Wagner et al.   Obesity

Low-Dose Rapamycin Treatment Increases the Ability of Human Regulatory T Cells to Inhibit Transplant ArteriosclerosisIn Vivo

(2012) J. Hester et al.   AMERICAN JOURNAL OF TRANSPLANTATION

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

(2012) Daniela Cipolletta et al.   NATURE

Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa

(2012) E. T. Clambey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Translating tolerogenic therapies to the clinic – where do we stand?

(2012) Fadi Issa et al.   Frontiers in Immunology

Mycophenolic Acid-Mediated Suppression of Human CD4+ T Cells: More Than Mere Guanine Nucleotide Deprivation

(2011) X. He et al.   AMERICAN JOURNAL OF TRANSPLANTATION

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dominant Th2 Differentiation of Human Regulatory T Cells upon Loss of FOXP3 Expression

(2011) L. Hansmann et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

(2010) David Finlay et al.   Annals of the New York Academy of Sciences

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Generation and Accumulation of Immunosuppressive Adenosine by Human CD4+CD25highFOXP3+Regulatory T Cells

(2009) Magis Mandapathil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes

(2009) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The receptor S1P1 overrides regulatory T cell–mediated immune suppression through Akt-mTOR

(2009) Guangwei Liu et al.   NATURE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells

(2008) H. J. P. M. Koenen et al.   BLOOD

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

(2008) Linda V Sinclair et al.   NATURE IMMUNOLOGY