Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases?

(2013) P. Marrack et al.   Cold Spring Harbor Perspectives in Medicine

Germline TRAV5D-4 T-Cell Receptor Sequence Targets a Primary Insulin Peptide of NOD Mice

(2012) M. Nakayama et al.   DIABETES

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A

(2012) T. Delong et al.   DIABETES

Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading

(2012) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

A novel pathway of presentation by class II-MHC molecules involving peptides or denatured proteins important in autoimmunity

(2012) James F. Mohan et al.   MOLECULAR IMMUNOLOGY

Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice

(2011) Li Zhang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure-Based Selection of Small Molecules To Alter Allele-Specific MHC Class II Antigen Presentation

(2011) A. W. Michels et al.   JOURNAL OF IMMUNOLOGY

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

(2011) F. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The anti-insulin trimolecular complex in type 1 diabetes

(2011) Aaron W Michels et al.   Current Opinion in Endocrinology Diabetes and Obesity

Molecular Targeting of Islet Autoantigens

(2010) Brian Stadinski et al.   IMMUNITY

Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence

(2010) Woelsung Yi et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromogranin A is an autoantigen in type 1 diabetes

(2010) Brian D Stadinski et al.   NATURE IMMUNOLOGY

Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

(2010) James F Mohan et al.   NATURE IMMUNOLOGY

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains

(2009) Li Zhang et al.   JOURNAL OF AUTOIMMUNITY

Insulin2Gene (Ins2) Transcription by NOD Bone Marrow-derived Cells Does Not Influence Autoimmune Diabetes Development in NOD-Ins2Knockout Mice

(2009) A. Martin-Pagola et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Combined insulin B:9-23 self-peptide and polyinosinic–polycytidylic acid accelerate insulitis but inhibit development of diabetes by increasing the proportion of CD4+Foxp3+ regulatory T cells in the islets in non-obese diabetic mice

(2008) Keiko Fukushima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proinsulin peptide immunotherapy in type 1 diabetes: report of a first-in-man Phase I safety study

(2008) S. L. Thrower et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

HLA DR-DQ Haplotypes and Genotypes and Type 1 Diabetes Risk: Analysis of the Type 1 Diabetes Genetics Consortium Families

(2008) H. Erlich et al.   DIABETES

Conserved T cell receptor  -chain induces insulin autoantibodies

(2008) M. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA