Design and development of therapies using chimeric antigen receptor-expressing T cells
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Title
Design and development of therapies using chimeric antigen receptor-expressing T cells
Authors
Keywords
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Journal
IMMUNOLOGICAL REVIEWS
Volume 257, Issue 1, Pages 107-126
Publisher
Wiley
Online
2013-12-13
DOI
10.1111/imr.12131
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Note: Only part of the references are listed.- Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor
- (2014) S. Wilkie et al. JOURNAL OF IMMUNOLOGY
- Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor
- (2013) Sarah Tettamanti et al. BRITISH JOURNAL OF HAEMATOLOGY
- Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells
- (2013) M. Hudecek et al. CLINICAL CANCER RESEARCH
- Interleukin-15 in Gene Therapy of Cancer
- (2013) Maria C. Ochoa et al. CURRENT GENE THERAPY
- The immunogenicity of virus-derived 2A sequences in immunocompetent individuals
- (2013) C Arber et al. GENE THERAPY
- Chimeric NKG2D CAR-Expressing T Cell-Mediated Attack of Human Ovarian Cancer Is Enhanced by Histone Deacetylase Inhibition
- (2013) De-Gang Song et al. HUMAN GENE THERAPY
- Collapse of the Tumor Stroma is Triggered by IL-12 Induction of Fas
- (2013) Sid P Kerkar et al. MOLECULAR THERAPY
- Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma
- (2013) Sunitha Kakarla et al. MOLECULAR THERAPY
- Persistence and Efficacy of Second Generation CAR T Cell Against the LeY Antigen in Acute Myeloid Leukemia
- (2013) David S. Ritchie et al. MOLECULAR THERAPY
- Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
- (2013) Cor HJ Lamers et al. MOLECULAR THERAPY
- Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
- (2013) Stephan A. Grupp et al. NEW ENGLAND JOURNAL OF MEDICINE
- A review of the treatment options for skin rash induced by EGFR-targeted therapies: Evidence from randomized clinical trials and a metaanalysis
- (2013) Janja Ocvirk et al. Radiology and Oncology
- CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia
- (2013) R. J. Brentjens et al. Science Translational Medicine
- Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy
- (2013) Perry B. Hackett et al. Translational Research
- The Basic Principles of Chimeric Antigen Receptor Design
- (2013) Michel Sadelain et al. Cancer Discovery
- Chimeric Antigen Receptor T Cells with Dissociated Signaling Domains Exhibit Focused Antitumor Activity with Reduced Potential for Toxicity In Vivo
- (2013) E. Lanitis et al. Cancer Immunology Research
- T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans
- (2013) M. V. Maus et al. Cancer Immunology Research
- TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy
- (2013) Zakaria Grada et al. Molecular Therapy-Nucleic Acids
- Memory T Cell Subsets, Migration Patterns, and Tissue Residence
- (2012) Scott N. Mueller et al. Annual Review of Immunology
- Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia
- (2012) W. Haso et al. BLOOD
- Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning
- (2012) H. J. Pegram et al. BLOOD
- CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results
- (2012) B. G. Till et al. BLOOD
- Genetically engineered T cells bearing chimeric nanoconstructed receptors harboring TAG-72-specific camelid single domain antibodies as targeting agents
- (2012) Zahra Sharifzadeh et al. CANCER LETTERS
- Abstract 3500: T cells redirected against HER2 for the adoptive immunotherapy for HER2-positive osteosarcoma
- (2012) Nabil Ahmed et al. CANCER RESEARCH
- A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor
- (2012) K. Urbanska et al. CANCER RESEARCH
- Interleukin 15 Provides Relief to CTLs from Regulatory T Cell-Mediated Inhibition: Implications for Adoptive T Cell-Based Therapies for Lymphoma
- (2012) S. K. Perna et al. CLINICAL CANCER RESEARCH
- Suppression of Human Glioma Xenografts with Second-Generation IL13R-Specific Chimeric Antigen Receptor-Modified T Cells
- (2012) S. Kong et al. CLINICAL CANCER RESEARCH
- Local Delivery of lnterleukin-12 Using T Cells Targeting VEGF Receptor-2 Eradicates Multiple Vascularized Tumors in Mice
- (2012) D. Chinnasamy et al. CLINICAL CANCER RESEARCH
- Redirecting Gene-Modified T Cells toward Various Cancer Types Using Tagged Antibodies
- (2012) K. Tamada et al. CLINICAL CANCER RESEARCH
- Stem-like Tumor-Initiating Cells Isolated from IL13R 2 Expressing Gliomas Are Targeted and Killed by IL13-Zetakine-Redirected T Cells
- (2012) C. E. Brown et al. CLINICAL CANCER RESEARCH
- Gene therapy for primary immunodeficiencies: part 1
- (2012) Marina Cavazzana-Calvo et al. CURRENT OPINION IN IMMUNOLOGY
- Effector memory and central memory NY-ESO-1-specific re-directed T cells for treatment of multiple myeloma
- (2012) P C Schuberth et al. GENE THERAPY
- Recognition of Glioma Stem Cells by Genetically Modified T Cells Targeting EGFRvIII and Development of Adoptive Cell Therapy for Glioma
- (2012) Richard A. Morgan et al. HUMAN GENE THERAPY
- T Cell Affinity Regulates Asymmetric Division, Effector Cell Differentiation, and Tissue Pathology
- (2012) Carolyn G. King et al. IMMUNITY
- Cancer-associated fibroblasts as targets for immunotherapy
- (2012) Sunitha Kakarla et al. Immunotherapy
- Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling
- (2012) Scott Wilkie et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions
- (2012) Kevin J. Curran et al. JOURNAL OF GENE MEDICINE
- Chimeric Antigen Receptor T Cells Shape Myeloid Cell Function within the Tumor Microenvironment through IFN- and GM-CSF
- (2012) P. Spear et al. JOURNAL OF IMMUNOLOGY
- Generation of Polyclonal CMV-specific T Cells for the Adoptive Immunotherapy of Glioblastoma
- (2012) Alexia Ghazi et al. JOURNAL OF IMMUNOTHERAPY
- Efficacy and safety of adoptive immunotherapy using anti-CD19 chimeric antigen receptor transduced T-cells: a systematic review of phase I clinical trials
- (2012) Xiao-Jun Xu et al. LEUKEMIA & LYMPHOMA
- Unknown
- (2012) David Davies et al. MOLECULAR MEDICINE
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- (2012) Adham S Bear et al. MOLECULAR THERAPY
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- (2012) Kevin KH Chow et al. MOLECULAR THERAPY
- Combinatorial antigen recognition with balanced signaling promotes selective tumor eradication by engineered T cells
- (2012) Christopher C Kloss et al. NATURE BIOTECHNOLOGY
- Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer
- (2012) Julie R. Brahmer et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genetic instability: tipping the balance
- (2012) A Janssen et al. ONCOGENE
- Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection
- (2012) Manfred Lehner et al. PLoS One
- IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
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- Peripheral tissue surveillance and residency by memory T cells
- (2012) Thomas Gebhardt et al. TRENDS IN IMMUNOLOGY
- Generation of CD19-chimeric antigen receptor modified CD8+ T cells derived from virus-specific central memory T cells
- (2011) S. Terakura et al. BLOOD
- T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies
- (2011) D. R. Shaffer et al. BLOOD
- B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
- (2011) J. N. Kochenderfer et al. BLOOD
- CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo
- (2011) D.-G. Song et al. BLOOD
- Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma
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- Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
- (2011) R. J. Brentjens et al. BLOOD
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- (2011) G. Huang et al. CANCER RESEARCH
- Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor
- (2011) E. K. Moon et al. CLINICAL CANCER RESEARCH
- Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy
- (2011) S. A. Rosenberg et al. CLINICAL CANCER RESEARCH
- Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy
- (2011) Carlos A Ramos et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells
- (2011) David M. Barrett et al. HUMAN GENE THERAPY
- CD28 costimulation improves expansion and persistence of chimeric antigen receptor–modified T cells in lymphoma patients
- (2011) Barbara Savoldo et al. JOURNAL OF CLINICAL INVESTIGATION
- PiggyBac-mediated Cancer Immunotherapy Using EBV-specific Cytotoxic T-cells Expressing HER2-specific Chimeric Antigen Receptor
- (2011) Yozo Nakazawa et al. MOLECULAR THERAPY
- Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment
- (2011) Ling Zhang et al. MOLECULAR THERAPY
- Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor
- (2011) Evripidis Lanitis et al. MOLECULAR THERAPY
- Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy
- (2011) Antonio Di Stasi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia
- (2011) David L. Porter et al. NEW ENGLAND JOURNAL OF MEDICINE
- T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia
- (2011) M. Kalos et al. Science Translational Medicine
- Engineered Tcells for pancreatic cancer treatment
- (2011) Usha L. Katari et al. HPB
- Antitransgene Rejection Responses Contribute to Attenuated Persistence of Adoptively Transferred CD20/CD19-Specific Chimeric Antigen Receptor Redirected T Cells in Humans
- (2010) Michael C. Jensen et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- A High Molecular Weight Melanoma-Associated Antigen-Specific Chimeric Antigen Receptor Redirects Lymphocytes to Target Human Melanomas
- (2010) W. R. Burns et al. CANCER RESEARCH
- Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor
- (2010) Y. Zhao et al. CANCER RESEARCH
- Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27
- (2010) Mingli Xu et al. Clinical & Developmental Immunology
- HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors
- (2010) N. Ahmed et al. CLINICAL CANCER RESEARCH
- Transiently redirected T cells for adoptive transfer
- (2010) Hilde Almåsbak et al. CYTOTHERAPY
- Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen
- (2010) S Peinert et al. GENE THERAPY
- Selective Expansion of Chimeric Antigen Receptor-targeted T-cells with Potent Effector Function using Interleukin-4
- (2010) Scott Wilkie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice
- (2010) Dhanalakshmi Chinnasamy et al. JOURNAL OF CLINICAL INVESTIGATION
- The Optimal Antigen Response of Chimeric Antigen Receptors Harboring the CD3 Transmembrane Domain Is Dependent upon Incorporation of the Receptor into the Endogenous TCR/CD3 Complex
- (2010) J. S. Bridgeman et al. JOURNAL OF IMMUNOLOGY
- Jekyll and Hyde: the role of the microenvironment on the progression of cancer
- (2010) Michael Allen et al. JOURNAL OF PATHOLOGY
- Engineering CD19-specific T lymphocytes with interleukin-15 and a suicide gene to enhance their anti-lymphoma/leukemia effects and safety
- (2010) V Hoyos et al. LEUKEMIA
- Depicting adoptive immunotherapy for prostate cancer in an animal model with magnetic resonance imaging
- (2010) Reinhard Meier et al. MAGNETIC RESONANCE IN MEDICINE
- T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms
- (2010) Jiali Sun et al. MOLECULAR THERAPY
- Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2
- (2010) Richard A Morgan et al. MOLECULAR THERAPY
- Improved Survival with Ipilimumab in Patients with Metastatic Melanoma
- (2010) F. Stephen Hodi et al. NEW ENGLAND JOURNAL OF MEDICINE
- T lymphocytes coexpressing CCR4 and a chimeric antigen receptor targeting CD30 have improved homing and antitumor activity in a Hodgkin tumor model
- (2009) A. Di Stasi et al. BLOOD
- Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients
- (2009) H. E. Heslop et al. BLOOD
- Cancer immunotherapy: co-stimulatory agonists and co-inhibitory antagonists
- (2009) K. S. Peggs et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- The Prioritization of Cancer Antigens: A National Cancer Institute Pilot Project for the Acceleration of Translational Research
- (2009) M. A. Cheever et al. CLINICAL CANCER RESEARCH
- Trans-presentation: A novel mechanism regulating IL-15 delivery and responses
- (2009) Spencer W. Stonier et al. IMMUNOLOGY LETTERS
- A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity
- (2009) Y. Zhao et al. JOURNAL OF IMMUNOLOGY
- Genetically engineered T cells to target EGFRvIII expressing glioblastoma
- (2009) Szofia S. Bullain et al. JOURNAL OF NEURO-ONCOLOGY
- Immunotherapy for Osteosarcoma: Genetic Modification of T cells Overcomes Low Levels of Tumor Antigen Expression
- (2009) Nabil Ahmed et al. MOLECULAR THERAPY
- Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo
- (2009) Michael C. Milone et al. MOLECULAR THERAPY
- Chimeric Antigen Receptors Combining 4-1BB and CD28 Signaling Domains Augment PI3kinase/AKT/Bcl-XL Activation and CD8+ T Cell–mediated Tumor Eradication
- (2009) Xiao-Song Zhong et al. MOLECULAR THERAPY
- Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
- (2009) C. Carpenito et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Detection of human cytomegalovirus in different histological types of gliomas
- (2008) Michael E. Scheurer et al. ACTA NEUROPATHOLOGICA
- PD-1 and Its Ligands in Tolerance and Immunity
- (2008) Mary E. Keir et al. Annual Review of Immunology
- Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells
- (2008) B. G. Till et al. BLOOD
- Efficacy of IL-2-versusIL-15-stimulated CD8 T cells in adoptive immunotherapy
- (2008) Katja Mueller et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Chimeric NKG2D receptor–expressing T cells as an immunotherapy for multiple myeloma
- (2008) Amorette Barber et al. EXPERIMENTAL HEMATOLOGY
- Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
- (2008) Claude Sportès et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Antitumor Activity of EBV-specific T Lymphocytes Transduced With a Dominant Negative TGF-?? Receptor
- (2008) Aaron E. Foster et al. JOURNAL OF IMMUNOTHERAPY
- Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma
- (2008) Martin A Pule et al. NATURE MEDICINE
- CANCER BIOLOGY: All in the Stroma: Cancer's Cosa Nostra
- (2008) J. Marx SCIENCE
- Tumor-specific immunotherapy targeting the EGFRvIII mutation in patients with malignant glioma
- (2008) John H. Sampson et al. SEMINARS IN IMMUNOLOGY
- Memory T cells in cancer immunotherapy: which CD8+T-cell population provides the best protection against tumours?
- (2008) R. Perret et al. TISSUE ANTIGENS
- Noninvasive detection of therapeutic cytolytic T cells with 18F–FHBG PET in a patient with glioma
- (2008) Shahriar S Yaghoubi et al. Nature clinical practice. Oncology
- Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma
- (2007) Duane A. Mitchell et al. NEURO-ONCOLOGY
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